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Showing 1–24 of 61 matching trials from the live ClinicalTrials.gov search.
Completed Early Phase 1 Interventional Results available

CIMT and taVNS for Hemiplegia in Infants

NCT05101707
Conditions
Infant Development, Hemiplegia, Constraint Induced Movement Therapy
Interventions
transcutaneous auricular vagus nerve stimulation, Constraint induced movement therapy
Device · Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
6 Months to 18 Months
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Charleston, South Carolina
Conditions
Cerebral Palsy
Interventions
Constraint Induced Movement Therapy, CIMT + VR
Behavioral
Lead sponsor
Texas Scottish Rite Hospital for Children
Other
Eligibility
5 Years to 16 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Dallas, Texas
Conditions
Cerebrovascular Disorders
Interventions
Constraint-Induced Movement Therapy
Procedure
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 1999
U.S. locations
1
States / cities
Birmingham, Alabama
Conditions
Cerebral Palsy
Interventions
Custom EMG triggered Soterix taVNS stimulation with CIMT therapy in lab, Custom EMG triggered Soterix taVNS stimulation with CIMT therapy in home
Combination Product
Lead sponsor
Medical University of South Carolina
Other
Eligibility
6 Months to 18 Months
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Charleston, South Carolina
Conditions
CVA (Cerebrovascular Accident), Stroke, Upper Extremity Paresis
Interventions
Keys Constraint-induced Movement Therapy protocol
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Birmingham, Alabama
Active, not recruiting Not applicable Interventional

Feasibility and Effectiveness of Therapy Together

NCT07225673
Conditions
Cerebral Palsy
Interventions
Therapy Together - 4 hour group, Therapy Together - 1 hour group
Behavioral
Lead sponsor
Texas Scottish Rite Hospital for Children
Other
Eligibility
3 Months to 59 Months
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Frisco, Texas
Conditions
Cerebral Palsy, Motor Deficits
Interventions
Pediatric Constraint-Induced Movement therapy, Conventional pediatric motor rehabilitation therapy
Behavioral
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
2 Years to 6 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2006
U.S. locations
1
States / cities
Birmingham, Alabama
Conditions
Stroke, Hemiparesis
Interventions
Traditional CI Therapy, Gaming CI Therapy, Gaming CI Therapy with Additional Contact via Video Conference, Traditional Occupational Therapy/Physical Therapy
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
193 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
5
States / cities
Birmingham, Alabama • Columbia, Missouri • Columbus, Ohio + 1 more
Conditions
Cerebrovascular Accident
Interventions
Constrained Induced Therapy
Procedure
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2004
U.S. locations
1
States / cities
Palo Alto, California
Conditions
Cerebrovascular Accident
Interventions
Constraint-induced movement therapy
Procedure
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
18 Years to 80 Years
Enrollment
229 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2006
U.S. locations
7
States / cities
Birmingham, Alabama • Los Angeles, California • Gainesville, Florida + 4 more
Conditions
Stroke
Interventions
D-cycloserine + distributed treatment, D-cycloserine + condensed treatment, Placebo + distributed treatment, Placebo + condensed treatment
Drug · Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
20 Years to 80 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Gainesville, Florida
Conditions
Hemiplegia, Brain Tumor
Interventions
Focused rigidity bi-valve long arm cast
Other
Lead sponsor
St. Jude Children's Research Hospital
Other
Eligibility
2 Years to 12 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Memphis, Tennessee
Conditions
Focal Dystonia
Interventions
constraint-induced movement therapy
Behavioral
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
Not listed
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2002
U.S. locations
1
States / cities
Bethesda, Maryland
Conditions
Chronic Stroke Survivors With Plegic Hand
Interventions
Constraint-Induced Movement (CI) Therapy, Stretching, Relaxation, & Biofeedback
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
Birmingham, Alabama
Conditions
Stroke, Hemiplegia
Interventions
Constraint-Induced Movement Therapy + auditory rhythm cues, Constraint-Induced Movement Therapy
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
21 Years to 95 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Gainesville, Florida
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Brain Stimulation-aided Stroke Rehabilitation: Neural Mechanisms of Recovery

NCT01539096
Conditions
Stroke
Interventions
tDCS: noninvasive brain stimulation, Constraint induced movement therapy (CIMT), Sham tDCS: placebo noninvasive brain stimulation
Procedure · Behavioral
Lead sponsor
The Cleveland Clinic
Other
Eligibility
21 Years and older
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2019
U.S. locations
1
States / cities
Cleveland, Ohio
Conditions
Hemiparesis, Cerebral Palsy, Brain Injury
Interventions
Variations in Pediatric Constraint-Induced Movement Therapy (P-CIMT) versus usual and customary rehabilitation
Behavioral
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
2 Years to 9 Years
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
Roanoke, Virginia
Conditions
Stroke, Hemiplegia, Hemiparesis
Interventions
iTBS&eCIMT
Combination Product
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Birmingham, Alabama
Conditions
Stroke, Ischemic, Motor Activity, Upper Extremity Paralysis
Interventions
Sham, Low dose tDCS, High dose tDCS, mCIMT
Device · Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years to 80 Years
Enrollment
129 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
14
States / cities
Birmingham, Alabama • Los Angeles, California • Washington D.C., District of Columbia + 11 more
Conditions
Hemiplegia, Perinatal Brain Injury
Interventions
sTMS, taVNS
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
8 Months to 24 Months
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Charleston, South Carolina
Conditions
Cerebral Palsy, Hemiplegia, Children
Interventions
Constraint-induced Movement Therapy, Hand-arm Bimanual Intensive Therapy
Other
Lead sponsor
Teachers College, Columbia University
Other
Eligibility
6 Years to 17 Years
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
New York, New York
Completed Not applicable Interventional Results available

Sensory Stimulation During CIMT

NCT03558230
Conditions
Cerebral Palsy
Interventions
Standardized Constraint-Induced Movement Therapy, Vibration, Placebo (for vibration)
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
3 Years to 9 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Charleston, South Carolina
Conditions
Unilateral Cerebral Palsy
Interventions
Therapy Together
Behavioral
Lead sponsor
Texas Scottish Rite Hospital for Children
Other
Eligibility
3 Months to 3 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Denton, Texas
Conditions
Hemiplegia, Cerebral Palsy, Unilateral Cerebral Palsy
Interventions
Neuromuscular electrical stimulation, Modified constraint induced movement therapy, Standard care for infant with asymmetrical hand function
Device · Behavioral
Lead sponsor
Kathy Grinde
Other
Eligibility
7 Months to 10 Months
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Maple Grove, Minnesota