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Showing 1–24 of 27 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Cooled Radiofrequency Clear all
Recruiting Not applicable Interventional

Fluoroscopic Versus Ultrasound Guidance for Cooled Radiofrequency Ablation of Geniculate Nerves in Knee Osteoarthritis: A Randomized Control Trial

NCT04472702
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
cRFA
Procedure
Lead sponsor
University of California, Davis
Other
Eligibility
35 Years to 99 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
2
States / cities
Sacramento, California • Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jun 15, 2026 · Synced Sep 3, 2026, 2:48 AM EDT
Completed Not applicable Interventional

A Study of Strategies for Electrical Isolation of Pulmonic Veins for Curative Treatment of Atrial Fibrillation

NCT00434694
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Pulmonary Vein Isolation (Radiofrequency Catheter Ablation)
Procedure
Lead sponsor
University of Pennsylvania
Other
Eligibility
40 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2006
U.S. locations
2
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 24, 2015 · Synced Sep 3, 2026, 2:48 AM EDT
Completed Not applicable Interventional

Lateral Branch Cooled Radiofrequency Denervation vs. Conservative Therapy for Sacroiliac Joint Pain

NCT03601949
View directory record Official record
Conditions
Sacroiliac Joint Pain
Interventions
SInergy Cooled Radiofrequency, Medical Management
Device · Other
Lead sponsor
Avanos Medical
Other
Eligibility
21 Years to 110 Years
Enrollment
210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
15
States / cities
Washington D.C., District of Columbia • Bloomington, Illinois • New Orleans, Louisiana + 11 more
Source: ClinicalTrials.gov public record
Updated Mar 21, 2023 · Synced Sep 3, 2026, 2:48 AM EDT
Terminated Not applicable Interventional Results available

Efficacy of Cooled and Monopolar Radiofrequency Ablation of the Geniculate Nerves for the Treatment of Chronic Osteoarthritic Knee Pain

NCT02260869
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Genicular nerve radiofrequency ablation, Pain Management Radiofrequency Kit
Procedure · Device
Lead sponsor
Millennium Pain Center
Other
Eligibility
18 Years to 100 Years
Enrollment
79 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
3
States / cities
Bloomington, Illinois • Decatur, Illinois • Peoria, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 25, 2022 · Synced Sep 3, 2026, 2:48 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Venus Versa Diamondpolar Applicator Treatment Followed by AC Dual Applicator Treatment for Facial Acne Vulgaris

NCT02924428
View directory record Official record
Conditions
Acne Vulgaris
Interventions
Venus Versa
Device
Lead sponsor
Venus Concept
Industry
Eligibility
18 Years to 55 Years
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 8, 2020 · Synced Sep 3, 2026, 2:48 AM EDT
Completed Not applicable Interventional

Optimal Performance of RFA of the Nerves Supplying the Posterior Sacroiliac Joint Complex.

NCT02808962
View directory record Official record
Conditions
Osteoarthritis Nos, of Sacroiliac Joint
Interventions
Cooled RFA of sacral lateral branches
Procedure
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 10, 2022 · Synced Sep 3, 2026, 2:48 AM EDT
Recruiting Not applicable Interventional

VR and Cooled Genicular Nerve Radio Frequency Ablation for Chronic Knee Pain

NCT06336447
View directory record Official record
Conditions
Pain, Chronic
Interventions
Experimental: Group #1: Virtual Reality Headset, Group 2 No Virtual Reality Headset
Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 27, 2024 · Synced Sep 3, 2026, 2:48 AM EDT
Terminated No phase listed Observational

Cooled Versus Conventional Genicular Radiofrequency Ablation for Chronic Knee Pain

NCT04275128
View directory record Official record
Conditions
Chronic Knee Pain
Interventions
Cooled radiofrequency ablation, Conventional radiofrequency ablation
Device
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 27, 2020 · Synced Sep 3, 2026, 2:48 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Trial Assessing Cooled Radiofrequency Denervation as a Treatment for Sacroiliac Joint Pain Using the Sinergy System

