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Conditions: Stroke, Dyslexia, Acquired
Interventions: Phono-Motor Therapy, Semantic Feature Analysis; Behavioral
Lead sponsor: Rutgers, The State University of New Jersey; Other
Eligibility: 18 Years to 85 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 3
States / cities: Tallahassee, Florida • Baltimore, Maryland • West Orange, New Jersey

Conditions: Persistent Atrial Fibrillation
Interventions: Scar-Based Radio-frequency Ablation, Rotor Anchors Radio-frequency Ablation, Conventional PVI by Radio-frequency Ablation; Device
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: PHYSIOLOGICAL PHENOMENA, Homeostasis, Physical Functional Performance, Cardiorespiratory Fitness, Cardiometabolic Risk Factors, Mobility Limitation
Interventions: Standardized Physiologic Resilience Challenge, Multimodal Whole-Body Physiologic Monitoring, Research-Only Whole-Body Digital Twin Analysis; Procedure · Other
Lead sponsor: Truway Health, Inc.; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 450 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2041
U.S. locations: 1
States / cities: New York, New York

Conditions: Recurrent Diffuse Large B-Cell Lymphoma, Refractory Diffuse Large B-Cell Lymphoma
Interventions: Chemotherapy, Computed Tomography, Fludeoxyglucose F-18, Positron Emission Tomography; Drug · Procedure
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 35 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2022
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Hearing Loss
Interventions: Cochlear implant Computer Model Implementation; Diagnostic Test
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 90 Years
Enrollment: 14 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: New York, New York

Conditions: Alzheimer Disease
Interventions: UCB-J, MRI Scan, PET Scan; Drug · Device
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 55 Years to 89 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2025
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Ventricular Tachycardia (VT), Premature Ventricular Contraction (PVC), Ventricular Fibrillation
Interventions: Computational electrocardiography and cardiac computed tomography mapping; Diagnostic Test
Lead sponsor: University of California, San Diego; Other
Eligibility: 21 Years to 90 Years
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2034
U.S. locations: 1
States / cities: La Jolla, California

Conditions: Veterans Referred to the St. Louis VAMC Stress Tes
Interventions: Regadenoson myocardial perfusion imaging stress test, Arm exercise electrocardiographic stress test, Treadmill electrocardiographic stress test, Coronary artery calcium score and cardiac computed tomographic angiography; Procedure
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 21 Years to 100 Years
Enrollment: 133 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Venous Thrombosis, Atrial Fibrillation, Myocardial Infarction
Interventions: Genomics; Device
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: 18 Years and older
Enrollment: 175 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2011
U.S. locations: 1
States / cities: Louisville, Kentucky

Conditions: Depression, Anxiety
Interventions: Go/No-Go Active Learning (GOAL); Behavioral
Lead sponsor: Northwestern University; Other
Eligibility: 21 Years to 40 Years
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Non Small Cell Lung Cancer, Pulmonary Metastases
Interventions: RF ablation (Rita Medical Systems Model 1500x); Device
Lead sponsor: Angiodynamics, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 106 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2007
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Multiple Sclerosis
Interventions: Transcranial Direct Current Stimulation (tDCS), Sham Transcranial Direct Current Stimulation, Cognitive Training Program; Device · Behavioral
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 70 Years
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: New York, New York

Conditions: Schizophrenia, Chronic Illness, Weight Gain, Psychotic Disorder
Interventions: Collaborative Chronic Illness Care Model; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 1,067 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2011
U.S. locations: 8
States / cities: Long Beach, California • West Los Angeles, California • Shreveport, Louisiana + 5 more

Conditions: Down Syndrome, Obstructive Sleep Apnea
Interventions: Not listed
Lead sponsor: Children's Hospital Medical Center, Cincinnati; Other
Eligibility: 1 Year to 90 Years
Enrollment: 73 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2028
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Treatment for Opioid Use Disorder
Interventions: Train and evaluate the accuracy and reliability of the Strength Band Platform in identifying acute opioid dosing events from time-stamped biometric data collected from wrist-worn devices.; Device
Lead sponsor: OpiAID; Industry
Eligibility: 22 Years and older
Enrollment: 420 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 4
States / cities: Wilmington, North Carolina • Austin, Texas • Cedar Park, Texas

Conditions: Blindness, Acquired
Interventions: Visual prosthesis; Device
Lead sponsor: University of California, Santa Barbara; Other
Eligibility: 18 Years and older
Enrollment: 7 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Santa Barbara, California

Conditions: Kidney Cancer
Interventions: IRIS 1.0; Device
Lead sponsor: Intuitive Surgical; Industry
Eligibility: 18 Years and older
Enrollment: 122 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 2
States / cities: Edison, New Jersey • Rochester, New York

