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Showing 1–24 of 93 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Control Chewing Gum Clear all
Completed Not applicable Interventional

Novel PAradigm to Improve Inflammatory Burden in ESRD (rePAIR): A Pilot and Feasibility Randomized Controlled Trial

NCT03241511
View directory record Official record
Conditions
Chronic Periodontitis, End Stage Renal Disease
Interventions
Test
Other
Lead sponsor
UConn Health
Other
Eligibility
21 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 4, 2025 · Synced Sep 2, 2026, 5:42 PM EDT
Active, not recruiting Phase 1 Interventional Accepts healthy volunteers

Nicotine Pouch Pharmacokinetics Abuse Liability

NCT07476144
View directory record Official record
Conditions
Smoking Behaviors
Interventions
Participants will place the pouch between their top lip and their gum for 30 minutes as per use instructions.
Drug
Lead sponsor
JT International SA
Industry
Eligibility
22 Years to 65 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
2
States / cities
Knoxville, Tennessee • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 2, 2026, 5:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Post-operative Sore Throat and Gum Chewing

NCT04859101
View directory record Official record
Conditions
Anesthesia, Surgery
Interventions
Gum, Control
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 75 Years
Enrollment
86 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 12, 2022 · Synced Sep 2, 2026, 5:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of a Cranberry Beverage on Intestinal Permeability and Gastrointestinal Function in Generally Healthy Adults

NCT03957239
View directory record Official record
Conditions
Intestinal Permeability, Gastrointestinal Function
Interventions
Cranberry Beverage, Control Beverage
Other
Lead sponsor
University of Florida
Other
Eligibility
21 Years to 50 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 6, 2020 · Synced Sep 2, 2026, 5:42 PM EDT
Not yet recruiting Phase 3 Interventional

Orthodontic Pain Alleviation With Chewing Gum

NCT07210697
View directory record Official record
Conditions
Orthodontic Appliances
Interventions
Xylitol Gum
Drug
Lead sponsor
West Virginia University
Other
Eligibility
Up to 18 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Oct 6, 2025 · Synced Sep 2, 2026, 5:42 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Star Matrix vs Autogenous Graft for Gingival Augmentation: Split-Mouth RCT

NCT07440303
View directory record Official record
Conditions
Lack of Keratinized Gingiva, Mucogingival Deformity - Insufficient Keratinized Tissue
Interventions
Starmatrix collagen membrane, Autogenous gingival graft
Device · Other
Lead sponsor
Harvard Medical School (HMS and HSDM)
Other
Eligibility
20 Years to 80 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 26, 2026 · Synced Sep 2, 2026, 5:42 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Study to Assess Repeated Doses of INDV-2000 in Healthy Volunteers and in Treatment Seeking Individuals With Opioid Use Disorder

NCT04976855
View directory record Official record
Conditions
Healthy Volunteer, Opioid-use Disorder
Interventions
INDV-2000, Placebo, SUBOXONE® sublingual film
Drug
Lead sponsor
Indivior Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
3
States / cities
Baltimore, Maryland • DeSoto, Texas • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Aug 20, 2024 · Synced Sep 2, 2026, 5:42 PM EDT
Completed Not applicable Interventional Results available

Quit For Life (QFL): Smoking Cessation Among Chinese Smokers Living With HIV

NCT05020899
View directory record Official record
Conditions
Smoking Cessation, HIV Infections
Interventions
Sessions with a trained counselor, Cell phone messages, Offered nicotine replacement therapy, Self-help guide for quitting smoking
Behavioral · Other
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older
Enrollment
109 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 11, 2024 · Synced Sep 2, 2026, 5:42 PM EDT
Terminated Phase 2 Interventional

Efficacy & Safety of RPh201 Treatment in Patients With Previous Nonarteritic Anterior Ischemic Optic Neuropathy (NAION)

