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Showing 1–24 of 40 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Community Reinforcement Approach Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Imaging the Neurobiology of a Behavioral Treatment for Cocaine Dependence

NCT00376558
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Community Reinforcement Approach
Behavioral
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
21 Years to 45 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2011
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 30, 2016 · Synced Sep 13, 2026, 9:21 AM EDT
Completed Phase 3 Interventional

Comparing Acute and Continuous Drug Abuse Treatment: A Randomized Clinical Trial

NCT01003496
View directory record Official record
Conditions
Drug Addiction
Interventions
Treatment as Usual (TAU), TAU + Long-Term Recovery Management
Behavioral
Lead sponsor
Wright State University
Other
Eligibility
18 Years to 80 Years
Enrollment
204 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 8, 2022 · Synced Sep 13, 2026, 9:21 AM EDT
Completed Phase 2 Interventional Results available

Evaluation of Treatments for Homeless Youths

NCT01143792
View directory record Official record
Conditions
Substance Abuse
Interventions
Community Reinforcement Approach (CRA) + HIV prevention, Case Management + HIV Prevention, Motivational Enhancement Therapy (MET) + HIV prevention
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
14 Years to 20 Years
Enrollment
270 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 15, 2013 · Synced Sep 13, 2026, 9:21 AM EDT
Completed Phase 3 Interventional

Adolescent Outpatient and Continuing Care Study

NCT01381133
View directory record Official record
Conditions
Substance Abuse, Substance Dependence
Interventions
Chestnut Bloomington Outpatient (CBOP), Motivational Enhancement Therapy/Cognitive Behavior Treatment (MET/CBT 7), Assertive Continuing Care (ACC)
Behavioral
Lead sponsor
Chestnut Health Systems
Other
Eligibility
12 Years to 18 Years
Enrollment
320 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2008
U.S. locations
1
States / cities
Bloomington, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 13, 2013 · Synced Sep 13, 2026, 9:21 AM EDT
Completed Not applicable Interventional Results available

Stage 1 Treatment Development With Homeless Mothers

NCT01193114
View directory record Official record
Conditions
Substance Abuse
Interventions
Ecologically Based Treatment (EBT), Treatment as Usual (TAU)
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older · Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 28, 2013 · Synced Sep 13, 2026, 9:21 AM EDT
Completed Phase 2 Interventional

Behavioral Treatment for Cocaine Dependent Women

NCT00914381
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Behavioral therapy
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
145 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1994 – 2002
U.S. locations
2
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 30, 2020 · Synced Sep 13, 2026, 9:21 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Testing Effectiveness of the Community Reinforcement Approach and Family Training (CRAFT) With American Indians

NCT03203889
View directory record Official record
Conditions
Substance Use Disorders, Family Members
Interventions
CRAFT-AI, TSF-CSO
Behavioral
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Zuni, New Mexico
Source: ClinicalTrials.gov public record
Updated Aug 21, 2022 · Synced Sep 13, 2026, 9:21 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Virtual Implicit Bias Reduction and Neutralization Training (VIBRANT)

NCT05970991
View directory record Official record
Conditions
Implicit Bias
Interventions
Brief Online Training (BOLT) for measurement-based care (MBC), Virtual Implicit Bias Reduction and Neutralization Training (VIBRANT), Live Post-Training Consultation, Asynchronous Discussion Board
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
11 Years to 99 Years
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Mar 11, 2025 · Synced Sep 13, 2026, 9:21 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Web-delivery of Evidence-based, Psychosocial Treatment for Substance Use Disorders

NCT01104805
View directory record Official record
Conditions
Substance Abuse
Interventions
Therapeutic Education System (TES), Treatment-as-Usual (TAU)
Behavioral
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 75 Years
Enrollment
507 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
10
States / cities
Danbury, Connecticut • Orlando, Florida • Waipahu, Hawaii + 7 more
Source: ClinicalTrials.gov public record
Updated Jul 10, 2017 · Synced Sep 13, 2026, 9:21 AM EDT
Completed Not applicable Interventional

Adaptive Treatment for Adolescent Cannabis Use Disorders

NCT01656707
View directory record Official record
Conditions
Mental Disorders, Addictive Behaviors, Cannabis Use Disorder
Interventions
ACRA, CBT
Behavioral
Lead sponsor
UConn Health
Other
Eligibility
13 Years to 18 Years
Enrollment
172 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 10, 2017 · Synced Sep 13, 2026, 9:21 AM EDT
Recruiting Not applicable Interventional

Examining the Effectiveness of the Early Start Denver Model in Community Programs Serving Young Autism

NCT06005285
View directory record Official record
Conditions
Autism
Interventions
Early Start Denver Model (ESDM), Early Intensive Behavioral Intervention (EIBI)
Behavioral
Lead sponsor
University of California, Davis
Other
Eligibility
12 Months and older
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Dec 4, 2025 · Synced Sep 13, 2026, 9:21 AM EDT
Completed Phase 2 Interventional

Opiate Dependence: Combined Naltrexone/Behavior Therapy - 1

NCT00238914
View directory record Official record
Conditions
Heroin Dependence
Interventions
Naltrexone, Behavioral Naltrexone Therapy (BNT), Compliance Enhancement (CE)
Drug · Behavioral
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 60 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2002
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 12, 2012 · Synced Sep 13, 2026, 9:21 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Family-based and Adolescent Residential Drug Treatment

