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Showing 1–24 of 58 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Energy Deficit Clear all
Completed Not applicable Interventional

The MONITOR Study: Remote Monitoring Of a Nutrition Intervention To Optimize Treatment Response

NCT06050395
View directory record Official record
Conditions
Pancreatic Cancer
Interventions
Quality fo Life Questionnaire (FHSI), Vioscreen Food Frequency Questionnaire (FFQ), Educational Handouts, NutritionCoaching, Follow-Up Survey, Functional Assessment of Anorexia/Cachexia Treatment (FAACT) Questionnaire, Patient Reported Outcomes Measure- Cognitive Function (PROMIS-Cog) Questionnaire
Behavioral
Lead sponsor
H. Lee Moffitt Cancer Center and Research Institute
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Sep 6, 2026, 4:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Maternal Metabolic and Molecular Changes Induced by Preconception Weight Loss and Their Effects on Birth Outcomes

NCT03244722
View directory record Official record
Conditions
Obesity; Familial, Pregnancy Related
Interventions
Very-low energy Diet (VLED), Standard of care (SOC)
Dietary Supplement · Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
147 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2025
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Sep 6, 2026, 4:27 AM EDT
Completed Not applicable Interventional

mDiet: A Text Message Intervention for Weight Loss

NCT01171586
View directory record Official record
Conditions
Overweight, Weight Loss
Interventions
mDiet
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
21 Years to 60 Years
Enrollment
318 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Dec 4, 2014 · Synced Sep 6, 2026, 4:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Inhibitory Control and Pediatric Weight Management

NCT04747548
View directory record Official record
Conditions
Overweight and Obesity
Interventions
Kurbo Only, Kurbo + PolyRules!
Behavioral
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
7 Years to 13 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 18, 2022 · Synced Sep 6, 2026, 4:27 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Diet and Exercise Plus Metformin to Treat Frailty in Obese Seniors

NCT04221750
View directory record Official record
Conditions
Frailty, Sarcopenic Obesity, Aging
Interventions
Lifestyle therapy, Metformin Hydrochloride, Placebo, Healthy Lifestyle
Behavioral · Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
65 Years to 85 Years
Enrollment
114 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 4, 2026 · Synced Sep 6, 2026, 4:27 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

The Effects of Repeated Operational Stress and Limited Recovery on Resilience Capacity

NCT06784544
View directory record Official record
Conditions
Sleep, Inadequate, Energy Deficit, Iron Absorption, High Physical Activity
Interventions
Operational Stressors
Other
Lead sponsor
United States Army Research Institute of Environmental Medicine
Federal
Eligibility
17 Years to 39 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Natick, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 19, 2025 · Synced Sep 6, 2026, 4:27 AM EDT
Terminated Not applicable Interventional

RCT of Caloric Restriction vs. Alternate-Day Fasting in Non-Alcoholic Fatty Liver Disease

NCT03365531
View directory record Official record
Conditions
NAFLD, Obesity, Diabetes Mellitus, Type 2
Interventions
Alternate Daily Fasting (ADF), Caloric Restriction (CR)
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 65 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 22, 2019 · Synced Sep 6, 2026, 4:27 AM EDT
Completed Not applicable Interventional

Exercise and Nutrition on Obese Microbiome

NCT04138303
View directory record Official record
Conditions
Overweight and Obesity
Interventions
Exercise Protocol, Calorie-Restrictive Low Carbohydrate Diet (CR-LC), Ancestral Diet (AD)
Other
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 65 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jan 6, 2020 · Synced Sep 6, 2026, 4:27 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

The Effects of Acute Erythropoietin on Hepcidin and Dietary Iron Absorption Following Military-relevant Exercise in Energy Deficit: Pilot Study

NCT07517562
View directory record Official record
Conditions
Iron Absorption
Interventions
Exercise test
Other
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
18 Years to 45 Years
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Sep 6, 2026, 4:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Study of a Personalized vs. Standard Approach to Weight Loss Recommendations

NCT04639076
View directory record Official record
Conditions
Overweight and Obesity
Interventions
Behavioral Weight Loss Program, Personalized Behavioral Weight Loss Program
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
20 Years to 65 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 6, 2021 · Synced Sep 6, 2026, 4:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Protein Quality on Post-exercise Skeletal Muscle and Whole-body Protein Kinetics During Energy Deficit

NCT04004715
View directory record Official record
Conditions
Whole-body Protein Balance, Muscle Protein Synthesis
Interventions
Essential Amino Acid Enriched Whey Protein, Whey Protein, Military Ration Entree
Dietary Supplement
Lead sponsor
United States Army Research Institute of Environmental Medicine
Federal
Eligibility
18 Years to 35 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Natick, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 11, 2020 · Synced Sep 6, 2026, 4:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Essential Amino Acid-enriched Whey and Carbohydrate Co-ingestion on Protein Kinetics

NCT04621175
View directory record Official record
Conditions
Energy Deficit
Interventions
EAA+W & Carbohydrate, EAA+W & EAA
Dietary Supplement
Lead sponsor
United States Army Research Institute of Environmental Medicine
Federal
Eligibility
18 Years to 35 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Natick, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 26, 2025 · Synced Sep 6, 2026, 4:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Exercise-Induced Epigenetic Modifications in Obese Aging Women

