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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Electronic cigarette Clear all
Terminated Not applicable Interventional Results available

Impact of Cigarette and E-cigarette Flavors on Adult Smoking Behavior

NCT04009850
View directory record Official record
Conditions
Tobacco Use
Interventions
Cigarette Brand Switching, E-cigarette Flavor
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 7, 2024 · Synced Sep 23, 2026, 11:33 PM EDT
Completed Not applicable Interventional Results available

Messages About Reduced Nicotine in Combusted Tobacco Products

NCT05506046
View directory record Official record
Conditions
Health Communication, Smoking, Smoking, Tobacco, Smoking Behaviors, Risk Behavior
Interventions
Reduced nicotine message exposure, Modified risk message exposure, Combined message exposure (reduced nicotine + modified risk), Control message exposure
Behavioral
Lead sponsor
Georgia State University
Other
Eligibility
18 Years and older
Enrollment
1,901 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 27, 2024 · Synced Sep 23, 2026, 11:33 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Human Factors Validation and Usability Testing of the IKE Age-Gating System

NCT06952569
View directory record Official record
Conditions
Vaping, Underage
Interventions
IKE System
Other
Lead sponsor
IKE Tech
Industry
Eligibility
18 Years and older
Enrollment
102 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
4
States / cities
Los Angeles, California • Chicago, Illinois • New York, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 30, 2025 · Synced Sep 23, 2026, 11:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cardiovascular Assessment of the Effects of Tobacco and Nicotine Delivery Products

NCT01964807
View directory record Official record
Conditions
Adverse Effect of Other Agents Primarily Affecting the Cardiovascular System, Initial Encounter
Interventions
Cigarette, NIDA test type with 16.6 mg nicotine, Cigarette, NIDA test type with <0.45 mg nicotine, Electronic cigarette with 18 mg/ml nicotine, Electronic Cigarette with no nicotine, Moist snuff, Sham Smoking, Secondhand cigarette smoke (SHS), Conditioned, filtered air, Sham Moist Snuff
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 50 Years
Enrollment
81 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2021
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Dec 26, 2021 · Synced Sep 23, 2026, 11:33 PM EDT
Completed Not applicable Interventional Results available

Evaluating E-Cigarette Nicotine Form, Concentration, and Flavors Among Youth

NCT05458895
View directory record Official record
Conditions
E-cigarette Use
Interventions
ECIG lab session 1, ECIG lab session 2, ECIG lab session 3, ECIG lab session 4, ECIG lab session 5, ECIG lab session 6, ECIG lab session 7, ECIG lab session 8
Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years to 25 Years
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 21, 2024 · Synced Sep 23, 2026, 11:33 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Pilot Study of the YES-CAN! Program to Prevent Youth Nicotine Vaping

NCT07009509
View directory record Official record
Conditions
Nicotine Vaping
Interventions
YES-CAN! program
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
9 Years and older
Enrollment
1,166 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 14, 2025 · Synced Sep 23, 2026, 11:33 PM EDT
Completed Not applicable Interventional

Electronic Cigarettes as a Harm Reduction Strategy Among Patients With COPD

NCT04465318
View directory record Official record
Conditions
COPD
Interventions
E-cigarette (EC), Nicotine Replacement Therapy (NRT), Smoking Harm Reduction Counseling Sessions
Other · Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
21 Years to 75 Years
Enrollment
146 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 14, 2023 · Synced Sep 23, 2026, 11:33 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Hippocampal Network Changes Following Mindfulness Training in Tobacco Vaping Adolescents in an Open-label, Pilot Study

NCT06503159
View directory record Official record
Conditions
Vaping Teens, Healthy Volunteers
Interventions
Mindfulness-based Stress Reduction (MBSR) Program, functional magnetic resonance imaging (fMRI)
Behavioral · Other
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
13 Years to 18 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 26, 2026 · Synced Sep 23, 2026, 11:33 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Attentional Bias Modification Training for E-cigarette Users

NCT05112562
View directory record Official record
Conditions
E-cigarette Use, Tobacco Use Cessation
Interventions
Computerized attentional bias modification training, Placebo attention control training
Behavioral
Lead sponsor
University of Wisconsin, Milwaukee
Other
Eligibility
18 Years to 29 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Nov 3, 2022 · Synced Sep 23, 2026, 11:33 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Adaptive Use of Nicotine Substitution to Maintain Smoking Reduction/Abstinence in Nicotine Responders

NCT06554873
View directory record Official record
Conditions
Smoking Cessation, Harm Reduction
Interventions
Nicoderm, Nicorette 4Mg Chewing Gum, Nicorette Lozenge Product, NJOY e-cigarette, on!
Drug · Other
Lead sponsor
Rose Research Center, LLC
Industry
Eligibility
22 Years to 65 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
2
States / cities
Charlotte, North Carolina • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Sep 23, 2026, 11:33 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effects of Social Media Use on Young Adults' E-Cigarette Use

NCT06142877
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
Social Media Use Reduction
Behavioral
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 25 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated May 6, 2024 · Synced Sep 23, 2026, 11:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Characterize the Nicotine Uptake and Subjective Effects With Use of JUUL Electronic Nicotine Delivery Systems

