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ClinicalTrials.gov public records Last synced Nov 15, 2026, 1:09 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 361–384 of 1,835 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Depression Intervention Clear all

Conditions: Low Back Pain, PTSD, Depression, Anxiety
Interventions: Study assessments; Other
Lead sponsor: Palmer College of Chiropractic; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018
U.S. locations: 4
States / cities: Coralville, Iowa • Davenport, Iowa • Iowa City, Iowa + 1 more

Conditions: Depression
Interventions: Attachment-Based Family Therapy; Behavioral
Lead sponsor: Pennsylvania Department of Health; Government
Eligibility: 12 Years to 18 Years
Enrollment: 240 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2007
U.S. locations: 3
States / cities: Allentown, Pennsylvania • Philadelphia, Pennsylvania • Pittsburgh, Pennsylvania

Conditions: Perinatal Depression
Interventions: MMBFM program with clinician coach support, MMBFM program with peer coach support, Patient facing strategy intervention arm, Patient facing plus clinic facing strategy intervention arm; Behavioral
Lead sponsor: Kaiser Permanente; Other
Eligibility: 18 Years and older · Female only
Enrollment: 423 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 4
States / cities: San Diego, California • Denver, Colorado • Atlanta, Georgia + 1 more

Conditions: Depression, Anxiety, Major Depression
Interventions: Psychoeducational course; Behavioral
Lead sponsor: Arizona State University; Other
Eligibility: 18 Years to 90 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Major Depression
Interventions: Guideline-Based Medical Management, Motivational Interviewing for Depression; Behavioral
Lead sponsor: Denver Health and Hospital Authority; Other
Eligibility: 18 Years and older
Enrollment: 168 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Denver, Colorado

Conditions: Major Depression
Interventions: Stress Management and Resiliency Training for Depression (SMART-D) Therapy; Behavioral
Lead sponsor: Mayo Clinic; Other
Eligibility: 25 Years to 80 Years
Enrollment: 27 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 3
States / cities: Albert Lea, Minnesota • Austin, Minnesota • Rochester, Minnesota

Conditions: Maternal Care Patterns
Interventions: Mom-Net, Coach-facilitated Treatment as Usual; Behavioral
Lead sponsor: Oregon Research Institute; Other
Eligibility: Female only
Enrollment: 266 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2017
U.S. locations: 2
States / cities: Eugene, Oregon

Conditions: Depressive Symptoms, Allostatic Load, Metabolic Syndrome
Interventions: Rise Together: Community Engagement Intervention, Adulting 101: Life Skills; Behavioral
Lead sponsor: Ann & Robert H Lurie Children's Hospital of Chicago; Other
Eligibility: 15 Years to 20 Years
Enrollment: 300 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Major Depressive Disorder, Alcohol Abuse, Alcohol Dependence
Interventions: acamprosate, escitalopram, Medical management, Placebo; Drug · Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 64 Years
Enrollment: 23 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: HIV, Mental Health, Substance Use, STI
Interventions: Automated Messaging & Monitoring, Peer Support, Coaching; Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 12 Years to 24 Years
Enrollment: 1,478 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2022
U.S. locations: 2
States / cities: Los Angeles, California • New Orleans, Louisiana

Conditions: PTSD, Depression, Aggression, Victimization
Interventions: GAIN Program; Behavioral
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 12 Years and older
Enrollment: 312 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2014
U.S. locations: 3
States / cities: Arnold, Missouri • St Louis, Missouri

Conditions: Major Depressive Disorder
Interventions: vagus nerve stimulation (VNS); Device
Lead sponsor: Cyberonics, Inc.; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 266 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2000 – 2005
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Suicide, Substance-Related Disorders
Interventions: Preventing Addiction Related Suicide (PARS), Intensive Outpatient Program standard session; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 906 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2020
U.S. locations: 16
States / cities: Auburn, Washington • Edmonds, Washington • Everett, Washington + 9 more