NCT03547206
View directory record Official record
Conditions
Nonarteritic Anterior Ischemic Optic Neuropathy
Interventions
RPh201 Cohort A, Placebo Cohort A, RPh201 Cohort B, Placebo Cohort B
Drug · Other
Lead sponsor
Regenera Pharma Ltd
Industry
Eligibility
50 Years and older
Enrollment
165 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
15
States / cities
Palo Alto, California • Pasadena, California • Orange, Connecticut + 12 more
Source: ClinicalTrials.gov public record
Updated Oct 11, 2020 · Synced Sep 2, 2026, 5:42 PM EDT
Completed Not applicable Interventional Results available

Improving Adherence to Web-Based Cessation Programs: A Social Network Approach

NCT01544153
View directory record Official record
Conditions
Smoking Cessation
Interventions
WEB, Social Network, Nicotine Replacement Therapy (NRT)
Behavioral
Lead sponsor
Truth Initiative
Other
Eligibility
18 Years and older
Enrollment
5,292 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Nov 12, 2017 · Synced Sep 2, 2026, 5:42 PM EDT
Completed Phase 1 Interventional

Double Blind Randomized Placebo Controlled Trial of FOSTRAP Chewing Gum in Patients With CKD and Hyperphosphatemia

NCT01057108
View directory record Official record
Conditions
Hyperphosphatemia, Chronic Kidney Disease
Interventions
FOSTRAP Chewing Gum, Placebo chewing gum
Other
Lead sponsor
Denver Nephrologists, P.C.
Other
Eligibility
18 Years and older
Enrollment
121 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 6, 2011 · Synced Sep 2, 2026, 5:42 PM EDT
Completed Phase 1Phase 2 Interventional

Acute Nicotine Gum and Tinnitus Loudness in Non-Smoking Adults

NCT07772089
View directory record Official record
Conditions
Tinnitus, Chronic Subjective Tinnitus
Interventions
Nicotine polacrilex gum 4 mg, Placebo gum
Drug · Other
Lead sponsor
Xianhui Wang
Other
Eligibility
18 Years to 80 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 2, 2026, 5:42 PM EDT
Withdrawn Not applicable Interventional

The Effect of Gum Chewing on Postoperative Ileus

NCT00879294
View directory record Official record
Conditions
Perforated Appendicitis
Interventions
Motion sickness wristband, Chewing Gum
Device · Dietary Supplement
Lead sponsor
Wake Forest University
Other
Eligibility
6 Years to 18 Years
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 5, 2017 · Synced Sep 2, 2026, 5:42 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Comparing Buccal and Vaginal Misoprostol in Management of Early Pregnancy Loss

NCT02141555
View directory record Official record
Conditions
Spontaneous Abortion in First Trimester
Interventions
Vaginal Misoprostol, Buccal Misoprostol
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
2
States / cities
La Jolla, California • San Diego, California
Source: ClinicalTrials.gov public record
Updated Aug 14, 2019 · Synced Sep 2, 2026, 5:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Clinical Study to Evaluate the Effectiveness of an Experimental Toothpaste in Improving Gum Health and Reducing Plaque Accumulation

NCT07255040
View directory record Official record
Conditions
Dental Plaque, Gingivitis
Interventions
Test Dentifrice, Parodontax Complete Protection, Colgate Cavity Protection
Drug
Lead sponsor
HALEON
Industry
Eligibility
18 Years and older
Enrollment
284 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 4, 2026 · Synced Sep 2, 2026, 5:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Study to Evaluate the Efficacy of a Stannous Fluoride Toothpaste With a Cetylpyridinium Chloride Mouthwash in Improving Gingival Health and Reducing Plaque Accumulation

NCT06660069
View directory record Official record
Conditions
Dental Plaque, Gingivitis
Interventions
Stannous Fluoride Toothpaste (Parodontax Complete Protection Toothpaste), CPC Mouthwash (Parodontax Active Gum Health Mouthwash), Regular Fluoride Toothpaste (Crest Cavity Protection)
Drug
Lead sponsor
HALEON
Industry
Eligibility
18 Years and older
Enrollment
199 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Sep 2, 2026, 5:42 PM EDT
Completed Not applicable Interventional Results available