NCT00802997
View directory record Official record
Conditions
Other Acute Pain, Chronic Pain
Interventions
Sinergy, Placebo sham
Device
Lead sponsor
Baylis Medical Company
Industry
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Bradenton, Florida
Source: ClinicalTrials.gov public record
Updated Dec 31, 2013 · Synced Sep 3, 2026, 2:48 AM EDT
Terminated Not applicable Interventional Results available

Impact of Renal SympAthetic DenerVation on Chronic HypErtension

NCT01628198
View directory record Official record
Conditions
Uncontrolled Hypertension
Interventions
Celcius Thermacool Catheter or Chilli II Cooled Ablation Catheter
Device
Lead sponsor
Vivek Reddy
Other
Eligibility
18 Years to 85 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 18, 2018 · Synced Sep 3, 2026, 2:48 AM EDT
Not listed Not applicable Interventional

Cooled RFA vs Conventional RFA to Manage Chronic Facetogenic Low Back Pain

NCT04803149
View directory record Official record
Conditions
Chronic Low-back Pain
Interventions
Cooled Radiofrequency, Conventional Radiofrequency
Device
Lead sponsor
Avanos Medical
Other
Eligibility
21 Years and older
Enrollment
79 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
10
States / cities
Washington D.C., District of Columbia • Bloomington, Illinois • New Orleans, Louisiana + 7 more
Source: ClinicalTrials.gov public record
Updated Jun 29, 2022 · Synced Sep 3, 2026, 2:48 AM EDT
Completed Not applicable Interventional

Coolief Cooled Radiofrequency vs. Conventional Radiofrequency to Manage OA Knee Pain

NCT04145011
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
Cooled Radiofrequency, Standard Radiofrequency
Device
Lead sponsor
Avanos Medical
Other
Eligibility
21 Years and older
Enrollment
153 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
7
States / cities
Altoona, Pennsylvania • Sewickley, Pennsylvania • State College, Pennsylvania + 4 more
Source: ClinicalTrials.gov public record
Updated Aug 7, 2023 · Synced Sep 3, 2026, 2:48 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Cooled RF Lesion MRI Characteristics

NCT03631030
View directory record Official record
Conditions
Arthritis;Lumbosacral, Osteo Arthritis Knee, Sacroiliitis, Hip Osteoarthritis, Arthritis, Degenerative
Interventions
Cooled radiofrequency ablation
Device
Lead sponsor
International Spine, Pain and Performance Center
Other
Eligibility
21 Years and older
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Arlington, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 6, 2019 · Synced Sep 3, 2026, 2:48 AM EDT
Not listed No phase listed Observational

Technical Description of Cooled Radiofrequency Ablation of Lumbar Medial Branches for the Treatment of Lumbar Facet Pain

NCT01590004
View directory record Official record
Conditions
Lumbar Facet Joint Pain
Interventions
Not listed
Lead sponsor
Mehul Desai
Industry
Eligibility
18 Years to 75 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2012
U.S. locations
1
States / cities
Edina, Minnesota
Source: ClinicalTrials.gov public record
Updated May 18, 2015 · Synced Sep 3, 2026, 2:48 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Genicular Radiofrequency Ablation for Unilateral Knee Arthroplasty Pain Management

NCT02925442
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
t-RFA, C-RFA, Control
Procedure
Lead sponsor
Lyman Medical Research Foundation, Inc.
Other
Eligibility
40 Years and older
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
2
States / cities
Coeur d'Alene, Idaho • Spokane, Washington
Source: ClinicalTrials.gov public record
Updated May 23, 2019 · Synced Sep 3, 2026, 2:48 AM EDT
Completed Not applicable Interventional

