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ClinicalTrials.gov public records Last synced Oct 18, 2026, 2:43 AM EDT

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Showing 289–312 of 413 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Deep Brain Stimulation Clear all
Completed Not applicable Interventional

Next-Generation Pre-Operative Targeting for Thalamic DBS in the Treatment of Tremor

NCT03875404
View directory record Official record
Conditions
Essential Tremor
Interventions
Functional MRI
Diagnostic Test
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 17, 2021 · Synced Oct 18, 2026, 2:43 AM EDT
Terminated Not applicable Interventional Results available

Thalamic Deep Brain Stimulation for the Treatment of Refractory Tourette Syndrome

NCT01817517
View directory record Official record
Conditions
Tourette Syndrome
Interventions
Medtronic Activa Deep Brain Stimulation System
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
15 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 28, 2026 · Synced Oct 18, 2026, 2:43 AM EDT
Not listed Not applicable Interventional

Interactions of Brain Regions in Visuomotor Adaptation

NCT04190940
View directory record Official record
Conditions
High Intensity Focused Ultrasound, Deep Brain Stimulation
Interventions
Behavioral Assessment
Behavioral
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 85 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 9, 2019 · Synced Oct 18, 2026, 2:43 AM EDT
Not yet recruiting Not applicable Interventional

Novel Brain Stimulation Treatment for Neuropsychiatric Symptoms in Alzheimer's Disease

NCT06835283
View directory record Official record
Conditions
Alzheimer&Amp;#39;s Disease-related Dementia, Alzheimer Disease, rTMS Stimulation
Interventions
Brain Stimulation
Device
Lead sponsor
Baylor College of Medicine
Other
Eligibility
65 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 5, 2026 · Synced Oct 18, 2026, 2:43 AM EDT
Recruiting Not applicable Interventional

Deep Brain Stimulation Surgery for Movement Disorders

NCT01581580
View directory record Official record
Conditions
Parkinson's Disease, Essential Tremor, Dystonia
Interventions
Medtronic Activa Tremor Control System, Deep Brain Stimulation
Device · Procedure
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years to 99 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2029
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 8, 2026 · Synced Oct 18, 2026, 2:43 AM EDT
Suspended Not applicable Interventional

Exploring Mechanisms for Neuropsychiatric Symptoms of Parkinson Disease Using Transcranial Direct Current Stimulation

NCT03074812
View directory record Official record
Conditions
Idiopathic Parkinson's Disease, Parkinson Disease, Depression
Interventions
Transcranial Direct Current Stimulation
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 95 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2028
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 23, 2026 · Synced Oct 18, 2026, 2:43 AM EDT
Recruiting Not applicable Interventional

Corticostriatal Contributions to Parkinson's Disease Cognitive Impairment

NCT04715984
View directory record Official record
Conditions
Parkinson Disease
Interventions
Neurophysiology recordings, Neural stimulation
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
40 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2029
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 12, 2026 · Synced Oct 18, 2026, 2:43 AM EDT
Recruiting Phase 1 Interventional

A Trial to Test Intermittent Deep Brain Stimulation of Nucleus Basalis of Meynert to Treat Alzheimers.

NCT07218081
View directory record Official record
Conditions
Alzheimer Dementia (AD)
Interventions
Intermittent deep brain stimulation of the nucleus basalis of Meynert
Device
Lead sponsor
Augusta University
Other
Eligibility
65 Years to 85 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Oct 18, 2026, 2:43 AM EDT
Recruiting No phase listed Observational

Naturalistic Sleep Assessed by Wearable Devices in Parkinson Disease

NCT05348837
View directory record Official record
Conditions
Parkinson Disease
Interventions
Deep brain stimulation
Procedure
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 80 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 4, 2025 · Synced Oct 18, 2026, 2:43 AM EDT
Terminated Not applicable Interventional Results available

Long Term Follow-up of Deep Brain Stimulation for Treatment-Resistant Depression

NCT03360942
View directory record Official record
Conditions
Treatment Resistant Depression, Depressive Disorder, Treatment-Resistant, Depression, Bipolar
Interventions
SCC DBS
Device
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years to 70 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Dec 12, 2024 · Synced Oct 18, 2026, 2:43 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Stimulating Deep Brain Regions With a Magnetic Stimulator

NCT00063245
View directory record Official record
Conditions
Healthy
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
Not listed
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2005
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 18, 2026, 2:43 AM EDT
Recruiting Early Phase 1 Interventional

Optimization of Deep Brain Stimulation Parameters in Patients With Medically Refractory Epilepsy

NCT05493722
View directory record Official record
Conditions
Refractory Epilepsy, Deep Brain Stimulation
Interventions
Physician-Selected Settings Stimulation, Optimized Settings Stimulation, DBS Setting Optimization
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2030
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 16, 2026 · Synced Oct 18, 2026, 2:43 AM EDT
Completed Not applicable Interventional

