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ClinicalTrials.gov public records Last synced Oct 4, 2026, 9:41 PM EDT

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Showing 49–72 of 157 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Combined Diet and Exercise Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Exercise & Diet Effects on CV Risk in Firefighters

NCT03344198
View directory record Official record
Conditions
Cardiovascular Risk Factor, Blood Pressure, Exercise, Diet Modification, Health Promotion
Interventions
Circuit Training exercise & Modified Mediterranean diet
Behavioral
Lead sponsor
University of New Hampshire
Other
Eligibility
18 Years to 70 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
San Marcos, California
Source: ClinicalTrials.gov public record
Updated Aug 7, 2023 · Synced Oct 4, 2026, 9:41 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Lifestyle Intervention and Metformin for Women With Polycystic Ovary Syndrome (PCOS)

NCT00151411
View directory record Official record
Conditions
Polycystic Ovary Syndrome
Interventions
Metformin, Placebo, Lifestyle Intervention
Drug · Behavioral
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
12 Years to 39 Years · Female only
Enrollment
114 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2008
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 21, 2018 · Synced Oct 4, 2026, 9:41 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Osteoarthritis Prevention Study

NCT05946044
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Diet and Exercise
Behavioral
Lead sponsor
Wake Forest University
Other
Eligibility
50 Years and older · Female only
Enrollment
1,230 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2029
U.S. locations
3
States / cities
Boston, Massachusetts • Chapel Hill, North Carolina • Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Oct 4, 2026, 9:41 PM EDT
Recruiting Not applicable Interventional

High-Intensity Exercise and High-Fiber Diet for Immunotherapy Outcomes in Melanoma Patients: The DUO Trial

NCT06298734
View directory record Official record
Conditions
Melanoma (Skin), Skin Cancer, Advanced Melanoma
Interventions
Exercise Program, Diet Program
Behavioral
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
2
States / cities
Boston, Massachusetts • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Oct 4, 2026, 9:41 PM EDT
Not listed Not applicable Interventional

Slow Wave Sleep As a Biomarker of Rehabilitation-induced Cognitive Improvement in PD

NCT04796506
View directory record Official record
Conditions
Parkinson Disease
Interventions
Progressive Resistance Training (PRT), Delayed Exercise Training (DE), Endurance Training (ET)
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
45 Years to 100 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced Oct 4, 2026, 9:41 PM EDT
Completed Phase 3 Interventional

Multimodal Intervention for Cachexia in Advanced Cancer Patients Undergoing Chemotherapy

NCT02330926
View directory record Official record
Conditions
Cachexia, Neoplasms
Interventions
standard care, nutritional supplements and advice, home-based self-assisted exercise program, Ibuprofen
Other · Dietary Supplement · Behavioral + 1 more
Lead sponsor
Norwegian University of Science and Technology
Other
Eligibility
18 Years and older
Enrollment
221 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 29, 2025 · Synced Oct 4, 2026, 9:41 PM EDT
Completed Not applicable Interventional Results available

Integrating Online Weight Management With Primary Care Support

NCT02656693
View directory record Official record
Conditions
Obesity
Interventions
Online weight management program, Population health management support
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
20 Years to 70 Years
Enrollment
840 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 5, 2020 · Synced Oct 4, 2026, 9:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Combined Effects of Nutritional and Exercise Countermeasures

NCT00447044
View directory record Official record
Conditions
Muscular Atrophy, Muscle Weakness
Interventions
Resistance Exercise, diet orange soda, essential amino acids
Behavioral · Dietary Supplement
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years to 50 Years
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Jun 19, 2009 · Synced Oct 4, 2026, 9:41 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Ketone Ester and Salt (KEAS) in Young Adults

NCT05545501
View directory record Official record
Conditions
Salt; Excess, Hypertension
Interventions
No Salt, No β-OHB, High Salt, No β-OHB, High Salt, High β-OHB
Dietary Supplement
Lead sponsor
Indiana University
Other
Eligibility
19 Years to 39 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Oct 4, 2026, 9:41 PM EDT
Terminated Phase 3 Interventional Results available

