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ClinicalTrials.gov public records Last synced Nov 4, 2026, 11:15 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 415 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: DEEP BRAIN STIMULATION Clear all

Conditions: Parkinson
Interventions: DBS; Device
Lead sponsor: Abbott Medical Devices; Industry
Eligibility: 18 Years to 70 Years
Enrollment: 10 participants
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Movement Disorders, Parkinson Disease, Essential Tremor, Tremor, Dystonia, Primary Dystonia, Secondary Dystonia
Interventions: Deep Brain Stimulation (DBS); Device
Lead sponsor: Abbott Medical Devices; Industry
Eligibility: Not listed
Enrollment: 1,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2030
U.S. locations: 23
States / cities: Tucson, Arizona • Los Angeles, California • Sacramento, California + 19 more

Conditions: Mesial Temporal Lobe Epilepsy
Interventions: Medtronic Deep Brain Stimulation; Device
Lead sponsor: George Washington University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2019
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Parkinson's Disease and Parkinsonism
Interventions: DBS; Device
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 85 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2030
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Posttraumatic Stress Disorder
Interventions: DBS of the Basolateral Nucleus of the Amygdala, Medtronic Activa PC DBS of the Basolateral Nucleus of the Amygdala; Procedure · Device
Lead sponsor: VA Greater Los Angeles Healthcare System; Federal
Eligibility: 25 Years to 70 Years · Male only
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2025
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Parkinson's Disease
Interventions: Deep brain stimulator; Other
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 18 Years to 75 Years
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Epilepsy
Interventions: Cognitive experiment, Electrical stimulation of the brain; Other
Lead sponsor: Stanford University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2029
U.S. locations: 1
States / cities: Stanford, California

Conditions: Obsessive-Compulsive Disorder
Interventions: Active DBS, Sham DBS; Device
Lead sponsor: Butler Hospital; Other
Eligibility: 18 Years to 75 Years
Enrollment: 27 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2024
U.S. locations: 9
States / cities: Redwood City, California • Washington D.C., District of Columbia • Gainesville, Florida + 6 more

Conditions: Brain, Sedation
Interventions: Remifentanil, Propofol, Dexmedetomidine; Drug
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years to 85 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Parkinson's Disease and Parkinsonism, Dyssomnia
Interventions: Polysomnography ON stimulation then OFF, Polysomnography OFF stimulation then ON; Device
Lead sponsor: The University of Texas Health Science Center at San Antonio; Other
Eligibility: 40 Years to 80 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: San Antonio, Texas

Conditions: Essential Tremor
Interventions: Functional MRI; Diagnostic Test
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Jacksonville, Florida

Conditions: Parkinson Disease, Essential Tremor, Multiple Sclerosis, Dystonia
Interventions: Therapeutic Stimulation Patterns, Symptogenic Stimulation Patterns; Procedure
Lead sponsor: Duke University; Other
Eligibility: 21 Years to 80 Years
Enrollment: 180 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2027
U.S. locations: 3
States / cities: Gainesville, Florida • Atlanta, Georgia • Durham, North Carolina

Conditions: Parkinson Disease
Interventions: Unilateral dual-target (STN/GPi) DBS; Device
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years to 89 Years
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Loss of Consciousness, Parkinson Disease, Essential Tremor, Anesthesia
Interventions: Propofol; Drug
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 57 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2025
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Surgical Wound Infections
Interventions: Vancomycin, Placebo (Saline Solution); Drug
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 18 Years to 99 Years
Enrollment: 214 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2014
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Parkinson Disease, Idiopathic
Interventions: Deep brain stimulation surgery - GPi, Deep Brain Stimulation Surgery - STN; Procedure
Lead sponsor: University of Florida; Other
Eligibility: 45 Years to 85 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Depression, Treatment Resistant Depression, Major Depressive Disorder, Depressive Disorder, Depressive Symptoms
Interventions: Medi-TBS; Combination Product
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years to 65 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: San Diego, California

Conditions: Tremor, Essential Tremor
Interventions: Deep Brain Stimulation; Device
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 21 Years and older
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Tourette Syndrome
Interventions: Medtronic Percept Neurostimulator; Device
Lead sponsor: University of Florida; Other
Eligibility: 18 Years to 85 Years
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Refractory Epilepsy, Deep Brain Stimulation
Interventions: Physician-Selected Settings Stimulation, Optimized Settings Stimulation, DBS Setting Optimization; Other
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2030
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Parkinson's Disease
Interventions: Transcranial Magnetic Stimulation (TMS), Motor Physiology Testing; Procedure
Lead sponsor: University of Florida; Other
Eligibility: 18 Years to 80 Years
Enrollment: 4 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2016
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Parkinson Disease
Interventions: Procedure/Surgery: Response Inhibition and Deep Brain Stimulation in Parkinson's disease; Other
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years and older
Enrollment: 140 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2028
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Epilepsy
Interventions: RNS® System implantation, RNS® System responsive stimulation; Procedure · Device
Lead sponsor: NeuroPace; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2007
U.S. locations: 12
States / cities: Phoenix, Arizona • New Haven, Connecticut • Jacksonville, Florida + 8 more

Conditions: Essential Tremor, Parkinson Disease, Dystonia
Interventions: Active biphasic pulse stimulation---Home Settings, Active biphasic pulse stimulation---VIN Biphasic, Active biphasic pulse stimulation---Stimulator Off; Device
Lead sponsor: University of Florida; Other
Eligibility: 18 Years to 80 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 2
States / cities: Gainesville, Florida

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Intraoperative Investigation of a Directional Lead and Local Field Potentials for the Optimization of Stimulation Efficacy

Abbott DBS Post-Market Study of Outcomes for Indications Over Time

Low Frequency Electrical Stimulation of the Fornix in Intractable Mesial Temporal Lobe Epilepsy (MTLE)

Aim 3 Particle Swarm Optimization PIGD

Deep Brain Stimulation of the Amygdala for Combat Post-Traumatic Stress Disorder

Non-invasive Measurement of Brain Oxygen Levels in People With Subthalamic Deep Brain Stimulators

Human Thalamus in Propagation of Temporal Lobe Seizures and Memory Formation

Effectiveness of Deep Brain Stimulation for Treating People With Treatment Resistant Obsessive-Compulsive Disorder

Deep Brain Stimulation (DBS) Sedation

Sensing in Sleep Deep Brain Stimulation

Next-Generation Pre-Operative Targeting for Thalamic DBS in the Treatment of Tremor

Effects of Stimulation Patterns of Deep Brain Stimulation

Stimulus-Evoked Directional Field Potentials to Guide Subthalamic and Pallidal DBS for PD

Brain Networks and Consciousness

Prevention of Neurosurgical Wound Infections

The Impact of Deep Brain Stimulation on Speech and Swallow Function in Parkinson Disease

Mindfulness Engaged Neurostimulation for Depression (MEND II)

Deep Brain Stimulation of the Deep Cerebellar Nuclei for Refractory Tremor

Tourette Deep Brain Stimulation (DBS) Target Detection & Suppression

Optimization of Deep Brain Stimulation Parameters in Patients With Medically Refractory Epilepsy

Subthalamic Deep Brain Stimulation (DBS) in Parkinson's Disease

Investigating Inhibitory Control Networks in Parkinson's Disease

RNS® System Feasibility Study

Physiology, Imaging and Modeling of Essential Tremor