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ClinicalTrials.gov public records Last synced Oct 21, 2026, 6:31 AM EDT

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Showing 1–24 of 91 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Discectomy Clear all
Completed No phase listed Observational Accepts healthy volunteers

Biopsychosocial Impact on Caregivers in Patients Undergoing Joint and Spine Surgery

NCT03059602
View directory record Official record
Conditions
Pain, Postoperative
Interventions
No specific treatment based intervention-health measurement instrument
Other
Lead sponsor
Defense and Veterans Center for Integrative Pain Management
Other
Eligibility
18 Years to 80 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 17, 2019 · Synced Oct 21, 2026, 6:31 AM EDT
Completed No phase listed Observational Results available

MaxAn Post Market Surveillance Validation

NCT01343693
View directory record Official record
Conditions
DDD, Deformity, Tumor, Fracture
Interventions
Not listed
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
119 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2018
U.S. locations
6
States / cities
Montgomery, Alabama • Tallahassee, Florida • Indianapolis, Indiana + 3 more
Source: ClinicalTrials.gov public record
Updated Jan 6, 2020 · Synced Oct 21, 2026, 6:31 AM EDT
Not listed No phase listed Observational

Injection of Autologous Bone Marrow Aspirate in Patients With Degenerative Disc Disease.

NCT05146583
View directory record Official record
Conditions
Lumbar Disc Disease
Interventions
Autologous bone marrow aspirate injected intradiscal after microdiscectomy, Discectomy only
Procedure
Lead sponsor
New York Presbyterian Hospital
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 21, 2021 · Synced Oct 21, 2026, 6:31 AM EDT
Suspended No phase listed Observational

Clinical and Radiological Outcomes of Oblique Lateral Lumbar Interbody Fusion

NCT03726190
View directory record Official record
Conditions
Degenerative Disc Disease, Spondylolisthesis, Lumbar Disc Herniation
Interventions
Oblique Lateral Lumbar Fusion
Procedure
Lead sponsor
Tristate Brain and Spine Institute
Other
Eligibility
Not listed
Enrollment
303 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2025
U.S. locations
1
States / cities
Alexandria, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 15, 2021 · Synced Oct 21, 2026, 6:31 AM EDT
Completed Not applicable Interventional

Pivotal IDE Study of the BRYAN(R) Cervical Disc Prosthesis in the Treatment of DDD Versus ACDF

NCT00437190
View directory record Official record
Conditions
Radiculopathy, Myelopathy, Cervical Degenerative Disc Disease
Interventions
ATLANTIS™ Cervical Plate System and allograft, BRYAN Cervical Disc Prosthesis
Device
Lead sponsor
Medtronic Spinal and Biologics
Industry
Eligibility
21 Years and older
Enrollment
494 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2016
U.S. locations
38
States / cities
Phoenix, Arizona • Little Rock, Arkansas • Campbell, California + 31 more
Source: ClinicalTrials.gov public record
Updated May 13, 2016 · Synced Oct 21, 2026, 6:31 AM EDT
Active, not recruiting Not applicable Interventional

The Synergy Disc To Anterior Cervical Discectomy and Fusion

NCT04469231
View directory record Official record
Conditions
Cervical Degenerative Disc Disease
Interventions
Anterior Cervical Discectomy & Fusion
Device
Lead sponsor
Synergy Spine Solutions
Industry
Eligibility
18 Years to 70 Years
Enrollment
175 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
20
States / cities
Phoenix, Arizona • Scottsdale, Arizona • Beverly Hills, California + 15 more
Source: ClinicalTrials.gov public record
Updated Nov 19, 2025 · Synced Oct 21, 2026, 6:31 AM EDT
Not listed Not applicable Interventional

Post-market Surveillance Study of FLXfit™ TLIF Interbody Fusion Device

NCT02805985
View directory record Official record
Conditions
Degenerative Disc Disease, Spondylolisthesis, Retrolisthesis
Interventions
FLXfit™ TLIF Interbody Fusion Device
Device
Lead sponsor
Expanding Orthopedics Ltd.
Industry
Eligibility
18 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 25, 2017 · Synced Oct 21, 2026, 6:31 AM EDT
Completed Not applicable Interventional Results available

LDR Spine USA Mobi-C(R) Cervical Disc Prosthesis IDE

NCT00389597
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Cervical Artificial Disc
Device
Lead sponsor
LDR Spine USA
Industry
Eligibility
18 Years to 69 Years
Enrollment
599 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2015
U.S. locations
24
States / cities
Phoenix, Arizona • Escondido, California • Laguna Hills, California + 21 more
Source: ClinicalTrials.gov public record
Updated Dec 11, 2017 · Synced Oct 21, 2026, 6:31 AM EDT
Completed No phase listed Observational

