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ClinicalTrials.gov public records Last synced Oct 22, 2026, 10:05 AM EDT

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Showing 1–24 of 145 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Dexmedetomidin Clear all
Completed Phase 4 Interventional Results available

Efficacy of Single-Shot Dexmedetomidine Versus Placebo in Preventing Pediatric Emergence Delirium in Strabismus Surgery

NCT01901588
View directory record Official record
Conditions
Strabismus, Delirium on Emergence, Pediatric Disorders
Interventions
Dexmedetomidine, Placebo
Drug · Other
Lead sponsor
NYU Langone Health
Other
Eligibility
1 Year to 7 Years
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 11, 2016 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Not applicable Interventional Results available

Sedation in Patients at Risk for Upper Airway Collapse

NCT01045122
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Propofol, Dexmedetomidine
Drug
Lead sponsor
University of Rochester
Other
Eligibility
18 Years to 75 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Apr 27, 2015 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Phase 4 Interventional Results available

Prevention of N-methyl-D-aspartate (NMDA) Antagonist-induced Psychosis in Kids

NCT00205712
View directory record Official record
Conditions
Psychoses, Substance-Induced
Interventions
Ketamine, Dexmedetomidine
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
7 Years to 17 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2007
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 14, 2016 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Not applicable Interventional

Opioid Sparing Anesthesia Care for Pediatric Patients Having Tonsil Surgery

NCT06326983
View directory record Official record
Conditions
Tonsillitis, Post-operative Nausea and Vomiting (PONV), Emergence Delirium, Opioid Analgesic Adverse Reaction, Anesthesia, Pain
Interventions
Dexmedetomidine, Acetaminophen, Ketorolac, Morphine
Drug
Lead sponsor
Boston Children's Hospital
Other
Eligibility
3 Years to 17 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Waltham, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Phase 2 Interventional Results available

The Effect of Opioid-Free Anesthesia in TMJ Surgery

NCT04724759
View directory record Official record
Conditions
Temporomandibular Joint Disorders
Interventions
Dexmedetomidine / Ketamine / Lidocaine
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 21, 2024 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Phase 2 Interventional Results available

Efficacy and Safety of Dexmedetomidine During Non-Invasive Positive Pressure Ventilation

NCT00871624
View directory record Official record
Conditions
Acute Respiratory Failure
Interventions
Dexmedetomidine, Placebo
Drug
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years to 85 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
2
States / cities
Boston, Massachusetts • Winchester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 18, 2017 · Synced Oct 22, 2026, 10:05 AM EDT
Active, not recruiting Phase 1Phase 2 Interventional Accepts healthy volunteers

Efficacy of Non-weight Based, Low Dose Dex-Dex Adjuncts in Prolonging Peripheral Nerve Blocks

NCT07099222
View directory record Official record
Conditions
Postoperative Pain, Nausea and Vomiting, Postoperative, Dizziness, Constipation, Duration of Response, Narcotics Consumption, Pain After Surgery
Interventions
Low, non-weight based dose of Dexamethasone and Dexmedetomidine in peripheral nerve blocks, Ropivacaine with low, non weight based Dexamethasone additive
Drug
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Feb 13, 2026 · Synced Oct 22, 2026, 10:05 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Is Dexmedetomidine Associated With a Lower Incidence of Postoperative Delirium When Compared to Propofol or Midazolam in Cardiac Surgery Patients

NCT00417664
View directory record Official record
Conditions
Delirium
Interventions
Dexmedetomidine, Propofol, Midazolam
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 89 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2004
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated May 27, 2022 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Phase 2 Interventional

Acute Neurological ICU Sedation Trial (ANIST)

NCT00390871
View directory record Official record
Conditions
Sedation
Interventions
Fentanyl/Dexmedetomidine, Fentanyl/Propofol, Fentanyl
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 80 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 16, 2019 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Phase 4 Interventional Results available

Perioperative Cognitive Function - Dexmedetomidine and Cognitive Reserve

NCT00561678
View directory record Official record
Conditions
Postoperative Delirium, PD, Postoperative Cognitive Dysfunction, POCD
Interventions
Precedex (Dexmedetomidine), Placebo
Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
68 Years and older
Enrollment
404 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
10
States / cities
Miami, Florida • Baltimore, Maryland • College Park, Maryland + 7 more
Source: ClinicalTrials.gov public record
Updated Apr 23, 2018 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Dexmedetomidine for the Control of Post-Operative Pain in Thoracotomy Patients

NCT00345384
View directory record Official record
Conditions
Post-operative Pain, Respiratory Depression
Interventions
Dexmedetomidine, Placebo (Normal Saline)
Drug · Other
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years to 85 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Feb 8, 2016 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Phase 4 Interventional Results available

Dexmedetomidine and IV Acetaminophen for the Prevention of Postoperative Delirium Following Cardiac Surgery

NCT02546765
View directory record Official record
Conditions
Delirium
Interventions
IV acetaminophen & IV propofol, IV acetaminophen & IV dexmedetomidine, IV propofol & placebo, IV dexmedetomidine & placebo
Drug
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
60 Years and older
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 9, 2020 · Synced Oct 22, 2026, 10:05 AM EDT
Withdrawn No phase listed Observational

