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ClinicalTrials.gov public records Last synced Oct 21, 2026, 9:59 AM EDT

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Showing 1–24 of 282 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Control lens Clear all
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Safety and Efficacy of Intracanalicular Dexamethasone Compared to Loteprednol Etabonate in Patients With Keratoconus

NCT04418999
View directory record Official record
Conditions
Keratoconus, Dry Eye, Allergy
Interventions
dexamethasone ophthalmic insert 0.4 mg, for intracanalicular use, Loteprednol Etabonate 0.38% Ophthalmic Gel/Jelly
Drug
Lead sponsor
Illinois College of Optometry
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 24, 2026 · Synced Oct 21, 2026, 9:59 AM EDT
Completed Phase 2 Interventional

Prolongation of Contact Lens Comfortable Wear Duration by CLM2 Topical Gel

NCT03994406
View directory record Official record
Conditions
Contact Lens Discomfort, Contact Lens-induced Corneal Disorder, Contact Lens Acute Red Eye, Contact Lens-induced Corneal Fluorescein Staining
Interventions
CLM2 topical gel, Placebo topical gel
Drug
Lead sponsor
Glia, LLC
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Berkeley, California
Source: ClinicalTrials.gov public record
Updated Mar 24, 2023 · Synced Oct 21, 2026, 9:59 AM EDT
Completed Phase 3 Interventional Results available

Safety, Efficacy and Pharmacokinetics of OMS302 in Subjects Undergoing Intraocular Lens Replacement With Phacoemulsification

NCT01579565
View directory record Official record
Conditions
Intraocular Lens Replacement
Interventions
OMS302, Placebo
Drug
Lead sponsor
Omeros Corporation
Industry
Eligibility
18 Years and older
Enrollment
416 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
13
States / cities
Chandler, Arizona • Los Angeles, California • Fort Myers, Florida + 10 more
Source: ClinicalTrials.gov public record
Updated Jun 14, 2017 · Synced Oct 21, 2026, 9:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Visual Performance of Two Types of Cosmetic Contact Lenses

NCT04534764
View directory record Official record
Conditions
Visual Acuity
Interventions
etafilcon A with cosmetic pattern, 1-Day Acuvue DEFINE Vivid Style
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 39 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Maitland, Florida
Source: ClinicalTrials.gov public record
Updated Sep 1, 2021 · Synced Oct 21, 2026, 9:59 AM EDT
Completed Phase 2 Interventional

A Study of MELT-300 (Midazolam and Ketamine Sublingual Tablets) for Sedation and Intraoperative Ocular Analgesia in Participants Undergoing Cataract Extraction With Lens Replacement (CELR)

NCT05133518
View directory record Official record
Conditions
Cataract
Interventions
MELT-300, Midazolam alone, Ketamine alone, Placebo
Drug
Lead sponsor
Melt Pharmaceuticals
Industry
Eligibility
55 Years and older
Enrollment
338 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
3
States / cities
Rancho Cordova, California • Jacksonville, Florida • West Fargo, North Dakota
Source: ClinicalTrials.gov public record
Updated Dec 19, 2022 · Synced Oct 21, 2026, 9:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of Approved Contact Lenses

NCT07174596
View directory record Official record
Conditions
Visual Acuity
Interventions
B+L Infuse spherical soft contact lenses, J&J ACUVUE OASYS 1-Day spherical soft contact lenses
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 39 Years
Enrollment
85 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
4
States / cities
Roswell, Georgia • New Bremen, Ohio • Salem, Virginia + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Oct 21, 2026, 9:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Validation of Senofilcon A With New UV / HEV Filter

NCT05099380
View directory record Official record
Conditions
Visual Acuity
Interventions
senofilcon A C3, senofilcon A
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 39 Years
Enrollment
296 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
17
States / cities
Cupertino, California • San Francisco, California • Jacksonville, Florida + 14 more
Source: ClinicalTrials.gov public record
Updated Feb 6, 2023 · Synced Oct 21, 2026, 9:59 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Mobility Performance in Daily Activities Among Children Wearing Spectacle Lenses

