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ClinicalTrials.gov public records Last synced Oct 25, 2026, 1:51 AM EDT

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Showing 865–888 of 4,838 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Depression Clear all
Completed No phase listed Observational Accepts healthy volunteers

Dopamine Receptor Imaging in Mood Disorders

NCT00116077
View directory record Official record
Conditions
Mood Disorders, Depressive Disorder, Major, Bipolar Disorder
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 55 Years
Enrollment
145 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2010
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Oct 25, 2026, 1:51 AM EDT
Recruiting Not applicable Interventional

Lay-Delivered Behavioral Activation in Senior Centers

NCT04621877
View directory record Official record
Conditions
Depression
Interventions
Volunteer-delivered Behavioral Activation, Master's level clinician-delivered Behavioral Activation
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
60 Years and older
Enrollment
288 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
25
States / cities
Brandon, Florida • Gibsonton, Florida • Ruskin, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Oct 15, 2024 · Synced Oct 25, 2026, 1:51 AM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

Rescuing the Ruminating Brain: Identifying Biomarkers of Rumination and Mindfulness Through Concurrent EEG and Functional Magnetic Resonance Imaging (fMRI) Studies of Schizophrenia and Depression

NCT03758495
View directory record Official record
Conditions
Schizophrenia, Depressive Disorder, Major
Interventions
Electroencephalography (EEG) and Magnetic Resonance Imaging (MRI)
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 65 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 10, 2019 · Synced Oct 25, 2026, 1:51 AM EDT
Recruiting Phase 2 Interventional

A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)

NCT06524830
View directory record Official record
Conditions
Treatment Resistant Depression
Interventions
VLS-01-203 BU, VLS-01-BU Placebo
Drug
Lead sponsor
atai Therapeutics, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
142 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
34
States / cities
Tucson, Arizona • Little Rock, Arkansas • Rogers, Arkansas + 30 more
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Oct 25, 2026, 1:51 AM EDT
Active, not recruiting Not applicable Interventional

DBS for Depression

NCT03437928
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Directional Deep Brain Stimulation
Device
Lead sponsor
Baylor College of Medicine
Other
Eligibility
22 Years to 70 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
2
States / cities
Dallas, Texas • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 1, 2026 · Synced Oct 25, 2026, 1:51 AM EDT
Completed Phase 1 Interventional

Omega-3 and Therapy Study for Childhood Bipolar Disorder- Not Otherwise Specified

NCT01507753
View directory record Official record
Conditions
Bipolar Disorder
Interventions
Omega-3 Supplementation, Psychoeducational Psychotherapy (PEP), Placebo
Drug · Behavioral · Other
Lead sponsor
L. Eugene Arnold
Other
Eligibility
7 Years to 14 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 8, 2016 · Synced Oct 25, 2026, 1:51 AM EDT
Completed Not applicable Interventional

Role of Exercise in Depression in Middle Aged and Older Adults

NCT01573728
View directory record Official record
Conditions
Depression
Interventions
Low dose exercise, Public Health Exercise
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
46 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Apr 1, 2016 · Synced Oct 25, 2026, 1:51 AM EDT
Completed Not applicable Interventional Results available

Integrating Depression Services Into DM Management

NCT01098253
View directory record Official record
Conditions
Type 2 Diabetes Mellitus, Depression
Interventions
Adherence Intervention
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
30 Years and older
Enrollment
182 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 9, 2012 · Synced Oct 25, 2026, 1:51 AM EDT
Completed Not applicable Interventional

Exercise to Augment TMS in Those With Treatment Resistant Depression

NCT05913401
View directory record Official record
Conditions
Treatment Resistant Depression
Interventions
Aerobic Exercise, Video Watching
Behavioral
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Oct 25, 2026, 1:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Brain Cooling Biomarkers

NCT06542419
View directory record Official record
Conditions
Mental Health, Neurological Health
Interventions
Brain Cooling
Device
Lead sponsor
Penn State University
Other
Eligibility
18 Years to 24 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 1, 2025 · Synced Oct 25, 2026, 1:51 AM EDT
Recruiting Not applicable Interventional

Families With Pride ("Familias Con Orgullo").

NCT06057337
View directory record Official record
Conditions
Depression, Drug Use
Interventions
Families with Pride ("Familias con Orgullo")
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
13 Years to 19 Years
Enrollment
306 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Oct 25, 2026, 1:51 AM EDT
Active, not recruiting Not applicable Interventional

Low Field Magnetic Stimulation: Imaging Biomarkers in Geriatric Bipolar Depression

NCT03484494
View directory record Official record
Conditions
Bipolar Disorder, Bipolar Depression, Bipolar I Disorder, Bipolar II Disorder
Interventions
Low Field Magnetic Stimulation
Device
Lead sponsor
Mclean Hospital
Other
Eligibility
50 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2026
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 23, 2026 · Synced Oct 25, 2026, 1:51 AM EDT
Completed Phase 2 Interventional

