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ClinicalTrials.gov public records Last synced Oct 3, 2026, 6:19 PM EDT

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Showing 1–24 of 39 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Epigallocatechin gallate (EGCG) Clear all
Completed Phase 1 Interventional

Defined Green Tea Catechin Extract in Treating Women With Hormone Receptor Negative Stage I-III Breast Cancer

NCT00516243
View directory record Official record
Conditions
Estrogen Receptor-negative Breast Cancer, Progesterone Receptor-negative Breast Cancer, Stage I Breast Cancer, Stage II Breast Cancer, Stage IIIA Breast Cancer, Stage IIIB Breast Cancer
Interventions
placebo, quality-of-life assessment, questionnaire administration, laboratory biomarker analysis, defined green tea catechin extract
Other · Procedure · Drug
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
21 Years to 65 Years · Female only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
4
States / cities
New York, New York • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 12, 2014 · Synced Oct 3, 2026, 6:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Gut-brain Axis in Food Reward and Alcohol Consumption

NCT01902069
View directory record Official record
Conditions
Impulsivity, Alcohol Consumption
Interventions
Phospholean, Placebo
Dietary Supplement
Lead sponsor
Yale University
Other
Eligibility
21 Years to 45 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 3, 2020 · Synced Oct 3, 2026, 6:19 PM EDT
Completed Phase 1 Interventional

Collagen-targeted Positron Emission Tomography (PET) Imaging for Assessment of EGCG Effect

NCT06265532
View directory record Official record
Conditions
Idiopathic Pulmonary Fibrosis
Interventions
EGCG 300 mg, Placebo for EGCG 300 mg, EGCG 600 mg, Placebo for EGCG 600 mg
Drug
Lead sponsor
Hal Chapman
Other
Eligibility
40 Years to 85 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
3
States / cities
Boston, Massachusetts • Ann Arbor, Michigan • Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Oct 3, 2026, 6:19 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Salivary Interactions With Chemosensations

NCT03883880
View directory record Official record
Conditions
Diet, Food Choice, Taste
Interventions
Epigallocatechin gallate, Epigallocatechin gallate control, Linoleic acid, Linoleic acid control, Capsaicin solution, Capsaicin control
Other
Lead sponsor
Purdue University
Other
Eligibility
18 Years to 45 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated May 25, 2023 · Synced Oct 3, 2026, 6:19 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Efficacy of a Tea Catechin Sports Drink for Enhancing Exercise-Induced Fat Loss

NCT00692731
View directory record Official record
Conditions
Overweight, Obesity
Interventions
500 mL/day of a beverage providing approximately 625 mg catechins, Control beverage matched for energy and caffeine content
Dietary Supplement · Other
Lead sponsor
Provident Clinical Research
Other
Eligibility
21 Years to 65 Years
Enrollment
132 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
2
States / cities
St. Petersburg, Florida • Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 6, 2008 · Synced Oct 3, 2026, 6:19 PM EDT
Active, not recruiting Phase 3 Interventional

FRIEND: Fibroids and Unexplained Infertility Treatment With Epigallocatechin Gallate; A Natural CompounD in Green Tea

NCT05364008
View directory record Official record
Conditions
Leiomyoma, Uterine
Interventions
Green Tea Extract, Placebo
Drug · Other
Lead sponsor
Yale University
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
4
States / cities
New Haven, Connecticut • Chicago, Illinois • Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Oct 3, 2026, 6:19 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Green Tea Extract (Polyphenon E) in Preventing Cancer in Healthy Participants

NCT00091325
View directory record Official record
Conditions
Unspecified Adult Solid Tumor, Protocol Specific
Interventions
defined green tea catechin extract
Dietary Supplement
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2004
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Jan 20, 2010 · Synced Oct 3, 2026, 6:19 PM EDT
Completed Phase 2 Interventional Results available

Green Tea Extract in Preventing Cervical Cancer in Patients With Human Papillomavirus and Low-Grade Cervical Intraepithelial Neoplasia

NCT00303823
View directory record Official record
Conditions
Cervical Cancer, Cervical Intraepithelial Neoplasia Grade 1, Human Papilloma Virus Infection
Interventions
placebo, defined green tea catechin extract, laboratory biomarker analysis
Drug · Dietary Supplement · Other
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years and older · Female only
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2011
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated May 5, 2015 · Synced Oct 3, 2026, 6:19 PM EDT
Completed Early Phase 1 Interventional

Chemopreventive Effects of Epigallocatechin Gallate (EGCG) in Colorectal Cancer (CRC) Patients

NCT02891538
View directory record Official record
Conditions
Colon Cancer
Interventions
Epigallocatechin gallate (EGCG)
Drug
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2025
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Oct 3, 2026, 6:19 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Green Tea and Reduction of Breast Cancer Risk

NCT00917735
View directory record Official record
Conditions
Breast Cancer
Interventions
Green tea extract supplement, Placebo
Drug · Other
Lead sponsor
University of Minnesota
Other
Eligibility
50 Years to 70 Years · Female only
Enrollment
1,075 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2014
U.S. locations
5
States / cities
Edina, Minnesota • Maple Grove, Minnesota • Minneapolis, Minnesota + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 22, 2016 · Synced Oct 3, 2026, 6:19 PM EDT
Completed Phase 1 Interventional

