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ClinicalTrials.gov public records Last synced Nov 15, 2026, 8:45 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 217–240 of 1,835 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Depression Intervention Clear all

Conditions: Depression, Anxiety
Interventions: IntelliCare; Behavioral
Lead sponsor: Adaptive Health, Inc; Industry
Eligibility: 18 Years and older
Enrollment: 82 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 2
States / cities: Chicago, Illinois • Florence, South Carolina

Conditions: Congestive Heart Failure, Emotions, Patient Compliance
Interventions: Qualitative Interview and Adherence Measurements; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Chronic Pulmonary Disorder
Interventions: breathing techniques, Self-Administered Baseline and Transition Dyspnea Indexes; Other · Behavioral
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 19 Years and older
Enrollment: 23 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2018
U.S. locations: 1
States / cities: New York, New York

Conditions: Opioid-use Disorder, Amphetamine Use Disorders
Interventions: Neurocognitive Empowerment for Addiction Treatment (NEAT), Active Control; Behavioral
Lead sponsor: Laureate Institute for Brain Research, Inc.; Other
Eligibility: 18 Years to 65 Years
Enrollment: 104 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Tulsa, Oklahoma

Conditions: Major Depressive Disorder
Interventions: Intermittent Theta Burst Stimulation (iTBS), Transcranial Alternating Current Stimulation (tACS), Psychotherapy, Sham (Placebo) Transcranial Alternating Current Stimulation (tACS); Device · Behavioral
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years to 70 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Depressive Disorder, Major
Interventions: Vortioxetine 10 mg/day, Vortioxetine 20 mg/day, Fluoxetine 20 mg/day, Placebo; Drug · Other
Lead sponsor: H. Lundbeck A/S; Industry
Eligibility: 12 Years to 17 Years
Enrollment: 784 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 42
States / cities: Dothan, Alabama • Tucson, Arizona • Little Rock, Arkansas + 37 more

Conditions: Major Depressive Disorder
Interventions: Transdermal estradiol, Progesterone, Transdermal placebo patch, placebo capsule; Drug
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Depression, Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Interventions: Collaborative care, Interview or Focus Group, Media/technology Intervention with collaborative care, Survey Administration; Other
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 297 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 4
States / cities: Auburn, Washington • Gig Harbor, Washington • Seattle, Washington + 1 more

Conditions: Anxiety, Depression, Stress, Pain, Heart Rate, Blood Pressure
Interventions: Conscious Breathing, Heartfulness Meditation, Emotional Freedom Technique; Other
Lead sponsor: WellSpan Health; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022
U.S. locations: 1
States / cities: York, Pennsylvania

Conditions: Gait, Hemiplegic, Physical Therapy
Interventions: Gait training with EksoNR, Backward gait training with EksoNR; Device · Procedure
Lead sponsor: Alvernia University; Other
Eligibility: 18 Years and older
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 2
States / cities: Schenectady, New York • Reading, Pennsylvania

Conditions: Nursing Home Resident, Skilled Nursing Facility, Depression, Feasibility Studies, Caregiver
Interventions: Interventions for Stressful Transitions in Later Life; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Major Depressive Disorder, Parkinson's Disease
Interventions: Cognitive Behavioral Therapy; Behavioral
Lead sponsor: Amy Farabaugh, PhD; Other
Eligibility: 40 Years to 80 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2013
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Depression, Postpartum
Interventions: standardized electronic messages, nurse phone call if requested, Staff nurse phone follow-up; Behavioral
Lead sponsor: Saint Anselm College; Other
Eligibility: 18 Years and older · Female only
Enrollment: 683 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: Manchester, New Hampshire

Conditions: Depressive Symptoms
Interventions: Surveys, Supportive Text messages, Personalized Feedback (PF) Report; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 17 Years and older
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Individuals at Risk for Depression
Interventions: AIM Web based intervention + surveillance, AIM web based intervention, Educational website; Behavioral
Lead sponsor: Northwestern University; Other
Eligibility: 19 Years and older
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Ecology, Anxiety
Interventions: Short videos; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 14 Years to 18 Years
Enrollment: 1,200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022
U.S. locations: 2
States / cities: New Haven, Connecticut