A Trial Investigating the Efficacy and Safety of Insulin Detemir Versus Insulin NPH in Combination With Metformin and Diet/Exercise in Children and Adolescents With Type 2 Diabetes Insufficiently Controlled on Metformin With or Without Other Oral Antidiabetic Drug(s) With or Without Basal Insulin

NCT02131272
View directory record Official record
Conditions
Diabetes, Diabetes Mellitus, Type 2
Interventions
Insulin detemir, Insulin NPH, Diet/exercise
Drug · Behavioral
Lead sponsor
Novo Nordisk A/S
Industry
Eligibility
10 Years to 18 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
23
States / cities
Tucson, Arizona • Los Angeles, California • Jacksonville, Florida + 19 more
Source: ClinicalTrials.gov public record
Updated Sep 10, 2018 · Synced Oct 4, 2026, 9:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Diet and Whole-body Vibration Training on Cardiovascular and Autonomic Function

NCT01741779
View directory record Official record
Conditions
Obesity, Pre-hypertension, Hypertension
Interventions
Whole Body Vibration Training, Hypocaloric diet, Whole body vibration training & diet
Other
Lead sponsor
Florida State University
Other
Eligibility
45 Years to 65 Years · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Dec 5, 2012 · Synced Oct 4, 2026, 9:41 PM EDT
Completed Not applicable Interventional

Placebo-Controlled Clinical Nutrition Study of the Safety and Metabolic Effects of Two Medical Foods in Type 2 Diabetes

NCT03893422
View directory record Official record
Conditions
Type 2 Diabetes Mellitus
Interventions
WB-010, WB-011, Placebo
Other
Lead sponsor
Pendulum Therapeutics
Industry
Eligibility
18 Years to 75 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
5
States / cities
Torrance, California • Tustin, California • Youngstown, Ohio + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 27, 2020 · Synced Oct 4, 2026, 9:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Patient-Centered Care and Asian Americans

NCT02139722
View directory record Official record
Conditions
Hepatitis B, Hepatitis C, Liver Disease
Interventions
Video Doctor, PA + PPN
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
431 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 21, 2020 · Synced Oct 4, 2026, 9:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Gestational Weight Gain and Postpartum Weight Loss in Active Duty Women (Moms Fit 2 Fight)

NCT03057808
View directory record Official record
Conditions
Weight Gain, Weight Loss
Interventions
Gestational weight gain intervention, Postpartum weight loss intervention
Behavioral
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years and older · Female only
Enrollment
430 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
2
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Dec 23, 2022 · Synced Oct 4, 2026, 9:41 PM EDT
Completed Phase 3 Interventional Results available

Study To Evaluate 24 Hour Blood Sugar Control (24-hour Mean Weighted Glucose) In Subjects That Are Taking Saxagliptin 5 mg Added Onto Metformin XR 1500 XR mg Compared To Subjects Taking Metformin XR 1500 mg Up-titrated To Metformin XR 2000 mg

NCT00918138
View directory record Official record
Conditions
Type 2 Diabetes
Interventions
Saxagliptin, Metformin XR, Placebo matching Metformin XR, Placebo matching Saxagliptin
Drug
Lead sponsor
AstraZeneca
Industry
Eligibility
18 Years to 78 Years
Enrollment
219 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
12
States / cities
Phoenix, Arizona • Redlands, California • Tustin, California + 9 more
Source: ClinicalTrials.gov public record
Updated May 21, 2015 · Synced Oct 4, 2026, 9:41 PM EDT
Completed Not applicable Interventional Results available

Behavioral Weight Loss and Stigma Reduction

NCT03704064
View directory record Official record
Conditions
Obesity
Interventions
Stigma-Reduction Intervention, Behavioral Weight Loss (BWL)
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 2, 2022 · Synced Oct 4, 2026, 9:41 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Breathing Training and Nitrate on Exercise at Simulated Altitude

