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ClinicalTrials.gov public records Last synced Nov 15, 2026, 1:55 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 457–480 of 1,835 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Depression Intervention Clear all

Conditions: Major Depressive Disorder
Interventions: aTAU + sTVi, aTAU + Attention Control Videos; Behavioral
Lead sponsor: Butler Hospital; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Major Depressive Disorder
Interventions: HOLD: Videogame; Device
Lead sponsor: Akili Interactive Labs, Inc.; Industry
Eligibility: 25 Years to 55 Years
Enrollment: 84 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 4
States / cities: Garden Grove, California • North Miami, Florida • Charleston, North Carolina

Conditions: End Stage Renal Disease, Sexual Dysfunction, Physiological, Pain, Depression
Interventions: Symptom management nurse intervention, Feedback intervention; Behavioral
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: 18 Years and older
Enrollment: 315 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2012
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Caregiver Burden, Depression, Cognitive Impairment
Interventions: SHARP - Physical and social activity; Behavioral
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 18 Years and older
Enrollment: 21 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Multiple Sclerosis
Interventions: Unified Protocol; Behavioral
Lead sponsor: Kessler Foundation; Other
Eligibility: 18 Years and older
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: East Hanover, New Jersey

Conditions: Suicide, Depression, Family Relationships
Interventions: Attachment-Based Family Therapy, Family-Enhanced Non-directive Supportive Therapy; Behavioral
Lead sponsor: Drexel University; Other
Eligibility: 12 Years to 18 Years
Enrollment: 129 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Obsessive Compulsive Disorder, Body Dysmorphic Disorder, Tourette Syndrome, Trichotillomania, Panic Disorder, Social Phobia, Generalized Anxiety Disorder, Depression, Post-Traumatic Stress Disorder, Attention Deficit Hyperactivity Disorder, Eating Disorder, Specific Phobia, General Medical Condition
Interventions: Cognitive behavioral therapy (CBT); Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2027
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Heart Failure, Heart Diseases, Cardiovascular Diseases
Interventions: Usual heart failure care, Interdisciplinary palliative care; Behavioral
Lead sponsor: Duke University; Other
Eligibility: 19 Years and older
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Depression
Interventions: Nurse-led case management, Treatment as usual; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 18 Years to 80 Years
Enrollment: 214 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2012
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Sleep Deprivation, Depression
Interventions: Reduced work hour schedule; Other
Lead sponsor: Providence Health & Services; Other
Eligibility: Not listed
Enrollment: 22 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Type 1 Diabetes Mellitus
Interventions: CARES Intervention; Behavioral
Lead sponsor: University of Kansas Medical Center; Other
Eligibility: 5 Years to 12 Years
Enrollment: 37 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Kansas City, Missouri

Conditions: Major Depression, Repetitive Transcranial Magnetic Stimulation
Interventions: Electroencephalogram (EEG); Diagnostic Test
Lead sponsor: Baptist Health South Florida; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2031
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Postpartum Depression
Interventions: ROSE (Reach Out, Stay Strong, Essentials for mothers of newborns), Enhanced Care as Usual (CAU); Behavioral
Lead sponsor: Michigan State University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 2,320 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Flint, Michigan

Conditions: Major Depressive Disorder
Interventions: Storytelling Video Intervention (sTVi); Behavioral
Lead sponsor: Butler Hospital; Other
Eligibility: 18 Years and older
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 2
States / cities: Pawtucket, Rhode Island • Providence, Rhode Island

Conditions: Major Depressive Disorder
Interventions: Cognitive Training A, Cognitive Training B; Behavioral
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 18 Years to 55 Years
Enrollment: 51 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: New York, New York

Conditions: Depressive Symptoms
Interventions: CBT without Personalization, CBT with Personalization, ADM without Personalization, ADM with Personalization, Combined Treatment without Personalization, Combined Treatment with Personalization; Other
Lead sponsor: Ohio State University; Other
Eligibility: 18 Years and older
Enrollment: 300 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Health Behavior
Interventions: momHealth, Standard of Care; Behavioral
Lead sponsor: University of Kansas Medical Center; Other
Eligibility: 15 Years to 20 Years · Female only
Enrollment: 78 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: Kansas City, Kansas

Conditions: Suicide Ideation, Depressed
Interventions: Behavioral Activation; Behavioral
Lead sponsor: Rutgers, The State University of New Jersey; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Piscataway, New Jersey

Conditions: Suicide, Suicidal Ideation
Interventions: STAT-PC, YST-III; Other
Lead sponsor: Elizabeth Arnold; Other
Eligibility: 18 Years to 24 Years
Enrollment: 1,485 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 3
States / cities: Pittsburgh, Pennsylvania • Austin, Texas • Dallas, Texas

Conditions: Depression
Interventions: Step Up Wellness Program, Usual care; Behavioral
Lead sponsor: Kaiser Permanente; Other
Eligibility: 18 Years to 75 Years
Enrollment: 52 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Major Depression Moderate, Major Depression Severe, Major Depression
Interventions: LSD, Risperidone; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 21 Years to 70 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Major Depressive Disorder
Interventions: No intervention will be administered as part of this study.; Other
Lead sponsor: Usona Institute; Other
Eligibility: 21 Years to 65 Years
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Lauderhill, Florida

Conditions: Major Depressive Disorder (MDD)
Interventions: Ketamine only; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 25 Years to 65 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Depressive Episode
Interventions: Pre and Post Treatment Presentations; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 1
States / cities: New Haven, Connecticut

Search by objective public record fields.

Storytelling Video Intervention for Depressed Primary Care Patients - Pilot Trial

Software Treatments for Actively Reducing Severity of Cognitive Deficits in MDD (STARS-MDD)

Pain, Sexual Dysfunction, and Depression in Hemodialysis Patients

Neighborhood-based Physical and Social Activity for Older Black Caregivers and People Living With Dementia

Meeting an Unmet Need in Multiple Sclerosis

Attachment Based Family Therapy for Suicidal Adolescents

Outcomes of Cognitive Behavioral Therapy (CBT) Interventions Provided by Unlicensed Professionals

Palliative Care in Heart Failure

Nurse-led Case Management for Diabetes and Cardiovascular Disease Patients With Depression

Work Hour Reductions, Medical Errors, and Intern Well-Being at Providence St. Vincent Medical Center Intensive Care Unit

Cognitive Adaptations to Reduce Emotional Stress Associated With Type 1 Diabetes

Using EEG to Predict Depression Treatment Response to rTMS in Patients With Major Depression

The ROSE Scale-up Study: Informing a Decision About ROSE as Universal PPD Prevention

Storytelling Video Intervention for Depressed Primary Care Patients - Open Trial

Cognitive Training for Depression II

Responses to Information on Treatments for Depression

momHealth: Multiple Health Behavior Change Intervention in Teen Pregnancy & Parenting Using Mobile Technology

Supplementing Inpatient Behavioral Activation Group Psychotherapy

Preventing Suicide Among Sexual and Gender Diverse Young Adults in Primary Care

Effectiveness of The Step Up Wellness Program for People With Depression

Shortened LSD Intervention for Major Depressive Disorder

PSIL201 Long-term Follow-up Study: Psilocybin or Niacin / Major Depressive Disorder

Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of Ketamine

Role Of Non-Specific Effects in The Treatment of Depression With Esketamine