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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Creatine supplementation Clear all
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Tyrosol and Creatine on Endurance, Strength, and Fatigue Resistance in Healthy Adults

NCT06883292
View directory record Official record
Conditions
Tyrosol, Creatine, Endurance Performance, Cognition
Interventions
Tyrosol, Creatine, Resistant Dextrin
Dietary Supplement
Lead sponsor
Applied Science & Performance Institute
Industry
Eligibility
18 Years to 50 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Sep 10, 2025 · Synced Sep 24, 2026, 1:29 PM EDT
Terminated No phase listed Observational

Observational Study of Males With Creatine Transporter Deficiency

NCT02931682
View directory record Official record
Conditions
Creatine Deficiency, X-linked
Interventions
Not listed
Lead sponsor
Ultragenyx Pharmaceutical Inc
Industry
Eligibility
6 Months to 65 Years · Male only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
9
States / cities
La Jolla, California • Chicago, Illinois • Bethesda, Maryland + 6 more
Source: ClinicalTrials.gov public record
Updated Nov 13, 2022 · Synced Sep 24, 2026, 1:29 PM EDT
Completed Early Phase 1 Interventional

Dose-Ranging Trial of Creatine Augmentation for Adolescent Females With Treatment-Resistant Major Depressive Disorder

NCT01601210
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Creatine monohydrate or placebo
Drug
Lead sponsor
Perry Renshaw
Other
Eligibility
13 Years to 21 Years · Female only
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Oct 24, 2016 · Synced Sep 24, 2026, 1:29 PM EDT
Completed Not applicable Interventional

High Intensity Resistance Training + Creatine in Perimenopause

NCT07027800
View directory record Official record
Conditions
Perimenopause
Interventions
Creatine Monohydrate, Placebo
Dietary Supplement
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
38 Years to 60 Years · Female only
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 10, 2026 · Synced Sep 24, 2026, 1:29 PM EDT
Completed Phase 4 Interventional

Apixaban During Atrial Fibrillation Catheter Ablation: Comparison to Vitamin K Antagonist Therapy

NCT02227550
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Vitamin K antagonist, Apixaban
Drug
Lead sponsor
Atrial Fibrillation Network
Other
Eligibility
18 Years and older
Enrollment
676 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
5
States / cities
New York, New York • Philadelphia, Pennsylvania • Nashville, Tennessee + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 19, 2017 · Synced Sep 24, 2026, 1:29 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Daily Upgrade Trial

NCT07792603
View directory record Official record
Conditions
Healthy Women
Interventions
Essential Amino Acid+, Non-Calorie Placebo, High intensity Interval Training, No Exercise
Dietary Supplement · Behavioral · Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
25 Years to 45 Years · Female only
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Sep 24, 2026, 1:29 PM EDT
Completed Phase 4 Interventional Results available

Assessing the Role of "Statin" Therapy and Perioperative Inflammatory Response in Patients Undergoing Major Orthopedic Surgery

NCT00656292
View directory record Official record
Conditions
Perioperative Inflammatory Response
Interventions
Simvastatin, Placebo
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2016
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 18, 2017 · Synced Sep 24, 2026, 1:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Assessment of the Efficacy of Carnipure® AAS on Body Composition, Muscle Thickness, and Strength Adaptations in Healthy Men

NCT05681806
View directory record Official record
Conditions
Muscle Hypotrophy
Interventions
Carnipure AAS, Creatine Monohydrate
Dietary Supplement
Lead sponsor
Applied Science & Performance Institute
Industry
Eligibility
18 Years to 40 Years · Male only
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated May 15, 2025 · Synced Sep 24, 2026, 1:29 PM EDT
Completed Phase 1 Interventional

Nutrition, Neuromuscular Electrical Stimulation (NMES) and Secondary Progressive Multiple Sclerosis (SPMS)

NCT01381354
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
Progressive exercise, Neuromuscular electrical stimulation delivered using the electrical therapy device EMPI 300 PV, Modified paleolithic diet, Omega 3 fatty acids, Full Spectrum vitamin, Essential - hydroxytyrosol, Maltodextrin fiber supplement, Mineral boost (magnesium), Niacinamide, Methyl B12, Taurine, creatine, thiamine, riboflavin, N acetylcysteine, alpha lipoic acid, L acetyl carnitine, methyl folate, coenzyme Q, meditation, self massage, learning, Coconut oil
Other · Device · Dietary Supplement + 1 more
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 65 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jun 25, 2018 · Synced Sep 24, 2026, 1:29 PM EDT
Recruiting No phase listed Observational

Characterization of Dysmorphology in Subjects With Creatine Transporter Deficiency

NCT05600946
View directory record Official record
Conditions
Cognitive Disorder, Metabolic Disease, Autism Spectrum Disorder
Interventions
Not listed
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
2 Years to 40 Years · Male only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 15, 2026 · Synced Sep 24, 2026, 1:29 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

5-hydroxytryptophan and Creatine for Treatment Resistant Depression Associated With Hypoxia in Females

NCT02356107
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
5-hydroxytryptophan and Creatine monohydrate
Drug
Lead sponsor
Perry Renshaw
Other
Eligibility
18 Years to 64 Years · Female only
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jan 28, 2018 · Synced Sep 24, 2026, 1:29 PM EDT
Completed Not applicable Interventional

Measuring Changes in Body Composition and Physical Function in Patients With Childhood Cancers

