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ClinicalTrials.gov public records Last synced Oct 15, 2026, 6:56 AM EDT

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Showing 409–432 of 450 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Enhance Treatment as Usual Clear all
Completed Not applicable Interventional Accepts healthy volunteers

An Evaluation of the Yes You Can... Make Smart Choices Curriculum

NCT05320666
View directory record Official record
Conditions
Pregnancy in Adolescence, Adolescent Health
Interventions
Yes You Can…Make Smart Choices! (YYC…MSC!) program
Behavioral
Lead sponsor
New Jersey Physicians Advisory Group
Other
Eligibility
10 Years to 21 Years
Enrollment
2,600 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
13
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Oct 15, 2026, 6:56 AM EDT
Completed Not applicable Interventional Results available

A Randomized Trial of Interim Methadone and Patient Navigation Initiated in Jail

NCT02334215
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Methadone, Patient Navigation, Enhanced Treatment as Usual (ETAU)
Drug · Behavioral
Lead sponsor
Friends Research Institute, Inc.
Other
Eligibility
18 Years and older
Enrollment
225 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 16, 2020 · Synced Oct 15, 2026, 6:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Healthier You: Optimizing Screening, Brief Interventions, and Referral to Treatment (SBIRT) in the Emergency Department

NCT01113190
View directory record Official record
Conditions
Drug Abuse
Interventions
Computer-delivered Brief Intervention (CBI), Intervener-delivered Brief Intervention (IBI), Adapted Motivational Enhancement Therapy (AMET), Enhanced Usual Care (EUC)
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 60 Years
Enrollment
878 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Flint, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 7, 2016 · Synced Oct 15, 2026, 6:56 AM EDT
Completed Not applicable Interventional

Group Self-Management of Depression and Medical Illness

NCT02017262
View directory record Official record
Conditions
Depression, Chronic Disease, Hispanic Americans
Interventions
Self-management group, Enhanced usual care
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 4, 2017 · Synced Oct 15, 2026, 6:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Partners at Meals - Respite Care and Home (PAM)

NCT03622814
View directory record Official record
Conditions
Dementia, Alzheimer Type, Weight Loss
Interventions
Partners at Meals, Enhanced Usual Condition
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
60 Years and older
Enrollment
106 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2023
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 10, 2025 · Synced Oct 15, 2026, 6:56 AM EDT
Completed Not applicable Interventional

Lung Cancer Information Study (LCIS-R01)

NCT01924416
View directory record Official record
Conditions
Non-Small-Cell Lung Cancer
Interventions
Enhanced Care (intervention group and comparison group), Usual care (routine chemotherapy cycles and imaging studies)
Behavioral
Lead sponsor
University of Virginia
Other
Eligibility
Not listed
Enrollment
196 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 19, 2018 · Synced Oct 15, 2026, 6:56 AM EDT
Completed Phase 2 Interventional

Family Therapy as Hospital Aftercare for Adolescent Suicide Attempters

NCT01195740
View directory record Official record
Conditions
Suicide Ideation, Depression, Family Conflict
Interventions
Attachment Based Family Therapy, Enhanced Usual Care
Behavioral
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
12 Years to 17 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 17, 2012 · Synced Oct 15, 2026, 6:56 AM EDT
Recruiting Not applicable Interventional

BMT-CARE: Psychosocial Intervention for Transplant Caregivers

NCT06472089
View directory record Official record
Conditions
Bone Marrow Transplant Complications, Hematologic Malignancy
Interventions
BMT-CARE, Usual Care
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
3
States / cities
Birmingham, Alabama • Tampa, Florida • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 15, 2025 · Synced Oct 15, 2026, 6:56 AM EDT
Completed Not applicable Interventional Results available

Behavioral and Enhanced Perinatal Intervention for Cessation (B-EPIC): Reducing Tobacco Use Among Opioid Addicted Women

NCT03796208
View directory record Official record
Conditions
Smoking Cessation
Interventions
Behavioral and Enhanced Perinatal Intervention for Cessation (B-EPIC), Treatment As Usual
Behavioral
Lead sponsor
Kristin Ashford
Other
Eligibility
18 Years to 49 Years · Female only
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
2
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 15, 2022 · Synced Oct 15, 2026, 6:56 AM EDT
Completed Not applicable Interventional Results available

Facilitating Aftercare for Alcohol Detox Patients

NCT00513708
View directory record Official record
Conditions
Alcohol Abuse, Alcohol Dependence
Interventions
Motivation Enhancement Therapy (MET), Peer-Twelve Step Facilitation (P-TSF)
Behavioral
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Oct 14, 2020 · Synced Oct 15, 2026, 6:56 AM EDT
Completed Not applicable Interventional Results available

Remotely-Delivered Benefits Counseling for Service Connection Applicants

NCT02677428
View directory record Official record
Conditions
Job Satisfaction, Unemployment
Interventions
Remotely-Delivered Benefits Counseling, Control
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 64 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
2
States / cities
West Haven, Connecticut • Leeds, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 20, 2020 · Synced Oct 15, 2026, 6:56 AM EDT
Completed Not applicable Interventional Results available

Skills Based Counseling for Adherence and Depression in HIV+ Methadone Patients - 1

NCT00218634
View directory record Official record
Conditions
Adherence, Depression, Heroin Dependence, Methadone, Motivational Interviewing, Substance-Related Disorders
Interventions
CBT-AD, ETAU
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 2, 2018 · Synced Oct 15, 2026, 6:56 AM EDT
Active, not recruiting Not applicable Interventional