Conditions: Colorectal Cancer, Lung Cancer, Breast Cancer
Interventions: Decision Making Support Tool; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 50 Years to 80 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Lung Cancer Screening, Current or Past Cigarette Smoker
Interventions: Surveys, Navigation, Focus groups, In-depth interviews; Behavioral
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 21 Years to 80 Years
Enrollment: 99 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2025
U.S. locations: 1
States / cities: New York, New York

Conditions: Lung Non-Small Cell Carcinoma, Stage IIIB Lung Cancer AJCC v8, Stage IV Lung Cancer AJCC v8
Interventions: Adagrasib, Anti-PD-L1 Monoclonal Antibody, Anti-PD1 Monoclonal Antibody, Bevacizumab, Biopsy Procedure, Biospecimen Collection, Chemotherapy, Computed Tomography, Durvalumab, Magnetic Resonance Imaging, Monitoring, Positron Emission Tomography, Surveillance, Tremelimumab; Drug · Biological · Procedure + 2 more
Lead sponsor: City of Hope Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 535 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 13
States / cities: Goodyear, Arizona • Corona, California • Duarte, California + 10 more

Conditions: Stress Disorders, Post-Traumatic
Interventions: Computational Model - Real-time Support Vector Machine; Device
Lead sponsor: University of Arkansas; Other
Eligibility: 21 Years to 50 Years · Female only
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2019
U.S. locations: 1
States / cities: Little Rock, Arkansas

Conditions: Prostate Cancer, Prostate Cancer (Diagnosis), High-risk Prostate Cancer, Localized Prostate Carcinoma, Very High Risk Prostate Carcinoma
Interventions: 177 Lutetium Prostate-Specific Membrane Antigen 617, Actinium-225 Prostate-Specific Membrane Antigen 617, Non-investigational, Prostatectomy, Prostate Tissue Collection, Single-photon emission computed tomography (SPECT)/Computerized tomography (CT), Blood Sample Collection; Drug · Procedure
Lead sponsor: Thomas Hope; Other
Eligibility: 18 Years and older · Male only
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Vocal Cord Atrophy
Interventions: Cone Beam Computed Tomography, Acoustic/Auerodynamic testing, Laryngovideostroboscopy; Other · Diagnostic Test
Lead sponsor: Duke University; Other
Eligibility: 65 Years to 80 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Health Knowledge, Environmental Exposure, Attitude, Practice
Interventions: Community-Centered Design Curriculum with EJT, Traditional Technical Curriculum; Behavioral
Lead sponsor: Stanford University; Other
Eligibility: 14 Years to 18 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Stanford, California

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Acquired Dyslexia Modeling and Treatment

The Substrate and Intervention Mechanisms for Persistent Atrial Fibrillation Trial

Truway Whole-Body Digital Twin and Physiologic Resilience Study (TRU-OMNIBODY)

Tumor-Specific Clonotype, Metabolic Profile, and PET/CT in Predicting Chemotherapy Response in Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma

A Computational Approach to Optimal Deactivation of Cochlear Implant Electrodes

The Synapse Project

Computational Cardiac Imaging Analysis to Guide Ventricular Tachycardia Ablation Procedures (AI-VT)

Arm Exercise Versus Pharmacologic Stress Testing for Clinical Outcome

Personalized Warfarin Dosing by Genomics and Computational Intelligence

Set Your Goal: Engaging Go/No-Go Active Learning

Radiofrequency Ablation of Pulmonary Tumors Response Evaluation

Pilot Study of Transcranial Direct Current Stimulation (tDCS)

Implementing Effective, Collaborative Care for Schizophrenia (EQUIP-2)

Computer Models of Airways in Children and Young Adults With Sleep Apnea and Down Syndrome

A Study to Train a Machine Learning Algorithm for an Evaluation of the Use of Biometric Data Captured at the Wrist for the Identification of Acute Opioid Use Events and the Quantification of Opioid Withdrawal in Opioid Dependent Individuals

AI-Powered Artificial Vision for Visual Prostheses

A Prospective Post-Market Study to Evaluate the Clinical Utility of IRIS, a Three-dimensional (3-D) Anatomical Modeling Software for Pre-operative Surgical Planning and Intra-operative Navigation for Nephrectomy

Technology-Based Cancer Screening Intervention

Informing the Adaptation of a CHW Model to Facilitate Lung Cancer Screening for the Chinese Community

Immunotherapy Biomarkers to Predict First-line PD(L)1-based Immunotherapy Response and Selection of Second-line Treatment in Stage IIIB-IV Non-small Cell Lung Cancer, IMMUNO-BIOMAP Trial

Real-time fMRI and Neurofeedback of Brain Networks Mediating Trauma Memory Recall in PTSD

Comparison of 177Lu-PSMA-617 and 225Ac-PSMA-617

Modeling the Effects of Vocal Cord Atrophy on Airflow and Voice Quality in Elderly Individuals

Planetary Health and Environmental Justice in Construction Career Education