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ClinicalTrials.gov public records Last synced Nov 15, 2026, 4:21 AM EST

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Showing 1–24 of 73 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: E-cigarette e-liquid Clear all

Conditions: Nicotine Dependence
Interventions: Nicotine, Vaporizer Device, Salt-HIgh Nicotine Unflavored (Product B), Free-Low Nicotine Tobacco Flavored (Product C), Salt-High Nicotine Tobacco Flavored (Product D); Drug · Device
Lead sponsor: Roswell Park Cancer Institute; Other
Eligibility: 21 Years to 55 Years
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Cigarette Smoking-Related Carcinoma
Interventions: Cigarette Smoking, Computed Tomography, Positron Emission Tomography, Questionnaire Administration; Behavioral · Procedure · Other
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 21 Years to 50 Years
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Electronic Cigarette Use, E-Cig Use, Cigarette Smoking, Cigarette Use, Electronic
Interventions: E-cigarette e-liquid self-administration; Other
Lead sponsor: University of Southern California; Other
Eligibility: 21 Years and older
Enrollment: 73 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Nicotine Dependence, Tobacco Toxicity, Nicotine Dependence, Cigarettes, Cardiovascular Risk Factor, Nicotine Withdrawal
Interventions: SREC; Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years to 70 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Smoking, Asthma, Electronic Cigarette Use, Cigarette Smoking
Interventions: Nicotine; Other
Lead sponsor: Brown University; Other
Eligibility: 21 Years to 65 Years
Enrollment: 17 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Electronic Cigarettes
Interventions: E-cigarette Lab Session 15 watts, 10 mg nicotine, E-cigarette Lab Session 15 watts, 30 mg nicotine, E-cigarette Lab Session 30 watts, 10 mg nicotine, E-cigarette Lab Session 30 watts, 30 mg nicotine, Own Brand Session - E-cigarette, Own Brand Session - E-cigarette/Cigarette; Other
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 21 Years to 55 Years
Enrollment: 48 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Electronic Cigarette Use, Cigarette Smoking, Cigarette Use, Electronic, Vaping
Interventions: Control Marketing Strategies, Experimental Marketing Strategies; Other
Lead sponsor: University of Southern California; Other
Eligibility: 21 Years and older
Enrollment: 601 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Smoking Cessation, Harm Reduction
Interventions: Nicoderm, Nicorette 4Mg Chewing Gum, Nicorette Lozenge Product, NJOY e-cigarette, on!; Drug · Other
Lead sponsor: Rose Research Center, LLC; Industry
Eligibility: 22 Years to 65 Years
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 2
States / cities: Charlotte, North Carolina • Raleigh, North Carolina

Conditions: Electronic Cigarette Use
Interventions: E-cigarette Flavor, Tobacco Free Nicotine Pouch; Other
Lead sponsor: Roswell Park Cancer Institute; Other
Eligibility: 21 Years to 55 Years
Enrollment: 163 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Tobacco Use Disorder
Interventions: Cigarettes with varying nicotine content, E-Cigarettes; Other
Lead sponsor: University of Vermont; Other
Eligibility: 21 Years to 70 Years
Enrollment: 326 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 2
States / cities: Baltimore, Maryland • Burlington, Vermont

Conditions: Tobacco-Related Carcinoma
Interventions: Biospecimen Collection, Carbon Monoxide Measurement, Vaping session, Survey Administration; Procedure · Other
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 21 Years to 65 Years
Enrollment: 375 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Nicotine, E-liquid Flavors
Interventions: Nicotine 0 mg/mL, Nicotine 6 mg/mL, Nicotine 12 mg/mL, Nicotine 24 mg/mL, 'Menthol' flavor, 'Menthol/Mint' flavor, 'Green Apple' flavor, 'Watermelon' flavor, 'Unflavored'; Drug · Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 30 Years
Enrollment: 54 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Tobacco Dependence
Interventions: Nicotine-Containing Electronic Cigarette, Non-Nicotine Electronic Cigarette; Other
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 21 Years to 70 Years
Enrollment: 105 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Hershey, Pennsylvania

