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Showing 1–24 of 77 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Endoscopic Sinus surgery Clear all
Completed Not applicable Interventional Results available

Clinical Evaluation of Propel Nova Sinus Implant in Peripheral Sinus Ostia

NCT02228720
View directory record Official record
Conditions
Chronic Sinusitis
Interventions
Propel Nova Sinus Implant
Device
Lead sponsor
Intersect ENT
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
2
States / cities
Miami, Florida • Dublin, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 3, 2017 · Synced Sep 5, 2026, 4:03 AM EDT
Completed Not applicable Interventional Results available

Balloon Sinus Dilation In Office or OR

NCT00939393
View directory record Official record
Conditions
Chronic Sinusitis
Interventions
FESS instruments with or without balloon treatment, Balloon Sinuplasty
Device
Lead sponsor
Integra LifeSciences Corporation
Industry
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Independence, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 11, 2024 · Synced Sep 5, 2026, 4:03 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Total Intravenous Anesthesia in Sinus Surgery

NCT02578862
View directory record Official record
Conditions
Advanced Chronic Rhinosinusitis
Interventions
Propofol, Sevoflurane
Drug
Lead sponsor
Ochsner Health System
Other
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Dec 20, 2018 · Synced Sep 5, 2026, 4:03 AM EDT
Completed No phase listed Observational

Medical Therapy Versus Sinus Surgery for Chronic Rhinosinusitis: A Prospective, Multi-institutional Study

NCT01255566
View directory record Official record
Conditions
Chronic Rhinosinusitis, Sinusitis
Interventions
Not listed
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years and older
Enrollment
186 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
3
States / cities
Chicago, Illinois • Philadelphia, Pennsylvania • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 23, 2013 · Synced Sep 5, 2026, 4:03 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Management of Pediatric Chronic Rhinosinusitis in Asthmatic Children

NCT03336671
View directory record Official record
Conditions
Chronic Sinusitis, Adenoid Disease - Chronic
Interventions
Endoscopic Sinus surgery, Adenoidectomy
Procedure
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
6 Years to 12 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Oct 12, 2021 · Synced Sep 5, 2026, 4:03 AM EDT
Completed No phase listed Observational

Clinical Study to Improve Diagnosis and Treatment of Sinusitis

NCT00962689
View directory record Official record
Conditions
Chronic Sinusitis
Interventions
Not listed
Lead sponsor
Ohio State University
Other
Eligibility
5 Years to 90 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 27, 2017 · Synced Sep 5, 2026, 4:03 AM EDT
Active, not recruiting Early Phase 1 Interventional Accepts healthy volunteers

In Vivo Imaging of the Olfactory Epithelium Using Confocal Laser Endomicroscopy

NCT07546617
View directory record Official record
Conditions
Endonasal Surgery, Endoscopic Sinus Surgery, Olfactory Dysfunction
Interventions
CONVIVO system, Fluorescein injection, USP 10%
Device · Drug
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Sep 5, 2026, 4:03 AM EDT
Recruiting Not applicable Interventional

Paclitaxel-Coated Balloon Treatment of Chronic Rhinosinusitis

NCT07290140
View directory record Official record
Conditions
Chronic Rhinosinusitis (CRS) With and Without Nasal Polyps
Interventions
Airiver ESSpand DCB, ESS
Combination Product · Procedure
Lead sponsor
Airiver Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
10
States / cities
Birmingham, Alabama • San Diego, California • Colorado Springs, Colorado + 6 more
Source: ClinicalTrials.gov public record
Updated Jul 29, 2026 · Synced Sep 5, 2026, 4:03 AM EDT
Recruiting No phase listed Observational

Impact of Sinus Surgery on Individuals With Cystic Fibrosis

NCT04469439
View directory record Official record
Conditions
Chronic Rhinosinusitis (Diagnosis), Cystic Fibrosis
Interventions
Not listed
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 99 Years
Enrollment
170 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
9
States / cities
Los Angeles, California • Stanford, California • Aurora, Colorado + 6 more
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Sep 5, 2026, 4:03 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers

Xylitol for Chronic Sinusitis

NCT03229551
View directory record Official record
Conditions
Chronic Rhinosinusitis, Rhinosinusitis, Sinusitis, Drain Sinus, Endoscopic Sinus Surgery, Biofilms, Bacterial Overgrowth
Interventions
Xylitol, Saline
Drug
Lead sponsor
Ochsner Health System
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Apr 6, 2023 · Synced Sep 5, 2026, 4:03 AM EDT
Completed Phase 3 Interventional Results available

A Clinical Evaluation of a Steroid-Coated Sinus Stent When Used Following Functional Endoscopic Sinus Surgery in Patients With Chronic Sinusitis

NCT01253577
View directory record Official record
Conditions
Chronic Sinusitis
Interventions
Sinus Stent with drug coating, Non Coated Sinus Stent
Device
Lead sponsor
Intersect ENT
Industry
Eligibility
18 Years and older
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
11
States / cities
Fresno, California • Colorado Springs, Colorado • Chicago, Illinois + 8 more
Source: ClinicalTrials.gov public record
Updated Jun 21, 2015 · Synced Sep 5, 2026, 4:03 AM EDT
Completed No phase listed Observational

Analysis of Inflammation and Microbiome in Patients With Sinusitis and Asthma

NCT02548598
View directory record Official record
Conditions
Asthma, Chronic Rhinosinusitis
Interventions
Endoscopic sinus surgery
Procedure
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 2, 2021 · Synced Sep 5, 2026, 4:03 AM EDT
Completed Phase 4 Interventional Results available

