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Showing 25–44 of 20 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Deprescribing intervention Clear all
Completed Not applicable Interventional Results available

Deprescribing to Reduce Injurious Falls Among Older Adults With Dementia

NCT05777772
View directory record Official record
Conditions
Dementia
Interventions
STOP Falls D Educational Intervention
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
123 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 6, 2024 · Synced Sep 25, 2026, 10:21 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Medication Management at Home Via Pharmacy Home Televisits

NCT04340570
View directory record Official record
Conditions
Polypharmacy, Deprescribing, Telemedicine
Interventions
Medication management via televisit to home
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
65 Years and older
Enrollment
304 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
2
States / cities
Bedford, Massachusetts • The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Sep 25, 2026, 10:21 PM EDT
Completed Early Phase 1 Interventional Results available

The INCREASE Study - Delaying the Onset of Alzheimer's Symptomatic Expression

NCT02849639
View directory record Official record
Conditions
Alzheimer's Disease, Dementia
Interventions
Placebo, Medication Therapy Management (MTM), Scopolamine patch
Other · Drug
Lead sponsor
Daniela Moga
Other
Eligibility
65 Years to 101 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 18, 2023 · Synced Sep 25, 2026, 10:21 PM EDT
Completed Not applicable Interventional Results available

Standardized Patient-Centered Medication Review in Home Hospice

NCT03972163
View directory record Official record
Conditions
Hospices, Poly Pharmacy, Deprescriptions, Caregivers, Palliative Care, Prescription Drug Overuse, Interdisciplinary Communication
Interventions
NIA Medication Management - Active Comparator, STOPPFrail (Screening Tool of Older Persons Prescriptions), "Discontinuing Medication Appropriately" and "Understanding the Art of Communication about Deprescribing", "Key Approaches to Support Informal Family Caregivers in Managing Medications"
Behavioral
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
65 Years to 110 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Danvers, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 20, 2025 · Synced Sep 25, 2026, 10:21 PM EDT
Not yet recruiting Not applicable Interventional

Sleep Harmonization Via Bundled Team-Based Interventions in the ICU

NCT07840560
View directory record Official record
Conditions
Sleep Deprivation, Critical Illness, Sleep-Wake Disorders, Bundle Care, Implementation Science, Delirium
Interventions
Nighttime noise & light reduction, Clustering patient-care interactions, Non-pharmacologic sleep aids, Daytime light exposure, Encourage out-of-bed activity, Medication management to support nighttime sleep
Behavioral · Other
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
62,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
7
States / cities
La Jolla, California • San Francisco, California • Orlando, Florida + 4 more
Source: ClinicalTrials.gov public record
Updated Sep 24, 2026 · Synced Sep 25, 2026, 10:21 PM EDT
Completed Not applicable Interventional Results available

Deprescribing Potentially Inappropriate Medications in the Emergency Department for Persons Living With Dementia

NCT06273917
View directory record Official record
Conditions
Dementia
Interventions
PRIDE
Other
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
18 Years to 120 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
3
States / cities
Chicago, Illinois • Lake Forest, Illinois • Palos Heights, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Sep 25, 2026, 10:21 PM EDT
Completed Not applicable Interventional Results available

Drug Reduction in Older Patients: The DROP Trial

NCT03722017
View directory record Official record
Conditions
Geriatric Assessment, Frail Elderly, Skilled Nursing Facilities, Patient-centered Care
Interventions
Deprescribing intervention
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
50 Years and older
Enrollment
260 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 26, 2024 · Synced Sep 25, 2026, 10:21 PM EDT
Recruiting Not applicable Interventional

Fall Risk Identification and Management for Older Veterans

NCT06573983
View directory record Official record
Conditions
Fall Risk
Interventions
Strengthening (Physical Therapy, Gerofit), Medication Reconciliation (Clinical Pharmacology), Home Safety Modification (Occupational Therapy)
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
65 Years and older
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Sep 25, 2026, 10:21 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Shared Decision Making About Medication Use for People With Multiple Health Problems

NCT05156073
View directory record Official record
Conditions
Polypharmacy, Dementia, Multiple Chronic Conditions, Deprescribing, Mild Cognitive Impairment
Interventions
Educational Materials
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
65 Years and older
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Reading, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 26, 2024 · Synced Sep 25, 2026, 10:21 PM EDT
Completed Not applicable Interventional Results available

