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ClinicalTrials.gov public records Last synced Nov 6, 2026, 11:40 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 49–72 of 113 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Computer Based Cognitive Behavioral Therapy Clear all

Conditions: Intolerance of Uncertainty, Anxiety, Intolerance of Uncertainty; Anxiety, Depression, Anxiety
Interventions: Uncertainty-focused single session intervention, Maintaining a healthy lifestyle single session intervention; Behavioral
Lead sponsor: Northwestern University; Other
Eligibility: 25 Years to 60 Years
Enrollment: 140 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Concussion
Interventions: Specialist and Pediatrician Co-Management for Early and Effective Concussion Care Delivery to Hasten Your Recovery (SPEEDY Recovery); Behavioral
Lead sponsor: University of Rhode Island; Other
Eligibility: 8 Years to 17 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Social Anxiety
Interventions: Coordinated Anxiety Learning and Management (CALM); Behavioral
Lead sponsor: Stanford University; Other
Eligibility: 18 Years to 50 Years
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Diabetes Mellitus, Type 1
Interventions: Motivational Enhancement System (MES), Question Prompt List (QPL), Text Message Reminders (TXT); Behavioral
Lead sponsor: Wayne State University; Other
Eligibility: 16 Years to 25 Years
Enrollment: 113 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2025
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Substance Abuse
Interventions: Standard Treatment As Usual (TAU), Individual clinician-provided CBT, CBT4CBT; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 164 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2018
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Generalized Anxiety Disorder, Panic Disorder, Social Anxiety Disorder, Alcohol Use Disorder, Depression
Interventions: Negative Emotions and Addiction Tools Program (NEAT)- Cognitive Behavioral Therapy, Progressive Muscle Relaxation Training (PMRT); Behavioral
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 65 Years
Enrollment: 256 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Chronic Post-Surgical Pain
Interventions: Computer-Assisted Preoperative CBT Intervention (PAINTrainer); Behavioral
Lead sponsor: University of Pennsylvania; Other
Eligibility: 22 Years and older
Enrollment: 54 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 4
States / cities: Philadelphia, Pennsylvania • Radnor, Pennsylvania

Conditions: Insomnia
Interventions: Digital cognitive-behavioral therapy for insomnia (dCBTI), Sleep hygiene education (SHE); Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years and older · Male only
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Affective Disorders, Anxiety Disorders, Attention Deficit Disorder, Substance Abuse
Interventions: Cognitive Remediation, Computer Skills Training; Behavioral
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 18 Years to 22 Years
Enrollment: 188 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2017
U.S. locations: 1
States / cities: New York, New York

Conditions: Schizoaffective Disorder, Schizophrenia
Interventions: Cognitive remediation, Social Cognitive skills training, hybrid intervention, skills training; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 60 Years
Enrollment: 85 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2009
U.S. locations: 1
States / cities: West Los Angeles, California

Conditions: Alcohol Abuse or Dependence
Interventions: Standard Treatment as Usual (TAU), Web-based CBT4CBT for alcohol plus TAU, Web-based CBT with minimal clinical contact; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 68 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 2
States / cities: New Haven, Connecticut

Conditions: Breast Cancer, Arthralgia, Pain, Chronic
Interventions: Online Pain Coping Skills Training, Education; Behavioral · Other
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 452 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 2
States / cities: Chicago, Illinois • Durham, North Carolina

Conditions: Depression, Major Depressive Disorder, Dysthymic Disorder, Depressive Symptoms, Type 2 Diabetes, PreDiabetes, Insulin Resistance
Interventions: Good Days Ahead (GDA), Problem Solving Treatment in Primary Care (PST-PC), Antidepressant Medications, Active Control; Behavioral · Drug · Other
Lead sponsor: Indiana University; Other
Eligibility: 18 Years and older
Enrollment: 46 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Depression, Anxiety
Interventions: Woebot for Adolescents (W-GenZD) Mobile Application, CBT-Lite Teletherapy Group; Device · Behavioral
Lead sponsor: Woebot Health; Industry
Eligibility: 13 Years to 17 Years
Enrollment: 141 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Norfolk, Virginia

