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ClinicalTrials.gov public records Last synced Oct 19, 2026, 8:02 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–14 of 14 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: EC with nicotine Clear all

Conditions: Smoking, Smoking, Cigarette, E-Cig Use, Nicotine Dependence
Interventions: very low nicotine content cigarettes, normal nicotine content cigarettes, Study e-cigarette; Other
Lead sponsor: Duke University; Other
Eligibility: 21 Years and older
Enrollment: 7 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Cigarette Smoking
Interventions: E-cigarette Switching, Financial Incentives; Behavioral
Lead sponsor: University of Oklahoma; Other
Eligibility: 21 Years to 100 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: COPD
Interventions: E-cigarette (EC), Nicotine Replacement Therapy (NRT), Smoking Harm Reduction Counseling Sessions; Other · Behavioral
Lead sponsor: NYU Langone Health; Other
Eligibility: 21 Years to 75 Years
Enrollment: 146 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: New York, New York

Conditions: Airway Morbidity, Smoking Cessation, Nicotine Adverse Reaction, Smoking, Tobacco, Smoking, Cigarette
Interventions: Electronic cigarette use, Control regular cigarette smokers; Device · Other
Lead sponsor: Miami VA Healthcare System; Federal
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2021
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Tobacco Use Disorder
Interventions: Either normal nicotine content cigarettes (15.8mg/g) or reduced nicotine content cigarettes (0.4mg/g), E-Cigarettes; Other
Lead sponsor: Brown University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 326 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 2
States / cities: Providence, Rhode Island • Burlington, Vermont

Conditions: Nicotine Dependence, Tobacco Toxicity, Cardiovascular Risk Factors
Interventions: Standardized Research E-Cigarette (SREC), Over the Counter E-Cigarette (EC), Biological Samples, Smoking-related Questionnaires; Other · Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years to 70 Years
Enrollment: 32 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Tobacco-Related Carcinoma
Interventions: Discrete Choice Study, Survey Administration; Other
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 15 Years and older
Enrollment: 3,400 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Cardiopulmonary Disease, Smoking Cessation, Inpatient
Interventions: Enhanced Usual Care (EUC), Nurse Practitioner Tobacco Treatment Team (NPT3); Other
Lead sponsor: Baystate Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 424 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Springfield, Massachusetts

Conditions: Smoking Cessation, Obesity and Obesity-related Medical Conditions
Interventions: Electronic Cigarettes (EC), Nicotine replacement therapy (NRT); Other
Lead sponsor: Brown University; Other
Eligibility: 21 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Cigarette Smoking
Interventions: E-cigarette (EC), Nicotine Replacement Therapy (NRT), Harm-Reduction Counseling, Ecological Momentary Intervention (EMI) Text Messaging; Other · Behavioral
Lead sponsor: NYU Langone Health; Other
Eligibility: 21 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Sudden Cardiac Death, Prolonged QTc Interval
Interventions: EC with nicotine, EC without nicotine, control, TC with nicotine (own brand), research TC with very low level nicotine; Other
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 21 Years to 45 Years
Enrollment: 110 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Tobacco Use Disorder
Interventions: Varying the nicotine content of cigarettes, E-Cigarettes; Other
Lead sponsor: University of Vermont; Other
Eligibility: 21 Years to 44 Years · Female only
Enrollment: 326 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 2
States / cities: Baltimore, Maryland • Burlington, Vermont

Conditions: Tobacco Use Disorder
Interventions: Cigarettes with varying nicotine content, E-Cigarettes; Other
Lead sponsor: University of Vermont; Other
Eligibility: 21 Years to 70 Years
Enrollment: 326 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 2
States / cities: Baltimore, Maryland • Burlington, Vermont

Conditions: Opioid Use Disorder, Cigarette Smoking
Interventions: Telehealth Motivational Counseling, Nicotine Replacement Product, National Institute on Drug Abuse (NIDA) Standardized Research Electronic Cigarette (SREC).; Behavioral · Drug · Device
Lead sponsor: NYU Langone Health; Other
Eligibility: 21 Years to 75 Years
Enrollment: 302 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 2
States / cities: New York, New York • The Bronx, New York

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Impact of New Standards for Tobacco Products Among Dual E-Cigarette/Combusted Cigarette Users - Project 2

E-Cigarettes and Financial Incentives to Promote Tobacco Harm Reduction Among Adults Accessing Shelter Services

Electronic Cigarettes as a Harm Reduction Strategy Among Patients With COPD

Adverse Airway Effects From Tobacco and E-Cigarettes

Low Nicotine Content Cigarettes in Vulnerable Populations: Affective Disorders

Pharmacokinetics and Pharmacodynamics of Nicotine With Use of Standardized Research Electronic Cigarette (SREC)

Studying the Impacts of Higher Taxes and Bans on Electronic Cigarettes to Improve Public Health

Smoking Cessation Pharmacotherapy-Nurse Practitioner Led Tobacco Treatment Team Study

Clinical Research Evaluating Smoking Cessation With E-Cigarettes and Nicotine Therapy

E-cigarettes for Harm Reduction Among Smokers With Serious Mental Illness

Smoking and Ventricular Repolarization

Low Nicotine Content Cigarettes in Vulnerable Populations: Women of Reproductive Age

Low Nicotine Content Cigarettes in Vulnerable Populations: Opioid Use Disorder

E-Cigarettes for Harm Reduction in Smokers With Opioid Use Disorder