NCT07216755
View directory record Official record
Conditions
Healthy Adults, Mechanical Ventilation Dependence, Hypoxia, Exercise Training, Exercise Intolerance, Dietary Supplement, Nitrate Supplementation, Inspiratory Muscle Training
Interventions
Respiratory Muscle Training (RMT), Sham Respiratory Muscle Training, Dietary Supplement: Beetroot Juice Concentrate, placebo beverage
Device · Dietary Supplement
Lead sponsor
Embry-Riddle Aeronautical University
Other
Eligibility
18 Years to 40 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Daytona Beach, Florida
Source: ClinicalTrials.gov public record
Updated Oct 15, 2025 · Synced Oct 4, 2026, 9:41 PM EDT
Completed Phase 4 Interventional Results available

A Research Study Comparing Wegovy to Other Weight Management Drugs in People Living With Obesity in America

NCT05579249
View directory record Official record
Conditions
Obesity
Interventions
Semaglutide, Orlistat, Phentermine/Topiramate, Naltrexone/Bupropion, Liraglutide
Drug
Lead sponsor
Novo Nordisk A/S
Industry
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Oct 4, 2026, 9:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Heart to Health: A Combined Lifestyle and Medication Intervention to Reduce Cardiovascular Disease (CVD) Risk

NCT01245686
View directory record Official record
Conditions
Cardiovascular Disease, Coronary Heart Disease
Interventions
Lifestyle and medication intervention
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
35 Years to 79 Years
Enrollment
489 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
5
States / cities
Durham, North Carolina • Eden, North Carolina • Kannapolis, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 6, 2013 · Synced Oct 4, 2026, 9:41 PM EDT
Recruiting Not applicable Interventional

Trial of Exercise and Lifestyle for Women With Ovarian and Endometrial Cancer

NCT05761561
View directory record Official record
Conditions
Ovarian Cancer
Interventions
Exercise and medical nutrition
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older · Female only
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
2
States / cities
New Haven, Connecticut • Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jul 20, 2026 · Synced Oct 4, 2026, 9:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Maintenance-Tailored Obesity Treatment

NCT00670462
View directory record Official record
Conditions
Obesity
Interventions
Standard Behavioral Treatment (SBT), Maintenance-Tailored Treatment (MTT)
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
213 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2010
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 22, 2017 · Synced Oct 4, 2026, 9:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Individual Counseling and/or Computer-Based Counseling in Helping Healthy Women Adopt a Cancer Prevention Diet

NCT00217490
View directory record Official record
Conditions
Unspecified Adult Solid Tumor, Protocol Specific
Interventions
dietary counseling via computer, dietary counseling via nutritionist, combined computer and nutritionist, physical activity counseling via computer
Behavioral · Other
Lead sponsor
Kaiser Permanente
Other
Eligibility
30 Years to 70 Years · Female only
Enrollment
621 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2008
U.S. locations
3
States / cities
Aurora, Colorado • Eugene, Oregon • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Apr 4, 2017 · Synced Oct 4, 2026, 9:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of the Combination of Nitrate and Caffeine on Critical Power In Trained Male Cyclists

NCT07501806
View directory record Official record
Conditions
Exercise Performance of Fit Athletes, Exercise Performance, Cycling Performance
Interventions
Dietary Nitrate, Caffeine, Placebo
Dietary Supplement · Other
Lead sponsor
Lindenwood University
Other
Eligibility
18 Years to 40 Years · Male only
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Saint Charles, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced Oct 4, 2026, 9:41 PM EDT
Completed Not applicable Interventional Results available

TRE With Physical Activity for Weight Management

NCT04978376
View directory record Official record
Conditions
Pre Diabetes, Overweight and Obesity
Interventions
Time restricted eating
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
50 Years to 70 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 18, 2024 · Synced Oct 4, 2026, 9:41 PM EDT