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Showing 1–16 of 16 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Continuous interscalene nerve block Clear all
Recruiting Phase 4 Interventional

Post Operative Infusion Pump Pain Study

NCT07349810
View directory record Official record
Conditions
Post Operative Pain
Interventions
Bupivacaine 0.5% Injectable Solution, Ropivacaine 0.2% Injectable Solution, 1.3% liposomal bupivacaine (Exparel), ambIT Infusion Pump
Drug · Device
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Somerset, New Jersey
Source: ClinicalTrials.gov public record
Updated Jan 20, 2026 · Synced Sep 2, 2026, 2:14 PM EDT
Recruiting No phase listed Observational

Evaluating Hemidiaphragmatic Paralysis With Prolonged Neural Blockade From an Interscalene Brachial Plexus Block

NCT04209504
View directory record Official record
Conditions
Shoulder Surgery, Shoulder Pain, Shoulder Injuries, Shoulder Arthritis, Shoulder Disease, Rotator Cuff Tears, Rotator Cuff Injuries, Rotator Cuff Arthropathy of Left Shoulder, Rotator Cuff Arthropathy of Right Shoulder, Rotator Cuff Repair
Interventions
Ultrasound, Ropivacaine, Bupivacaine, MediPines AGM100 Advanced Respiratory Monitoring System
Diagnostic Test · Drug · Device
Lead sponsor
Duke University
Other
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 30, 2025 · Synced Sep 2, 2026, 2:14 PM EDT
Completed Not applicable Interventional

Interscalene Bupivacaine With Either Liposomal Bupivacaine or Continuous Peripheral Nerve Block for Shoulder Arthroscopy

NCT03816982
View directory record Official record
Conditions
Shoulder Pain
Interventions
Single-injection bupivacaine HCl plus liposomal bupivacaine, Single-injection bupivacaine HCl plus a subsequent bupivacaine CISB
Procedure
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 22, 2023 · Synced Sep 2, 2026, 2:14 PM EDT
Completed No phase listed Observational

Comparison of Pain Relief After Non Stimulating Interscalene Catheter Placement vs Stimulating Catheter Placement in Total Shoulder Arthroplasty.

NCT01122732
View directory record Official record
Conditions
Pain, Shoulder, Arthroplasty
Interventions
Not listed
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 90 Years
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 31, 2016 · Synced Sep 2, 2026, 2:14 PM EDT
Completed Not applicable Interventional

Comparison of Pulmonary Function and Efficacy of Different Nerve Block Catheters for Shoulder Surgery

NCT02117778
View directory record Official record
Conditions
Post-Operative Pain
Interventions
Continuous Nerve Block
Procedure
Lead sponsor
Benaroya Research Institute
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 2, 2017 · Synced Sep 2, 2026, 2:14 PM EDT
Terminated Phase 4 Interventional

Liposomal Bupivacaine Infiltration vs Continuous Perineural Ropivacaine Infusion for Post-operative Pain After Total Shoulder Arthroplasty

NCT02787226
View directory record Official record
Conditions
Postoperative Pain, Shoulder Arthritis
Interventions
Liposomal Bupivacaine Infiltration, Continuous Perineural Ropivicaine Infusion
Drug
Lead sponsor
Eric Shepard
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 8, 2018 · Synced Sep 2, 2026, 2:14 PM EDT
Withdrawn Phase 4 Interventional

Effective Pain Management During Shoulder Replacement Surgery With EXPAREL

NCT03474510
View directory record Official record
Conditions
Pain, Postoperative, Shoulder Osteoarthritis
Interventions
local infiltration of liposomal bupivacaine, continuous infusion of ropivacaine interscalene nerve block
Drug · Other
Lead sponsor
TriHealth Inc.
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 28, 2021 · Synced Sep 2, 2026, 2:14 PM EDT
Completed Phase 4 Interventional Results available

