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ClinicalTrials.gov public records Last synced Nov 14, 2026, 10:13 PM EST

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Showing 1–24 of 117 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Creatine Supplementation Clear all

Conditions: Creatine Absorption in Healthy Adults
Interventions: OptiCreatine, Creatine Monohydrate; Dietary Supplement
Lead sponsor: TSI Group LTD; Industry
Eligibility: 18 Years to 45 Years
Enrollment: 17 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Creatine Absorption in Healthy Adults
Interventions: Create Wellness Creatine Gummies, Creatine Monohydrate Powder; Dietary Supplement
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years to 45 Years
Enrollment: 16 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Norman, Oklahoma

Conditions: Tyrosol, Creatine, Endurance Performance, Cognition, Mood
Interventions: Tyrosol, Creatine Monohydrate, Resistant Dextrin; Dietary Supplement
Lead sponsor: Applied Science & Performance Institute; Industry
Eligibility: 20 Years to 55 Years · Male only
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Tampa, Florida

Conditions: Perioperative Inflammatory Response
Interventions: Simvastatin, Placebo; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 80 Years
Enrollment: 61 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2016
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Major Depressive Disorder
Interventions: Creatine monohydrate or placebo; Drug
Lead sponsor: Perry Renshaw; Other
Eligibility: 13 Years to 21 Years · Female only
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Major Depressive Disorder
Interventions: 5-hydroxytryptophan and Creatine, Placebo control; Drug · Other
Lead sponsor: Brent Michael Kious, MD, PhD; Other
Eligibility: 25 Years to 40 Years · Female only
Enrollment: 32 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2020
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Healthy
Interventions: Vanilla Protein Formula, Chocolate Protein Formula; Dietary Supplement
Lead sponsor: Qualia Life Sciences; Industry
Eligibility: 21 Years to 65 Years
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Carlsbad, California

Conditions: Depression, Anxiety, Methamphetamine Dependence
Interventions: Creatine monohydrate; Drug
Lead sponsor: Montana State University; Other
Eligibility: 18 Years to 59 Years
Enrollment: 29 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Missoula, Montana

Conditions: Major Depressive Disorder
Interventions: 5-hydroxytryptophan and Creatine monohydrate; Drug
Lead sponsor: Perry Renshaw; Other
Eligibility: 18 Years to 64 Years · Female only
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Cirrhosis, Frailty, Sarcopenia
Interventions: HEAL-ME digital app, Creatine supplementation, Whey protein supplementation, Placebo; Behavioral · Dietary Supplement
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Mitochondrial Diseases
Interventions: Creatine Chemical Exchange Saturation Transfer (CrCEST) Imaging Sequence; Diagnostic Test
Lead sponsor: Children's Hospital of Philadelphia; Other
Eligibility: 7 Years to 75 Years
Enrollment: 230 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2028
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Dihydrotestosterone, Testosterone, Hair Loss
Interventions: Creatine Monohydrate Supplementation, Placebo Supplementation; Dietary Supplement
Lead sponsor: Texas Tech University; Other
Eligibility: 18 Years to 35 Years · Male only
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Lubbock, Texas

Conditions: Concussion, Brain
Interventions: Creatine; Dietary Supplement
Lead sponsor: San Diego State University; Other
Eligibility: 18 Years to 35 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: San Diego, California

Conditions: Endothelial Dysfunction
Interventions: Creatine Monohydrate, Maltodextrin (Placebo); Other
Lead sponsor: Florida State University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Tallahassee, Florida

Conditions: Depression
Interventions: Creatine monohydrate, Placebo; Drug
Lead sponsor: Mike O'Callaghan Military Hospital; Federal
Eligibility: 18 Years to 65 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019
U.S. locations: 1
States / cities: Las Vegas, Nevada