Clinical Trial of Felbamate for Treatment-Resistant Bipolar Depression

NCT00034229
View directory record Official record
Conditions
Bipolar Disorder
Interventions
Felbamate
Drug
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
Not listed
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2006
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 25, 2026, 1:51 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Examining Prison Inmates' Attitudes and Internal Emotional States

NCT04374357
View directory record Official record
Conditions
Forgiveness
Interventions
Not listed
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
Male only
Enrollment
103 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Portage, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jun 9, 2020 · Synced Oct 25, 2026, 1:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Positive Family Support Project - Partnering With Families for a Successful Transition to School

NCT02289092
View directory record Official record
Conditions
Achievement
Interventions
Family Check-Up
Behavioral
Lead sponsor
University of Oregon
Other
Eligibility
Not listed
Enrollment
848 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2019
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Jun 21, 2022 · Synced Oct 25, 2026, 1:51 AM EDT
Completed Phase 4 Interventional Results available

Escitalopram in the Treatment of Dysthymic Disorder, Double Blind

NCT00220701
View directory record Official record
Conditions
Dysthymic Disorder
Interventions
Lexapro (escitalopram)
Drug
Lead sponsor
St. Luke's-Roosevelt Hospital Center
Other
Eligibility
18 Years to 65 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2009
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 11, 2015 · Synced Oct 25, 2026, 1:51 AM EDT
Completed Phase 1Phase 2 Interventional

Therapy for Depression With Co-occurring Panic or Anxiety Symptoms

NCT00051207
View directory record Official record
Conditions
Depression, Anxiety Disorders, Panic Disorder
Interventions
Interpersonal Psychotherapy (IPT), IPT for Depression with Co-occurring Panic and Anxiety Symptoms (IPT-PS)
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 60 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2005
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 25, 2013 · Synced Oct 25, 2026, 1:51 AM EDT
Not listed Not applicable Interventional

An Idiographic Examination of Treatment Mechanisms in Emotion Regulation Therapy

NCT05590741
View directory record Official record
Conditions
Rumination, Worry, Self-Criticism, Anxiety, Depression, Distress, Emotional
Interventions
Emotion Regulation Therapy via Telehealth
Behavioral
Lead sponsor
Teachers College, Columbia University
Other
Eligibility
18 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 4, 2024 · Synced Oct 25, 2026, 1:51 AM EDT
Withdrawn Phase 2 Interventional Accepts healthy volunteers

Adjunctive Pregnenolone in Post-Traumatic Stress Disorder (PTSD) and Depression in Operations Enduring Freedom and Iraqi Freedom (OEF/OIF) Veterans

NCT00993629
View directory record Official record
Conditions
Post-traumatic Stress Disorder, Major Depressive Disorder
Interventions
pregnenolone, placebo
Drug
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 55 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 27, 2014 · Synced Oct 25, 2026, 1:51 AM EDT
Completed Phase 1Phase 2 Interventional Results available

An Adaptive Treatment Strategy for Adolescent Depression

NCT01802437
View directory record Official record
Conditions
Adolescent Depression
Interventions
Fluoxetine, Increased Dose of Interpersonal Psychotherapy, Continue to Receive Initial Dose of Interpersonal Psychotherapy
Drug · Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
12 Years to 17 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 11, 2019 · Synced Oct 25, 2026, 1:51 AM EDT
Not listed Not applicable Interventional

Cognitive Control Training as an Adjunct to Behavioral Activation Therapy in the Treatment of Depression

NCT01694719
View directory record Official record
Conditions
Depression
Interventions
Brief Behavioral Activation Treatment for Depression, Cognitive Control Training
Behavioral
Lead sponsor
Boston University
Other
Eligibility
18 Years to 65 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 27, 2012 · Synced Oct 25, 2026, 1:51 AM EDT
Completed Not applicable Interventional

Aloud Real-time Reading of ICU Diaries for Prevention of Negative Post-ICU Psychological Outcomes

NCT04510272
View directory record Official record
Conditions
Anxiety, Depression, PTSD
Interventions
Aloud Real-time Reading of ICU Diaries
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 1, 2023 · Synced Oct 25, 2026, 1:51 AM EDT
Completed Not applicable Interventional

Acupuncture for Symptoms of Nerve Damage

NCT03183037
View directory record Official record
Conditions
Peripheral Neuropathy, Chemotherapy-induced Peripheral Neuropathy
Interventions
Acupuncture, Sham Acupuncture, Usual Care Group, questionnaires
Procedure · Other · Behavioral
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
2
States / cities
Commack, New York • New York, New York
Source: ClinicalTrials.gov public record
Updated May 3, 2024 · Synced Oct 25, 2026, 1:51 AM EDT
Completed Phase 4 Interventional Results available

A Study of Duloxetine in Major Depressive Disorder (MDD) and Associated Painful Symptoms

NCT01000805
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Duloxetine, Placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years and older
Enrollment
528 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
16
States / cities
Beverly Hills, California • Sherman Oaks, California • Jacksonville, Florida + 13 more
Source: ClinicalTrials.gov public record
Updated Jan 13, 2012 · Synced Oct 25, 2026, 1:51 AM EDT