Liposomal Bupivacaine Single-Injection Interscalene Block vs. Continuous Interscalene Block for Primary Total Shoulder Arthroplasty

NCT05005260
View directory record Official record
Conditions
Pain, Postoperative, Brachial Plexus Block
Interventions
Bupivacaine HCl, Liposomal bupivacaine + Bupivacaine Hcl 0.5% Inj
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 6, 2024 · Synced Sep 2, 2026, 2:14 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Analgesic Efficacy of Interscalene Nerve Block Versus Local Infiltration Analgesia Following Total Shoulder Arthroplasty

NCT02876055
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Single shot interscalene nerve block, Continuous interscalene nerve block, Local Infiltration Analgesia (LIA)
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
125 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 15, 2019 · Synced Sep 2, 2026, 2:14 PM EDT
Not listed Not applicable Interventional

Efficacy of Nerve Blockade Performed Prior to Surgical Intervention Versus Following Surgical Intervention

NCT02666118
View directory record Official record
Conditions
Pain, Shoulder Injury
Interventions
Preemptive Interscalene Block - Single Shot, Postoperative Interscalene Block- Single Shot, Preemptive Interscalene Block - Catheter, Postoperative Interscalene Block - Catheter
Procedure
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
10 Years to 21 Years
Enrollment
79 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2025
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 1, 2024 · Synced Sep 2, 2026, 2:14 PM EDT
Completed Phase 4 Interventional

Perineural Catheter Insertion Distance for Continuous Peripheral Nerve Blocks

NCT00997867
View directory record Official record
Conditions
Lower Extremity Surgery, Upper Extremity Surgery, Post-operative Pain
Interventions
Sciatic catheter left 0-1cm past needle tip vs. 5-6cm past needle tip
Procedure
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Oct 27, 2010 · Synced Sep 2, 2026, 2:14 PM EDT
Completed No phase listed Observational

Continuous Blockade of the Brachial Plexus

NCT02769429
View directory record Official record
Conditions
Arthroses, Degenerative Disorder, Osteoarthritis
Interventions
Ultrasound-guided CISB, nerve stimulator-guided CCPVB
Device
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 80 Years
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
2
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 24, 2019 · Synced Sep 2, 2026, 2:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Bupivacaine Versus Ropivacaine on Diaphragmatic Motility and Ventilatory Function

NCT02059070
View directory record Official record
Conditions
Paresis
Interventions
Ropivacaine, Bupivacaine
Drug
Lead sponsor
Anesthesiology WSU/DMC-NorthStar
Other
Eligibility
18 Years to 70 Years
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Madison Heights, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 24, 2014 · Synced Sep 2, 2026, 2:14 PM EDT
Terminated Not applicable Interventional

Prospective Evaluation of Interscalene Nerve Catheters vs. Single Injection Blocks

NCT01385449
View directory record Official record
Conditions
Pain
Interventions
interscalene catheter, interscalene block
Procedure
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 79 Years
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
2
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 17, 2019 · Synced Sep 2, 2026, 2:14 PM EDT
Completed Not applicable Interventional Results available

Initial Local Anesthetic Dose With Continuous Interscalene Analgesia

NCT00672100
View directory record Official record
Conditions
Post-operative Pain
Interventions
Ropivacaine
Drug
Lead sponsor
Corewell Health East
Other
Eligibility
18 Years to 80 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
2
States / cities
Royal Oak, Michigan • Troy, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 6, 2017 · Synced Sep 2, 2026, 2:14 PM EDT
Terminated Phase 4 Interventional

Shoulder Adhesive Capsulitis and Ambulatory Continuous Interscalene Nerve Blocks

NCT00875862
View directory record Official record
Conditions
Adhesive Capsulitis, Post-operative Pain
Interventions
Interscalene catheter with Ropivicaine or normal saline
Procedure
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jul 24, 2019 · Synced Sep 2, 2026, 2:14 PM EDT