Study to Evaluate Safety and Effectiveness of AdvaCoat Sinus Gel

NCT00554190
View directory record Official record
Conditions
Ethmoid Sinusitis, Rhinosinusitis
Interventions
AdvaCoat sinus gel, Merogel Injectable
Device
Lead sponsor
Carbylan Therapeutics, Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007
U.S. locations
4
States / cities
Birmingham, Alabama • San Francisco, California • Chicago, Illinois + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 22, 2009 · Synced Sep 5, 2026, 4:03 AM EDT
Completed Phase 2 Interventional Results available

Esmolol vs. Labetalol in Endoscopic Sinus Surgery

NCT03661346
View directory record Official record
Conditions
Chronic Sinusitis
Interventions
Labetalol, Esmolol
Drug
Lead sponsor
The University of Texas Medical Branch, Galveston
Other
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Galveston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 7, 2021 · Synced Sep 5, 2026, 4:03 AM EDT
Completed Phase 4 Interventional Results available

The PIO II Study: In-office Post-op Placement of a Steroid-eluting Sinus Implant

NCT02668302
View directory record Official record
Conditions
Chronic Sinusitis, Ethmoidal
Interventions
Steroid-eluting sinus implant, Post-op standard of care
Combination Product · Other
Lead sponsor
Collin County Ear Nose & Throat
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Frisco, Texas
Source: ClinicalTrials.gov public record
Updated Oct 11, 2018 · Synced Sep 5, 2026, 4:03 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Pediatric Chronic Rhinosinusitis in Asthmatic Children

NCT06194097
View directory record Official record
Conditions
Sinusitis in Children
Interventions
adenoidectomy versus endoscopic sinus surgery with adenoidectomy
Procedure
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
6 Years to 12 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Jan 7, 2024 · Synced Sep 5, 2026, 4:03 AM EDT
Terminated Not applicable Interventional Results available

Safety and Effectiveness of the Peregrine Drivable ENT Scope for Endoscopy of the Paranasal Sinuses

NCT04096482
View directory record Official record
Conditions
Sinus Problem
Interventions
Peregrine Drivable ENT Scope, Standard 30° 4mm Endoscope
Device
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 14, 2021 · Synced Sep 5, 2026, 4:03 AM EDT
Completed Phase 4 Interventional Results available

Postoperative Pain and Functional Patient Outcomes After Functional Endoscopic Sinus Surgery

NCT00927888
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Bupivacaine Block, Placebo
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 70 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated May 18, 2016 · Synced Sep 5, 2026, 4:03 AM EDT
Completed Not applicable Interventional Results available

Prospective Hemodynamic and Pharmacokinetic Analysis of Oxymetazoline Absorption

NCT02453841
View directory record Official record
Conditions
Adenoidectomy, Functional Endoscopic Sinus Surgery (FESS), Turbinate Surgery
Interventions
Oxymetazoline
Drug
Lead sponsor
Richard Cartabuke
Other
Eligibility
2 Years to 18 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 17, 2018 · Synced Sep 5, 2026, 4:03 AM EDT
Withdrawn Early Phase 1 Interventional

Comparison of Two Steroid Nasal Implants Following Endoscopic Sinus Surgery for Chronic Rhinosinusitis

NCT03729310
View directory record Official record
Conditions
Chronic Sinusitis, Rhinosinusitis
Interventions
Propel 'implant', Triamcinolone, Nasopore
Device · Drug
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 100 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 27, 2020 · Synced Sep 5, 2026, 4:03 AM EDT
Completed Phase 2 Interventional Results available

Effectiveness of Antibiotic Delivery Via Bio-absorbable Sponge

NCT01222832
View directory record Official record
Conditions
Paranasal Sinus Disease
Interventions
Bacitracin
Drug
Lead sponsor
Steward St. Elizabeth's Medical Center of Boston, Inc.
Other
Eligibility
18 Years and older
Enrollment
226 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Brighton, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 30, 2017 · Synced Sep 5, 2026, 4:03 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

TIVA vs TXA in Sinus Surgery to Evaluate Operative Blood Loss and Surgical Field Quality

NCT05639686
View directory record Official record
Conditions
Rhinosinusitis Chronic, Sinus Cancer, Sinus Polyp, Encephalocele
Interventions
Tranexamic acid injection, Total Intravenous Anesthesia, Inhalational isoflurane
Drug
Lead sponsor
Our Lady of the Lake Hospital
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Mar 22, 2023 · Synced Sep 5, 2026, 4:03 AM EDT
Withdrawn Not applicable Interventional

Pilot Study To Evaluate A Pharmacologically Active Nasal Sponge Following Endoscopic Sinus Surgery

NCT00705354
View directory record Official record
Conditions
Sinusitis, Chronic Sinusitis
Interventions
Bacitracin, Nasopore sponge soaked with saline
Drug · Procedure
Lead sponsor
Lahey Clinic
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Burlington, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 12, 2012 · Synced Sep 5, 2026, 4:03 AM EDT
Completed Not applicable Interventional Results available

XprESS Registry Study

NCT01115309
View directory record Official record
Conditions
Sinusitis
Interventions
XprESS Balloon Device
Device
Lead sponsor
Entellus Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
175 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Oct 26, 2020 · Synced Sep 5, 2026, 4:03 AM EDT