Cooled Radiofrequency Ablation vs. Thermal Radiofrequency Ablation

NCT02073292
View directory record Official record
Conditions
Chronic Thoracic Back Pain
Interventions
c-RFA, tRFA
Procedure
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 90 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2022
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 22, 2023 · Synced Sep 3, 2026, 2:48 AM EDT
Terminated Not applicable Interventional

Trial Comparing Treatment With SInergy™ System to Conservative Treatment for Chronic Sacroiliac Joint Pain

NCT01158092
View directory record Official record
Conditions
Chronic Sacroiliac Joint Pain
Interventions
Treatment with SInergy™ System, Conservative Treatment
Device · Other
Lead sponsor
Baylis Medical Company
Industry
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2010
U.S. locations
1
States / cities
Chestnut Hill, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 5, 2013 · Synced Sep 3, 2026, 2:48 AM EDT
Completed Phase 3 Interventional

A Trial of Cooled Radiofrequency Ablation of Medial Branch Nerves for theTreatment of Lumbar Facet Syndrome

NCT02478437
View directory record Official record
Conditions
Low Back Pain
Interventions
Conventional radiofrequency ablation (RFA), Cooled Radiofrequency Ablation (CRFA)
Procedure
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 79 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 5, 2018 · Synced Sep 3, 2026, 2:48 AM EDT
Completed Not applicable Interventional Results available

C-RFA of Residual Limb Neuroma

NCT04538417
View directory record Official record
Conditions
Phantom Limb Pain, Neuroma Amputation
Interventions
Cooled Radiofrequency Ablation
Device
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jan 7, 2025 · Synced Sep 3, 2026, 2:48 AM EDT
Completed Not applicable Interventional Results available

Cooled Radiofrequency vs. Hyaluronic Acid to Manage Knee Pain

NCT03381248
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
Cooled Radiofrequency, Hyaluronic Acid Injection, Crossover from Hyaluronic Acid Injection to Cooled Radiofrequency
Device · Other
Lead sponsor
Avanos Medical
Other
Eligibility
21 Years and older
Enrollment
177 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
10
States / cities
Coeur d'Alene, Idaho • New Orleans, Louisiana • Rochester, Minnesota + 7 more
Source: ClinicalTrials.gov public record
Updated Oct 9, 2023 · Synced Sep 3, 2026, 2:48 AM EDT
Not listed Not applicable Interventional

Use of Cooled Radiofrequency for the Treatment of Hip Pain Associated With Hip OA Compared to Intra-articular Steroid Injections

NCT04329884
View directory record Official record
Conditions
Osteoarthritis, Hip
Interventions
Cooled RFA treatment with COOLIEF* device, intra-articular corticosteroid injection
Procedure · Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 31, 2020 · Synced Sep 3, 2026, 2:48 AM EDT
Not listed Not applicable Interventional

Use of Cooled Radiofrequency for the Treatment of Hip Pain Associated With OA of the Hip Compared to Intra-articular Steroid Injections

NCT03647332
View directory record Official record
Conditions
Osteo Arthritis of Hip
Interventions
Cooled RFA treatment, Steroid Drug
Procedure · Drug
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 26, 2018 · Synced Sep 3, 2026, 2:48 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Fractional CO2 Laser System (Fraxel Repair Laser) Intended for Treatment of Perioral Rhytides/Wrinkles

NCT03715049
View directory record Official record
Conditions
Wrinkle
Interventions
Fraxel Laser Treatment
Procedure
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 75 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 21, 2018 · Synced Sep 3, 2026, 2:48 AM EDT
Withdrawn No phase listed Observational

Preop Cooled Radiofrequency Ablation for Total Knee Replacement

NCT03893292
View directory record Official record
Conditions
Postoperative Pain, Knee Osteoarthritis
Interventions
Total knee replacement, COOLIEF
Procedure · Device
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
65 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 12, 2020 · Synced Sep 3, 2026, 2:48 AM EDT