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ClinicalTrials.gov public records Last synced Nov 15, 2026, 5:19 AM EST

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Showing 49–72 of 73 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: E-cigarette e-liquid Clear all

Conditions: Electronic Cigarette Use
Interventions: Low strength nicotine e-liquid, High strength nicotine e-liquid; Drug
Lead sponsor: Yale University; Other
Eligibility: 21 Years to 55 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Cigarette Smoker, Current Every Day Smoker
Interventions: Bronchoscopy with Bronchoalveolar Lavage, Cigarette, Electronic Cigarette, Laboratory Biomarker Analysis, Nicotine Replacement, Questionnaire Administration; Procedure · Drug · Other
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 21 Years to 52 Years
Enrollment: 66 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2024
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Tobacco Use Disorder
Interventions: Either normal nicotine content cigarettes (15.8mg/g) or reduced nicotine content cigarettes (0.4mg/g), E-Cigarettes; Other
Lead sponsor: Brown University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 326 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 2
States / cities: Providence, Rhode Island • Burlington, Vermont

Conditions: Nicotine Vaping, Nicotine, Vaping
Interventions: CA35, CM35, Cig; Other
Lead sponsor: Philip Morris Products S.A.; Industry
Eligibility: 24 Years to 65 Years
Enrollment: 36 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022
U.S. locations: 1
States / cities: High Point, North Carolina

Conditions: Tobacco Use
Interventions: Normal Nicotine Content Vape with all flavor e-liquids, Normal nicotine content vape with tobacco e-liquids, Low nicotine content vape with all flavor e-liquids, Low nicotine content vape with tobacco e-liquids; Other
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 21 Years and older
Enrollment: 69 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Smoking, Healthy
Interventions: Cinnamaldehyde e-liquid, PG/VG e-liquid; Other
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years to 40 Years
Enrollment: 19 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Cigarette Smoking-Related Carcinoma
Interventions: Not listed
Lead sponsor: UConn Health; Other
Eligibility: 16 Years to 45 Years · Female only
Enrollment: 182 participants
Timeline: 2018 – 2023
U.S. locations: 6
States / cities: Denver, Colorado • Farmington, Connecticut • Hartford, Connecticut + 2 more

Conditions: Electronic Cigarette Use
Interventions: Beverage with ethanol and E-cigarette liquid with ethanol, Beverage with ethanol and E-cigarette liquid without ethanol, Beverage without ethanol and E-cigarette liquid with ethanol, Beverage without ethanol and E-cigarette liquid without ethanol; Other
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 21 Years to 55 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Electronic Cigarette Use, Smoking, Cigarette, Nicotine Dependence
Interventions: NJOY ACE e-cigarette; Other
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 50 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Nicotine Dependence
Interventions: one time exposure to e-cig with nicotine, one time exposure to e-cig without nicotine, one time exposure to empty e-cig; Other
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 21 Years to 45 Years
Enrollment: 148 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2022
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Nicotine Dependence, Nicotine Vaping
Interventions: (S)-Nicotine, (R)- nicotine, Racemic nicotine; Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years to 65 Years
Enrollment: 18 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Electronic Cigarettes
Interventions: E-cigarette with sweetness type 1 and pronation level 1, E-cigarette with sweetness type 1 and pronation level 2, E-cigarette with sweetness type 2 and pronation level 1, E-cigarette with sweetness type 2 and pronation level 2; Other
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 13 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Nicotine Dependence
Interventions: one time exposure to e-cig with nicotine, One time exposure to e-cigarette without nicotine, one time exposure to empty e-cigarette; Other
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 21 Years to 45 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2021
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Nicotine Addiction, E-Cig Use, Cigarette Smoking, Sex Differences
Interventions: E-liquid Flavor 1, E-liquid Flavor 2, E-liquid Flavor 3; Other
Lead sponsor: Yale University; Other
Eligibility: 21 Years to 44 Years
Enrollment: 66 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Head and Neck Squamous Cell Carcinoma, Lung Non-Small Cell Carcinoma, Stage I Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8, Stage I Lung Cancer AJCC v8, Stage IA1 Lung Cancer AJCC v8, Stage IA2 Lung Cancer AJCC v8, Stage IA3 Lung Cancer AJCC v8, Stage IB Lung Cancer AJCC v8, Stage II Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8, Stage II Lung Cancer AJCC v8, Stage IIA Lung Cancer AJCC v8, Stage IIB Lung Cancer AJCC v8, Stage III Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8, Stage III Lung Cancer AJCC v8, Stage IIIA Lung Cancer AJCC v8, Stage IIIB Lung Cancer AJCC v8, Stage IIIC Lung Cancer AJCC v8, Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8
Interventions: Best Practice, Nicotine Replacement, Quality-of-Life Assessment, Questionnaire Administration; Other · Drug
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 21 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Nicotine Use Disorder
Interventions: E-liquid coolant (No WS-3) for non-menthol (1), E-liquid coolant (No WS-3) for low (0.1%) menthol (1), E-liquid coolant (No WS-3) for high (2.0%) menthol (1), E-liquid coolant (Low [0.1%] WS-3) for non-menthol (2), E-liquid coolant (Low [0.1%] WS-3) for low (0.1%) menthol (2), E-liquid coolant (Low [0.1%] WS-3) for high (2.0%) menthol (2), E-liquid coolant (High [2.0%] WS-3) for non-menthol (3), E-liquid coolant (High [2.0%] WS-3) for low (0.1%) menthol (3), E-liquid coolant (High [2.0%] WS-3) for high (2.0%) menthol (3), E-liquid coolant (Low [0.1%] WS-23) for non-menthol (4), E-liquid coolant (Low [0.1%] WS-23) for low (0.1%) menthol (4), E-liquid coolant (Low [0.1%] WS-23) for high (2.0%) menthol (4), E-liquid coolant (High [2.0%] WS-23) for non-menthol (5), E-liquid coolant (High [2.0%] WS-23) for low (0.1%) menthol (5), E-liquid coolant (High [2.0%] WS-23) for high (2.0%) menthol (5), E-liquid coolant (4% WS-23) for non-menthol (6), E-liquid coolant (4% WS-23) for low (0.1%) menthol (6), E-liquid coolant (4% WS-23) for high (2.0%) menthol (6); Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 66 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Cigarette Smoking, Vaping
Interventions: Tobacco e-liquids, Menthol and Tobacco e-liquids, Mint, Menthol and Tobacco e-liquids, All e-liquid flavors; Behavioral
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 21 Years and older
Enrollment: 66 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Healthy, Nicotine Addiction, Electronic Cigarette Use
Interventions: Lower nicotine e-liquid, Higher nicotine eliquid; Drug
Lead sponsor: Rochester Institute of Technology; Other
Eligibility: 21 Years and older
Enrollment: 72 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Nicotine Dependence
Interventions: IV nicotine, Menthol flavor, green apple, green apple and menthol; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 30 Years
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: West Haven, Connecticut