Pharmacokinetic and Subjective Effects of Heated Tobacco Products

NCT06356610
View directory record Official record
Conditions
Tobacco Use
Interventions
Product A, Product B, Product C, Product D, Product E, Product F
Other
Lead sponsor
Altria Client Services LLC
Industry
Eligibility
22 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
3
States / cities
Lexington, Kentucky • Springfield, Missouri • Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 26, 2026 · Synced Sep 2, 2026, 5:42 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Twelve Week Study of Prototypes Mouth Rinses

NCT05526586
View directory record Official record
Conditions
Healthy
Interventions
Colgate Cavity Protection Toothpaste, Zero Alcohol Gum Prototype, Alcohol Gum Prototype, Listerine Cool Mint Antiseptic Mouthwash, 5% Hydroalcohol
Other
Lead sponsor
Johnson & Johnson Consumer Inc. (J&JCI)
Industry
Eligibility
18 Years and older
Enrollment
192 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 4, 2023 · Synced Sep 2, 2026, 5:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Safety and Efficacy of KH-1 for Stimulating Autophagy in Non-diabetic Adults With Elevated Blood Glucose Concentration

NCT06445569
View directory record Official record
Conditions
PreDiabetes, Aging
Interventions
KH-1, Placebo
Dietary Supplement · Other
Lead sponsor
Kalin Health, LLC
Industry
Eligibility
50 Years and older
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 5, 2024 · Synced Sep 2, 2026, 5:42 PM EDT
Not yet recruiting Not applicable Interventional

Early Time-Restricted Eating for Cardiovascular Health

NCT07634926
View directory record Official record
Conditions
Hypertension, Breakfast Skipper
Interventions
Early Time-Restricted Eating (eTRE)
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
60 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Sep 2, 2026, 5:42 PM EDT
Completed Not applicable Interventional

Chewing Gum Facilitates an Earlier Return to Bowel Function in Pediatric Scoliosis Patients: A Prospective Randomized Study

NCT02165436
View directory record Official record
Conditions
Scoliosis
Interventions
Chewing gum, Control
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
10 Years to 18 Years
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 16, 2014 · Synced Sep 2, 2026, 5:42 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Two-Week Study of Clinical Safety and Saliva Flow Quantification

NCT05645705
View directory record Official record
Conditions
Healthy
Interventions
Colgate Cavity Protection Toothpaste, LISTERINE Cool Mint Antiseptic Mouthwash, Listerine Advanced Gum Alcohol, Listerine Advanced Gum Zero, LISTERINE ULTRACLEAN Tartar Control Antiseptic Mouthwash Cool Mint
Other
Lead sponsor
Johnson & Johnson Consumer Inc. (J&JCI)
Industry
Eligibility
18 Years and older
Enrollment
270 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 9, 2023 · Synced Sep 2, 2026, 5:42 PM EDT
Withdrawn Phase 1Phase 2 Interventional

ACE2 Chewing Gum on SARS-CoV-2 Viral Load (COVID 19)

NCT05433181
View directory record Official record
Conditions
SARS-CoV-2
Interventions
ACE2 Chewing Gum, Placebo Chewing Gum
Drug · Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 29, 2025 · Synced Sep 2, 2026, 5:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Saving Lives at Birth: Primary Prevention of Periodontal Disease in Relation to Preterm Birth in Malawi

NCT02333227
View directory record Official record
Conditions
Preterm Birth, Periodontal Disease, Caries, Dental
Interventions
Xylitol gum
Dietary Supplement
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 64 Years · Female only
Enrollment
10,069 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2021
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 7, 2024 · Synced Sep 2, 2026, 5:42 PM EDT