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ClinicalTrials.gov public records Last synced Nov 15, 2026, 7:42 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 73–96 of 1,835 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Depression Intervention Clear all

Conditions: Bipolar Depression
Interventions: Medtronic Percept RC System, One Month Blinded Discontinuation Period; Device · Behavioral
Lead sponsor: Wayne Goodman MD; Other
Eligibility: 22 Years to 64 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2030
U.S. locations: 4
States / cities: Boston, Massachusetts • Houston, Texas • Seattle, Washington

Conditions: Lifestyle
Interventions: Yoga, Cognitive Behavioral Therapy, Music; Behavioral
Lead sponsor: Imad Najm MD; Other
Eligibility: 18 Years to 75 Years
Enrollment: 1,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2028
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Depression, Anxiety, Loneliness
Interventions: Stay Connected, Treatment as usual; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 60 Years and older
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Acute Coronary Syndrome, Depression
Interventions: Problem Solving Therapy, Sertraline, citalopram, or bupropion, Standard care; Behavioral · Drug · Other
Lead sponsor: Columbia University; Other
Eligibility: 35 Years and older
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 5
States / cities: New Haven, Connecticut • Atlanta, Georgia • St Louis, Missouri + 2 more

Conditions: Chronic Pain, Musculoskeletal Pain, Depression, Health Equity
Interventions: Coaching and Decision Aid; Behavioral
Lead sponsor: Indiana University; Other
Eligibility: 18 Years and older
Enrollment: 304 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Burnout, Professional, Stress, Psychological, Stress, Physiological, Psychological Well-Being, Mind-Body Therapies, Work Related Stress
Interventions: Sudarshan Kriya Yoga (SKY) Breathing and Sahaj Meditation, Health Education Program (HEP); Behavioral · Other
Lead sponsor: Lancaster General Hospital; Other
Eligibility: 25 Years to 70 Years
Enrollment: 180 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 6
States / cities: Boston, Massachusetts • Plainsboro, New Jersey • Lancaster, Pennsylvania + 1 more

Conditions: LGBTQ, Racial Disparities, Family Relationships, Minority Stress, Depression, Anxiety, Drug Use, Teen Dating Violence, Sexual Risk Reduction
Interventions: Adapted Lakota Family Acceptance Program; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 13 Years and older
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 2
States / cities: Pine Ridge, South Dakota • Rapid City, South Dakota

Conditions: Mental Health Wellness 1, Mental Health Wellness 2, Occupational Problems
Interventions: iCareer Soft Skills Training for Employment; Behavioral
Lead sponsor: Rutgers, The State University of New Jersey; Other
Eligibility: 16 Years to 24 Years
Enrollment: 126 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Newark, New Jersey

Conditions: Post Intensive Care Syndrome, Depression, Anxiety, Quality of Life
Interventions: Companion Dog Walking, Attention Control Group; Behavioral
Lead sponsor: University of Missouri, Kansas City; Other
Eligibility: 18 Years and older
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 2
States / cities: Colorado Springs, Colorado

Conditions: Smoking Cessation
Interventions: Mindfulness with Contingency Management, Active Control; Behavioral
Lead sponsor: Fordham University; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Traumatic Brain Injury, Fatigue
Interventions: Bright White Light (BWL), Dim Red Light (DRL); Device
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 18 Years and older
Enrollment: 88 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2017
U.S. locations: 1
States / cities: New York, New York

Conditions: Pediatric Asthma, Maternal Depression
Interventions: MAADRE, MAAS; Behavioral
Lead sponsor: Rhode Island Hospital; Other
Eligibility: 18 Years and older · Female only
Enrollment: 114 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Depression, Suicidal Ideation, Major Depressive Disorder, Depressive Disorder
Interventions: "Engage & Connect" Psychotherapy, Symptom Review and Psychoeducation (SRP); Behavioral
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 50 Years to 80 Years
Enrollment: 128 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: New York, New York

Conditions: Major Depressive Disorder, Nicotine Dependence
Interventions: bupropion and smoking cessation behavioral intervention; Drug
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2007
U.S. locations: 1
States / cities: Stanford, California

