Search | Clinical Trials Finder

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ClinicalTrials.gov public records Last synced Nov 12, 2026, 4:51 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 99 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Depakote-ER Clear all

Conditions: Bipolar I or II Depression and Alcohol Abuse or Dependence
Interventions: Depakote ER; Drug
Lead sponsor: The University of Texas Medical Branch, Galveston; Other
Eligibility: 18 Years to 65 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2005
U.S. locations: 1
States / cities: Galveston, Texas

Conditions: Alcohol Withdrawal Syndrome
Interventions: Gabapentin, Benzodiazepines, Divalproex Sodium; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 88 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: ALPS, Hypersplenism, Lymphadenopathy
Interventions: Valproic Acid, CT Scan, Blood Sample; Drug · Procedure
Lead sponsor: Koneti Rao; NIH
Eligibility: 2 Years to 70 Years
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2011
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Bipolar Disorder, Schizophrenia
Interventions: Divalproex-extended release (DVP-ER), Lithium, Quetiapine; Drug
Lead sponsor: Palo Alto Veterans Institute for Research; Other
Eligibility: 18 Years to 65 Years
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2010
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Schizophrenia, Bipolar Disorder, Psychotic Disorders
Interventions: divalproex sodium ER/paliperidone ER; Drug
Lead sponsor: Johnson & Johnson Pharmaceutical Research & Development, L.L.C.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009
U.S. locations: 3
States / cities: Kissimmee, Florida • Austin, Texas • Portsmount, Virginia

Conditions: Bipolar Disorder
Interventions: Divalproex Sodium ER, Placebo; Drug
Lead sponsor: University Hospitals Cleveland Medical Center; Other
Eligibility: 16 Years to 65 Years
Enrollment: 54 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2004 – 2008
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Epilepsy
Interventions: Divalproex Sodium Extended-release 250mg, DEPAKOTE 250mg; Drug
Lead sponsor: Vince & Associates Clinical Research, Inc.; Other
Eligibility: 18 Years to 55 Years
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013
U.S. locations: 1
States / cities: Overland Park, Kansas

Conditions: Bipolar Disorder
Interventions: Valproic Acid; Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 19 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2011
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Hematuria, Bladder Cancer
Interventions: Valproic Acid; Drug
Lead sponsor: State University of New York - Upstate Medical University; Other
Eligibility: 21 Years and older
Enrollment: 43 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: Syracuse, New York

Conditions: Bipolar Disorder
Interventions: lithium carbonate, Depakote-ER, risperidone, olanzapine, paroxetine, bupropion, lamotrigine, venlafaxine, tranylcypromine, mirtazapine; Drug
Lead sponsor: University of Pittsburgh; Other
Eligibility: 60 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2004
U.S. locations: 2
States / cities: Pittsburgh, Pennsylvania

Conditions: Spinal Muscular Atrophy
Interventions: Valproic Acid and Levocarnitine, Placebo; Drug
Lead sponsor: University of Utah; Other
Eligibility: 2 Years to 17 Years
Enrollment: 94 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2007
U.S. locations: 5
States / cities: Baltimore, Maryland • Detroit, Michigan • Columbus, Ohio + 2 more

Conditions: Elderly, Epilepsy, Seizures
Interventions: Divalproex Sodium Extended-Release Tablets; Drug
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 60 Years and older
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2008
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Bipolar Disorder
Interventions: divalproex ER, quetiapine; Drug
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2008
U.S. locations: 1
States / cities: San Diego, California

Conditions: PTSD
Interventions: Divalproex; Drug
Lead sponsor: Tuscaloosa Research & Education Advancement Corporation; Other
Eligibility: 19 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2005
U.S. locations: 1
States / cities: Tuscaloosa, Alabama

Conditions: Major Depressive Disorder, Bipolar Disorder
Interventions: chronobiological augmentation, sertraline, lithium, one night of sleep deprivation and two FDG PET scans; Other · Drug · Radiation
Lead sponsor: University of California, Irvine; Other
Eligibility: 18 Years to 75 Years
Enrollment: 49 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2001 – 2011
U.S. locations: 2
States / cities: Irvine, California • La Jolla, California