Conditions: Electronic Cigarette Use, Cigarette Use, Electronic, Vaping, Cigarette Smoking
Interventions: E-cigarette e-liquid; Drug
Lead sponsor: University of Southern California; Other
Eligibility: 21 Years and older
Enrollment: 124 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Marijuana Dependence
Interventions: Nicotine, Cannabis, PAX Loose Leaf Vaporizer; Drug · Device
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years to 70 Years
Enrollment: 8 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Smoking, Tobacco Use
Interventions: Low Power, High Power, Low Concentration, High Concentration; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 21 Years and older
Enrollment: 93 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Coronary Artery Disease, Myocardial Perfusion
Interventions: Cigarettes, E-cigarettes (nicotine free e-liquid), E-cigarettes (low nicotine e-liquid), E-cigarettes (high nicotine e-liquid); Other
Lead sponsor: Cedars-Sinai Medical Center; Other
Eligibility: 18 Years to 49 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Electronic Cigarette Use, Cigarette Smoking, Cigarette Use, Electronic, Vaping
Interventions: E-cigarette; Other
Lead sponsor: University of Southern California; Other
Eligibility: 21 Years and older
Enrollment: 461 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Hiv, Lung Injury
Interventions: Not listed
Lead sponsor: Pennington Biomedical Research Center; Other
Eligibility: 18 Years and older
Enrollment: 23 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 2
States / cities: Baton Rouge, Louisiana • New Orleans, Louisiana

Conditions: Nicotine Addiction, Cigarette Smoking
Interventions: Smoking research cigarettes with e-cigarette, Nicotine discrimination thresholds; Drug
Lead sponsor: Rose Research Center, LLC; Industry
Eligibility: 21 Years to 65 Years
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 2
States / cities: Charlotte, North Carolina • Raleigh, North Carolina

Conditions: E-cigarette Use
Interventions: ECIG lab session 1, ECIG lab session 2, ECIG lab session 3, ECIG lab session 4, ECIG lab session 5, ECIG lab session 6, ECIG lab session 7, ECIG lab session 8; Other
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 21 Years to 25 Years
Enrollment: 88 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Nicotine Dependence
Interventions: ECIG Session; Other
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 38 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Smoking, Cigarette
Interventions: Standardized Research E-cigarette (SREC); Drug
Lead sponsor: Masonic Cancer Center, University of Minnesota; Other
Eligibility: 18 Years to 65 Years
Enrollment: 47 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Smoking, Tobacco Use
Interventions: Electronic Cigarette; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 21 Years and older
Enrollment: 638 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: Charleston, South Carolina

Search by objective public record fields.

Pharmacokinetics, Subjective Effects, and Abuse Liability of Nicotine Salt-Based Vaping Products With Tobacco or Unflavored E-liquids, SALTVAPE Study

Free-Base Nicotine or Nicotine Salt e-Liquids in Current E-Cigarette Smokers, PeloPET Study

Effects of e-Cigarettes on Perceptions and Behavior - Substudy 2

Cigarette Harm Reduction With Electronic Cigarette Use

E-cigarettes for Harm Reduction in Adults With Asthma

Effects of E-Cigarette Power and Nicotine Content in Dual Users and Vapers

Effects of e-Cigarettes on Perceptions and Behavior - Remote Substudy # 1

Adaptive Use of Nicotine Substitution to Maintain Smoking Reduction/Abstinence in Nicotine Responders

Effect of E-Liquid Flavor on Respiratory Symptoms in People Using Electronic Nicotine Delivery Systems

Low Nicotine Content Cigarettes in Vulnerable Populations: Opioid Use Disorder

Manipulating E-Cigarette Nicotine to Promote Public Health

Impact of Flavors on Nicotine Perception and Self-Administration Via E-cigarettes

Does Switching to Nicotine Containing Electronic Cigarettes Reduce Health Risk Markers

Effects of e-Cigarettes on Perceptions and Behavior - Substudy 1

Vaping THC From Electronic Cigarettes

Impact of E-cigarette Characteristics on Reinforcement and Tobacco Use Patterns

E-Cigarette Aerosol, Conventional Cigarette Smoke, and Myocardial Perfusion

Effects of e-Cigarettes on Perceptions and Behavior - Remote Substudy # 2

Effects of Using E-Cigarettes on Lungs in People With HIV (HBS Ancillary)

Abuse Liability of Reduced Nicotine Content Cigarettes in the Context of Concurrent E-Cigarette Use

Evaluating E-Cigarette Nicotine Form, Concentration, and Flavors Among Youth

The Influence of Electronic (ECIG) Heater Resistance on ECIG Acute Effects

Biomarkers of Exposure and Effect in Standardized Research E-cigarette (SREC) Users

Clinical Outcomes of a Nationwide, Naturalistic E-Cig Trial (CONNECT)