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ClinicalTrials.gov public records Last synced Oct 18, 2026, 1:12 AM EDT

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Showing 241–264 of 413 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Deep Brain Stimulation Clear all
Withdrawn No phase listed Observational

Optimizing DBS Electrode Placement and Programming

NCT01820390
View directory record Official record
Conditions
Parkinson's Disease, Essential Tremor
Interventions
Not listed
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
2
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 20, 2014 · Synced Oct 18, 2026, 1:12 AM EDT
Completed Not applicable Interventional Results available

Tandem DBS for Parkinson's Disease: A Pilot Study Utilizing STN/GPi + Hypothalamic Stimulation

NCT01563341
View directory record Official record
Conditions
Parkinson's Disease, Deep Brain Stimulation
Interventions
Deep brain stimulation
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
40 Years to 80 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2023
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Dec 27, 2024 · Synced Oct 18, 2026, 1:12 AM EDT
Recruiting Not applicable Interventional

Neurophysiology of the Basal Ganglia, Thalamus, and Cerebellum in Patients With Movement Disorders

NCT06848530
View directory record Official record
Conditions
Movement Disorders
Interventions
Prescribed Medications, Deep brain stimulation adjustment
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Oct 18, 2026, 1:12 AM EDT
Completed No phase listed Observational Results available

Intraoperative Investigation of a Directional Lead and Local Field Potentials for the Optimization of Stimulation Efficacy

NCT03630302
View directory record Official record
Conditions
Parkinson
Interventions
DBS
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years to 70 Years
Enrollment
10 participants
Timeline
2018 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 28, 2021 · Synced Oct 18, 2026, 1:12 AM EDT
Recruiting Not applicable Interventional

Globus Pallidus Stimulation to Treat Insomnia

NCT04116996
View directory record Official record
Conditions
Parkinson Disease
Interventions
DEEP BRAIN STIMULATION
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
40 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2029
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Dec 1, 2025 · Synced Oct 18, 2026, 1:12 AM EDT
Active, not recruiting Not applicable Interventional

Pilot/Pivotal Study of DBS+Rehab After Stroke

NCT05701280
View directory record Official record
Conditions
Stroke, Upper Extremity Paresis
Interventions
Deep Brain Stimulation, Rehabilitation
Device · Other
Lead sponsor
Enspire DBS Therapy, Inc.
Industry
Eligibility
21 Years and older
Enrollment
202 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2030
U.S. locations
9
States / cities
Phoenix, Arizona • Baltimore, Maryland • Boston, Massachusetts + 6 more
Source: ClinicalTrials.gov public record
Updated Oct 5, 2026 · Synced Oct 18, 2026, 1:12 AM EDT
Completed Early Phase 1 Interventional

Testing a Transdiagnostic TMS Treatment Target

NCT06282146
View directory record Official record
Conditions
Major Depressive Disorder, Depression, Psychiatric Disorder, Mood Disorders, Mental Disorder, Anxiety Disorders, OCD, PTSD
Interventions
transcranial magnetic stimulation
Procedure
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Oct 18, 2026, 1:12 AM EDT
Enrolling by invitation No phase listed Observational

LFP Sensing From Directional Leads in the Acute Clinical Setting

NCT06872203
View directory record Official record
Conditions
Parkinson Disease, Idiopathic, Parkinson Disease
Interventions
Deep brain stimulation
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 75 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 17, 2025 · Synced Oct 18, 2026, 1:12 AM EDT
Active, not recruiting Not applicable Interventional

Remote Optimization, Adjustment and Measurement for Deep Brain Stimulation

NCT05269862
View directory record Official record
Conditions
Parkinson Disease
Interventions
Abbott Infinity DBS systems with the NeuroSphere Virtual Clinic feature, Abbott Infinity DBS systems with the NeuroSphere Virtual Clinic feature (virtual clinic and in-clinic sessions)
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
21 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
11
States / cities
Tucson, Arizona • Sacramento, California • Miami, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated Jul 21, 2023 · Synced Oct 18, 2026, 1:12 AM EDT
Completed Not applicable Interventional

Identifying the Neural Signature of Exercise to Advance Treatment of PD Cognitive Declines

NCT05972759
View directory record Official record
Conditions
Parkinson Disease
Interventions
Forced and voluntary exercise
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 16, 2026 · Synced Oct 18, 2026, 1:12 AM EDT
Completed Not applicable Interventional

Exercise in Advanced Parkinson's Disease (PD) With Deep Brain Stimulation (DBS)

NCT05204680
View directory record Official record
Conditions
Parkinson Disease
Interventions
Aerobic Exercise
Behavioral
Lead sponsor
St. Joseph's Hospital and Medical Center, Phoenix
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Nov 21, 2023 · Synced Oct 18, 2026, 1:12 AM EDT
Completed No phase listed Observational Results available

Parkinson Disease and DBS: Cognitive Effects in GBA Mutation Carriers

NCT03234478
View directory record Official record
Conditions
Parkinson, Parkinson Disease, Genetic Predisposition, GBA Gene Mutation, Cognitive Decline
Interventions
Not listed
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
30 Years to 75 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Jul 29, 2026 · Synced Oct 18, 2026, 1:12 AM EDT
Recruiting No phase listed Observational