Conditions: Depression
Interventions: Supportive Therapy SSI, Behavioral Activation SSI, Growth Mindset SSI; Behavioral
Lead sponsor: Stony Brook University; Other
Eligibility: 13 Years to 16 Years
Enrollment: 2,452 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Stony Brook, New York

Conditions: Depression
Interventions: Exercise; Behavioral
Lead sponsor: Liberty University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 11 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013
U.S. locations: 2
States / cities: Lynchburg, Virginia

Conditions: Gulf War Illness, Depression
Interventions: Transcranial Magnetic Stimulation, Sham Transcranial Magnetic Stimulation; Device
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 65 Years
Enrollment: 204 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2025
U.S. locations: 3
States / cities: Palo Alto, California • San Diego, California • Decatur, Georgia

Conditions: Hepatitis C, Depression
Interventions: Home-based walking program, Educational intervention; Behavioral · Other
Lead sponsor: Portland VA Medical Center; Federal
Eligibility: 18 Years and older
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2014
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Depression, Anxiety
Interventions: TODAY! App and Coaching; Behavioral
Lead sponsor: Ann & Robert H Lurie Children's Hospital of Chicago; Other
Eligibility: 14 Years to 24 Years · Male only
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Bipolar Disorder
Interventions: MCN36 (nutritional supplement), Placebo; Drug
Lead sponsor: University of Calgary; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2009
U.S. locations: 1
States / cities: San Diego, California

Conditions: Depression Mild, Depressive Disorder, Major, Mild Cognitive Impairment
Interventions: Computerized Cognitive Remediation of Executive Functioning (CCR-EF), Active Control; Other
Lead sponsor: UConn Health; Other
Eligibility: 60 Years and older
Enrollment: 38 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Farmington, Connecticut

Conditions: Dementia, Alzheimer Disease
Interventions: Brain Health Assessment; Other
Lead sponsor: Kaiser Permanente; Other
Eligibility: 65 Years and older
Enrollment: 3,417 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 5
States / cities: Burien, Washington • Kent, Washington • Renton, Washington + 1 more

Conditions: Opioid Use Disorder, Parent-Child Relations
Interventions: Mom Power; Behavioral
Lead sponsor: Stony Brook University; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 2
States / cities: Ann Arbor, Michigan • Stony Brook, New York

Conditions: Treatment Resistant Depression (TRD)
Interventions: aiTBS; Device
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 18 Years to 65 Years
Enrollment: 247 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2031
U.S. locations: 3
States / cities: San Diego, California • New York, New York • Dallas, Texas

Search by objective public record fields.

Deep Brain Stimulation of Treatment-Resistant Bipolar Depression

Creating a Healthy L.I.F.E: Lifestyle Interventions For Epilepsy

Stay Connected: Testing an Intervention to Combat Coronavirus-related Social Isolation Among Older Adults

Comparison of Depression Interventions After Acute Coronary Syndrome

Equipping Patients Using Interventions for Pain and Depression

Foundational Programs to Combat Clinician Stress

Lakota Family Acceptance Project Pilot RCT

Internet Assisted Career-Oriented Soft-skills Training for Transition Age Youth with Mental Health Conditions

Companion Dog Walking for ICU Survivor Health

Smoking Cessation Intervention for Smokers With Depression Receiving Outpatient Psychiatric Treatment

Treatment of Post-Traumatic Brain Injury (Post-TBI) Fatigue With Light Therapy

Intervention for Depressed Latina Mothers of Children With Asthma

Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality

Treatment of Nicotine Dependence and Acute Depression

Testing Scalable, Single-Session Interventions for Adolescent Depression in the Context of COVID-19

The Effects of Exercise on Depression Symptoms Using Levels of Neurotransmitters and EEG as Markers

rTMS in Alleviating Pain and Co-Morbid Symptoms in Gulf War Veterans Illness (GWVI)

Efficacy of an Exercise Intervention to Decrease Depressive Symptoms in Veterans With Hepatitis C

TODAY! A Mobile App Study

Clinical Trial of a Nutritional Supplement in Adults With Bipolar Disorder

Cognitive Fitness for Depression in Older Adults

The Brain Health Study: A Pragmatic, Patient-Centered Trial

Postpartum Intervention for Mothers With Opioid Use Disorders (R33)

Neuronavigated aiTBS for TRD