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Showing 1–19 of 19 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Effects of Nasal Cannula Flow Clear all
Completed No phase listed Observational

Prematurity-Related Ventilatory Control

NCT03464396
View directory record Official record
Conditions
Respiratory Control in Premature Infants
Interventions
Bedside Physiology study, Carotid Body Function Test, Room Air Challenge, Hypoxia Challenge Test, Effects of Nasal Cannula Flow, Magnetic Resonance Imaging, Echocardiogram, Blood Sample
Other · Diagnostic Test
Lead sponsor
Washington University School of Medicine
Other
Eligibility
1 Day to 28 Days
Enrollment
177 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 30, 2023 · Synced Sep 25, 2026, 10:16 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of High Velocity/Hyperoxic Breathing Therapy on Blood Lactate Decline

NCT05984186
View directory record Official record
Conditions
Dyspnea, Lactic Acidosis, Muscle, Breathlessness, Exercise, Recovery
Interventions
High Velocity Therapy
Device
Lead sponsor
Vapotherm, Inc.
Industry
Eligibility
18 Years to 30 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Auburn, Alabama
Source: ClinicalTrials.gov public record
Updated Oct 7, 2024 · Synced Sep 25, 2026, 10:16 AM EDT
Completed Not applicable Interventional

Pilot Study of Physiological Effect of High-Flow Nasal Cannula on Respiratory Pattern and Work of Breathing

NCT02514798
View directory record Official record
Conditions
COPD
Interventions
Esophageal and gastric balloons, Respiratory Inductance Plethysmography (RIP) system, Sentec transcutaneous monitoring system, High-flow humidified nasal oxygen delivery system, CPAP (Positive Control)
Other · Device
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 9, 2022 · Synced Sep 25, 2026, 10:16 AM EDT
Withdrawn Not applicable Interventional

Non-Inferiority Trial of Acute HFT Versus nCPAP

NCT01860560
View directory record Official record
Conditions
Mild-Moderate Obstructive Sleep Disordered Breathing
Interventions
High-Flow Therapy, Continuous Positive Airway Pressure
Device
Lead sponsor
Vapotherm, Inc.
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Glen Burnie, Maryland
Source: ClinicalTrials.gov public record
Updated May 2, 2023 · Synced Sep 25, 2026, 10:16 AM EDT
Terminated Not applicable Interventional Results available

HFNC Effect on BCSS in Patients With COPD

NCT02825043
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease
Interventions
High-Flow Nasal Cannula
Device
Lead sponsor
University of Oklahoma
Other
Eligibility
35 Years to 80 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jun 28, 2020 · Synced Sep 25, 2026, 10:16 AM EDT
Recruiting Not applicable Interventional

Physiologic Effects of Nasal High Flow on Exercise Tolerance in COPD

NCT06578156
View directory record Official record
Conditions
COPD
Interventions
Nasal High Flow Cannula, Nasal Low Flow Cannula
Device
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 100 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Sep 25, 2026, 10:16 AM EDT
Terminated Not applicable Interventional

Effects of High Flow Nasal Cannula on Sputum Clearance in Acute Exacerbation of Chronic Obstructive Pulmonary Disease

NCT04217746
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease, COPD Exacerbation, Airflow Obstruction
Interventions
High Flow Nasal Cannula
Device
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 21, 2025 · Synced Sep 25, 2026, 10:16 AM EDT
Completed No phase listed Observational

Use of Oxygen Hoods in Patients Failing on Conventional High-flow Oxygen Delivery Systems, Effects on Oxygenation in Hypoxic COVID-19 Patients. Prospective Cohort Study.

NCT04407260
View directory record Official record
Conditions
COVID -19, Respiratory Failure, Hypoxia
Interventions
Oxygen Hood
Device
Lead sponsor
Northwell Health
Other
Eligibility
Not listed
Enrollment
136 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Sleepy Hollow, New York
Source: ClinicalTrials.gov public record
Updated Dec 1, 2022 · Synced Sep 25, 2026, 10:16 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Flow Settings During High Flow Nasal Cannula for Adult Hypoxemia Patients

NCT03738345
View directory record Official record
Conditions
Hypoxemia
Interventions
HFNC flow
Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 90 Years
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 22, 2021 · Synced Sep 25, 2026, 10:16 AM EDT
Not listed Not applicable Interventional