Stand Down-Think Before You Drink: An RCT of a Mobile App for Hazardous Drinking With Peer Phone Support

NCT05473598
View directory record Official record
Conditions
Alcoholism
Interventions
Stand Down app, Peer-Supported Stand Down, Usual Care
Behavioral · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Enrollment
234 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
2
States / cities
Palo Alto, California • Syracuse, New York
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced Oct 15, 2026, 6:56 AM EDT
Terminated Not applicable Interventional

Adjunctive Psychotherapy for Perinatal Bipolar Disorder

NCT02402738
View directory record Official record
Conditions
Bipolar Disorder
Interventions
Interpersonal and Social Rhythm Therapy, Enhanced Treatment as Usual
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years and older · Female only
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jan 16, 2019 · Synced Oct 15, 2026, 6:56 AM EDT
Completed Not applicable Interventional

Improving Activity and Quality of Life Following Orthopaedic Trauma: The Trauma Collaborative Care Study (TCCS)

NCT01907893
View directory record Official record
Conditions
Severe Orthopedic Trauma
Interventions
Trauma Collaborative Care Plus Treatment as Usual
Behavioral
Lead sponsor
Major Extremity Trauma Research Consortium
Other
Eligibility
18 Years to 60 Years
Enrollment
900 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
13
States / cities
Denver, Colorado • Tampa, Florida • Indianapolis, Indiana + 9 more
Source: ClinicalTrials.gov public record
Updated Apr 18, 2017 · Synced Oct 15, 2026, 6:56 AM EDT
Completed Not applicable Interventional Results available

Pilot of Mindfulness Oriented Recovery Enhancement in MethadoneTreatment

NCT03894501
View directory record Official record
Conditions
Opioid Use, Chronic Pain
Interventions
Mindfulness Oriented Recovery Enhancement, Methadone program behavioral treatment as usual
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Jan 11, 2022 · Synced Oct 15, 2026, 6:56 AM EDT
Completed Not applicable Interventional

SmartCare: Innovations in Caregiving Interventions

NCT02058745
View directory record Official record
Conditions
Primary Malignant Brain Tumors
Interventions
CAU+ (Enhanced Care as Usual), Beating the Blues, SmartCare
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
21 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 29, 2017 · Synced Oct 15, 2026, 6:56 AM EDT
Recruiting Not applicable Interventional

Leveraging Adult Protective Service Interaction to Offer Evidence-Based Treatment for Depression in Elder Neglect/Self Neglect

NCT06910267
View directory record Official record
Conditions
Depression in Old Age
Interventions
APS Treatment as Usual, Intervention-Behavioral Activation (BA)
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
65 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Oct 15, 2026, 6:56 AM EDT
Completed Not applicable Interventional

Optimizing Suicide Prevention Strategies for Pediatric Primary Care

NCT06194331
View directory record Official record
Conditions
Suicidal Ideation, Suicidal and Self-injurious Behavior, Depression
Interventions
iCHART/cASAP, Treatment as usual
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
12 Years to 17 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Itasca, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Oct 15, 2026, 6:56 AM EDT
Recruiting Not applicable Interventional

A Toolkit to Improve Mental Health Treatment for Autistic Individuals

NCT07539519
View directory record Official record
Conditions
Autism, Mental Health Conditions
Interventions
Enhanced Psychotherapy, Treatment as Usual (TAU)
Behavioral
Lead sponsor
Florida International University
Other
Eligibility
13 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jul 10, 2026 · Synced Oct 15, 2026, 6:56 AM EDT
Not yet recruiting Phase 2 Interventional

Health Coaching and Veteran Reintegration

NCT07725536
View directory record Official record
Conditions
Reintegration Into Civilian Life
Interventions
Health Coaching, Enhanced treatment as usual
Behavioral · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
398 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2030
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jul 24, 2026 · Synced Oct 15, 2026, 6:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Skills to Enhance Positivity in Young Adults

NCT06621992
View directory record Official record
Conditions
Positive Affect, Mindfulness, Gratitude, Savoring, Depression
Interventions
Skills to Enhance Positivity, Treatment as Usual
Other
Lead sponsor
Rhode Island Hospital
Other
Eligibility
18 Years to 26 Years
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced Oct 15, 2026, 6:56 AM EDT
Recruiting Not applicable Interventional

Project STRONGER: Stepped Care for Opioid Use Disorder Treatment Engagement and Recovery

NCT07115030
View directory record Official record
Conditions
Opioid Use Disorder, Intimate Partner Violence (IPV), Post Traumatic Stress Disorder PTSD
Interventions
PCT+2HOPE
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older · Female only
Enrollment
532 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
3
States / cities
Bridgeport, Connecticut • Enfield, Connecticut • West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Oct 15, 2026, 6:56 AM EDT
Completed Not applicable Interventional Results available

Management of Chronic Low Back Pain in Older Adults Using Auricular Point Acupressure

NCT03589703
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Target ear points related to chronic low back pain (T-APA), Non-Target ear Points not related to chronic low back pain (NT-APA), Enhanced Educational Control Group (CG-2)
Other
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
60 Years and older
Enrollment
272 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
2
States / cities
Baltimore, Maryland • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 24, 2024 · Synced Oct 15, 2026, 6:56 AM EDT