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ClinicalTrials.gov public records Last synced Oct 22, 2026, 2:29 PM EDT

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Showing 1–24 of 277 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Directive Intervention Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Brief Intervention for Rural Women at High Risk for HIV/HCV

NCT01840722
View directory record Official record
Conditions
Acquired Immune Deficiency Syndrome Virus, Hepatitis C, Drug Abuse
Interventions
MI-based HIV Risk Reduction
Other
Lead sponsor
Michele Staton
Other
Eligibility
18 Years and older · Female only
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2019
U.S. locations
1
States / cities
Hazard, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 8, 2019 · Synced Oct 22, 2026, 2:29 PM EDT
Completed Not applicable Interventional

Continuous Glucose Monitoring, Contingency Management, and Motivational Interviewing for Patients With Type 2 Diabetes in Kansas City

NCT06374186
View directory record Official record
Conditions
Type 2 Diabetes
Interventions
Behavioral Intervention with financial rewards and coaching, Control
Behavioral
Lead sponsor
University of Missouri, Kansas City
Other
Eligibility
18 Years to 65 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Oct 22, 2026, 2:29 PM EDT
Completed Not applicable Interventional

Remotivation Process for Improving Adherence to Lymphedema Treatment Programs in Patients With Breast Cancer-Related Lymphedema

NCT04465253
View directory record Official record
Conditions
Breast Carcinoma, Lymphedema
Interventions
Best Practice, Motivational Interviewing, Quality-of-Life Assessment, Questionnaire Administration
Other · Behavioral
Lead sponsor
City of Hope Medical Center
Other
Eligibility
21 Years and older · Female only
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Duarte, California
Source: ClinicalTrials.gov public record
Updated Oct 19, 2026 · Synced Oct 22, 2026, 2:29 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Comparing the Stanford Letter Project Form to Traditional Advance Directives

NCT02799537
View directory record Official record
Conditions
Advance Directives, Palliative Care
Interventions
Randomized clinical study
Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2026
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Apr 8, 2024 · Synced Oct 22, 2026, 2:29 PM EDT
Completed Not applicable Interventional

Healthy Transitions in Late Stage Kidney Disease

NCT02085837
View directory record Official record
Conditions
Chronic Kidney Disease
Interventions
Education, Daily weight measurement and monitoring, Universal Dietary education, Medication review, Focused advanced directive program, Countdown to fistula program
Other
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Great Neck, New York
Source: ClinicalTrials.gov public record
Updated Jan 5, 2017 · Synced Oct 22, 2026, 2:29 PM EDT
Completed Not applicable Interventional Results available

A Psychological-behavioral Intervention for Physical Activity in Type 2 Diabetes

NCT03150199
View directory record Official record
Conditions
Type2 Diabetes
Interventions
Positive Psychology + Motivational Interviewing, MI-based Health Education Intervention
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 19, 2020 · Synced Oct 22, 2026, 2:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Randomized Clinical Trial of Culturally Tailored MI

NCT01996280
View directory record Official record
Conditions
Alcohol Drinking
Interventions
Motivational Interviewing, Culturally Tailored MI
Behavioral
Lead sponsor
Northeastern University
Other
Eligibility
18 Years to 65 Years
Enrollment
301 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 1, 2019 · Synced Oct 22, 2026, 2:29 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Medications for Stopping Cocaine Dependence and Preventing Relapse

NCT00218023
View directory record Official record
Conditions
Cocaine Abuse, Cocaine-Related Disorders
Interventions
Modafinil, Levodopa/Carbidopa, Naltrexone HCl, Placebo, Motivational Interviewing (MI), Contingency management (CM), Cognitive-Behavioral Therapy (CBT)
Drug · Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 55 Years
Enrollment
101 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2012
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 9, 2017 · Synced Oct 22, 2026, 2:29 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Strong Families Start at Home/Familias Fuertes Comienzan en Casa

NCT06099288
View directory record Official record
Conditions
Metabolic Syndrome, Protection Against, Diet, Healthy
Interventions
Home-Based Video and Motivational Interviewing Intervention, Read Educate and Develop Youth (READY) Comparison
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years and older
Enrollment
257 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Oct 22, 2026, 2:29 PM EDT
Completed Not applicable Interventional Results available

A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity

NCT02655354
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Depression, Alcohol-Related Disorders, Suicidal Ideation, Substance-Related Disorders, Mild Cognitive Impairment, Quality of Life, Pain, Wounds and Injury, Brain Injuries, Chronic Disease
Interventions
Motivational Interviewing, Cognitive Behavioral Therapy Elements, Care Management, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Citalopram, Venlafaxine, Duloxetine, Mirtazapine, Diphenhydramine, Trazodone, Prazosin
Behavioral · Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
635 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
24
States / cities
Scottsdale, Arizona • Beverly Hills, California • Sacramento, California + 20 more
Source: ClinicalTrials.gov public record
Updated Jul 2, 2021 · Synced Oct 22, 2026, 2:29 PM EDT
Completed Not applicable Interventional

Primary Care-Based Interventions to Reduce Alcohol Use Among HIV Patients

NCT01671501
View directory record Official record
Conditions
HIV, Acquired Immunodeficiency Syndrome, Alcoholism, Alcoholic Intoxication, Substance-Related Disorders
Interventions
Motivational Interviewing, Email Feedback, Usual Care
Behavioral · Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 100 Years
Enrollment
614 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 10, 2018 · Synced Oct 22, 2026, 2:29 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Helpline Pilot Factorial Trial