Conditions: Opioid Use
Interventions: brief motivational intervention (BMI), cognitive behavioral therapy; Behavioral
Lead sponsor: University of Rochester; Other
Eligibility: 18 Years and older
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Tobacco Dependence
Interventions: Brief Intervention, Extended Treatment, Usual Care; Behavioral
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 956 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2015
U.S. locations: 3
States / cities: Berkeley, California • San Francisco, California • Stanford, California

Conditions: Advanced Lung Cancer, Physical Function
Interventions: PROMOTE Digital Health App Intervention, Enhanced Usual Care; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Depression and Suicide
Interventions: Cognitive Behavioral Therapy CBT, TAU; Behavioral · Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 93 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 3
States / cities: Birmingham, Alabama • New Haven, Connecticut • Atlanta, Georgia

Conditions: HIV-related Mild Neurocognitive Disorder
Interventions: Transcranial Direct Current Stimulation (tDCS), Computer-based Cognitive Training, Watching Educational Videos; Procedure · Behavioral
Lead sponsor: Nova Southeastern University; Other
Eligibility: 50 Years and older
Enrollment: 46 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Fort Lauderdale, Florida

Conditions: Depressive Symptoms
Interventions: Raising Our Spirits Together, Enhanced Control Condition; Behavioral · Other
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 2
States / cities: Hillsdale, Michigan • Jonesville, Michigan

Conditions: Post-Treatment Lyme Disease
Interventions: Transcranial Direct Current Stimulation (tDCS), Cognitive training; Device · Behavioral
Lead sponsor: Columbia University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 110 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 2
States / cities: San Francisco, California • New York, New York

Conditions: Traumatic Brain Injury With Brief Loss of Consciousness, Traumatic Brain Injury With No Loss of Consciousness
Interventions: Cognitive Rehab, Brainworks, Informational Handout/Provider Visits; Behavioral
Lead sponsor: Brooke Army Medical Center; Federal
Eligibility: 18 Years and older
Enrollment: 143 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: San Antonio, Texas

Conditions: Cognitive Impairment
Interventions: Group 1, Group 2, Group 3, Group 4; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 65 Years and older
Enrollment: 126 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2011
U.S. locations: 2
States / cities: San Francisco, California

Conditions: IBS - Irritable Bowel Syndrome
Interventions: SynerGI, Sham VR; Device
Lead sponsor: Christopher Almario; Other
Eligibility: 10 Years and older
Enrollment: 73 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025
U.S. locations: 2
States / cities: Los Angeles, California • Cleveland, Ohio

Search by objective public record fields.

Test of Target Engagement of Ambiguity Aversion

Telehealth Specialty Concussion Treatment for Youth

Using the Neuroscience of Fear Extinction for Anxiety Reduction

Improving Diabetes in Emerging Adulthood

Computer Based Training in Cognitive Behavioral Therapy Web-based

Validating an Autonomous Interactive Internet-Based Delivery of an Empirically Supported Cognitive Behavioral Therapy for Comorbidity

Pre-op Cognitive Behavior Therapy to Decrease Chronic Post-Surgical Pain in TKA

Digital Behavioral Therapy for Sleep Problems

Cognitive Skills Training for Homeless Youth

Improving Basic and Social Cognition in Veterans With Schizophrenia

Web-based CBT4CBT for Alcohol

Web-based Pain Coping Skills Training for Breast Cancer Survivors With AI-Associated Arthralgia

eIMPACT-DM Pilot Trial: Depression Treatment to Reduce Diabetes Risk

Feasibility and Acceptability of W-GenZD vs CBT-light Teletherapy for Adolescents Seeking Mental Health Services

Preventing Premature Death in Patients With Serious Opioid-related Infection

Evaluation of Tobacco Treatment Strategies for Inpatient Psychiatry

A Digital Health Intervention to Improve Physical Function and Wellness of Lung Cancer Survivors

Cognitive Behavioral Therapy Following Esketamine for Major Depression and Suicidal Ideation for Relapse Prevention

Computer Training and Transcranial Direct Current Stimulation for Cognition in HIV

A Systems-Level Intervention for Rural Adults With Depression

Transcranial Direct Current Stimulation for Post Treatment Lyme Disease

The Study of Cognitive Rehabilitation Effectiveness for Mild Traumatic Brain Injury

The Mental Activity and eXercise Trial for Seniors

RCT of VR Therapy for IBS