Conditions: Smoking
Interventions: E-cigarettes with varying concentrations of nicotine & flavor; Other
Lead sponsor: Oregon State University; Other
Eligibility: 18 Years to 35 Years
Enrollment: 19 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018
U.S. locations: 1
States / cities: Corvallis, Oregon

Conditions: Nicotine Use Disorder
Interventions: Nicotine, Flavor; Drug
Lead sponsor: Yale University; Other
Eligibility: 21 Years to 50 Years
Enrollment: 130 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Smoking, Tobacco Smoking Behavior, Cigarette Smoking
Interventions: Usual brand cigarettes, Lower nicotine content cigarettes, Electronic cigarettes 1, Electronic cigarettes 2; Other
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Oxidative Stress, Tobacco Use, Electronic Cigarettes
Interventions: High temperature wattage setting on electronic cigarette, Low temperature wattage setting on electronic cigarette, High concentration of Propylene Glycol, Low concentration of Propylene Glycol; Other
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 21 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Hershey, Pennsylvania

Conditions: Tobacco Use
Interventions: 3 mg/mL nicotine strength e-liquid, 6 mg/mL nicotine strength e-liquid, 12 mg/mL nicotine strength e-liquid, 24 mg/mL nicotine strength e-liquid; Drug
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 18 Years and older
Enrollment: 81 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Roanoke, Virginia

Search by objective public record fields.

Understanding Factors That Influence Electronic Cigarette Nicotine Delivery Through PET Imaging of Beta-2 Nicotinic Acetylcholine Receptors

Bronchoscopy in Determining the Effect of E-Cigarette Smoking on Biomarkers in the Lungs

Low Nicotine Content Cigarettes in Vulnerable Populations: Affective Disorders

Nicotine Pharmacokinetics Following Use of the P4M3 Gen 2.0 E-Cigarette Compared to Smoking Cigarettes

Cigarette and E-cigarette Nicotine Content in an Electronic Tobacco Marketplace (ETM)

In-vivo Effects of E-cigarette Aerosol on Innate Lung Host Defense

Electronic Cigarette Use During Pregnancy

The Impact of Oral Ethanol and Vaped Ethanol on the Evaluation of Impairment

Assessing E-Cigarettes for Tobacco Harm Reduction in the Context of Lung Cancer Screening

E-cigarettes and Blood Vessel Function

Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine

Determination of Liquid Flavor and Nicotine Form Outcomes

E-Cigarettes and SNA

Sex Differences in E-cig Perception: Study 1

Pilot Trial of E Cigarettes in Pts Diagnosed With Cancer of the Head, Neck, and Lung

Effects of Novel E-cigarette Constituents on Adults TCORS 3.0

Menthol and Mint Experimental Tobacco Marketplace (ETM) Study

Compensatory Behavior of E-cig Users in Response to Reduced Nicotine E-liquids

Effects of Flavors on Nicotine Reinforcement in Smokers

Sensory Perception of Sweet Flavors in E-Cigarette

Effects of E-Cigarette Flavors on Adults TCORS 2.0

Novel Approaches to Reducing Tobacco Related Harm

Impact of Electronic Cigarette Temperature and Solvent on Biomarkers

Electronic Cigarette Unit Price Manipulations in the Experimental Tobacco Marketplace