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ClinicalTrials.gov public records Last synced Oct 2, 2026, 4:07 AM EDT

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Showing 1–20 of 20 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: End tidal CO2 (EtCO2) Clear all
Completed Not applicable Interventional Accepts healthy volunteers

End Tidal CO2 and Masks: Is There a Correlation?

NCT06437301
View directory record Official record
Conditions
Hypercapnia
Interventions
Baseline measure of ETCO2 without mask, Baseline ETCO2 with mask, ETCO2 after 200 meter walk with mask, ETCO2 after 200 meter walk without mask
Other
Lead sponsor
CHRISTUS Health
Other
Eligibility
18 Years to 75 Years
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Corpus Christi, Texas
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 2, 2026, 4:07 AM EDT
Terminated Not applicable Interventional

Functional Magnetic Resonance Imaging (fMRI) Vascular Reactivity in Cerebral Cavernous Malformations (CCM)

NCT05298709
View directory record Official record
Conditions
Cerebral Cavernous Malformation
Interventions
Hyperventilation and CO2 challenge
Other
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Jun 11, 2025 · Synced Oct 2, 2026, 4:07 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Spire Medical Health Tag Respiratory Rate Validation in Adults

NCT04104737
View directory record Official record
Conditions
Respiratory Rate
Interventions
Spire Medical Health Tag
Device
Lead sponsor
Spire, Inc.
Industry
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
2
States / cities
San Francisco, California • Louisville, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 30, 2019 · Synced Oct 2, 2026, 4:07 AM EDT
Completed Not applicable Interventional

The Effects of MAP and EtCO2 on Venous Sinus Pressures

NCT03867461
View directory record Official record
Conditions
Idiopathic Intracranial Hypertension
Interventions
Venous Sinus Stenting, Adjustment to end-tidal carbon dioxide concentrations ( 38-40 mmHg range), Adjustment to Mean Arterial Pressure (100-110 mmHg range), Adjustment to Mean Arterial Pressure (60-80 mmHg range), Adjustment to end-tidal carbon dioxide concentrations (24-26 mmHg range)
Procedure · Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated May 12, 2020 · Synced Oct 2, 2026, 4:07 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

The Comparison of Pulse Oximetry, End-tidal Capnometry, and Integrated Pulmonary Index (IPI)

NCT01191528
View directory record Official record
Conditions
Postoperative Care
Interventions
capnostream 20, Oridian Medical 1987 ltd, Needham MA
Device
Lead sponsor
Allenmore Hospital
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Dec 13, 2010 · Synced Oct 2, 2026, 4:07 AM EDT
Recruiting Not applicable Interventional

Pilot Feasibility Trial of the SafeLM Supraglottic Airway (SGA)

NCT05989880
View directory record Official record
Conditions
Anesthesia
Interventions
SafeLM as a supraglottic airway device with video capability, SafeLM as a supraglottic airway device without video capability, SafeLM as a conduit for intubation using an endotracheal tube with video capability, SafeLM as a conduit for intubation using a bougie with video capability
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 10, 2024 · Synced Oct 2, 2026, 4:07 AM EDT
Terminated Not applicable Interventional Results available

Cerebral Oximetry in Single Lung Ventilation Thoracic Surgery

NCT01866657
View directory record Official record
Conditions
Hypoxia
Interventions
Vasoconstrictor Agents, Head/neck repositioning, Increase ETCO2, IV fluid bolus, Additional anesthesia, RBC transfusion, Increase FiO2
Drug · Other · Biological
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
65 Years and older
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 5, 2022 · Synced Oct 2, 2026, 4:07 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Clinical Validation of Non-Contact Vital Signs

NCT07362641
View directory record Official record
Conditions
Vital Sign Evaluation
Interventions
SmartSpectra Vital Signs Monitor measurement
Device
Lead sponsor
Presage Technologies, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
111 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Oct 2, 2026, 4:07 AM EDT
Completed Not applicable Interventional

Fontan Physiology Ventilation Strategy

NCT04672538
View directory record Official record
Conditions
Anesthesia, Congenital Heart Disease
Interventions
Low Vt protocol, High Vt protocol
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
Not listed
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 17, 2023 · Synced Oct 2, 2026, 4:07 AM EDT
Completed Not applicable Interventional

Goal-directed CPR Using Cerebral Oximetry

NCT04924985
View directory record Official record
Conditions
Ischemia, Reperfusion Injury
Interventions
Non-Physiological Feedback CPR, Physiological Feedback CPR
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 80 Years
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Oct 2, 2026, 4:07 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Respiratory Rate Validation Study

