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Showing 1–24 of 45 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Colgate Cavity protection toothpaste Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Study to Evaluate the Effect of a Stannous Fluoride Toothpaste on the Oral Microbiome

NCT06048809
View directory record Official record
Conditions
Oral Health
Interventions
Stannous Fluoride Toothpaste (Sensodyne Repair and Protect), Regular Fluoride Toothpaste (Colgate Cavity Protection)
Other
Lead sponsor
HALEON
Industry
Eligibility
18 Years to 65 Years
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 9, 2025 · Synced Sep 6, 2026, 6:20 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Gingivitis Reduction After Use of 0.45% Stannous Fluoride Toothpaste

NCT06300866
View directory record Official record
Conditions
Gingivitis, Plaque, Dental
Interventions
Test, Control
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 70 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Mar 7, 2024 · Synced Sep 6, 2026, 6:20 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Study of Virtually Supervised Mouth Rinses and Flossing

NCT05600231
View directory record Official record
Conditions
Healthy
Interventions
LISTERINE COOL MINT Antiseptic Mouthwash, LISTERINE COOL MINT ZERO Alcohol Mouthwash, Reach Unflavored Waxed Dental Floss, Colgate Cavity Protection Toothpaste
Other
Lead sponsor
Johnson & Johnson Consumer Inc. (J&JCI)
Industry
Eligibility
18 Years and older
Enrollment
284 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 17, 2023 · Synced Sep 6, 2026, 6:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Determination of the Oral Irritation Potential of a Fluoride Rinse in Children

NCT06798441
View directory record Official record
Conditions
Healthy
Interventions
Brush Only, Brush / Rinse (Jolly Rancher Prototype), Brush / Rinse (LISTERINE® Total Care Zero Alcohol)
Other
Lead sponsor
Johnson & Johnson Consumer and Personal Products Worldwide
Industry
Eligibility
6 Years to 11 Years
Enrollment
161 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 11, 2025 · Synced Sep 6, 2026, 6:20 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Study to Investigate the Efficacy of an Experimental Dentifrice Containing Stannous Fluoride in Improving Gingival Health

NCT07704905
View directory record Official record
Conditions
Dental Plaque, Gingivitis
Interventions
Test Dentifrice, Reference Dentifrice (Colgate Cavity Protection Dentifrice)
Drug
Lead sponsor
HALEON
Industry
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Sep 6, 2026, 6:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Oral Hygiene and Maternity Outcomes Multicenter Study (OHMOM)

NCT01549587
View directory record Official record
Conditions
Gingivitis, Pregnancy
Interventions
0.243% sodium fluoride, toothbrush, dental floss, 0.454% stannous fluoride, 0.07% Cetylpyridinium chloride
Drug · Device
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older · Female only
Enrollment
746 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
2
States / cities
Birmingham, Alabama • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 20, 2023 · Synced Sep 6, 2026, 6:20 PM EDT
Completed Not applicable Interventional Results available

A Study of the Relief of Tooth Sensitivity of an Experimental Mouthrinse Device

NCT01345292
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Mouthwash, Potassium nitrate toothpaste, Sodium fluoride toothpaste
Device · Drug
Lead sponsor
Johnson & Johnson Consumer and Personal Products Worldwide
Industry
Eligibility
18 Years and older
Enrollment
226 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jun 9, 2015 · Synced Sep 6, 2026, 6:20 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Study of Virtually Supervised Mouthwash and Interdental Brushes

NCT05756673
View directory record Official record
Conditions
Healthy
Interventions
Colgate Cavity Protection Toothpaste, LISTERINE ZERO Alcohol Mouthwash COOL MINT, LISTERINE COOL MINT Antiseptic Mouthwash, TePe Original Interdental Brush
Drug · Device
Lead sponsor
Johnson & Johnson Consumer Inc. (J&JCI)
Industry
Eligibility
18 Years and older
Enrollment
292 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 16, 2023 · Synced Sep 6, 2026, 6:20 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