Udall Project 2 Aim 2A&C

NCT05656586
View directory record Official record
Conditions
Parkinson Disease
Interventions
observational-- no intervention
Other
Lead sponsor
University of Minnesota
Other
Eligibility
Not listed
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 3, 2026 · Synced Oct 18, 2026, 1:12 AM EDT
Recruiting Not applicable Interventional

Image-guided, Robot Navigated Transcranial Magnetic Stimulation (IR-TMS) for Alcohol Use Disorder (AUD)

NCT06648642
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Transcranial Magnetic Stimulation (TMS)
Device
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 65 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Oct 18, 2026, 1:12 AM EDT
Withdrawn Not applicable Interventional

In-depth Investigation of Brain Network Interactions

NCT04748146
View directory record Official record
Conditions
Episodic Memory
Interventions
Brain stimulation
Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 25, 2025 · Synced Oct 18, 2026, 1:12 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Mapping and Modulating the Spatiotemporal Dynamics of Socio-Affective Processing

NCT05418894
View directory record Official record
Conditions
Treatment Resistant Depression, Epilepsy
Interventions
Device: Directional Deep Brain Stimulation
Device
Lead sponsor
Baylor College of Medicine
Other
Eligibility
22 Years to 70 Years
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 27, 2025 · Synced Oct 18, 2026, 1:12 AM EDT
Not yet recruiting Early Phase 1 Interventional

Human Cognition During Surgery: Stimulation-based and Cholinergic Modulation

NCT07721272
View directory record Official record
Conditions
Epilepsy, Essential Tremor, Seizures, Memory Consolidation, Memory Disorders, Memory Replay, Memory Encoding, Cognitive Control, Motor Abilities
Interventions
Cobenfy KarXT pill (50/20 mg), Placebo
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Oct 18, 2026, 1:12 AM EDT
Active, not recruiting Phase 1Phase 2 Interventional

Deep Brain Stimulation (DBS) for Methamphetamine Use Disorder

NCT05558358
View directory record Official record
Conditions
Methamphetamine Use Disorder
Interventions
Experimental 1 - DBS of bilateral NAc - 6 months of active stimulation -- > 6 months of sham stimulation, Experimental 2 - DBS of bilateral NAc - 6 months of sham stimulation -- > 6 months of active stimulation
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
22 Years to 65 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 30, 2025 · Synced Oct 18, 2026, 1:12 AM EDT
Recruiting Not applicable Interventional

Deep Brain Stimulation Neural Recordings of Varied Stimulation During Sleep in Parkinson's Disease

NCT07110376
View directory record Official record
Conditions
Parkinson Disease
Interventions
Nighttime Deep Brain Stimulation with Varying Amplitude Settings
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 28, 2026 · Synced Oct 18, 2026, 1:12 AM EDT
Completed Phase 4 Interventional Results available

RECHARGE Sub-Study to the Implantable Systems Performance Registry (ISPR)

NCT00998660
View directory record Official record
Conditions
Parkinson's Disease, Essential Tremor, Dystonia
Interventions
Activa RC
Device
Lead sponsor
MedtronicNeuro
Industry
Eligibility
7 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
5
States / cities
Washington D.C., District of Columbia • Cincinnati, Ohio • Nashville, Tennessee + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 6, 2015 · Synced Oct 18, 2026, 1:12 AM EDT
Enrolling by invitation Not applicable Interventional

Understanding Freezing of Gait Using Brain Signals and Virtual Reality

NCT07092995
View directory record Official record
Conditions
Parkinson&Amp;#39;s Disease, Freezing of Gait, Freezing of Gait Symptoms in Parkinson&Amp;#39;s Disease
Interventions
VR Freezing Task, Dual Task, External Cueing
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Oct 18, 2026, 1:12 AM EDT
Recruiting Not applicable Interventional

Insula Neuromodulation for Chronic Neuropathic Pain

NCT05404581
View directory record Official record
Conditions
Neuropathic Pain, Chronic Pain
Interventions
neuromodulation
Device
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 80 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 5, 2026 · Synced Oct 18, 2026, 1:12 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Gait Analysis in Neurological Disease

NCT02994719
View directory record Official record
Conditions
Parkinson's Disease, Parkinsonian Disorders, Atypical Parkinson Disease, Progressive Supranuclear Palsy, Multiple System Atrophy, Corticobasal Degeneration, Gait, Frontal, Huntington Disease, Ataxia, Spinocerebellar
Interventions
Anti-Parkinson medication, Deep Brain Stimulation
Drug · Device
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years to 85 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Oct 18, 2026, 1:12 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Can Short Latency Afferent Inhibition Give us Clues to Better DYT 1 Dystonia Treatments?

NCT01435681
View directory record Official record
Conditions
DYT-1, DYT1, DYT 1, Dystonia
Interventions
Not listed
Lead sponsor
University of Florida
Other
Eligibility
10 Years to 80 Years
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 8, 2016 · Synced Oct 18, 2026, 1:12 AM EDT