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Showing 1–24 of 49 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Culturelle Clear all
Recruiting Phase 2 Interventional

Intravesical LGG VS Saline Bladder Wash RCT

NCT05230511
View directory record Official record
Conditions
Spinal Cord Injuries, Neurogenic Bladder
Interventions
Lactobacillus RhamnosusGG, Saline bladder wash
Drug
Lead sponsor
Medstar Health Research Institute
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Aug 28, 2025 · Synced Sep 6, 2026, 2:32 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Probiotics for Prevention of Antibiotic Associated Diarrhea and Clostridium Difficile Associated Disease

NCT02076438
View directory record Official record
Conditions
Diarrhea
Interventions
Probiotics
Dietary Supplement
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 89 Years
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Nov 22, 2016 · Synced Sep 6, 2026, 2:32 AM EDT
Terminated Phase 1 Interventional

Probiotic LGG for Prevention of Side Effects in Patients Undergoing Chemoradiation for Gastrointestinal Cancer

NCT01790035
View directory record Official record
Conditions
Gastrointestinal Neoplasms
Interventions
LGG, Placebo
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2021
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 15, 2022 · Synced Sep 6, 2026, 2:32 AM EDT
Completed Phase 2Phase 3 Interventional

Probiotics-Supplemented Feeding in Extremely Low Birth Weight Infants

NCT01164124
View directory record Official record
Conditions
Low Birth Weight
Interventions
Probiotic supplementation (Lactobacillus rhamnosus GG and Bifidobacterium infantis), Placebo
Dietary Supplement · Other
Lead sponsor
Vermont Oxford Network
Network
Eligibility
1 Day to 14 Days
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
3
States / cities
Detroit, Michigan • St Louis, Missouri • Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Jul 1, 2018 · Synced Sep 6, 2026, 2:32 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Symbiotic Use in Post-Bariatric Surgery Patients

NCT06252558
View directory record Official record
Conditions
Bariatric Surgery Candidate
Interventions
Symbiotic, Placebo
Dietary Supplement
Lead sponsor
University of North Florida
Other
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Feb 8, 2024 · Synced Sep 6, 2026, 2:32 AM EDT
Completed Phase 4 Interventional

Rhinovirus Study With Lactobacillus Rhamnosus GG

NCT01229917
View directory record Official record
Conditions
Respiratory Tract Infections [C08.730]
Interventions
Fruit juice with Lactobacillus rhamnosus GG, version 1, Fruit juice with Lactobacillus rhamnosus GG, version 2, Standard fruit juice
Other
Lead sponsor
Valio Ltd
Industry
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 6, 2011 · Synced Sep 6, 2026, 2:32 AM EDT
Terminated Not applicable Interventional Results available

Novel Therapies in Moderately Severe Acute Alcoholic Hepatitis

NCT01922895
View directory record Official record
Conditions
Acute Alcoholic Hepatitis
Interventions
Lactobacillus Rhamnosus GG, Placebo for Probiotic
Dietary Supplement · Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
21 Years to 70 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2021
U.S. locations
3
States / cities
Louisville, Kentucky • Cleveland, Ohio • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 1, 2022 · Synced Sep 6, 2026, 2:32 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Study to Evaluate the Impact of Lactobacillus Rhamnosus GG on Proton Pump Inhibitor-Induced Gut Dysbiosis

NCT05517928
View directory record Official record
Conditions
Healthy
Interventions
Omeprazole, Lactobacillus rhamnosus GG, Placebo
Drug · Dietary Supplement
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Sep 6, 2026, 2:32 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of Lactobacillus Rhamnosus GG (LGG) on Infant Colic

NCT01279265
View directory record Official record
Conditions
Colic, Inflammation
Interventions
Nutramigen with Enflora, Nutramigen A+
Dietary Supplement
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
3 Weeks to 3 Months
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 10, 2015 · Synced Sep 6, 2026, 2:32 AM EDT
Not yet recruiting Early Phase 1 Interventional

Coupled Gentamicin-Lactobacillus Rhamnosus in NLUTD

NCT07643974
View directory record Official record
Conditions
Spinal Cord Injury, Neurogenic Bladder (NB), Neurogenic Lower Urinary Tract Dysfunction, Multiple Sclerosis, Spina Bifida, Urinary Tract Infection(UTI)
Interventions
Gentamicin, Lactobacillus Rhamnosus GG
Drug
Lead sponsor
Medstar Health Research Institute
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Sep 6, 2026, 2:32 AM EDT
Terminated Not applicable Interventional

The Effects of Probiotic Supplementation on Extremely Low Birthweight Infants

NCT01788761
View directory record Official record
Conditions
Feeding Tolerance
Interventions
Probiotic Supplemented Group, Control Group
Dietary Supplement
Lead sponsor
Mercy Health System
Network
Eligibility
Up to 14 Days
Enrollment
133 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
1
States / cities
Rockford, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 10, 2018 · Synced Sep 6, 2026, 2:32 AM EDT
Enrolling by invitation Phase 4 Interventional

Probiotics in the Prevention of Recurrent Prosthetic Joint Infection of the Hip and Knee

NCT06636669
View directory record Official record
Conditions
Prosthetic-joint Infection, Dysbiosis
Interventions
Probiotic, Standard of care
Drug · Other
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years to 90 Years
Enrollment
152 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
Boston, Massachusetts • New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Sep 6, 2026, 2:32 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Safety of Lactobacillus Rhamnosus GG ATCC 53103 (LGG) in Healthy Volunteers