Engaging Patients to Promote Deprescribing

NCT04294901
View directory record Official record
Conditions
Medical Overuse, Inappropriate Prescribing, Deprescriptions
Interventions
Direct to patient medication brochure
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Enrollment
5,946 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
4
States / cities
San Francisco, California • Boston, Massachusetts • Leeds, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated May 17, 2025 · Synced Sep 25, 2026, 10:21 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

e-ALIGN: A Patient Portal-based Intervention to Align Medications With What Matters Most

NCT07454824
View directory record Official record
Conditions
Dementia, Potentially Inappropriate Medication Use, Mild Cognitive Impairment (MCI)
Interventions
e-ALIGN Patient-Portal Deprescribing
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
65 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 15, 2026 · Synced Sep 25, 2026, 10:21 PM EDT
Completed Not applicable Interventional Results available

Deprescribing in Patients Living With Dementia With Caregiver and Provider Nudges

NCT06347172
View directory record Official record
Conditions
Alzheimer Disease, Mild Cognitive Impairment, Dementia
Interventions
Nudge Intervention
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
65 Years and older
Enrollment
262 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 29, 2026 · Synced Sep 25, 2026, 10:21 PM EDT
Completed No phase listed Observational Results available

Deprescribing for Older Dialysis Patients

NCT03631290
View directory record Official record
Conditions
Kidney Failure, Chronic
Interventions
Deprescribing Intervention
Behavioral
Lead sponsor
Duke University
Other
Eligibility
55 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 2, 2025 · Synced Sep 25, 2026, 10:21 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Adapting the Shed-MEDS Deprescribing Intervention to Dementia Care in Assisted Living

NCT05956665
View directory record Official record
Conditions
Polypharmacy, Dementia, Quality of Life
Interventions
Shed-MEDS deprescribing intervention
Behavioral
Lead sponsor
Vanderbilt University
Other
Eligibility
65 Years and older
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
2
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Sep 25, 2026, 10:21 PM EDT
Completed Not applicable Interventional

Brief Cognitive Behavioral Therapy to Enhance Benzodiazepine Deprescribing

NCT06119308
View directory record Official record
Conditions
Benzodiazepine Use, Insomnia, Anxiety
Interventions
Benzodiazepine Medication Taper with Cognitive Behavioral Therapy
Other
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
55 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Sep 25, 2026, 10:21 PM EDT
Completed Not applicable Interventional

Decreasing Harms and Improving Child Health

NCT07392489
View directory record Official record
Conditions
Psychotropic Drugs, Psychiatric Drugs, Children, Shared Decision Making, Patient Decision Aid
Interventions
AWARE Shared Decision Making Medication Review
Behavioral
Lead sponsor
Glyn Jones-Elwyn
Other
Eligibility
6 Years to 17 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
4
States / cities
Hanover, New Hampshire • Lebanon, New Hampshire • Auburn, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Sep 25, 2026, 10:21 PM EDT
Completed Not applicable Interventional

Optimal Medication Management in Alzheimer's Disease and Dementia

NCT03984396
View directory record Official record
Conditions
Dementia
Interventions
Educational Materials - Patient & Clinician
Other
Lead sponsor
Kaiser Permanente
Other
Eligibility
65 Years and older
Enrollment
7,398 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 31, 2024 · Synced Sep 25, 2026, 10:21 PM EDT
Active, not recruiting Not applicable Interventional

Population Health Approach to Optimizing Medications in Older Adults

NCT06110156
View directory record Official record
Conditions
Medication Adverse Effects, Older Adults (65 Years and Older), Polypharmacy, Polypharmacy Patients, Deprescribing
Interventions
Patient-tailored deprescribing assessment and intervention
Behavioral
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
65 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 26, 2026 · Synced Sep 25, 2026, 10:21 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Bundled Hyperpolypharmacy Deprescribing

NCT05616689
View directory record Official record
Conditions
Polypharmacy
Interventions
Bundled hyperpolypharmacy
Other
Lead sponsor
Kaiser Permanente
Other
Eligibility
76 Years and older
Enrollment
2,471 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Oakland, California
Source: ClinicalTrials.gov public record
Updated Dec 14, 2023 · Synced Sep 25, 2026, 10:21 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Aligning Medications With What Matters Most

NCT04938648
View directory record Official record
Conditions
Polypharmacy, Alzheimer Disease and Related Dementias
Interventions
Pharmacist-led deprescribing intervention
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
65 Years and older
Enrollment
138 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
2
States / cities
Aurora, Colorado • Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Sep 25, 2026, 10:21 PM EDT