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Conditions: Mastectomy, Implant Based Breast Reconstruction
Interventions: Interi Manifold Drain System, Jackson Pratt Drain System; Device
Lead sponsor: Stanford University; Other
Eligibility: 18 Years to 65 Years · Female only
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Community Acquired Bacterial Pneumonia, Paraneumonic Effusion
Interventions: Video Assisted Thorascopic Surgery Thoracostomy Tube Placement & Drainage; Procedure
Lead sponsor: Corewell Health West; Other
Eligibility: 0 Years to 18 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2004
U.S. locations: 1
States / cities: Grand Rapids, Michigan

Conditions: Lung Transplant, Pulmonary Hypertension
Interventions: Protek Solo Transseptal Cannula; Device
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 80 Years
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Jacksonville, Florida

Conditions: Stage III Ovarian Cancer, Stage IV Ovarian Cancer
Interventions: Culdocentesis, Vaginal Swab, Chromopertubation, Blood collection, Tissue collection; Procedure
Lead sponsor: Dana-Farber Cancer Institute; Other
Eligibility: 18 Years and older · Female only
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 2
States / cities: Boston, Massachusetts

Conditions: Pleural Diseases
Interventions: Chest thoracoscopy, Chest fibrinolytic therapy, tPA, DNase; Procedure · Drug
Lead sponsor: University of Florida; Other
Eligibility: 18 Years to 90 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Pancreas Tumor, Pancreatitis
Interventions: No Drains, Drains; Procedure
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 18 Years and older
Enrollment: 399 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2017
U.S. locations: 12
States / cities: Gainesville, Florida • Tampa, Florida • Indianapolis, Indiana + 8 more

Conditions: Hydrocephalus, Hydrocephalus, Communicating
Interventions: eShunt® Implant; Device
Lead sponsor: CereVasc Inc; Industry
Eligibility: 21 Years and older
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 2
States / cities: New Haven, Connecticut • New York, New York

Conditions: Ventral Hernia
Interventions: Strattice Arm, Bio-A Arm; Device
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 28 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2017
U.S. locations: 1
States / cities: Charlotte, North Carolina

Conditions: Thyroglossal Duct Cysts
Interventions: Post-surgical drain, No post-surgical drain; Procedure
Lead sponsor: University of Rochester; Other
Eligibility: 3 Years to 17 Years
Enrollment: 178 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 5
States / cities: Los Angeles, California • Hartford, Connecticut • Chicago, Illinois + 2 more

Conditions: Air Leak From Lung, Pneumothorax
Interventions: Pleural gas analysis; Device
Lead sponsor: Lung Healing Technologies Inc; Industry
Eligibility: 18 Years and older
Enrollment: 33 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Evanston, Illinois

Conditions: Primary Spontaneous Pneumothorax
Interventions: Early Chest Tube Removal, Standard Chest Tube Removal, Apical Chest Tube; Procedure · Device
Lead sponsor: Swedish Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Acute Otitis Media
Interventions: Moxidex otic solution, Moxifloxacin otic solution, Vehicle, Tympanostomy tubes; Drug · Other · Device
Lead sponsor: Alcon Research; Industry
Eligibility: 6 Months to 12 Years
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Fort Worth, Texas

Conditions: Normal Pressure Hydrocephalus
Interventions: Programmable Shunt Insertion (Codman, Medtronic), Assessments in physical therapy, occupational therapy, and speech therapy; Device · Behavioral
Lead sponsor: University of California, Irvine; Other
Eligibility: 18 Years and older
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2009
U.S. locations: 1
States / cities: Orange, California

Conditions: Wound Infection
Interventions: Purse string closure, Primary closure; Procedure
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 125 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2012
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Pleural Effusion, Pleural Diseases, Malignant Pleural Effusion
Interventions: Indwelling pleural catheter placement, Fentanyl Citrate, Talc Slurry, Drainage collection bag; Device · Drug
Lead sponsor: The Cooper Health System; Other
Eligibility: 18 Years and older
Enrollment: 124 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Camden, New Jersey

Conditions: Clinical Need for Craniotomy or Craniectomy, Clinical Need for Cranioplasty
Interventions: Mechanical Tissue Resuscitation™ (MTR®); Device
Lead sponsor: Renovo Concepts, Inc.; Industry
Eligibility: 22 Years to 65 Years
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 3
States / cities: Buffalo, New York • Winston-Salem, North Carolina • Morgantown, West Virginia