NCT00934453
View directory record Official record
Conditions
Healthy
Interventions
Lactobacillus rhamnosus GG ATCC 53103, Placebo
Biological
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 50 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 10, 2017 · Synced Sep 6, 2026, 2:32 AM EDT
Completed Phase 2 Interventional Results available

Impact of Probiotics on Urinary Symptoms in Spinal Cord Injury SCI and SB

NCT02748317
View directory record Official record
Conditions
Lower Urinary Tract Symptoms
Interventions
Lactobacillus rhamnosus GG
Drug
Lead sponsor
Medstar Health Research Institute
Other
Eligibility
18 Years and older
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
2
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated May 11, 2020 · Synced Sep 6, 2026, 2:32 AM EDT
Completed Not applicable Interventional Results available

Lactobacillus Rhamnosus GG in Reducing Incidence of Graft-Versus-Host Disease in Patients Who Have Undergone Donor Stem Cell Transplant

NCT02144701
View directory record Official record
Conditions
Graft Versus Host Disease
Interventions
Lactobacillus rhamnosus GG, laboratory biomarker analysis was not performed because of no differences in the clinical outcomes
Dietary Supplement · Other
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 26, 2021 · Synced Sep 6, 2026, 2:32 AM EDT
Completed Phase 4 Interventional Results available

The Use of Probiotics to Evaluate Colonization With Antimicrobial Resistant Bacteria

NCT01551186
View directory record Official record
Conditions
Infectious Disease of Digestive Tract
Interventions
Lactobacillus rhamnosus GG
Dietary Supplement
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 16, 2018 · Synced Sep 6, 2026, 2:32 AM EDT
Completed Phase 1Phase 2 Interventional

Does Weight Loss Surgery and Probiotic Supplementation Lead to a "Lean" Gut Microbiota?

NCT01870544
View directory record Official record
Conditions
Obesity
Interventions
Lactobacillus Rhamnosus GG, Placebo
Dietary Supplement
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 9, 2016 · Synced Sep 6, 2026, 2:32 AM EDT
Terminated Phase 2 Interventional

Study of Culturelle in the Prophylaxis of Infection and Diarrhea

NCT01605747
View directory record Official record
Conditions
Pediatric Burns
Interventions
Culturelle, Placebo
Dietary Supplement
Lead sponsor
Shriners Hospitals for Children
Other
Eligibility
6 Months to 18 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 12, 2013 · Synced Sep 6, 2026, 2:32 AM EDT
Active, not recruiting Phase 2 Interventional

Intravesical Lactobacillus for Urinary Symptoms Among People With NLUTD Who Use Indwelling Catheters

NCT04323735
View directory record Official record
Conditions
Neurogenic Bladder
Interventions
Culturelle 10 Billion CFU Capsule
Drug
Lead sponsor
Medstar Health Research Institute
Other
Eligibility
18 Years and older
Enrollment
182 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Sep 6, 2026, 2:32 AM EDT
Completed Phase 1 Interventional

Effect of Lactobacillus Probiotic on Healthy Adults

NCT00748748
View directory record Official record
Conditions
Antibiotic-associated Diarrhea
Interventions
Culturelle
Biological
Lead sponsor
Fargo VA Medical Center
Federal
Eligibility
18 Years to 64 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Fargo, North Dakota
Source: ClinicalTrials.gov public record
Updated Jul 3, 2012 · Synced Sep 6, 2026, 2:32 AM EDT
Completed Phase 4 Interventional Results available

Probiotics to Promote Intestinal Health

NCT02046512
View directory record Official record
Conditions
Communicable Diseases, Infection, Anti-Infective Agents, Therapeutic Uses, Pharmacologic Actions
Interventions
Probiotic, Placebo
Dietary Supplement · Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 3, 2022 · Synced Sep 6, 2026, 2:32 AM EDT
Completed Phase 4 Interventional

Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial

NCT02462590
View directory record Official record
Conditions
Ventilator Associated Pneumonia, Infections, C-Difficile, Antibiotic-associated Diarrhea, Diarrhea
Interventions
L. rhamnosus GG - Probiotic, Placebo - Microcrystalline Cellulose
Drug
Lead sponsor
McMaster University
Other
Eligibility
18 Years and older
Enrollment
2,650 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
2
States / cities
Rochester, Minnesota • St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 16, 2020 · Synced Sep 6, 2026, 2:32 AM EDT
Recruiting Phase 2 Interventional

LGG Supplementation in Patients With AUD and ALD

NCT05178069
View directory record Official record
Conditions
Alcohol Use Disorder, Alcohol-associated Liver Disease
Interventions
: Placebo for Probiotic, Lactobacillus Rhamnosus GG
Drug · Dietary Supplement
Lead sponsor
University of Louisville
Other
Eligibility
21 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 30, 2025 · Synced Sep 6, 2026, 2:32 AM EDT
Terminated Phase 1 Interventional

Probiotic Lactobacillus GG to Eliminate VRE Colonization

NCT00756262
View directory record Official record
Conditions
Vancomycin Resistant Enterococcal Colonization
Interventions
Lactobacillus GG or Culturelle
Biological
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 4, 2024 · Synced Sep 6, 2026, 2:32 AM EDT