NCT01977885
View directory record Official record
Conditions
Metabolic Syndrome
Interventions
High Protein Diet, Exercise
Behavioral
Lead sponsor
University of Georgia
Other
Eligibility
50 Years to 64 Years · Female only
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Athens, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 24, 2015 · Synced Sep 6, 2026, 4:27 AM EDT
Completed Not applicable Interventional Results available

Meals for Moms: Medically-Tailored Meals for Women Who Had Gestational Diabetes

NCT04866823
View directory record Official record
Conditions
Diabetes, Gestational, Gestational Weight Gain, Postpartum Weight Retention
Interventions
Medically Tailored Meals
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older · Female only
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 28, 2025 · Synced Sep 6, 2026, 4:27 AM EDT
Terminated Not applicable Interventional

Surgical vs. Lifestyle in Obese Older Adults

NCT03137329
View directory record Official record
Conditions
Obesity
Interventions
Exercise program, Nutrition, WLS
Behavioral · Dietary Supplement · Procedure
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
55 Years to 75 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 22, 2019 · Synced Sep 6, 2026, 4:27 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Physiological and Psychological Effects of Testosterone During Severe Energy Deficit and Recovery

NCT02734238
View directory record Official record
Conditions
Caloric Restriction, Exercise
Interventions
Sesame Oil, testosterone enanthate
Drug
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
18 Years to 39 Years · Male only
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Jan 15, 2019 · Synced Sep 6, 2026, 4:27 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Optimized Carbohydrate Fueling to Enhance Physical Performance During Energy Deficit

NCT06394401
View directory record Official record
Conditions
Energy Supply; Deficiency
Interventions
BAL:GLU, BAL:GLU+FRU, DEF:GLU, DEF:GLU+FRU
Dietary Supplement
Lead sponsor
United States Army Research Institute of Environmental Medicine
Federal
Eligibility
18 Years to 39 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Natick, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 30, 2024 · Synced Sep 6, 2026, 4:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Intermittent Fasting Versus Daily Caloric Restriction for Weight Loss

NCT03411356
View directory record Official record
Conditions
Obesity
Interventions
Daily Caloric Restriction (DCR), Intermittent Fasting (IMF)
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 60 Years
Enrollment
165 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2023
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Sep 6, 2026, 4:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Adding Sleep Intervention to Traditional Diet and Exercise Approach to Weight Loss

NCT01135342
View directory record Official record
Conditions
Sleep Initiation and Maintenance Disorders, Obesity
Interventions
Diet and exercise, Cognitive Behavioral Therapy, Passion and Balance
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Feb 21, 2023 · Synced Sep 6, 2026, 4:27 AM EDT
Active, not recruiting Not applicable Interventional

Solutions for Hunger And Regulating Eating

NCT05004883
View directory record Official record
Conditions
Overweight and Obesity
Interventions
Regulation of Cues Enhanced, Behavioral Weight Loss, Nutrition Education, Stress Management and Social Support
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 65 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Apr 20, 2026 · Synced Sep 6, 2026, 4:27 AM EDT
Withdrawn Not applicable Interventional

Improving Glycemic Control Using a Virtual Weight Control Program Among Adults With Type 2 Diabetes

NCT05663554
View directory record Official record
Conditions
Diabetes Mellitus, Type 2, Obesity
Interventions
WW Intervention, Usual Care
Behavioral · Other
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
18 Years to 75 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
3
States / cities
Baton Rouge, Louisiana • Greensboro, North Carolina • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 27, 2026 · Synced Sep 6, 2026, 4:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Balance: A Pragmatic Trial of a Digital Health Intervention to Prevent Weight Gain in Primary Care

NCT03003403
View directory record Official record
Conditions
Obesity, Overweight, Overnutrition, Nutrition Disorders, Signs and Symptoms
Interventions
Intervention Program
Behavioral
Lead sponsor
Duke University
Other
Eligibility
21 Years and older
Enrollment
443 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2023
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 15, 2025 · Synced Sep 6, 2026, 4:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Dietary Intervention and Varying Physical Activity in Seniors

NCT01893684
View directory record Official record
Conditions
Obesity
Interventions
Exercise, Higher Protein Diet, Conventional Carbohydrate Diet
Behavioral
Lead sponsor
University of Georgia
Other
Eligibility
65 Years to 80 Years · Female only
Enrollment
81 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Athens, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 6, 2017 · Synced Sep 6, 2026, 4:27 AM EDT
Completed Not applicable Interventional

Lifestyle Intervention for Senior Diabetics

NCT02348801
View directory record Official record
Conditions
Diabetes Mellitus, Aging, Overweight
Interventions
Weight loss and Exercise, Healthy lifestyle
Behavioral
Lead sponsor
Baylor College of Medicine
Other
Eligibility
65 Years to 85 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 13, 2021 · Synced Sep 6, 2026, 4:27 AM EDT