NCT07229352
View directory record Official record
Conditions
Myopia, Myopia Progression, Juvenile Myopia
Interventions
Novel spectacle lens design, Spectacle lenses
Device
Lead sponsor
SightGlass Vision, Inc.
Industry
Eligibility
6 Years to 12 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Glendale, Arizona
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Oct 21, 2026, 9:59 AM EDT
Enrolling by invitation Not applicable Interventional

Effectiveness of a Large Language Model-Based Educational Tool on Intraocular Lens Options

NCT07317661
View directory record Official record
Conditions
Eye Disorders, Cataract Extraction, Cataract and IOL Surgery, Cataract Surgery Experience, Cataract Surgery, Intraocular Lens
Interventions
LLM-based Education
Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Jan 5, 2026 · Synced Oct 21, 2026, 9:59 AM EDT
Not yet recruiting Not applicable Interventional

Contact Lenses to Slow Myopia Progression in Adults

NCT07747311
View directory record Official record
Conditions
Myopia, Myopia Progression
Interventions
Dual Focus Soft Contact Lens, Single Vision Soft Contact Lens
Device
Lead sponsor
University of California, Berkeley
Other
Eligibility
18 Years to 30 Years
Enrollment
152 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Berkeley, California
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Oct 21, 2026, 9:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Effects of Contact Lenses With UV/HEV-Filter on Visual Function

NCT05601544
View directory record Official record
Conditions
Visual Acuity
Interventions
ACUVUE OASYS 1-Day, ACUVUE OASYS MAX 1-Day, ACUVUE OASYS Multifocal, ACUVUE OASYS MAX 1-Day Multifocal, ACUVUE OASYS 1-Day for Astigmatism, senofilcon A based contact lens (toric) with new UV/HEV filter
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
145 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Athens, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 27, 2025 · Synced Oct 21, 2026, 9:59 AM EDT
Completed Not applicable Interventional Results available

Evaluation of the Performance of Two Contact Lenses Compared to a Marketed Lens

NCT01484028
View directory record Official record
Conditions
Refractive Ametropia
Interventions
etafilcon A control lens (1DM), etafilcon A with print and PVP for light eyes (EALE), etafilcon A with print and PVP for dark eyes (EADE)
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 34 Years · Female only
Enrollment
275 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
15
States / cities
Mission Viejo, California • Pismo Beach, California • Sarasota, Florida + 11 more
Source: ClinicalTrials.gov public record
Updated Jun 19, 2018 · Synced Oct 21, 2026, 9:59 AM EDT
Completed Phase 3 Interventional Results available

Evaluation of New or Worsening Lens Opacifications in Men With Non-metastatic Prostate Cancer Receiving Denosumab for Bone Loss

NCT00925600
View directory record Official record
Conditions
Cancer, Cataract, Low Bone Mineral Density, Osteopenia, Osteoporosis, Prostate Cancer
Interventions
Denosumab, Placebo
Biological
Lead sponsor
Amgen
Industry
Eligibility
30 Years to 120 Years · Male only
Enrollment
769 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2016
U.S. locations
52
States / cities
Anaheim, California • Laguna Hills, California • Murrieta, California + 45 more
Source: ClinicalTrials.gov public record
Updated May 30, 2017 · Synced Oct 21, 2026, 9:59 AM EDT
Completed Not applicable Interventional Results available

A Post-Market Evaluation of LipiFlow Treatment in Cataract Surgery Practice

NCT03708367
View directory record Official record
Conditions
Cataracts, Meibomian Gland Dysfunction (MGD)
Interventions
LipiFlow Thermal Pulsation System
Device
Lead sponsor
Johnson & Johnson Surgical Vision, Inc.
Industry
Eligibility
22 Years and older
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
5
States / cities
Bakersfield, California • Chevy Chase, Maryland • Pennington, New Jersey + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 27, 2021 · Synced Oct 21, 2026, 9:59 AM EDT
Completed Not applicable Interventional Results available

