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Showing 1–24 of 33 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Couples-based treatment- Partner Clear all
Completed No phase listed Observational Accepts healthy volunteers

Couple-Based Mindfulness Intervention for Metastatic Colorectal Cancer

NCT05840263
View directory record Official record
Conditions
Metastatic Colorectal Cancer
Interventions
Qualitative interview, Cognitive Interviews
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 85 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Sep 7, 2026, 2:33 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Couple-Based Meditation for Metastatic Lung Cancer Patients and Their Partners

NCT02596490
View directory record Official record
Conditions
Lung Cancer
Interventions
Questionnaires, Meditation and Discussion Sessions, Cancer-Related Discussion Program
Behavioral
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2026
U.S. locations
2
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Sep 7, 2026, 2:33 PM EDT
Completed Not applicable Interventional Results available

Pilot Study of an Intimacy Enhancement Intervention for Couples Facing Breast Cancer

NCT02721147
View directory record Official record
Conditions
Breast Cancer
Interventions
Intimacy Enhancing Intervention, Living Healthy Together, Partner-Assisted Coping Skills Training, Behavioral, Psychological or Informational Intervention
Behavioral
Lead sponsor
Fox Chase Cancer Center
Other
Eligibility
21 Years and older · Female only
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 24, 2018 · Synced Sep 7, 2026, 2:33 PM EDT
Completed Phase 2 Interventional

Multimedia Training for Family Caregivers in Use of Touch and Massage in Supportive Cancer Care

NCT00632398
View directory record Official record
Conditions
Cancer
Interventions
Attention control (reading), Touch, Caring and Cancer DVD program
Behavioral
Lead sponsor
Collinge and Associates, Inc.
Other
Eligibility
21 Years to 120 Years
Enrollment
228 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
3
States / cities
Kittery, Maine • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 14, 2015 · Synced Sep 7, 2026, 2:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of a Couple-Based Physical Activity Intervention

NCT06073951
View directory record Official record
Conditions
Hematopoietic and Lymphoid System Neoplasm, Malignant Solid Neoplasm
Interventions
Best Practice, Exercise Counseling, Exercise Intervention, Medical Device Usage and Evaluation, Physical Performance Testing, Questionnaire Administration
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
96 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated Sep 23, 2025 · Synced Sep 7, 2026, 2:33 PM EDT
Completed Phase 3 Interventional

Individual PE vs Couples' CBT for Combat-Related Posttraumatic Stress Disorder

NCT02336971
View directory record Official record
Conditions
PTSD, Marital Relationship
Interventions
CBCT for PTSD, Prolonged Exposure
Behavioral
Lead sponsor
Toronto Metropolitan University
Other
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
3
States / cities
Fort Hood, Texas • Fort Sam Houston, Texas • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Oct 6, 2016 · Synced Sep 7, 2026, 2:33 PM EDT
Completed Not applicable Interventional Results available

Coping Together After Breast Cancer

NCT03930797
View directory record Official record
Conditions
Breast Cancer
Interventions
Intimacy Enhancement, Living Healthy Together
Behavioral
Lead sponsor
Fox Chase Cancer Center
Other
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 10, 2024 · Synced Sep 7, 2026, 2:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Protect and Connect: Couple HIV Prevention for Drug Involved Male Offenders

NCT01690494
View directory record Official record
Conditions
Sexually Transmitted Diseases, Unsafe Sex, Substance-Related Disorders
Interventions
PACT, TAU
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
480 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 17, 2018 · Synced Sep 7, 2026, 2:33 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Together After Cancer

NCT05645471
View directory record Official record
Conditions
Breast Cancer, Quality of Life, Communication
Interventions
Together After Cancer
Behavioral
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 80 Years
Enrollment
480 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
3
States / cities
Miami, Florida • Orlando, Florida • Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Sep 7, 2026, 2:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Acceptability, Feasibility and Preliminary Impact of OurPlan, an mHealth HIV Prevention Intervention for Male Couples

NCT04836091
View directory record Official record
Conditions
HIV/AIDS
Interventions
Waitlist, Intervention
Behavioral
Lead sponsor
Florida International University
Other
Eligibility
18 Years and older
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Sep 15, 2021 · Synced Sep 7, 2026, 2:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Implementation of Strength at Home for Military Couples

NCT04517994
View directory record Official record
Conditions
Intimate Partner Violence
Interventions
Active Treatment, Supportive Treatment
Behavioral
Lead sponsor
Boston VA Research Institute, Inc.
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2021
U.S. locations
1
States / cities
Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Apr 27, 2022 · Synced Sep 7, 2026, 2:33 PM EDT
Recruiting Not applicable Interventional

Intensive Multi-Couple Therapy for PTSD Versus Relationship Education in Military Couples

NCT06047691
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Abbreviated, Intensive, Multi-Couple Group Cognitive-Behavioral Conjoint Therapy for PTSD, Prevention and Relationship Education Program
Behavioral
Lead sponsor
Penn State University
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated May 13, 2025 · Synced Sep 7, 2026, 2:33 PM EDT
Completed Not applicable Interventional

Testing A Couple-based Program for Alcohol Risk Reduction in the National Guard

NCT03589508
View directory record Official record
Conditions
Alcohol; Harmful Use
Interventions
In-person sessions: ABCP_P, Video conference sessions: ABCP_T
Behavioral
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 22, 2019 · Synced Sep 7, 2026, 2:33 PM EDT
Completed Not applicable Interventional

