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ClinicalTrials.gov public records Last synced Oct 4, 2026, 11:55 AM EDT

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Showing 25–48 of 92 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Dental Plaque Clear all
Completed Phase 4 Interventional Accepts healthy volunteers

A Twelve Week Study of Supervised Mouth Rinse and Flossing

NCT04696536
View directory record Official record
Conditions
Healthy
Interventions
Colgate Cavity Protection Toothpaste, American Dental Association (ADA) Referenced Toothbrush, 5% Hydroalcohol Mouth Rinse, REACH Dental Floss, Alcohol-containing Essential Oil (AEO) Mouth Rinse (Listerine Cool Mint, marketed)
Other
Lead sponsor
Johnson & Johnson Consumer Inc. (J&JCI)
Industry
Eligibility
18 Years and older
Enrollment
149 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 28, 2021 · Synced Oct 4, 2026, 11:55 AM EDT
Completed No phase listed Observational

Meta-analysis of Stannous Fluoride and the Effects on Dental Plaque

NCT04006483
View directory record Official record
Conditions
Dental Plaque
Interventions
Stannous fluoride dentifrice, Positive control dentifrice, Negative control dentifrice
Drug
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
2,359 participants
Timeline
2018
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 18, 2023 · Synced Oct 4, 2026, 11:55 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Novel Dental Gel as an Adjunct to Scaling and Root Planing

NCT05384132
View directory record Official record
Conditions
Periodontal Diseases, Gingival Diseases, Gingival Pocket, Gum Bleed, Plaque, Dental
Interventions
SRP + Livfresh Dental Gel, SRP + standard flouride dentifrice
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 85 Years
Enrollment
76 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2028
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 17, 2025 · Synced Oct 4, 2026, 11:55 AM EDT
Completed Phase 3 Interventional

Obstetrics and Periodontal Therapy (OPT) Study

NCT00066131
View directory record Official record
Conditions
Periodontitis, Infant, Premature
Interventions
Periodontal scaling and root planing, Scaling and root planing
Procedure
Lead sponsor
University of Minnesota
Other
Eligibility
16 Years and older · Female only
Enrollment
823 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2006
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 27, 2015 · Synced Oct 4, 2026, 11:55 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Clinical Investigation of a Toothpaste Containing Stannous Fluoride as Compared to Colgate Fluoride Toothpaste

NCT04033575
View directory record Official record
Conditions
Gingivitis
Interventions
Colgate Total SF, Colgate Cavity Protection toothpaste
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 70 Years
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Melbourne, Florida
Source: ClinicalTrials.gov public record
Updated Sep 27, 2022 · Synced Oct 4, 2026, 11:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Safety and Efficacy of the ToothWave -12 Weeks Calculus Study

NCT04092075
View directory record Official record
Conditions
Gingivitis, Plaque, Calculus, Dental
Interventions
RF-utilizing powered toothbrush, Control placebo with no RF
Device
Lead sponsor
Home Skinovations Ltd.
Industry
Eligibility
18 Years to 70 Years
Enrollment
87 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jul 29, 2020 · Synced Oct 4, 2026, 11:55 AM EDT
Not yet recruiting Not applicable Interventional

Clinical Assessment of the Safety and Efficacy of Flaus Electric Flosser on Plaque and Gingivitis Compared to a Manual Toothbrush

NCT07805148
View directory record Official record
Conditions
Gingivitis, Gingival Bleeding, Dental Plaque
Interventions
Device: Electric Flosser, Manual toothbrush
Device
Lead sponsor
Flaus, Inc
Industry
Eligibility
18 Years to 70 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Noblesville, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 4, 2026 · Synced Oct 4, 2026, 11:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of the Efficacy and Safety of a Loop Stretchable Dental Floss

NCT06515483
View directory record Official record
Conditions
Gingivitis, Supragingival Plaque
Interventions
Brushing and Flossing of teeth, Brushing Only
Device · Other
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 65 Years
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 13, 2025 · Synced Oct 4, 2026, 11:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Plaque and Gingivitis Evaluation of a U-Shaped Toothbrush in a 30-Day Model

NCT06122376
View directory record Official record
Conditions
Plaque Induced Gingivitis
Interventions
U-shaped Power Toothbrush, Soft Manual Toothbrush
Device
Lead sponsor
Lander Enterprises, LLC
Industry
Eligibility
5 Years to 65 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Nov 8, 2023 · Synced Oct 4, 2026, 11:55 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Imaging-based Assessment of Oral Biofilm and Gingival Health

NCT05470023
View directory record Official record
Conditions
Plaque, Dental, Gingivitis
Interventions
OTC Toothpastes or Mouthrinses
Other
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older
Enrollment
275 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2028
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Oct 4, 2026, 11:55 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Efficacy of Eco-Friendly Toothpaste Tablets Versus Conventional Toothpaste Using PI and GI Index

NCT05805865
View directory record Official record
Conditions
Gingival Inflammation
Interventions
Toothpaste Tablet, Conventional Toothpaste
Drug
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Feb 21, 2025 · Synced Oct 4, 2026, 11:55 AM EDT
Completed Phase 1 Interventional