NCT01737632
View directory record Official record
Conditions
Substance Use, Delinquency
Interventions
Multidimensional Family Therapy (MDFT), Adolescent Residential Treatment
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
13 Years to 17 Years
Enrollment
113 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2000 – 2010
U.S. locations
2
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Nov 28, 2012 · Synced Sep 13, 2026, 9:21 AM EDT
Completed Not applicable Interventional Results available

Effect of Mindfulness on Opioid Use and Anxiety During Primary Care Buprenorphine Treatment (R33 Phase)

NCT04278586
View directory record Official record
Conditions
Opioid-use Disorder, Stress Related Disorder, Anxiety, Pain Interference
Interventions
Live-Online M-ROCC, Live-Online Control
Behavioral
Lead sponsor
Cambridge Health Alliance
Other
Eligibility
18 Years to 70 Years
Enrollment
260 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Somerville, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 21, 2025 · Synced Sep 13, 2026, 9:21 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of EBT With Young, Substance Abusing Homeless Mothers

NCT02577666
View directory record Official record
Conditions
Substance Use
Interventions
Ecologically Based Therapy, Housing Only, Treatment as Usual
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 24 Years · Female only
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 23, 2019 · Synced Sep 13, 2026, 9:21 AM EDT
Completed Not applicable Interventional

OUD Smartphone Services

NCT06134882
View directory record Official record
Conditions
Opioid-Related Disorders, Drug Abuse
Interventions
Contingency management, Cognitive-Behavior Therapy Modules, Peer Contingency Management (CM) Guide, Drug testing, Wellness modules, Peer technical support
Behavioral
Lead sponsor
Western Michigan University
Other
Eligibility
18 Years and older
Enrollment
97 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Kalamazoo, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Sep 13, 2026, 9:21 AM EDT
Active, not recruiting Not applicable Interventional

Socializing a Science-Based Digital Therapeutic for Substance Use Disorders

NCT05648786
View directory record Official record
Conditions
Substance Use Disorders, Substance-Related Disorders
Interventions
Laddr® plus Behavioral- Group and individual counseling, Behavioral- Group and individual counseling
Behavioral
Lead sponsor
Square2 Systems, Inc.
Industry
Eligibility
18 Years and older
Enrollment
189 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Manchester, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jan 5, 2025 · Synced Sep 13, 2026, 9:21 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Training and Implementation of RUBI in Community Mental Health Settings

NCT05742464
View directory record Official record
Conditions
Autism Spectrum Disorder
Interventions
RUBI
Behavioral
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
Not listed
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Augusta, Maine
Source: ClinicalTrials.gov public record
Updated Feb 23, 2023 · Synced Sep 13, 2026, 9:21 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Reduction of Drug Use and HIV Risk Among Out-of-Treatment Methamphetamine Users

NCT01161485
View directory record Official record
Conditions
HIV Infections
Interventions
HIV Testing and Counseling, Contingency Management, Strengths-based case management
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years and older
Enrollment
502 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2016
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 19, 2017 · Synced Sep 13, 2026, 9:21 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Testing a Promising Treatment for Youth Substance Abuse in a Community Setting

NCT02130479
View directory record Official record
Conditions
Substance Abuse, Delinquency, Mental Health
Interventions
Contingency Management-Family Engagement, Treatment as Usual
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
12 Years to 17 Years
Enrollment
101 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
Florence, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 5, 2018 · Synced Sep 13, 2026, 9:21 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

mHealth App for Changing Alcohol Use in Alaska Native American Indian People

NCT05326438
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
CIRCLE mHealth app
Behavioral
Lead sponsor
Southcentral Foundation
Other
Eligibility
21 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Anchorage, Alaska
Source: ClinicalTrials.gov public record
Updated May 22, 2023 · Synced Sep 13, 2026, 9:21 AM EDT
Completed Not applicable Interventional Results available

Web-based Addiction Treatment: Cultural Adaptation With American Indians

NCT03363256
View directory record Official record
Conditions
Substance Use Disorders
Interventions
TES-NAV, TAU
Behavioral
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 99 Years
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Sep 13, 2026, 9:21 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Scalable Digital Delivery of Evidence-based Training for Family to Maximize Treatment Admission Rates of Opioid Use Disorder in Loved Ones

NCT05666856
View directory record Official record
Conditions
Community Reinforcement And Family Training, Family Health, Substance-Related Disorders
Interventions
Community Reinforcement And Family Training, We The Village Peer Community Forum
Behavioral
Lead sponsor
We The Village, Inc.
Other
Eligibility
19 Years and older
Enrollment
212 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 8, 2024 · Synced Sep 13, 2026, 9:21 AM EDT
Not listed Not applicable Interventional

Preventing OUD in Justice-Involved Youth

NCT04901312
View directory record Official record
Conditions
Substance Use Disorders, Recidivism
Interventions
Adolescent Community Reinforcement Approach, Assertive Continuing Care, Trauma Affect Regulation Guide for Education and Therapy, Motivational Interviewing, Opioid Education Workbook
Behavioral · Other
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
15 Years to 25 Years
Enrollment
215 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Olympia, Washington
Source: ClinicalTrials.gov public record
Updated Oct 26, 2022 · Synced Sep 13, 2026, 9:21 AM EDT