Conditions: Unipolar Depression
Interventions: Not listed
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 75 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 2
States / cities: Boston, Massachusetts

Conditions: Sleep Disturbance, Sleep, Depression, Suicide
Interventions: TranS-C, Sleep Feedback; Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 12 Years to 18 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 2
States / cities: Philadelphia, Pennsylvania • Pittsburgh, Pennsylvania

Conditions: Anxiety
Interventions: Calmer Life; Behavioral
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 50 Years and older
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2016
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Depression, Suicidal Ideation
Interventions: Text2Connect; Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 12 Years to 26 Years
Enrollment: 47 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 4
States / cities: McMurray, Pennsylvania • Natrona Heights, Pennsylvania • Pittsburgh, Pennsylvania

Conditions: Depression
Interventions: AIMS, AIMS plus; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 85 Years
Enrollment: 53 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Posttraumatic Stress Disorder, Cancer
Interventions: Cancer Distress Coach Mobile App; Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 569 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Pregnancy, Substance Use, Depression, Anxiety
Interventions: Listening to Women and Pregnant and Postpartum People; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 41 Years · Female only
Enrollment: 415 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Depression, Major Depressive Disorder, Dysthymic Disorder, Depressive Symptoms, Type 2 Diabetes, PreDiabetes, Insulin Resistance
Interventions: Good Days Ahead (GDA), Problem Solving Treatment in Primary Care (PST-PC), Antidepressant Medications, Active Control; Behavioral · Drug · Other
Lead sponsor: Indiana University; Other
Eligibility: 18 Years and older
Enrollment: 46 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Indianapolis, Indiana

Search by objective public record fields.

Integrating a Suite of Mental Health Apps for Depression in a Healthcare Setting

Researching Emotions And Cardiac Health

Breath Training Exercise for the Reduction of Chronic Dyspnea

Neurocognitive Empowerment for Addiction Treatment (NEAT) in Opioid Use Disorder and Amphetamine Use Disorder

CARED : A Novel Rapid Treatment Paradigm for Depression

Active Reference (Fluoxetine) Fixed-dose Study of Vortioxetine in Paediatric Patients Aged 12 to 17 Years With Major Depressive Disorder (MDD)

Ovarian Hormone Withdrawal, Anhedonia, and Reward Sensitivity in Women With Premenstrual Exacerbations of Depression

Using Technology to Optimize Collaborative Care Management of Depression in Urban and Rural Cancer Centers, SCOPE

Impact of Complimentary and Alternative Practices on Patient Wellbeing During Rehabilitation

Effects of Backward Gait Training With Exoskeleton on Motor Functions

Behavioral Health Program for Short-Stay Nursing Facility Residents & Care Partners

Psychosocial Treatment of Depression in Parkinson's Disease

Effectiveness of a Web-based Nursing Intervention in the Reduction of Postpartum Depression and Parenting Stress.

College Student Stress: Transitions Over Time

Internet Intervention for the Prevention of Depression - Approaches to Improving Mood

Reducing Eco-anxiety Using Selfies

Sensor-based Characterization of Depression

Transdiagnostic Sleep and Circadian Intervention + Bright Light in Adolescents With Elevated Depression (TranS-C+BL)

Calmer Life: A Worry Reduction Program for Older Adults

Text2Connect, Component 2 of iCHART (Integrated Care to Help At-Risk Teens)

Pilot Study of Annie Text Messaging for Depression Treatment Adherence

Cancer Distress Coach Mobile App Trial

Pilot Randomized Controlled Trial (RCT): Remote SBIRT Vs. In-Person SBIRT

eIMPACT-DM Pilot Trial: Depression Treatment to Reduce Diabetes Risk