Cervical Spondylotic Myelopathy - Cost Observational Surgical Trial

NCT05994404
View directory record Official record
Conditions
Cervical Spondylosis With Myelopathy
Interventions
ACDF, Posterior Cervical Fusion, Cervical Laminoplasty
Procedure
Lead sponsor
Lahey Clinic
Other
Eligibility
45 Years to 80 Years
Enrollment
269 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
2
States / cities
Burlington, Massachusetts • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 16, 2023 · Synced Oct 21, 2026, 6:31 AM EDT
Completed Phase 3 Interventional

XL TDR® eXtreme Lateral Total Disc Replacement for the Treatment of Lumbar Degenerative Disc Disease (DDD)

NCT00927238
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
XL TDR, Lumbar fusion surgery
Device · Other
Lead sponsor
NuVasive
Industry
Eligibility
18 Years to 70 Years
Enrollment
246 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
17
States / cities
Campbell, California • Thousand Oaks, California • Durango, Colorado + 14 more
Source: ClinicalTrials.gov public record
Updated Jul 30, 2015 · Synced Oct 21, 2026, 6:31 AM EDT
Completed No phase listed Observational

Osteocel® Plus in Anterior Cervical Discectomy and Fusion (ACDF)

NCT00942045
View directory record Official record
Conditions
Degenerative Disc Disease in Cervical Spine
Interventions
Biologic - Osteocel Plus
Biological
Lead sponsor
NuVasive
Industry
Eligibility
18 Years to 70 Years
Enrollment
182 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
17
States / cities
La Jolla, California • Redwood City, California • San Diego, California + 14 more
Source: ClinicalTrials.gov public record
Updated Dec 24, 2025 · Synced Oct 21, 2026, 6:31 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Fusion Status After ACDF

NCT05986006
View directory record Official record
Conditions
Spine Fusion, Spine Surgery
Interventions
Anterior Cervical Disc Fusion (ACDF) Surgery w/ machined bone allograft, Anterior Cervical Disc Fusion (ACDF) Surgery w/ Iliac Crest Bone Graft
Procedure
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
124 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 14, 2023 · Synced Oct 21, 2026, 6:31 AM EDT
Completed Phase 4 Interventional

Spine Patient Outcomes Research Trial (SPORT) - Intervertebral Disc Herniation

NCT00000410
View directory record Official record
Conditions
Herniated Disc, Low Back Pain
Interventions
Diskectomy, Non-surgical treatments
Procedure
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
501 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2015
U.S. locations
13
States / cities
Oakland, California • San Francisco, California • Decatur, Georgia + 9 more
Source: ClinicalTrials.gov public record
Updated Aug 4, 2015 · Synced Oct 21, 2026, 6:31 AM EDT
Completed Not applicable Interventional Results available

An Assessment of P-15 Bone Putty in Anterior Cervical Fusion With Instrumentation

NCT00310440
View directory record Official record
Conditions
Intervertebral Disk Degeneration
Interventions
P-15 Synthetic osteoconductive bone substitute, Autologous bone
Device · Other
Lead sponsor
CeraPedics, Inc
Industry
Eligibility
18 Years to 70 Years
Enrollment
319 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2019
U.S. locations
10
States / cities
San Francisco, California • Thornton, Colorado • Sarasota, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Mar 12, 2020 · Synced Oct 21, 2026, 6:31 AM EDT
Active, not recruiting No phase listed Observational

M6-C Post Approval Study (PAS)

NCT04122248
View directory record Official record
Conditions
Cervical Degenerative Disc Disease, Cervical Radiculopathy, Cervical Spinal Cord Compression, Cervical Disc Herniation
Interventions
standard radiographic imaging, cervical total disc replacement
Other · Device
Lead sponsor
Spinal Kinetics
Industry
Eligibility
21 Years to 68 Years
Enrollment
152 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
21
States / cities
Phoenix, Arizona • Sun City West, Arizona • Beverly Hills, California + 17 more
Source: ClinicalTrials.gov public record
Updated Jul 30, 2025 · Synced Oct 21, 2026, 6:31 AM EDT
Completed Not applicable Interventional Results available