NCT05823740
View directory record Official record
Conditions
Cancer, Malignant Neoplasm
Interventions
Bioelectrical impedance Analysis (BIA), D3-Creatine Dilution (D3Cr), 6-Minute Walk Test (6MWT), Timed Up and Go (TUG), 30-second Sit-to-Stand (STS), Hand Grip Strength (GS), PBTL p16 expression, CT, MR and PET Imaging
Other
Lead sponsor
UNC Lineberger Comprehensive Cancer Center
Other
Eligibility
8 Years to 21 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Sep 24, 2026, 1:29 PM EDT
Completed Phase 1Phase 2 Interventional

Creatine Therapy for Huntington's Disease

NCT00026988
View directory record Official record
Conditions
Huntington's Disease
Interventions
Creatine
Drug
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2006
U.S. locations
4
States / cities
Boston, Massachusetts • Long Island City, New York • New York, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 17, 2006 · Synced Sep 24, 2026, 1:29 PM EDT
Completed Phase 2 Interventional

Creatine Safety and Tolerability in Premanifest HD: PRECREST

NCT00592995
View directory record Official record
Conditions
Huntington Disease
Interventions
Creatine monohydrate, Placebo
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
26 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 9, 2014 · Synced Sep 24, 2026, 1:29 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Increased Dietary Protein Intake During GLP-1 Medication Use (in Middle-aged Women With Overweight/Obesity)

NCT07480109
View directory record Official record
Conditions
Obesity, Women (Between 30 to 60 Years Old)
Interventions
Protein Rich Foods
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
30 Years to 60 Years · Female only
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
2
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Sep 24, 2026, 1:29 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Creatine Treatment for Female Adolescents With Depression Who Are Non-Responders to Fluoxetine or Escitalopram

NCT00851006
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Creatine Monohydrate
Drug
Lead sponsor
University of Utah
Other
Eligibility
13 Years to 18 Years · Female only
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated May 11, 2017 · Synced Sep 24, 2026, 1:29 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Creatine Supplementation At Simulated Altitude

NCT06489587
View directory record Official record
Conditions
Exercise Performance
Interventions
Placebo, Creatine
Dietary Supplement
Lead sponsor
California Polytechnic State University-San Luis Obispo
Other
Eligibility
18 Years to 40 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
San Luis Obispo, California
Source: ClinicalTrials.gov public record
Updated Jul 7, 2024 · Synced Sep 24, 2026, 1:29 PM EDT
Not listed Phase 3 Interventional

Study of Creatine Monohydrate in Patients With Amyotrophic Lateral Sclerosis

NCT00069186
View directory record Official record
Conditions
Amyotrophic Lateral Sclerosis (ALS)
Interventions
Creatine Monohydrate
Drug
Lead sponsor
The Avicena Group
Industry
Eligibility
21 Years to 80 Years
Enrollment
107 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
8
States / cities
San Francisco, California • Kansas City, Kansas • Albuquerque, New Mexico + 5 more
Source: ClinicalTrials.gov public record
Updated Jun 23, 2005 · Synced Sep 24, 2026, 1:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Muscle Injury Prevention & Rehabilitation in Military Personnel

NCT02077413
View directory record Official record
Conditions
Muscle Injury
Interventions
Healthy Muscle Group, Stretch-Contract Pre-rehabilitation Group, Stretch-Contract Control Group, Muscle Atrophy
Procedure
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 40 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Nov 16, 2016 · Synced Sep 24, 2026, 1:29 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Placebo-controlled Trial of 5-hydroxytryptophan and Creatine for SSRI or SNRI Augmentation in Treatment Resistant Depression in Females

NCT02922725
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
5-hydroxytryptophan and Creatine, Placebo control
Drug · Other
Lead sponsor
Brent Michael Kious, MD, PhD
Other
Eligibility
25 Years to 40 Years · Female only
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated May 30, 2022 · Synced Sep 24, 2026, 1:29 PM EDT
Recruiting Not applicable Interventional

Creatine Supplementation in Concussion Recovery

NCT06208813
View directory record Official record
Conditions
Concussion, Brain
Interventions
Creatine
Dietary Supplement
Lead sponsor
San Diego State University
Other
Eligibility
18 Years to 35 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Sep 24, 2026, 1:29 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Gastrointestinal and Fluid Retention Symptoms Associated With Creatine Monohydrate With and Without Loading Dose Over 28 Days of Supplementation

NCT07176325
View directory record Official record
Conditions
Side Effects of Creatine Monohydrate Dosing
Interventions
Creatine Monohydrate
Other
Lead sponsor
Vireo Systems, Inc.
Industry
Eligibility
18 Years to 60 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Raritan, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 15, 2025 · Synced Sep 24, 2026, 1:29 PM EDT
Completed Phase 2 Interventional

Premanifest Huntington's Disease: Creatine Safety & Tolerability Extension Study

NCT01411150
View directory record Official record
Conditions
Huntington's Disease
Interventions
Creatine Monohydrate
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
26 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 9, 2014 · Synced Sep 24, 2026, 1:29 PM EDT
Completed Phase 3 Interventional

Efficacy and Safety Study of KIACTA in Preventing Renal Function Decline in AA Amyloidosis

NCT01215747
View directory record Official record
Conditions
Amyloidosis
Interventions
KIACTA (eprodisate disodium), Placebo
Drug
Lead sponsor
C.T. Development America, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
261 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
3
States / cities
Glendale, California • Boston, Massachusetts • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 9, 2016 · Synced Sep 24, 2026, 1:29 PM EDT