A Phase 3 Clinical Study Investigating the Gingivitis Efficacy of a Test Dentifrice Containing Stannous Fluoride

NCT04123665
View directory record Official record
Conditions
Gingivitis
Interventions
Stannous fluoride, Sodium monofluorophosphate
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years and older
Enrollment
98 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Jan 30, 2020 · Synced Sep 6, 2026, 6:20 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Twelve Week Study of Prototypes Mouth Rinses

NCT05526586
View directory record Official record
Conditions
Healthy
Interventions
Colgate Cavity Protection Toothpaste, Zero Alcohol Gum Prototype, Alcohol Gum Prototype, Listerine Cool Mint Antiseptic Mouthwash, 5% Hydroalcohol
Other
Lead sponsor
Johnson & Johnson Consumer Inc. (J&JCI)
Industry
Eligibility
18 Years and older
Enrollment
192 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 4, 2023 · Synced Sep 6, 2026, 6:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Study Assessing the Effects of an Experimental Dentifrice in Maintaining Tooth Color Following Tooth Bleaching

NCT06150573
View directory record Official record
Conditions
Dentin Sensitivity, Oral Hygiene
Interventions
Test Dentifrice, Reference Dentifrice (Aquafresh Cavity Protection)
Drug
Lead sponsor
HALEON
Industry
Eligibility
18 Years to 65 Years
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jul 23, 2025 · Synced Sep 6, 2026, 6:20 PM EDT
Completed Phase 4 Interventional

A Study of Mouth Rinses in Type 1 and Type 2 Diabetic Participants

NCT04449952
View directory record Official record
Conditions
Gingivits in Diabetics
Interventions
Listerine Cool Mint, 5% Hydroalcohol Mouth Rinse, Colgate Cavity Protection Toothpaste, Alcohol-Free Essential Oil Containing (AFEO) Mouth Rinse Lead Formula, Concept Curve Winter Series Toothbrush, Listerine Cool Mint Floss
Other · Device
Lead sponsor
Johnson & Johnson Consumer Inc. (J&JCI)
Industry
Eligibility
18 Years and older
Enrollment
154 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 6, 2023 · Synced Sep 6, 2026, 6:20 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Two-Week Study of an Anticavity Low pH Mouthwash

NCT06010758
View directory record Official record
Conditions
Healthy
Interventions
Listerine Experimental Mouthwash, Colgate Cavity Protection Toothpaste, Listerine Total Care Zero, Listerine Cool Mint Zero
Drug · Other
Lead sponsor
Johnson & Johnson Consumer Inc. (J&JCI)
Industry
Eligibility
18 Years and older
Enrollment
163 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Jan 11, 2024 · Synced Sep 6, 2026, 6:20 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

A Clinical Study Investigating the Efficacy of a Stannous Fluoride Dentifrice in Improving Gingival Health After Twice Daily Use for 3 Weeks

NCT04050722
View directory record Official record
Conditions
Gingivitis
Interventions
Sensodyne Repair and Protect, Colgate Cavity Protection
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
130 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Nov 18, 2020 · Synced Sep 6, 2026, 6:20 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Clinical Study to Assess the Efficacy of New Toothpaste Containing SnF as Compared to Colgate Cavity Protection Toothpaste on the Reduction of Enamel Erosion

NCT07442136
View directory record Official record
Conditions
Enamel Erosion
Interventions
New Toothpaste Containing SnF, Fluoride Toothpaste
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 70 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Sep 6, 2026, 6:20 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Clinical Investigation to Examine Toothpaste Effect on Oral Bacteria

NCT02194621
View directory record Official record
Conditions
Oral Bacteria Levels in the Mouth
Interventions
Total Flavor option 1, Total Flavor option 2, Placebo toothpaste: Crest Cavity Protection toothpaste
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
22 Years to 58 Years
Enrollment
128 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 14, 2016 · Synced Sep 6, 2026, 6:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Oral Tissue Tolerance of a Mouthrinse