NCT04123041
View directory record Official record
Conditions
Electronic Cigarette Use, Tobacco Smoking
Interventions
JUUL ENDS, Combustible cigarette, comparator e-cigarette, Nicorette gum
Other
Lead sponsor
Juul Labs, Inc.
Industry
Eligibility
21 Years to 65 Years
Enrollment
137 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
2
States / cities
Kansas City, Kansas • Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Feb 12, 2020 · Synced Sep 23, 2026, 11:33 PM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Kick-Nic! Youth Quit Vaping App

NCT06662305
View directory record Official record
Conditions
Nicotine Vaping
Interventions
Kick-Nic! mobile phone application, NCI Quit Vaping website
Behavioral
Lead sponsor
Yale University
Other
Eligibility
12 Years to 19 Years
Enrollment
306 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 30, 2026 · Synced Sep 23, 2026, 11:33 PM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Understanding Vape Marketing Study

NCT07129265
View directory record Official record
Conditions
E-cigarette, Vaping, Tobacco, Nicotine, Adolescent Behavior, Video Information, Digital Education Interventions
Interventions
Working group, Focus group
Other
Lead sponsor
Boston Children's Hospital
Other
Eligibility
13 Years and older
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 18, 2025 · Synced Sep 23, 2026, 11:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Impact of E-cigarette Device Warnings

NCT05714982
View directory record Official record
Conditions
Vaping Behaviors
Interventions
Label with text health warning, Label with pictorial health warning, Label with neutral statements about vaping
Other
Lead sponsor
UNC Lineberger Comprehensive Cancer Center
Other
Eligibility
21 Years and older
Enrollment
1,369 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 11, 2025 · Synced Sep 23, 2026, 11:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Chicago Community Health Study

NCT04460417
View directory record Official record
Conditions
Smoking
Interventions
Enhanced Care, TAU
Behavioral
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
204 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 6, 2020 · Synced Sep 23, 2026, 11:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Nicotine Flux, a Potentially Powerful Tool for Regulating Nicotine Delivery From Electronic Cigarettes

NCT05706701
View directory record Official record
Conditions
Nicotine Vaping
Interventions
Nicotine vaping visit 1 (free-base nicotine), Nicotine vaping visit 1 (protonated nicotine), Nicotine vaping visit 2 (free-base nicotine), Nicotine vaping visit 2 (protonated nicotine)
Other
Lead sponsor
Yale University
Other
Eligibility
21 Years and older
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Nov 17, 2025 · Synced Sep 23, 2026, 11:33 PM EDT
Completed Phase 2 Interventional Results available

CAN-DOSE Study: Cessation With Augmented Nicotine for Dual Use Of Smoking and E-cigarettes

NCT06087328
View directory record Official record
Conditions
Smoking Cessation, Electronic Cigarette Use, Cigarette Smoking
Interventions
Regular Nicotine patch and lozenge dose, Augmented Nicotine patch and lozenge dose
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Nov 25, 2025 · Synced Sep 23, 2026, 11:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Tobacco Product Susceptibility and Substitutability by Rurality and Alcohol Use

NCT07010601
View directory record Official record
Conditions
Alcohol Use, E-cigarette Use, Cigarette Use
Interventions
Experimental Tobacco Marketplace, Hypothetical Novel Nicotine Product Purchase Tasks
Behavioral
Lead sponsor
Mark J Rzeszutek, PhD
Other
Eligibility
21 Years and older
Enrollment
737 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Sep 22, 2025 · Synced Sep 23, 2026, 11:33 PM EDT
Not yet recruiting Phase 1 Interventional

Impact of Sweeteners on the Addictive Threshold of Nicotine

NCT07771725
View directory record Official record
Conditions
Smoking ( Cigarette)
Interventions
Nicotine 0.05 mg/pulse and 0.1 mg/pulse, Saline Placebo (0.5mL injection), sucralose, Sugar syrup (Placebo)
Drug · Dietary Supplement
Lead sponsor
Yale University
Other
Eligibility
21 Years to 59 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 30, 2026 · Synced Sep 23, 2026, 11:33 PM EDT
Recruiting Not applicable Interventional

Behavioral Intervention for Youth to Promote Vaping Cessation

NCT06765291
View directory record Official record
Conditions
Vaping, Vaping Teens, Nicotine Dependence
Interventions
QuitVaping, This is Quitting (TIQ)
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
14 Years to 19 Years
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Sep 23, 2026, 11:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Project 2 Cigarette and E-cigarette Nicotine Content and E-liquid Flavors

NCT03185546
View directory record Official record
Conditions
Smoking
Interventions
NNC Spectrum Cigarette, VLNC Spectrum Cigarette, Moderate nicotine level e-liquid, Low nicotine level e-liquid, Tobacco Flavors, Tobacco and non-tobacco e-liquid flavors
Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
156 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
2
States / cities
Winston-Salem, North Carolina • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 13, 2021 · Synced Sep 23, 2026, 11:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Electronic Hookah and Endothelial Cell Function

NCT04133376
View directory record Official record
Conditions
Smoking, Endothelial Dysfunction
Interventions
Electronic hookah vaping with nicotine, Electronic hookah vaping without nicotine
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
21 Years to 39 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 11, 2026 · Synced Sep 23, 2026, 11:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Nicotine Delivery From Novel Non-Tobacco Electronic System in Smokers

NCT02575885
View directory record Official record
Conditions
Cigarette Smoker, Current Smoker, Healthy Subject
Interventions
Electronic Cigarette, Laboratory Biomarker Analysis, Pharmacological Study, Questionnaire Administration
Other
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
18 Years to 55 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jun 11, 2018 · Synced Sep 23, 2026, 11:33 PM EDT