Effect of Dexmedetomidine on Pacemaker Function Following Cardiac Surgery

NCT02709200
View directory record Official record
Conditions
Congenital Heart Disease
Interventions
Dexmedetomidine
Drug
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
6 Months and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 28, 2019 · Synced Oct 22, 2026, 10:05 AM EDT
Withdrawn Phase 4 Interventional

Dexmedetomidine Cycling and Sleep in the Pediatric ICU

NCT05003102
View directory record Official record
Conditions
Critical Illness, Sedation Complication, Delirium
Interventions
Dexmedetomidine Hydrochloride - Cycling, Fentanyl - PICU Standard, Dexmedetomidine Hydrochloride - PICU Standard
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
12 Years to 17 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 10, 2022 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Phase 3 Interventional Results available

Cerebral Perfusion Pressure Using Precedex and Other Sedatives

NCT01169467
View directory record Official record
Conditions
Endotracheal Intubation, Continuous IV Sedation, ICP Monitoring
Interventions
Standard-of-Care plus Dexmedetomidine, Standard-of-Care
Drug · Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 2, 2015 · Synced Oct 22, 2026, 10:05 AM EDT
Terminated Phase 4 Interventional Results available

The Effects of Dexmedetomidine Dose on Motor Evoked Potentials

NCT03378973
View directory record Official record
Conditions
Spinal Fusion
Interventions
Dexmedetomidine
Drug
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 28, 2020 · Synced Oct 22, 2026, 10:05 AM EDT
Not yet recruiting Phase 4 Interventional

Comparing Intramuscular Fentanyl and Ketorolac With Nerve of Arnold (NOA) Block for Bilateral Myringotomy

NCT07276906
View directory record Official record
Conditions
Postoperative Pain
Interventions
Fentanyl, Ketorolac, Nerve of Arnold Block, Sham Intramuscular Injection, Sham Nerve of Arnold Block, Dexmedetomidine, Bupivacaine
Drug · Procedure
Lead sponsor
University of South Alabama
Other
Eligibility
6 Months to 6 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Mobile, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 11, 2025 · Synced Oct 22, 2026, 10:05 AM EDT
Terminated Phase 1 Interventional Results available

Pharmacokinetic Study of Intranasal Dexmedetomidine in Pediatric Patients With Congenital Heart Disease

NCT03417999
View directory record Official record
Conditions
Dexmedetomidine, Congenital Heart Disease
Interventions
Dexmedetomidine
Drug
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
1 Month to 6 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 22, 2024 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Dexmedetomidine for Reversal of Cocaine's Effects on the Heart

NCT01927640
View directory record Official record
Conditions
Chest Pain, Acute Coronary Syndrome
Interventions
Dexmedetomidine, Normal Saline, Intranasal cocaine
Drug
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
115 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 14, 2020 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Patient-Controlled Anxiolysis With Dexmedetomidine (PCA-DEX) for Burn-care Dressing Changes

NCT02409810
View directory record Official record
Conditions
Anxiety, Burns
Interventions
Dexmedetomidine
Drug
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 89 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 14, 2023 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Phase 4 Interventional

Does Nightly Dexmedetomidine Improve Sleep and Reduce Delirium in ICU Patients?

NCT01791296
View directory record Official record
Conditions
Sleep Deprivation, Delirium
Interventions
Dexmedetomidine, Placebo
Drug · Other
Lead sponsor
Maisonneuve-Rosemont Hospital
Other
Eligibility
18 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 17, 2017 · Synced Oct 22, 2026, 10:05 AM EDT
Terminated Phase 4 Interventional Results available

Dexmedetomidine (Precedex®) for Severe Alcohol Withdrawal Syndrome (AWS) and Alcohol Withdrawal Delirium (AWD)

NCT01362205
View directory record Official record
Conditions
Alcohol Withdrawal Delirium, Alcohol Withdrawal Associated Autonomic Hyperactivity, Alcohol Withdrawal Hallucinosis, Alcohol Withdrawal-Induced Delirium Tremens
Interventions
Dexmedetomidine, Placebos
Drug
Lead sponsor
Denver Health and Hospital Authority
Other
Eligibility
18 Years to 89 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
7
States / cities
Colorado Springs, Colorado • Denver, Colorado • Lakewood, Colorado + 2 more
Source: ClinicalTrials.gov public record
Updated Nov 6, 2017 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Phase 4 Interventional Results available

Dexmedetomidine and Propofol in Children With History of Obstructive Sleep Apnea

NCT01344759
View directory record Official record
Conditions
Sleep Apnea, Obstructive
Interventions
Dexmedetomidine, Propofol
Drug
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
12 Months to 25 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 8, 2018 · Synced Oct 22, 2026, 10:05 AM EDT
Completed Not applicable Interventional Results available

The Effects of Dexmedetomidine and Propofol on Cerebral Blood Flow and Brain Oxygenation During Deep Brain Stimulation

NCT01200433
View directory record Official record
Conditions
Intracranial Neurosurgery
Interventions
dexmedetomidine, propofol
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 14, 2016 · Synced Oct 22, 2026, 10:05 AM EDT