Safety and Efficacy of a Contact Lens for Daily Disposable Use

NCT01365039
View directory record Official record
Conditions
Myopia
Interventions
Test, daily disposable contact lens, SofLens daily disposable contact lens
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years to 40 Years
Enrollment
173 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jan 8, 2014 · Synced Oct 21, 2026, 9:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Feasibility Evaluation of Daily Disposable Toric Soft Contact Lenses Manufactured With an Alternative Hydration Process

NCT05427539
View directory record Official record
Conditions
Ocular Physiology
Interventions
TEST LENS, CONTROL LENS
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 39 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
6
States / cities
Jacksonville, Florida • Maitland, Florida • Vestal, New York + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 2, 2023 · Synced Oct 21, 2026, 9:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Effects of Contact Lenses With Experimental Dye on Visual Function

NCT03556579
View directory record Official record
Conditions
Ametropia
Interventions
senofilcon A with new UV blocker, senofilcon A
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Statesboro, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 18, 2019 · Synced Oct 21, 2026, 9:59 AM EDT
Completed Not applicable Interventional Results available

Performance of Wearers of Stenfilcon A Contact Lenses After A Refit With Test Lenses

NCT03496701
View directory record Official record
Conditions
Myopia
Interventions
Test lens, control lens
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
18 Years to 35 Years
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
4
States / cities
San Diego, California • Whittier, California • Sarasota, Florida + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 30, 2021 · Synced Oct 21, 2026, 9:59 AM EDT
Completed No phase listed Interventional Results available

Clinical Validation of the Apollo Daily Disposable Soft Contact Lenses

NCT05035017
View directory record Official record
Conditions
Myopia
Interventions
Test Lens, Control Lens
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 12, 2024 · Synced Oct 21, 2026, 9:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluate the Safety and Effectiveness of the Biotrue ONEday for Astigmatism

NCT03681808
View directory record Official record
Conditions
Astigmatism
Interventions
Control, Test
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years and older
Enrollment
242 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
13
States / cities
Irvine, California • San Diego, California • San Francisco, California + 9 more
Source: ClinicalTrials.gov public record
Updated Jan 8, 2021 · Synced Oct 21, 2026, 9:59 AM EDT
Not listed Not applicable Interventional

Evaluation of Curriculum for Teen Pregnancy Prevention: Decisions, Responsibility, Empowerment, Accountability, Motivations & Success

NCT03311061
View directory record Official record
Conditions
Teen Pregnancy
Interventions
DREAMS Curriculum
Other
Lead sponsor
Winter Rose Services, LLC
Other
Eligibility
13 Years to 19 Years
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 16, 2017 · Synced Oct 21, 2026, 9:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

High Refractive Index Material 510(k)

NCT00766168
View directory record Official record
Conditions
Myopia, Hyperopia
Interventions
HDS HI 1.54; pahrifocon A, FluoroPerm 30 RGP; paflufocon C
Other · Device
Lead sponsor
CooperVision International Limited (CVIL)
Industry
Eligibility
12 Years and older
Enrollment
76 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
8
States / cities
Lake Elsinore, California • Englewood, Colorado • East Lansing, Michigan + 5 more
Source: ClinicalTrials.gov public record
Updated Jun 14, 2012 · Synced Oct 21, 2026, 9:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Evaluation of Daily Disposable Etafilcon A Cosmetic Contact Lenses

NCT04529109
View directory record Official record
Conditions
Visual Acuity
Interventions
etafilcon A investigational cosmetic lens 1, etafilcon A investigational cosmetic lens 2
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 29 Years · Female only
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
2
States / cities
Jacksonville, Florida • Tyler, Texas
Source: ClinicalTrials.gov public record
Updated Nov 24, 2021 · Synced Oct 21, 2026, 9:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Design Validation of Senofilcon A With New UV-blocking Additive

NCT03707821
View directory record Official record
Conditions
Visual Acuity
Interventions
senofilcon A TEST Lens, senofilcon A CONTROL Lens
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 49 Years
Enrollment
253 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
10
States / cities
Cupertino, California • Maitland, Florida • Tallahassee, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Dec 5, 2019 · Synced Oct 21, 2026, 9:59 AM EDT