Behavioral Interventions to Prevent or Delay Dementia

NCT02265757
View directory record Official record
Conditions
Mild Cognitive Impairment, Memory Disorders, Mild Dementia, Impaired Cognition, Mild Cognitive Disorder, Amnestic Disorder, Dementia and Amnestic Conditions, Poor Short-term Memory, Memory Impairment
Interventions
Cognitive Rehabilitation, Computer Brain Fitness Training, Support Group (patient and partner), Wellness Education, Physical Exercise
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
50 Years and older
Enrollment
272 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
3
States / cities
Scottsdale, Arizona • Jacksonville, Florida • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 21, 2019 · Synced Sep 7, 2026, 2:33 PM EDT
Completed Not applicable Interventional Results available

Building and Pilot Testing a Couples-based Smartphone Systems to Address Alcohol Use Disorder

NCT04059549
View directory record Official record
Conditions
Alcohol Use Disorder, Couples, Behavior, Addictive
Interventions
PartnerCHESS, A-CHESS
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Fall River, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 21, 2025 · Synced Sep 7, 2026, 2:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Automated & Coached Web-based Programs to Improve and Strengthen Romantic Relationships

NCT03568565
View directory record Official record
Conditions
Relationship, Marital
Interventions
ePREP Program, OurRelationship Program
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 64 Years
Enrollment
2,500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated Sep 13, 2020 · Synced Sep 7, 2026, 2:33 PM EDT
Completed Not applicable Interventional

Couple-Based Intervention for Patients With Head and Neck Cancer and Their Partners

NCT01785576
View directory record Official record
Conditions
Head and Neck Cancer
Interventions
Couple-Based CBT Intervention
Behavioral
Lead sponsor
Endeavor Health
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Evanston, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 22, 2019 · Synced Sep 7, 2026, 2:33 PM EDT
Completed Not applicable Interventional

Behavioral Weight and Symptom Management for Breast Cancer Survivors and Partners

NCT02574507
View directory record Official record
Conditions
Breast Cancer
Interventions
Couples-Based Behavioral Weight and Symptom Management
Behavioral
Lead sponsor
Duke University
Other
Eligibility
21 Years to 80 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 5, 2020 · Synced Sep 7, 2026, 2:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Web-based Programs to Improve and Strengthen Romantic Relationships

NCT02806635
View directory record Official record
Conditions
Romantic Relationship
Interventions
OurRelationship, PREP Online
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 64 Years
Enrollment
1,484 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated Jan 7, 2019 · Synced Sep 7, 2026, 2:33 PM EDT
Completed Not applicable Interventional Results available

Enhancing Survivorship Care Planning for Patients With Localized Prostate Cancer Using A Couple-focused Web-based Tailored Symptom Self-management Program

NCT04350788
View directory record Official record
Conditions
Prostate Cancer
Interventions
Survivorship Care Plan, Enhanced Survivorship Care Plan
Other
Lead sponsor
UNC Lineberger Comprehensive Cancer Center
Other
Eligibility
18 Years to 99 Years
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 22, 2020 · Synced Sep 7, 2026, 2:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mindfulness Based Couples Therapy

NCT02349217
View directory record Official record
Conditions
Breast Cancer
Interventions
Mindfulness-Based Relationship Enhancement (MBRE), Self-Help Materials, Pain Assessment, Questionnaires, Neurocognitive Tests, Cortisol Tests, Interviews
Behavioral · Procedure
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
21 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2022
U.S. locations
2
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 23, 2022 · Synced Sep 7, 2026, 2:33 PM EDT
Active, not recruiting Not applicable Interventional

Relationship Checkups to Reduce Veteran Suicide Risk

NCT05525676
View directory record Official record
Conditions
Relationship Distress, Mental Health
Interventions
Brief Relationship Checkup (BRC), Co-Located Collaborative Care (CCC)
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
245 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Canandaigua, New York
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 7, 2026, 2:33 PM EDT
Recruiting Not applicable Interventional

A Dyadic Intervention for Young Adult Patients With Cancer and Their Partner Caregivers

NCT06172907
View directory record Official record
Conditions
Cancer, Survivorship, Caregiver Burden, Psychological Distress, Coping Skills, Couples
Interventions
Young Adults Coping with Cancer Together Intervention
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
25 Years to 39 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
4
States / cities
Boston, Massachusetts • Concord, Massachusetts • Danvers, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 11, 2026 · Synced Sep 7, 2026, 2:33 PM EDT
Enrolling by invitation Phase 2 Interventional

Nuestro Sueno: Cultural Adaptation of a Couples Intervention to Improve PAP Adherence and Sleep Health Among Latino Couples With Implications for Alzheimer's Disease Risk

NCT06649929
View directory record Official record
Conditions
Sleep Apnea, Sleep Disturbance
Interventions
Couples-based treatment- Patient, Couples-based treatment- Partner, Information control- Patient, Information control- Partner
Behavioral · Other
Lead sponsor
University of Utah
Other
Eligibility
35 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
2
States / cities
Tuscon, Arizona • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Sep 7, 2026, 2:33 PM EDT