NCT06591026
View directory record Official record
Conditions
Heavy Drinking
Interventions
Standard Helpline (SH), Motivational Interviewing (MI), Coping Skills Training (CST), Automated Text Messaging (ATM)
Behavioral
Lead sponsor
The National Center on Addiction and Substance Abuse at Columbia University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 21, 2026 · Synced Oct 22, 2026, 2:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Self-Care for Dementia Caregivers

NCT05309577
View directory record Official record
Conditions
Aging, Mental Disorder, Eating, Healthy, Physical Inactivity, Prodromal Symptoms, Sleep, Alzheimer Disease, Dementia, Circadian Rhythm Disorders
Interventions
Behavioral Self-Monitoring + Motivational Interviewing
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
50 Years to 99 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 23, 2026 · Synced Oct 22, 2026, 2:29 PM EDT
Recruiting Not applicable Interventional

Need to be Needed (N2BN) Intervention

NCT06510439
View directory record Official record
Conditions
Loneliness, Social Isolation
Interventions
Need to Be Needed Intervention, Active Control Group
Behavioral · Other
Lead sponsor
Temple University
Other
Eligibility
18 Years to 99 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2035
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 21, 2026 · Synced Oct 22, 2026, 2:29 PM EDT
Completed Not applicable Interventional

Exercise-based Motivational Interviewing for Fibromyalgia

NCT00573612
View directory record Official record
Conditions
Fibromyalgia
Interventions
Attention Control Counseling, Motivational Interviewing
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 65 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Apr 6, 2012 · Synced Oct 22, 2026, 2:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Multi-Component Breath Alcohol Intervention

NCT06124898
View directory record Official record
Conditions
Alcohol Use, Alcohol Drinking, Drinking Behavior
Interventions
Alcohol-related mobile health technologies, Motivational interview and psychoeducation on blood/breath alcohol concentration, Lower tech facilitation
Device · Behavioral
Lead sponsor
Northeastern University
Other
Eligibility
18 Years to 25 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Oct 22, 2026, 2:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Low-Insulinemic Dietary Intervention to Reduce Breast Cancer Risk in High-Risk Women

NCT06635005
View directory record Official record
Conditions
Feasibility Pilot Study, Compliance
Interventions
Biospecimen Collection, Dietary Intervention, Medical Device Usage and Evaluation, Motivational Interviewing, Nutritional Assessment, Questionnaire Administration
Procedure · Other · Behavioral
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
45 Years and older · Female only
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Oct 22, 2026, 2:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

FAmily CEntered (FACE) Advance Care Planning for Teens With Cancer

NCT01670461
View directory record Official record
Conditions
Cancer
Interventions
FACE, Standard of Care (SOC) Control
Behavioral
Lead sponsor
Maureen Lyon
Other
Eligibility
14 Years to 90 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2013
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Mar 8, 2019 · Synced Oct 22, 2026, 2:29 PM EDT
Completed Not applicable Interventional

Screening Mammography and Latinas: A Multilevel Intervention

NCT02010008
View directory record Official record
Conditions
Breast Cancer
Interventions
Motivational Interviewing Intervention
Behavioral
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
40 Years to 74 Years · Female only
Enrollment
540 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jul 2, 2015 · Synced Oct 22, 2026, 2:29 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Testing Counseling Styles to Motivate Smokers to Quit

NCT01188018
View directory record Official record
Conditions
Smoking, Tobacco Use, Nicotine Dependence
Interventions
Brief Advice (BA), Motivational Interviewing (MI), Health Education (HE)
Behavioral
Lead sponsor
University of Missouri, Kansas City
Other
Eligibility
18 Years and older
Enrollment
255 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 4, 2012 · Synced Oct 22, 2026, 2:29 PM EDT
Completed Not applicable Interventional Results available

SPIRIT for Persons With Dementia and Complex Multimorbidity

NCT04108000
View directory record Official record
Conditions
End Stage Renal Disease
Interventions
SPIRIT-Dementia, Usual Care
Behavioral
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
4
States / cities
Atlanta, Georgia • Decatur, Georgia
Source: ClinicalTrials.gov public record
Updated May 24, 2023 · Synced Oct 22, 2026, 2:29 PM EDT
Completed Not applicable Interventional Results available

Integrated Services for Pain: Interventions to Reduce Pain Effectively

NCT03454555
View directory record Official record
Conditions
Chronic Pain
Interventions
Shared Decision Making, Motivational Interviewing and Cognitive Behavioral Therapy for Chronic Pain
Behavioral
Lead sponsor
RTI International
Other
Eligibility
18 Years to 85 Years
Enrollment
543 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
3
States / cities
Chapel Hill, North Carolina • Durham, North Carolina • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 12, 2025 · Synced Oct 22, 2026, 2:29 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Testing Feasibility of Care Coordination and Motivational Interviewing for Women With a Recent Preterm Birth

NCT05120843
View directory record Official record
Conditions
Preterm Birth, Health Care Utilization, Tobacco Use, Contraceptive Usage, Depression, Weight, Birth
Interventions
Care coordination and motivational interviewing
Behavioral
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
14 Years to 45 Years · Female only
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Oct 22, 2026, 2:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

MassCONECT (Massachusetts Community Networks to Eliminate Cancer Disparities Through Education) 4 Kids: Promoting Smoke-free Homes

NCT01537874
View directory record Official record
Conditions
Tobacco Smoking Behavior
Interventions
Motivational Interview, Usual best practices
Behavioral
Lead sponsor
Harvard School of Public Health (HSPH)
Other
Eligibility
17 Years and older
Enrollment
138 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
3
States / cities
Boston, Massachusetts • Lawrence, Massachusetts • Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 20, 2014 · Synced Oct 22, 2026, 2:29 PM EDT