NCT01009554
View directory record Official record
Conditions
Dental Health
Interventions
Potassium Oxylate Mouthwash, Sodium Fluoride Dentifrice
Device · Drug
Lead sponsor
Johnson & Johnson Consumer and Personal Products Worldwide
Industry
Eligibility
18 Years and older
Enrollment
96 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009
U.S. locations
1
States / cities
Paramus, New Jersey
Source: ClinicalTrials.gov public record
Updated Jul 2, 2015 · Synced Sep 6, 2026, 6:20 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Two-Week Study of Clinical Safety and Saliva Flow Quantification

NCT05645705
View directory record Official record
Conditions
Healthy
Interventions
Colgate Cavity Protection Toothpaste, LISTERINE Cool Mint Antiseptic Mouthwash, Listerine Advanced Gum Alcohol, Listerine Advanced Gum Zero, LISTERINE ULTRACLEAN Tartar Control Antiseptic Mouthwash Cool Mint
Other
Lead sponsor
Johnson & Johnson Consumer Inc. (J&JCI)
Industry
Eligibility
18 Years and older
Enrollment
270 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 9, 2023 · Synced Sep 6, 2026, 6:20 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Six Week Study of Experimental Mouth Rinses: Effect on Gingivitis and Plaque

NCT04921371
View directory record Official record
Conditions
Gingivitis, Plaque
Interventions
Colgate® Cavity Protection Toothpaste, Listerine® Cool Mint®, Concept Curve Winter Series Toothbrush, 5% Hydroalcohol Mouthrinse, Mouthrinse Prototype 1, Mouthrinse Prototype 2
Other
Lead sponsor
Johnson & Johnson Consumer Inc. (J&JCI)
Industry
Eligibility
18 Years and older
Enrollment
157 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 27, 2023 · Synced Sep 6, 2026, 6:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Determination of the Oral Irritation Potential of Two Alcohol-Free Rinses

NCT07160166
View directory record Official record
Conditions
Oral Health
Interventions
Prototype 1, Prototype 2, Marketed Comparator
Other
Lead sponsor
Kenvue Brands LLC
Industry
Eligibility
18 Years and older
Enrollment
169 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 7, 2025 · Synced Sep 6, 2026, 6:20 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Oothpaste Containing 8% Arginine Compared to Colgate Cavity Protection Toothpaste in Reducing Dentinal Hypersensitivity

NCT07257042
View directory record Official record
Conditions
Hypersensitivity
Interventions
Toothpaste containing 8% Arginine, Colgate Cavity Protection Toothpaste
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 70 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Dec 4, 2025 · Synced Sep 6, 2026, 6:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Pilot Study to Evaluate a Molecular Method for Plaque

NCT02574221
View directory record Official record
Conditions
Plaque, Gingivitis
Interventions
stannous fluoride toothpaste, cavity protection toothpaste
Drug
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 5, 2017 · Synced Sep 6, 2026, 6:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Caries Prevention Products & Dentinal Hypersensitivity

NCT02136576
View directory record Official record
Conditions
Hypersensitivity
Interventions
Sensodyne, Crest Cavity Protection & MI Paste Plus, Clinpro 5000
Device
Lead sponsor
Tufts University
Other
Eligibility
18 Years and older
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 9, 2020 · Synced Sep 6, 2026, 6:20 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Clinical Study Comparing Dental Plaque and Gingivitis Reduction After Using One of Three Oral Hygiene Multi-component Regimens (Using of a Manual Toothbrush, a Toothpaste and a Mouthwash)

NCT02366689
View directory record Official record
Conditions
Dental Plaque, Gingivitis
Interventions
Triclosan/fluoride toothpaste, stannous fluoride toothpaste, fluoride only toothpaste, Cetylpyridinium chloride mouthwash, Fluoride only mouthwash
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 70 Years
Enrollment
179 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Cedar Knolls, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 29, 2016 · Synced Sep 6, 2026, 6:20 PM EDT