Livionex Oral Microbiome and Dental Plaque Control in HSCT Recipients

NCT02617407
View directory record Official record
Conditions
Dental Plaque
Interventions
Livionex® Dental Gel, PreviDent 5000 plus/Tom's of Maine Children's toothpaste, Kolibree Toothbrush
Drug · Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
Not listed
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 23, 2024 · Synced Oct 4, 2026, 11:55 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Clinical Study Comparing Dental Plaque and Gingivitis Reduction After Using One of Three Oral Hygiene Multi-component Regimens (Using of a Manual Toothbrush, a Toothpaste and a Mouthwash)

NCT02366689
View directory record Official record
Conditions
Dental Plaque, Gingivitis
Interventions
Triclosan/fluoride toothpaste, stannous fluoride toothpaste, fluoride only toothpaste, Cetylpyridinium chloride mouthwash, Fluoride only mouthwash
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 70 Years
Enrollment
179 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Cedar Knolls, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 30, 2016 · Synced Oct 4, 2026, 11:55 AM EDT
Completed Phase 2 Interventional Results available

Impact of Periodontal Therapy on Patients With Diabetes

NCT04830969
View directory record Official record
Conditions
Diabetes Mellitus, Type II, Periodontitis
Interventions
Chlorhexidine gluconate oral rinse, Scaling & Root Planing, Soft Picks
Drug · Procedure · Device
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
25 Years and older
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Mar 1, 2023 · Synced Oct 4, 2026, 11:55 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Study of Virtually Supervised Mouth Rinses and Flossing

NCT05600231
View directory record Official record
Conditions
Healthy
Interventions
LISTERINE COOL MINT Antiseptic Mouthwash, LISTERINE COOL MINT ZERO Alcohol Mouthwash, Reach Unflavored Waxed Dental Floss, Colgate Cavity Protection Toothpaste
Other
Lead sponsor
Johnson & Johnson Consumer Inc. (J&JCI)
Industry
Eligibility
18 Years and older
Enrollment
284 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 18, 2023 · Synced Oct 4, 2026, 11:55 AM EDT
Completed Not applicable Interventional

Evaluating the Efficacy of a Gum Health Formulation on Teeth Whitening in Patients With Gingivitis and Periodontitis

NCT02906982
View directory record Official record
Conditions
Tooth Discoloration, Periodontal Diseases
Interventions
Gum health formulation in intra-oral device, Gum health formulation on toothbrush
Other
Lead sponsor
Glo Science, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 20, 2016 · Synced Oct 4, 2026, 11:55 AM EDT
Completed Phase 4 Interventional Results available

The Effect of Silver Diamine Fluoride (SDF) on Bacteria Involved in Root or Cervical Carious Lesions

NCT02953886
View directory record Official record
Conditions
Caries
Interventions
Silver Diamine Fluoride (SDF)
Device
Lead sponsor
Heba Mitwalli
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 28, 2018 · Synced Oct 4, 2026, 11:55 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Evaluate Dental Plaque Benefit of a Preventive Treatment Gel

NCT03546491
View directory record Official record
Conditions
Dental Plaque
Interventions
Preventive Gel, Marketed Control
Drug
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Mason, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 4, 2019 · Synced Oct 4, 2026, 11:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparion of Effects of Two Different Power Toothbrushes on Plaque and Gum Health

NCT07813546
View directory record Official record
Conditions
Gingiviits
Interventions
oscillating-rotating powered toothbrush, side-to-side powered toothbrush
Device
Lead sponsor
Philips Clinical & Medical Affairs Global
Industry
Eligibility
18 Years to 59 Years
Enrollment
295 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Oct 4, 2026, 11:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Clinical Investigation Examining Plaque and Gingivitis Connected Toothbrush Compared to Non-Connected Toothbrush

NCT04221334
View directory record Official record
Conditions
Gingivitis, Plaque, Dental
Interventions
Electric Toothbrush, oral health care application
Device · Other
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 70 Years
Enrollment
79 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jan 9, 2020 · Synced Oct 4, 2026, 11:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

ToothWave Plaque and Gingivitis Study

NCT03885323
View directory record Official record
Conditions
Gingivitis, Plaque, Calculus, Dental
Interventions
RF utilizing powered toothbrush, Control placebo with no RF
Device
Lead sponsor
Home Skinovations Ltd.
Industry
Eligibility
18 Years to 70 Years
Enrollment
86 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Nov 25, 2020 · Synced Oct 4, 2026, 11:55 AM EDT
Completed Not applicable Interventional Results available

Oral Hygiene in Assisted Living

NCT03892200
View directory record Official record
Conditions
Aging, Long-Term Care
Interventions
Aim2 - Daily Mouth Care, Aim3 - Daily Mouth Care
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
1,405 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Oct 4, 2026, 11:55 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Collection of Dental Plaque and Saliva for Studies of Bacterial Colonization of Teeth

NCT00098267
View directory record Official record
Conditions
Healthy
Interventions
Not listed
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
3 Months and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2009
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Oct 4, 2026, 11:55 AM EDT
Completed Not applicable Interventional

Providing Preventive Periodontal Treatment to Hospitalized Patients With Diabetes

NCT02914743
View directory record Official record
Conditions
Type II Diabetes, Periodontal Disease
Interventions
Motivational Interviewing, Dental cleaning
Behavioral · Procedure
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 6, 2019 · Synced Oct 4, 2026, 11:55 AM EDT