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Showing 1–17 of 17 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Constraint-Induced Movement (CI) Therapy Clear all
Withdrawn Phase 2 Interventional

RCT of a Neuroplasticity Agent and CI Therapy for Severe Arm Paresis After Stroke

NCT01963832
View directory record Official record
Conditions
Severe Stroke With Affected Arm Motor Function
Interventions
Fluoxetine, Placebo, eCMIT, Usual Care
Drug · Procedure
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
40 Years and older · Male only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 11, 2015 · Synced Sep 28, 2026, 10:53 AM EDT
Completed Not applicable Interventional

Examining How Motor Rehabilitation Promotes Brain Reorganization Following Stroke, an MRI Study

NCT01725919
View directory record Official record
Conditions
Stroke, Hemiparesis
Interventions
CI therapy
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2025
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 2, 2025 · Synced Sep 28, 2026, 10:53 AM EDT
Completed Not applicable Interventional

Brain and Behavior Correlates of Arm Rehabilitation

NCT04989920
View directory record Official record
Conditions
Stroke, Cardiovascular
Interventions
Experimental group: CIMT group (Constraint-Induced Movement Therapy)
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2011
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 3, 2021 · Synced Sep 28, 2026, 10:53 AM EDT
Completed Not applicable Interventional Results available

Intensive Unimanual (CIMT) and Bimanual Training (HABIT) in Children With Hemiplegia

NCT02918890
View directory record Official record
Conditions
Cerebral Palsy, Hemiplegia, Children
Interventions
Constraint-induced Movement Therapy, Hand-arm Bimanual Intensive Therapy
Other
Lead sponsor
Teachers College, Columbia University
Other
Eligibility
6 Years to 17 Years
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 15, 2024 · Synced Sep 28, 2026, 10:53 AM EDT
Recruiting Not applicable Interventional

Constraint-Induced Movement Therapy for Adults Post-Stroke With Mild Upper Extremity Impairment

NCT05492513
View directory record Official record
Conditions
CVA (Cerebrovascular Accident), Stroke, Upper Extremity Paresis
Interventions
Grade 1 CI Therapy +Sensory Components
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Sep 28, 2026, 10:53 AM EDT
Not listed Phase 2 Interventional

Improving Hand Use in Multiple Sclerosis

NCT01081275
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
CI Therapy, CAM treatments
Behavioral
Lead sponsor
National Multiple Sclerosis Society
Other
Eligibility
21 Years to 80 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Apr 14, 2015 · Synced Sep 28, 2026, 10:53 AM EDT
Terminated Not applicable Interventional Results available

Brain Stimulation and Rehabilitation for Adults With Chronic, Severe Arm Motor Impairment After Stroke

NCT03538795
View directory record Official record
Conditions
Stroke, Hemiplegia, Hemiparesis
Interventions
iTBS&eCIMT
Combination Product
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 20, 2020 · Synced Sep 28, 2026, 10:53 AM EDT
Completed Phase 1 Interventional

Constraint-Induced (CI) Movement Therapy for Progressive Multiple Sclerosis (MS)

NCT00695084
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
Constraint-Induced Movement Therapy
Behavioral
Lead sponsor
National Multiple Sclerosis Society
Other
Eligibility
21 Years to 80 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 10, 2008 · Synced Sep 28, 2026, 10:53 AM EDT
Completed Not applicable Interventional Results available

Effectiveness of Virtual Reality Gaming Therapy Versus CI Therapy for Upper Extremity Rehabilitation

NCT02631850
View directory record Official record
Conditions
Stroke, Hemiparesis
Interventions
Traditional CI Therapy, Gaming CI Therapy, Gaming CI Therapy with Additional Contact via Video Conference, Traditional Occupational Therapy/Physical Therapy
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
193 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
5
States / cities
Birmingham, Alabama • Columbia, Missouri • Columbus, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 4, 2021 · Synced Sep 28, 2026, 10:53 AM EDT
Completed Phase 2 Interventional

Automated Constraint-Induced Therapy for Restoring Movement After Stroke

NCT00037960
View directory record Official record
Conditions
Cerebrovascular Accident
Interventions
Constrained Induced Therapy
Procedure
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2004
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Jan 20, 2009 · Synced Sep 28, 2026, 10:53 AM EDT
Recruiting Not applicable Interventional

Constraint-Induced Movement Therapy Plus Sensory Components After Stroke

NCT05515237
View directory record Official record
Conditions
CVA (Cerebrovascular Accident), Stroke, Upper Extremity Paresis
Interventions
Grade 2-5 CI Therapy + Sensory Components
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 89 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Sep 28, 2026, 10:53 AM EDT
Completed Not applicable Interventional

Video Game-based Therapy for Arm Weakness In Progressive Multiple Sclerosis

NCT03094364
View directory record Official record
Conditions
Primary Progressive Multiple Sclerosis, Hemiparesis
Interventions
Gaming CI Therapy
Behavioral
Lead sponsor
University of Massachusetts, Lowell
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 17, 2019 · Synced Sep 28, 2026, 10:53 AM EDT
Completed Phase 1Phase 2 Interventional

Constraint-Induced Therapy Modified for Rehabilitating Arm Function in Stroke Survivors w/Plegic Hands

NCT00366210
View directory record Official record
Conditions
Chronic Stroke Survivors With Plegic Hand
Interventions
Constraint-Induced Movement (CI) Therapy, Stretching, Relaxation, & Biofeedback
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 24, 2014 · Synced Sep 28, 2026, 10:53 AM EDT
Completed Not applicable Interventional Results available

Application of a Reimbursable Form of Constraint-Induced Movement Therapy for Upper Extremity

NCT05311384
View directory record Official record
Conditions
CVA (Cerebrovascular Accident), Stroke, Upper Extremity Paresis
Interventions
Keys Constraint-induced Movement Therapy protocol
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Mar 6, 2025 · Synced Sep 28, 2026, 10:53 AM EDT
Not listed Phase 2 Interventional

Constraint-Based Therapy to Improve Motor Function in Children With Cerebral Palsy

NCT00061139
View directory record Official record
Conditions
Cerebral Palsy, Motor Deficits
Interventions
Pediatric Constraint-Induced Movement therapy, Conventional pediatric motor rehabilitation therapy
Behavioral
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
2 Years to 6 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2006
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 23, 2005 · Synced Sep 28, 2026, 10:53 AM EDT
Completed Not applicable Interventional

The Brave Initiative: Bringing Rehabilitation to American Veterans in an Enriched Environment

NCT02339220
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Constraint-Induced Movement Therapy (CIMT), Lakeshore Enriched Fitness Training (LEFT), standard Transfer Package (sTP), enhanced Transfer Package (eTP)
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 90 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 5, 2023 · Synced Sep 28, 2026, 10:53 AM EDT
Completed Phase 2 Interventional

Treatment for Movement Problems in Elderly Stroke Patients

NCT00059696
View directory record Official record
Conditions
Cerebrovascular Disorders
Interventions
Constraint-Induced Movement Therapy
Procedure
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 1999
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Sep 25, 2016 · Synced Sep 28, 2026, 10:53 AM EDT