Spineology Clinical Outcomes Trial: An IDE Investigation

NCT02347410
View directory record Official record
Conditions
Lumbar Degenerative Disc Disease
Interventions
SIFS graft containment device
Device
Lead sponsor
Spineology, Inc
Industry
Eligibility
21 Years to 80 Years
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
10
States / cities
DeLand, Florida • Shreveport, Louisiana • Thibodaux, Louisiana + 7 more
Source: ClinicalTrials.gov public record
Updated Oct 20, 2021 · Synced Oct 21, 2026, 6:31 AM EDT
Recruiting Not applicable Interventional

Function After Anterior Cervical Discectomy and Fusion Surgery: Timing of Physical Therapy

NCT06202443
View directory record Official record
Conditions
Cervical Spine Degeneration, ACDF Surgery
Interventions
Early PT, Delayed PT
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 75 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
4
States / cities
Honolulu, Hawaii • Nashville, Tennessee • Fort Sam Houston, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 27, 2026 · Synced Oct 21, 2026, 6:31 AM EDT
Completed Not applicable Interventional

Rehabilitation Following Lumbar Disc Surgery

NCT00894972
View directory record Official record
Conditions
Lumbar Disc Herniation, Radiculopathy
Interventions
Rehabilitation following lumbar disc surgery (discectomy)
Other
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 60 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Nov 6, 2012 · Synced Oct 21, 2026, 6:31 AM EDT
Withdrawn No phase listed Observational

Incidence of Large Annular Defects in Primary Lumbar Discectomy Patients

NCT03252691
View directory record Official record
Conditions
Lumbar Disc Herniation, Anular Tear of Lumbar Disc, Nucleus Pulp Hernia;Lumbosac
Interventions
Not listed
Lead sponsor
Intrinsic Therapeutics
Industry
Eligibility
18 Years to 75 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated May 20, 2021 · Synced Oct 21, 2026, 6:31 AM EDT
Completed Phase 3 Interventional

Neurosurgery Patient Outcomes in Treating Spinal Disorders

NCT01220921
View directory record Official record
Conditions
Symptomatic Lumbar Disc Herniation, Symptomatic Grade I Lumbar Spondylolisthesis
Interventions
Lumbar Discectomy, Single-level lumbar fusion
Procedure
Lead sponsor
Greenwich Hospital
Other
Eligibility
18 Years to 80 Years
Enrollment
198 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
12
States / cities
San Francisco, California • Greenwich, Connecticut • New Haven, Connecticut + 9 more
Source: ClinicalTrials.gov public record
Updated Dec 4, 2015 · Synced Oct 21, 2026, 6:31 AM EDT
Not listed Phase 1Phase 2 Interventional

Randomized Controlled Trials of the Effects of Decadron on Swallowing, Airway, and Arthrodesis

NCT01065961
View directory record Official record
Conditions
Swallowing
Interventions
Decadron, Saline
Drug
Lead sponsor
Albany Medical College
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2016
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated Feb 10, 2010 · Synced Oct 21, 2026, 6:31 AM EDT
Enrolling by invitation Not applicable Interventional

Effectiveness of AlloWrap® for the Reduction of Inflammation in ACDF Procedures

NCT04684901
View directory record Official record
Conditions
Cervical Stenosis, Spondylolisthesis, Cervical Radiculopathy, Cervical Disc Disorder
Interventions
AlloWrap® Amniotic Membrane
Other
Lead sponsor
AlloSource
Industry
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Nov 21, 2025 · Synced Oct 21, 2026, 6:31 AM EDT
Completed Not applicable Interventional

Confirmatory Clinical Study of Oxiplex

NCT03433391
View directory record Official record
Conditions
Herniated Lumbar Disk
Interventions
Oxiplex, Surgery Only
Device · Other
Lead sponsor
FzioMed
Industry
Eligibility
22 Years to 70 Years
Enrollment
135 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
17
States / cities
Phoenix, Arizona • Tucson, Arizona • Sacramento, California + 14 more
Source: ClinicalTrials.gov public record
Updated Jun 27, 2024 · Synced Oct 21, 2026, 6:31 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Salt Water Gargling on Swallowing Following ACDF

NCT06475365
View directory record Official record
Conditions
Degeneration Spine, Cervical Radiculopathy, Cervical Stenosis, Cervical Spondylosis, Cervical Myelopathy, Dysphagia
Interventions
Sodium chloride gargle
Other
Lead sponsor
University of Southern California
Other
Eligibility
18 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 18, 2025 · Synced Oct 21, 2026, 6:31 AM EDT