Conditions: Depression, Substance Abuse, Substance Use, Neuroimaging, Dual Diagnosis
Interventions: Creatine monohydrate; Drug
Lead sponsor: Perry Renshaw; Other
Eligibility: 13 Years to 64 Years · Female only
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Head and Neck Cancer, Cancer Survivorship, Treatment-related Muscle Loss, Physical Function
Interventions: Creatine Supplementation, Resistance Training; Dietary Supplement · Other
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Perimenopause
Interventions: Creatine Monohydrate, Placebo; Dietary Supplement
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 38 Years to 60 Years · Female only
Enrollment: 55 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Prehabilitation
Interventions: Prehabilitation Program; Combination Product
Lead sponsor: University of Texas at Austin; Other
Eligibility: 18 Years to 90 Years
Enrollment: 92 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Healthy Women
Interventions: Triple protein support, Placebo; Dietary Supplement
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 30 Years to 60 Years · Female only
Enrollment: 39 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Healthy Women
Interventions: Essential Amino Acid+, Non-Calorie Placebo, High intensity Interval Training, No Exercise; Dietary Supplement · Behavioral · Other
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 25 Years to 45 Years · Female only
Enrollment: 44 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Acute Kidney Injury
Interventions: Creatine Monohydrate, Creatine Ethyl Ester; Dietary Supplement
Lead sponsor: Beth Israel Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009
U.S. locations: 1
States / cities: New York, New York

Conditions: Metastatic Prostate Cancer
Interventions: creatine monohydrate, Placebo, Home-based, telehealth; Dietary Supplement · Other · Behavioral
Lead sponsor: University of Utah; Other
Eligibility: 18 Years and older · Male only
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Health Behavior
Interventions: Creatine Monohydrate Supplementation; Dietary Supplement
Lead sponsor: University of Idaho; Other
Eligibility: 18 Years to 22 Years · Female only
Enrollment: 27 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023
U.S. locations: 1
States / cities: Moscow, Idaho

Search by objective public record fields.

Impact of OptiCreatine on Plasma Creatine and Gastrointestinal Effects in Males and Females

Acute Pharmacokinetics of Create Wellness Gummies in Healthy Adults

The Effects of Tyrosol and Creatine on Exercise Performance and Cognition in Healthy Adults

Assessing the Role of "Statin" Therapy and Perioperative Inflammatory Response in Patients Undergoing Major Orthopedic Surgery

Dose-Ranging Trial of Creatine Augmentation for Adolescent Females With Treatment-Resistant Major Depressive Disorder

Placebo-controlled Trial of 5-hydroxytryptophan and Creatine for SSRI or SNRI Augmentation in Treatment Resistant Depression in Females

An Open-Label, Two-Arm Pilot Study of the Tolerability, Consumer Acceptability, and Exploratory Well-Being Outcomes of a Multi-Ingredient Protein Formula in Two Flavors in Healthy Adults

Creatine for Depressed Male and Female Methamphetamine Users

5-hydroxytryptophan and Creatine for Treatment Resistant Depression Associated With Hypoxia in Females

Prehab and Creatine/Whey Supplementation in Frailty Among Patients With Cirrhosis

CrCest Study in Primary Mitochondrial Disease

Influence of Creatine Monohydrate Supplementation on Androgens and Global Hair Assessments

Creatine Supplementation in Concussion Recovery

The Effect of NADPH Oxidase and Creatine Supplementation on Microvascular Blood Flow Regulation

Creatine Monohydrate Use for Preventing Altitude Induced Depression

Creatine as a Treatment Option for Depression in Methamphetamine Using Females

Resistance Training and Creatine Supplementation for Head and Neck Cancer

High Intensity Resistance Training + Creatine in Perimenopause

Application of Ergogenic Aids to the Prehabilitation of Abdominal Cancer Patients Undergoing Cancer Surgery

GLOW Study: Effects of Triple Protein in Women

Daily Upgrade Trial

Effect of Creatine on Serum and Urine Creatinine

Creatine Supplementation and Resistance Training to Preserve Muscle Mass and Attenuate Cancer Progression

Creatine Supplementation and Resistance Training in Premenopausal Females