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ClinicalTrials.gov public records Last synced Nov 15, 2026, 1:00 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 337–360 of 1,835 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Depression Intervention Clear all

Conditions: Perinatal Mental Health, Fathers, Stress Management
Interventions: Fathers and Babies Program, Mothers and Babies Program; Behavioral
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years and older
Enrollment: 624 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Opioid-use Disorder, Anxiety Disorders, Depressive Disorder
Interventions: Smartphone-Based Digital Intervention; Behavioral
Lead sponsor: Trustees of Dartmouth College; Other
Eligibility: 18 Years and older
Enrollment: 63 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Lebanon, New Hampshire

Conditions: Hepatitis C, Major Depressive Disorder
Interventions: Exercise, Health Education; Behavioral
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 18 Years to 65 Years
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Mood Disorders, Hypertension, Diabetes, Hypercholesterolemia
Interventions: Acceptance and Commitment Therapy plus Illness Management; Behavioral
Lead sponsor: Lilian N. Dindo; Other
Eligibility: 18 Years to 75 Years
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Depression, Cognitive Decline
Interventions: Therapist-Assisted Internet Cognitive-Behavioral Therapy for Depression, Active Control; Behavioral
Lead sponsor: Indiana University; Other
Eligibility: 50 Years and older
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 2
States / cities: Indianapolis, Indiana

Conditions: Depression
Interventions: Quality Improvement (QI) for depression, Usual Care; Other
Lead sponsor: Agency for Healthcare Research and Quality (AHRQ); Federal
Eligibility: 13 Years to 21 Years
Enrollment: 418 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1999 – 2003
U.S. locations: 5
States / cities: Los Angeles, California • Venice, California • Ventura, California + 1 more

Conditions: Depression, Anxiety
Interventions: IDgenetix Neuropsychiatric Test Panel; Genetic
Lead sponsor: AltheaDx; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 220 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015
U.S. locations: 1
States / cities: Raleigh, North Carolina

Conditions: Smoking Cessation
Interventions: rTMS Active 20Hz, rTMS Sham; Device
Lead sponsor: The City College of New York; Other
Eligibility: 21 Years to 65 Years
Enrollment: 29 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: New York, New York

Conditions: History of Cancer
Interventions: qualitative interviews; Behavioral
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 8 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2018
U.S. locations: 1
States / cities: New York, New York

Conditions: Anxiety, Depression, Unspecified Adult Solid Tumor, Protocol Specific, Cancer, Cognitive Behavioral Therapy
Interventions: Brief Cognitive Behavioral Therapy; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 49 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Pain, Depressive Symptoms, Aging
Interventions: SPARK; Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 50 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Disabling Medical Events, Disabled, Depression
Interventions: Enhanced Medical Rehabilitation, Standard of Care Rehabilitation; Behavioral
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 65 Years and older
Enrollment: 229 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2018
U.S. locations: 3
States / cities: St Louis, Missouri

Conditions: Diabetes, Sedentary Lifestyle
Interventions: Tailored Physical Activity Intervention, Standard of Care; Behavioral
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years to 70 Years
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: La Jolla, California

Conditions: Depression, Heart Failure, Congestive
Interventions: Interpersonal and behavioral psychotherapy, Attention control (AC) condition; Behavioral
Lead sponsor: University of Iowa; Other
Eligibility: 55 Years and older
Enrollment: 66 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2010
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Major Depressive Disorder (MDD), fNIRS
Interventions: fNIRS measurement; Other
Lead sponsor: Kernel; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 11 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 2
States / cities: Los Angeles, California • Sunnyvale, California

Conditions: Dementia, Alzheimer's Disease
Interventions: UCF Caregiver Support Group, Community Support Groups; Behavioral
Lead sponsor: University of Central Florida; Other
Eligibility: 18 Years and older
Enrollment: 41 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2020
U.S. locations: 1
States / cities: Orlando, Florida