Effects of High Flow Nasal Cannula on Deadspace Reduction and Regional Distribution of Ventilation

NCT02460653
View directory record Official record
Conditions
Respiratory Insufficiency, Hypoxia
Interventions
HFNC Flow Rate
Device
Lead sponsor
Boston Children's Hospital
Other
Eligibility
4 Weeks to 17 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
2
States / cities
Boston, Massachusetts • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 3, 2019 · Synced Sep 25, 2026, 10:16 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Phamacological Reversal of Airway Instability During Sedation

NCT01171118
View directory record Official record
Conditions
Upper Airway Obstruction
Interventions
Physostigmine, Oxygen, Placebo
Drug
Lead sponsor
University of Rochester
Other
Eligibility
18 Years to 45 Years · Male only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Apr 26, 2015 · Synced Sep 25, 2026, 10:16 AM EDT
Completed Not applicable Interventional

Tolerance and Acute Effects of a New HFNT Nasal Cannula

NCT05182294
View directory record Official record
Conditions
COPD Exacerbation Acute
Interventions
AIRVO 2, the new asymmetric nasal cannula
Device
Lead sponsor
Temple University
Other
Eligibility
40 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 5, 2023 · Synced Sep 25, 2026, 10:16 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Effects of Different Flow Settings on Lung Impedance

NCT06228703
View directory record Official record
Conditions
Healthy
Interventions
High-flow nasal cannula device with flow setting at 40 L/min or higher
Device
Lead sponsor
Rush University Medical Center
Other
Eligibility
21 Years to 65 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Forest Park, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Sep 25, 2026, 10:16 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Physiological Study to Assess Awake Prone Positioning and Respiratory Support in Healthy Volunteers

NCT05512585
View directory record Official record
Conditions
Healthy
Interventions
awake prone positioning with advanced respiratory support (high-flow nasal cannula or continuous positive airway pressure)
Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
21 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 8, 2022 · Synced Sep 25, 2026, 10:16 AM EDT
Completed Not applicable Interventional

Treating Sleep Apnea Induced Hypoxemia With Oxygen in Acute Stroke Patients

NCT03300063
View directory record Official record
Conditions
Stroke, Acute
Interventions
Low flow nocturnal oxygen
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 24, 2021 · Synced Sep 25, 2026, 10:16 AM EDT
Completed Not applicable Interventional

High Flow Nasal Cannula With Noninvasive Ventilation

NCT04507425
View directory record Official record
Conditions
Acute Respiratory Failure
Interventions
Standard of Care - Nasal Cannula, High-flow nasal cannula, HFNC plus non-invasive ventilation
Other
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 100 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Nov 20, 2023 · Synced Sep 25, 2026, 10:16 AM EDT
Recruiting Not applicable Interventional

Physiological Effects of Continuous Negative External Pressure for Acute Hypoxemic Respiratory Failure

NCT05675345
View directory record Official record
Conditions
Acute Hypoxemic Respiratory Failure
Interventions
HFNC only, HFNC + CNEP10, HFNC + CNEP20, HFNC + CNEP30
Device
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 3, 2024 · Synced Sep 25, 2026, 10:16 AM EDT
Terminated Not applicable Interventional Results available

Effect of Synchronized vs. Continuous HFNC Using NAVA on WOB in Infants With BPD

NCT04274192
View directory record Official record
Conditions
Bronchopulmonary Dysplasia
Interventions
Synchronized HFNC at 6 liters per minute (LPM), Continuous HFNC at 6 liters per minute (LPM), Synchronized HFNC at 8 liters per minute (LPM), Continuous HFNC at 8 liters per minute (LPM)
Other
Lead sponsor
University of Arkansas
Other
Eligibility
28 Days to 1 Year
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated May 4, 2022 · Synced Sep 25, 2026, 10:16 AM EDT
Not yet recruiting Not applicable Interventional

WIN Ratio Analysis to Determine a Strategy of Non- Invasive SUpport for Respiratory Failure in the EmeRgency Department

NCT07558265
View directory record Official record
Conditions
Acute Hypoxic Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS)
Interventions
Non-Invasive Positive Pressure Ventilation, High Flow Nasal Oxygen
Device
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
2
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Sep 25, 2026, 10:16 AM EDT