Conditions: Child Abuse, Sexual
Interventions: Trauma focused cognitive behavioral therapy (TF-CBT), Brief abuse-focused treatment, Brief coping skills treatment, Extended abuse-focused treatment, Extended coping skills treatment; Behavioral
Lead sponsor: Rowan University; Other
Eligibility: 4 Years to 11 Years
Enrollment: 210 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2009
U.S. locations: 1
States / cities: Stratford, New Jersey

Conditions: Recruitment
Interventions: Healthy Mood Project Website; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 1,226 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Epilepsy
Interventions: Using Practice and Learning to Increase Favorable Thoughts, Usual Care; Behavioral
Lead sponsor: NYU Langone Health; Other
Eligibility: 21 Years and older
Enrollment: 72 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: New York, New York

Conditions: Multiple Sclerosis
Interventions: Yoga/meditation; Behavioral
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019
U.S. locations: 1
States / cities: Lebanon, New Hampshire

Conditions: Depression, Anxiety
Interventions: IntelliCare with automated motivational messaging; Behavioral
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years to 80 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Cancer, Anxiety, Depressive Symptoms
Interventions: My Wellbeing Guide; Behavioral
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years and older
Enrollment: 6,516 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2028
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Postpartum Depression
Interventions: Behavioral Intervention for PPD; Behavioral
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 18 Years to 35 Years · Female only
Enrollment: 54 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2018
U.S. locations: 1
States / cities: New York, New York

Conditions: Depression, Postpartum, Depression
Interventions: Behavioral education intervention; Behavioral
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 18 Years and older · Female only
Enrollment: 590 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2010
U.S. locations: 1
States / cities: New York, New York

Conditions: Post-Traumatic Stress Disorder
Interventions: Yoga treatment; Behavioral
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years and older
Enrollment: 108 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Human Immunodeficiency Virus, Depression
Interventions: Integrating Nuanced Support for Perinatal adherence and Depression; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 23 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Bipolar Disorder, Bipolar Depression, Manic Depression
Interventions: Uridine, Placebo; Drug
Lead sponsor: University of Utah; Other
Eligibility: 13 Years to 21 Years
Enrollment: 62 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Salt Lake City, Utah

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Care Outcomes for Chiropractic Outpatient Veterans

Pennsylvania Adolescent Intervention Research Study (PAIRStudy)

Accelerating Implementation of Mindful Mood Balance for Moms

Mindfulness and Lifestyle Interventions for Depression and Anxiety: A Pilot Study

Motivational Interviews for Depression in Primary Care

Stress Management and Resiliency Training for Depression vs Treatment as Usual in the Treatment of Major Depression

Depressed Mothers in Rural Areas: Web-Facilitated Cognitive Behavioral Treatment

Rise & Thrive: Community-Engagement Intervention for Stress and Depression in Youth.

Acamprosate Added to Escitalopram and Behavioral Treatment for Comorbid Depression and Alcoholism

Engaging Seronegative Youth to Optimize HIV Prevention Continuum

Violence Prevention for Adolescent Girls With Prior Maltreatment

Pivotal Trial (D02) of Vagus Nerve Stimulation (VNS) for Treatment-Resistant Depression (TRD)

Preventing Addiction Related Suicide (PARS)

Optimal Treatment Strategies for Sexually Abused Children

Healthy Mood Internet Recruitment Study

Adapting Project UPLIFT for Hispanic Patients With Epilepsy II

LoveYourBrain Yoga for Multiple Sclerosis

Toward Understanding Drivers of Patient Engagement With Digital Mental Health Interventions - Part I

My Wellbeing Guide: A Novel Tool for Managing Stress and Improving Quality of Life

Behavioral Change in the Mother-Infant Dyad: Preventing Postpartum Depression

Using a Preparation and Education Intervention to Reduce Postpartum Depression Among New Mothers (The MADE IT 2 Study)

Evaluation of a Yoga Intervention for Post-Traumatic Stress Disorder

Support for Perinatal Adherence and Depression

Uridine Adolescent Bipolar Depression Randomized Controlled Trial