Conditions: Bipolar Disorder
Interventions: Lithium, Divalproex, Placebo; Drug
Lead sponsor: University Hospitals Cleveland Medical Center; Other
Eligibility: 16 Years to 65 Years
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1997 – 2006
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Migraine
Interventions: divalproex sodium; Drug
Lead sponsor: Abbott; Industry
Eligibility: 12 Years to 17 Years
Enrollment: 315 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2005
U.S. locations: 1
States / cities: North Chicago, Illinois

Conditions: Autism
Interventions: Divalproex Sodium ER; Drug
Lead sponsor: Montefiore Medical Center; Other
Eligibility: 18 Years to 65 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2007
U.S. locations: 1
States / cities: New York, New York

Conditions: Irritable Aggression
Interventions: Divalproex; Drug
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 7 Years to 11 Years
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1997 – 2004
U.S. locations: 1
States / cities: New York, New York

Conditions: Partial Seizures
Interventions: Divalproex Sodium (Depakote Sprinkle Capsules); Drug
Lead sponsor: Abbott; Industry
Eligibility: 3 Years to 10 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2005
U.S. locations: 10
States / cities: Northport, Alabama • Phoenix, Arizona • Tampa, Florida + 7 more

Conditions: Epilepsy
Interventions: Not listed
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 13 Years to 45 Years · Female only
Enrollment: 48 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2009
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Substance Abuse, Bipolar Depression
Interventions: divalproex sodium ER, risperidone; Drug
Lead sponsor: Tuscaloosa Research & Education Advancement Corporation; Other
Eligibility: 19 Years to 65 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2007
U.S. locations: 1
States / cities: Tuscaloosa, Alabama

Conditions: Schizophrenia
Interventions: Valproate, Placebo; Drug
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years to 60 Years
Enrollment: 164 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2008
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Epilepsy, Mental Retardation, Developmental Disabilities
Interventions: Swallow instruction; Behavioral
Lead sponsor: Children's National Research Institute; Other
Eligibility: 4 Years to 18 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2007
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

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Open-Label Depakote ER in Patients With Bipolar I or II Depression and Alcohol Abuse or Dependence

Gabapentin for Alcohol Withdrawal Syndrome

Valproic Acid (Depakote[Registered Trademark]) to Treat Autoimmune Lymphoproliferative Syndrome (ALPS)

Treatment of Mania Symptoms With Drug Therapy

A Drug Interaction Study of Valproic Acid and Paliperidone Extended-Release (ER) in Patients With Schizophrenia, Bipolar I Disorder, or Schizoaffective Disorder

Double-blind, Placebo-Controlled Divalproex Sodium ER in Bipolar I or Bipolar II Depression

A Study in Stable Epilepsy Patients Comparing Brand and Generic Divalproex Sodium Extended Release Tablets

Bipolar Disorder in Late Life

Impact of Valproate on Angiogenesis and Histone Deacetylation in Bladder Cancer

Treatment of Geriatric Bipolar Mood Disorders: A Pilot Study

Valproic Acid and Carnitine in Patients With Spinal Muscular Atrophy

Tolerability and Efficacy of Depakote-extended Release in the Elderly

Naturalistic Study, Comparison of Divalproex Extended Release (ER) and Quetiapine for Adults With Acute Mania or Mixed Episodes

Maintenance Phase Treatment With Divalproex for Post Traumatic Stress Disorder

The Role of Dopamine Metabolism in the Antidepressant Effects of Sleep Deprivation and Sertraline in Depressed Patients

Lithium and Divalproex for the Treatment of Comorbid Rapid Cycling Bipolar Disorder and Substance Abuse Disorder

Study Designed to Evaluate the Safety of Prophylactic Depakote ER in the Treatment of Adolescents With Migraine

Divalproex Sodium ER in Adult Autism

Depakote (Divalproex Sodium) for Children With Temper Dysregulation and Severe Mood Swings

A Study for Treatment of Partial Seizures in Children

A Study to Look at Antiepileptic Drug Levels While on Lamictal or Depakote With or Without an Oral Contraceptive

Divalproex ER vs. Risperidone for Bipolar Disorder With Comorbid Substance Use Disorder

Determining Metabolic Effects of Valproate and Antipsychotic Therapy

Use of Sustained Release Antiepileptic Medication (Depakote® ER) for Pediatric Epilepsy in a Mental Retardation/Developmental Disorder Population