NCT07147907
View directory record Official record
Conditions
Respiration Rate, Monitoring, Physiologic
Interventions
Chest Worn Respiratory Rate Monitor
Device
Lead sponsor
Perin Health Devices
Industry
Eligibility
22 Years and older
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Louisville, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 29, 2025 · Synced Oct 2, 2026, 4:07 AM EDT
Not listed No phase listed Observational

Capnography in the Post-Anesthesia Care Unit (PACU)

NCT03076047
View directory record Official record
Conditions
Obstructive Sleep Apnea, Bariatric Surgery Candidate, Respiratory Insufficiency
Interventions
end-tidal CO2 (ETCO2) monitoring
Device
Lead sponsor
University of South Florida
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Jun 30, 2022 · Synced Oct 2, 2026, 4:07 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

The Effect of Povidone-iodine Ophthalmic Surgical Prep Solution on Respiration in Children Undergoing Strabismus Surgery With General Anesthesia.

NCT03349515
View directory record Official record
Conditions
Strabismus
Interventions
Provodine-Iodine Solution, Group B will receive three drops in each eye of ophthalmic balanced salt solution.
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
1 Year to 17 Years
Enrollment
106 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Sep 16, 2019 · Synced Oct 2, 2026, 4:07 AM EDT
Withdrawn Phase 3 Interventional

Nalmefene vs Naloxone for the Treatment of Recurrent Respiratory Depression After Opioid Overdose

NCT06408714
View directory record Official record
Conditions
Opioid Overdose, Opiate Overdose
Interventions
Nalmefene Injection, Naloxone Injection
Drug
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Feb 10, 2025 · Synced Oct 2, 2026, 4:07 AM EDT
Completed Not applicable Interventional Results available

Improved Patient Recovery After Anesthesia With Hypercapnia Hyperpnoea

NCT00708526
View directory record Official record
Conditions
Hypercapnia
Interventions
standard of care for phase one anesthesia care, Quick Emergence Device
Other · Device
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Nov 29, 2022 · Synced Oct 2, 2026, 4:07 AM EDT
Completed Not applicable Interventional Results available

Quantitative End Tidal CO2 Monitoring in the Delivery Room (DR)

NCT01381068
View directory record Official record
Conditions
Delivery Room Resuscitation
Interventions
End tidal CO2 monitor
Device
Lead sponsor
Neil Finer
Other
Eligibility
Up to 15 Minutes
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Dec 17, 2019 · Synced Oct 2, 2026, 4:07 AM EDT
Withdrawn Not applicable Interventional

Employing End Tidal Capnography in Continuous Flow Ventricular Assist Device Patients

NCT02838355
View directory record Official record
Conditions
Cardiomyopathy, Cardiovascular Disease, Heart Disease
Interventions
Respiratory Depression Monitoring with End Tidal Carbon Dioxide Nasal Cannula (ETCO2- NC), Standard Non-invasive Respiratory Depression Monitoring
Device · Other
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 20, 2018 · Synced Oct 2, 2026, 4:07 AM EDT
Completed Not applicable Interventional Results available

Comparative Analysis of CO2 Monitoring Methods in Patients With CF Undergoing General Anesthesia

NCT03734822
View directory record Official record
Conditions
Cystic Fibrosis
Interventions
End tidal CO2 (EtCO2), Transcutaneous CO2 (TCO2), Capillary CO2 (CapCO2), Arterial blood gas (ABG)
Other · Device · Diagnostic Test
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
Not listed
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 14, 2019 · Synced Oct 2, 2026, 4:07 AM EDT
Active, not recruiting No phase listed Observational

End-Tidal CO2 (ETCO2) Trends in Out-of-Hospital Cardiac Arrest

NCT07632430
View directory record Official record
Conditions
Prehospital Resuscitation, End-Tidal Carbon Dioxide, Cardiac Arrest, Out-Of-Hospital, Prehospital Emergency Medical Services
Interventions
Not listed
Lead sponsor
Office of the Medical Director for EMS in Oklahoma City and Tulsa
Other
Eligibility
18 Years and older
Enrollment
3,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Oct 2, 2026, 4:07 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Respiratory Rate Validation Study - ChroniSense Polso

NCT05246358
View directory record Official record
Conditions
Respiratory Rate
Interventions
ChoniSense Polso
Device
Lead sponsor
ChroniSense Medical Ltd.
Industry
Eligibility
18 Years to 52 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Louisville, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 18, 2022 · Synced Oct 2, 2026, 4:07 AM EDT