Novel Paradigms of Deep Brain Stimulation for Movement Disorders

NCT04563143
View directory record Official record
Conditions
Parkinson Disease
Interventions
Novel DBS Stimulation
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
40 Years to 80 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 29, 2025 · Synced Oct 18, 2026, 2:43 AM EDT
Recruiting No phase listed Observational

Circuit-Based Deep Brain Stimulation for Parkinson's Disease P1A2&3 Catalyst

NCT05658302
View directory record Official record
Conditions
Parkinson Disease
Interventions
Not listed
Lead sponsor
University of Minnesota
Other
Eligibility
21 Years and older · Female only
Enrollment
30 participants
Timeline
2023 – 2028
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Oct 18, 2026, 2:43 AM EDT
Recruiting Not applicable Interventional

Deep Brain Stimulation in Laryngeal Dystonia and Voice Tremor

NCT05150093
View directory record Official record
Conditions
Laryngeal Dystonia, Spasmodic Dysphonia, Tremor, Dystonia
Interventions
Deep Brain Stimulation
Procedure
Lead sponsor
Massachusetts Eye and Ear Infirmary
Other
Eligibility
18 Years to 80 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 2, 2025 · Synced Oct 18, 2026, 2:43 AM EDT
Completed Phase 1 Interventional

Deep Brain Stimulation to Treat Cervical Dystonia

NCT00132340
View directory record Official record
Conditions
Cervical Dystonia
Interventions
Electrodes
Device
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 6, 2006 · Synced Oct 18, 2026, 2:43 AM EDT
Active, not recruiting Not applicable Interventional

Low Intensity Focused Ultrasound for Mild Cognitive Impairment and Mild Alzheimer's Disease

NCT05417555
View directory record Official record
Conditions
Mild Cognitive Impairment, Amnestic Mild Cognitive Disorder, Deep Brain Stimulation, Mild Alzheimer's Disease
Interventions
Low-Intensity Focused Ultrasound Pulsation (LIFUP)
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
50 Years to 90 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Oct 18, 2026, 2:43 AM EDT
Not listed Not applicable Interventional

The Effects of Ultrasound on Central Nervous System

NCT04192149
View directory record Official record
Conditions
Focused Ultrasound
Interventions
Focused Ultrasound
Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 85 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 10, 2019 · Synced Oct 18, 2026, 2:43 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Low Intensity Focused Ultrasound Pulses (LIFUP) to Modulate Pain

NCT04339972
View directory record Official record
Conditions
Healthy Adults
Interventions
LIFUP, Sham LIFUP
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 45 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 19, 2021 · Synced Oct 18, 2026, 2:43 AM EDT
Completed Not applicable Interventional

Novel DBS Device in Parkinson's Disease

NCT07213999
View directory record Official record
Conditions
Parkinson's Disease (PD)
Interventions
Novel neural recorder
Device
Lead sponsor
University of Minnesota
Other
Eligibility
22 Years to 75 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 9, 2025 · Synced Oct 18, 2026, 2:43 AM EDT
Completed Not applicable Interventional Results available

Deep Brain Stimulation (DBS) for Treatment-Resistant Depression (TRD)

NCT01898429
View directory record Official record
Conditions
Treatment Resistant Depression, Depressive Disorder, Treatment-Resistant, Depression, Bipolar
Interventions
SCC DBS
Device
Lead sponsor
Paul Holtzheimer
Other
Eligibility
22 Years to 70 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jul 25, 2019 · Synced Oct 18, 2026, 2:43 AM EDT
Completed Not applicable Interventional Results available

Bilateral Closed Loop Deep Brain Stimulation for Freezing of Gait Using Neural and Kinematic Feedback

NCT04043403
View directory record Official record
Conditions
Parkinson Disease
Interventions
Open Loop DBS, Adaptive (Closed Loop) DBS, Intermittent Open Loop DBS
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 80 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Oct 7, 2026 · Synced Oct 18, 2026, 2:43 AM EDT
Recruiting Not applicable Interventional

Connectomic Deep Brain Stimulation for Obsessive Compulsive Disorder

NCT05160129
View directory record Official record
Conditions
Obsessive Compulsive Disorder (OCD)
Interventions
Selective focal stimulation of ALIC-pathways
Device
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Oct 18, 2026, 2:43 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Temporal Interference Methods for Non-invasive Deep Brain Stimulation, Study 1.2

NCT07339072
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Temporal Interference (TI) Electrical Stimulation - NAcc 5 Hz TI Active, Temporal Interference (TI) Electrical Stimulation - NAcc 5 Hz TI Sham, Temporal Interference (TI) Electrical Stimulation - NAcc 10 Hz TI Active, Temporal Interference (TI) Electrical Stimulation - NAcc 10 Hz TI Sham
Device
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 50 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 15, 2026 · Synced Oct 18, 2026, 2:43 AM EDT