Conditions: Pleural Effusion
Interventions: Suction-Driven Thoracentesis, Gravity-Driven Thoracentesis; Procedure
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 138 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Infections, Quality of Life
Interventions: Showering 48 hours after surgery; Other
Lead sponsor: University of Missouri-Columbia; Other
Eligibility: 18 Years to 100 Years · Female only
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: Columbia, Missouri

Conditions: Glaucoma
Interventions: Baerveldt 350 implant, Ahmed ClearPath 350 implant; Device
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 90 Years
Enrollment: 76 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Cesarean Section Complications, Post Partum Hemorrhage, Uterine Atony With Hemorrhage, Uterine Bleeding
Interventions: DAISY Uterine Drain; Device
Lead sponsor: Raydiant Oximetry, Inc.; Industry
Eligibility: 18 Years and older · Female only
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Norfolk, Virginia

Conditions: Perioperative/Postoperative Complications, Prostate Cancer
Interventions: robot-assisted laparoscopic surgery, questionnaire administration, intraoperative complication management/prevention; Procedure · Other
Lead sponsor: City of Hope Medical Center; Other
Eligibility: 18 Years and older · Male only
Enrollment: 191 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2017
U.S. locations: 1
States / cities: Duarte, California

Conditions: Wound Complications, Wound Infection, Wound Separation
Interventions: Prospective wound complication protocol; Procedure
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years to 89 Years · Female only
Enrollment: 105 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Osteoarthritis
Interventions: Wound drainage, Total Shoulder Arthroplasty; Procedure
Lead sponsor: Columbia University; Other
Eligibility: Not listed
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 1
States / cities: New York, New York

Conditions: Osteoarthritis
Interventions: Antimicrobial Barrier Dressing, Negative Pressure Wound Therapy (NPWT); Combination Product · Device
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 100 Years
Enrollment: 230 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: New York, New York

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Assessment of the Interi Manifold in Implant-Based Breast Reconstruction

Study of Fluid Collection of the Chest in Children With Pneumonia

Bridge to Lung Transplant With Trans-septal Extra-corporeal Membrane Oxygenation (ECMO) for Right Heart Failure From Pulmonary Hypertension

Detection of Tumor Associated Cell-free DNA in Peritoneal Fluid Obtained by Culdocentesis

Fibrinolytic Therapy Versus Medical Thoracoscopy

Pancreas Resection With and Without Drains

Pilot Study to Evaluate the CereVasc® EShunt® System in the Treatment of Communicating Hydrocephalus

The Use of Biologic Mesh vs Bioabsorbable Mesh During Ventral Hernia Repair in At-risk Patients

Assessing Post-operative Outcomes After Children's Sistrunk Procedure With or Without a Drain

Feasibility and Accuracy of a Novel Pleural Drain Gas Analyzer in Detecting Air Leaks

Early Chest Tube Removal After Surgery for Primary Spontaneous Pneumothorax: A Randomized Controlled Trial

Safety and Efficacy of Moxidex Otic

Factors Predicting Response to Shunting in Normal Pressure Hydrocephalus

A Randomized Trial of Ostomy Closure Techniques

Talc Outpatient Pleurodesis With Indwelling Catheter

A Multi-center, Early Feasibility Study of Using the Mechanical Tissue Resuscitation™ (MTR®) Therapy System for Removal of Excess Fluid in Subjects Who Have Had a Portion of Their Skull Removed to Expose the Dura/Brain and Require Drainage for Fluid Removal.

Gravity- Versus Suction-driven Large Volume Thoracentesis

Effect of Drain Care on Infection Rate and Quality of Life in Implant-Based Breast Reconstruction.

The Baerveldt Versus ClearPath Comparison Study

DAISY Uterine Drain Device Evaluation

Robotic Assisted Laparoscopic Prostatectomy With or Without Pelvic Drain Placement in Reducing Adverse Events After Surgery in Patients With Prostate Cancer

A Study to Evaluate a Quality Improvement Intervention to Reduce Wound Separation Rates in Obese Gynecologic Oncology Service Patients Undergoing Abdominal Surgery

Closed Suction Drainage in Shoulder Arthroplasty

Antimicrobial Barrier Dressing Versus Closed-incision Negative Pressure Therapy in the Obese Primary Total Joint Arthroplasty