Conditions: PostPartum Depression
Interventions: Wellness Control, Exercise Intervention; Behavioral
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older · Female only
Enrollment: 130 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Musculoskeletal Injury Trauma
Interventions: Integrated care (ICare), Usual Care (UsCare), Patient-Reported Outcomes Measurement Information System, Lower Extremity Gain Scale (LEGS), Dynamometer, Active Range of Motion (AROM), Posttraumatic Stress Disorder (PTSD), Beck Depression Inventory-II, State-Trait Anxiety Inventory (STAI), Tampa Scale of Kinesiophobia-11 (TSK-11); Procedure · Other
Lead sponsor: University of Florida; Other
Eligibility: 18 Years to 85 Years
Enrollment: 88 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2023
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Depression, Postpartum, Depression
Interventions: The Postpartum Prevention Program (PPP), Enhanced care as usual (ECU); Behavioral
Lead sponsor: Women and Infants Hospital of Rhode Island; Other
Eligibility: 18 Years to 40 Years · Female only
Enrollment: 207 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2012
U.S. locations: 3
States / cities: Providence, Rhode Island • Woonsocket, Rhode Island

Conditions: Pediatric Brain Tumor
Interventions: Survivor's Journey+; Behavioral
Lead sponsor: Children's Hospital Medical Center, Cincinnati; Other
Eligibility: 15 Years to 25 Years
Enrollment: 72 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 2
States / cities: Cincinnati, Ohio • Columbus, Ohio

Conditions: HIV/AIDS
Interventions: LinkPositively; Behavioral
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 53 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: San Diego, California

Conditions: Depression in Old Age
Interventions: Engage-A, Training and utilizing Engage-A therapy; Behavioral · Other
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 55 Years and older
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: White Plains, New York

Conditions: Postpartum Depression, Parenting, Parent-Child Relations
Interventions: Social Media-Based Parenting Program, MoodGym; Behavioral
Lead sponsor: Children's Hospital of Philadelphia; Other
Eligibility: 18 Years and older · Female only
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Depression
Interventions: Mom-Net, Treatment as Usual/Waitlist; Behavioral
Lead sponsor: Oregon Research Institute; Other
Eligibility: 2 Years and older
Enrollment: 960 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Springfield, Oregon

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Fathers and Babies (FAB) Research Study

Digital Intervention to Treat Anxiety and Depression Among Persons Receiving Treatment for Opioid Use Disorder

A Health Intervention to Prevent Depression Hepatitis C Patients

One-Day Acceptance and Commitment Training Intervention in Primary Care Patients

Attenuating DEPression With Internet CBT to Slow Cognitive Decline in Older ICU Survivors(ADEPT-ICU)

Youth Partners in Care: Depression and Quality Improvement

Clinical Study to Evaluate Patient Outcomes Following Pharmacogenetic Testing of Subjects Exhibiting Neuropsychiatric Disorders

Enhancing Relapse Prevention for Smoking Cessation With Repetitive Transcranial Magnetic Stimulation

A Safety Study Assessing the Effects of Receiving Genome Sequencing Results

Brief CBT for Anxiety and Advanced Cancer

Strength and Pain-Coping Through Resilience and Knowledge

Enhanced Medical Rehabilitation in Older Adults

Primary Care-Based Physical Activity for Diabetic Latinas

Interpersonal Psychotherapy for Depression in People With Heart Failure

Prediction of REsponse to Depression Interventions (Accelerated rTMS) Using Clinical and TD-fNIRS Measurements

Caregiver Burden and Depression: Caring for Those Who Care for Others

The Effect of Exercise on Preventing PostPartum Depression

An Integrated-Delivery-of-Care Approach to Improve Patient Outcomes, Safety, Well-Being After Orthopaedic Trauma

Depression Prevention for Pregnant Women on Public Assistance

Survivors Journey+

LinkPositively: A Technology-Delivered Peer Navigation and Social Networking Intervention to Improve HIV Care

Reaching and Engaging Depressed Senior Center Clients

Social Media-Based Parenting Program for Women With Postpartum Depressive Symptoms

ICBT (Internet Based Cognitive Behavioral Therapy) for Maternal Depression: Community Implementation in Head Start