Defined Green Tea Catechins in Treating Patients With Prostate Cancer Undergoing Surgery to Remove the Prostate

NCT00459407
View directory record Official record
Conditions
Adenocarcinoma of the Prostate, Stage I Prostate Cancer, Stage II Prostate Cancer
Interventions
defined green tea catechin extract, placebo, immunohistochemistry staining method, immunoenzyme technique, laboratory biomarker analysis, biopsy, mass spectrometry, high performance liquid chromatography
Dietary Supplement · Drug · Other + 1 more
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years and older · Male only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Oct 8, 2014 · Synced Oct 3, 2026, 6:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Gut-brain Axis: a Novel Target for Treating Behavioral Alterations in Obesity

NCT01976156
View directory record Official record
Conditions
Neural Response in Caudate, Weight Loss Trial, Impulsivity
Interventions
PhosphoLean, Placebo
Dietary Supplement
Lead sponsor
Yale University
Other
Eligibility
18 Years to 45 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 27, 2018 · Synced Oct 3, 2026, 6:19 PM EDT
Completed Phase 1 Interventional Results available

Study to Evaluate Safety and Toxicity of Polyphenon E (EGCG) in HIV-1-Infected Individuals

NCT01433289
View directory record Official record
Conditions
HIV Infection
Interventions
Polyphenon E, Placebo
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 65 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
2
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 19, 2023 · Synced Oct 3, 2026, 6:19 PM EDT
Completed Phase 2 Interventional Results available

Reducing Frailty for Older Cancer Survivors Using Supplements

NCT04553666
View directory record Official record
Conditions
Frailty, Inflammation
Interventions
Epigallocatechin-3-Gallate (EGCG) plus Ascorbic Acid (Vitamin C)
Drug
Lead sponsor
University of Rochester
Other
Eligibility
65 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Oct 3, 2026, 6:19 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

LEAN Project: Weight Loss and Appetite Suppression

NCT00153790
View directory record Official record
Conditions
Weight Loss
Interventions
PhosphoLean
Drug
Lead sponsor
The Cooper Institute
Other
Eligibility
30 Years to 45 Years · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2006
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 13, 2014 · Synced Oct 3, 2026, 6:19 PM EDT
Terminated Phase 2 Interventional

Green Tea Extract: a Non-Surgical Alternative for Treatment of Uterine Fibroids

NCT01311869
View directory record Official record
Conditions
Leiomyoma
Interventions
EGCG ( Green Tea extract), Brown rice pills
Dietary Supplement
Lead sponsor
Meharry Medical College
Other
Eligibility
18 Years and older · Female only
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 24, 2013 · Synced Oct 3, 2026, 6:19 PM EDT
Active, not recruiting Phase 2 Interventional

Clinical Trial of Green Tea Catechins in Men on Active Surveillance

NCT04300855
View directory record Official record
Conditions
Prostate Cancer, Prostate Adenocarcinoma
Interventions
Sunphenon, Placebo
Drug
Lead sponsor
H. Lee Moffitt Cancer Center and Research Institute
Other
Eligibility
18 Years and older · Male only
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
2
States / cities
Tampa, Florida • Westwood, Kansas
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Oct 3, 2026, 6:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Acute Effects of Fitness Drink Formulas on Energy Expenditure and Fat Metabolism

NCT04455009
View directory record Official record
Conditions
Caffeine, Diet, Healthy, Fat Burn, Cognitive Change, Fatigue
Interventions
Fitness Drink Formula
Dietary Supplement
Lead sponsor
University of Central Florida
Other
Eligibility
18 Years to 35 Years
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Jul 2, 2020 · Synced Oct 3, 2026, 6:19 PM EDT
Completed Phase 1 Interventional

Defined Green Tea Catechin Extract in Preventing Esophageal Cancer in Patients With Barrett's Esophagus

NCT00233935
View directory record Official record
Conditions
Barrett Esophagus
Interventions
placebo, defined green tea catechin extract
Other · Drug
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
3
States / cities
New York, New York • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 11, 2014 · Synced Oct 3, 2026, 6:19 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Fibroblast Specific Inhibition of LOXL2 and TGFbeta1 Signaling in Patients With Pulmonary Fibrosis.

NCT03928847
View directory record Official record
Conditions
Idiopathic Pulmonary Fibrosis
Interventions
Epigallocatechin-3-gallate (EGCG)
Drug
Lead sponsor
Hal Chapman
Other
Eligibility
40 Years to 70 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Dec 22, 2022 · Synced Oct 3, 2026, 6:19 PM EDT
Completed Phase 2 Interventional Results available

Green Tea Extract and Prostate Cancer

NCT00676780
View directory record Official record
Conditions
Prostate Cancer
Interventions
Polyphenon E (EGCG)
Drug
Lead sponsor
Louisiana State University Health Sciences Center Shreveport
Other
Eligibility
18 Years to 75 Years · Male only
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
1
States / cities
Shreveport, Louisiana
Source: ClinicalTrials.gov public record
Updated Aug 8, 2012 · Synced Oct 3, 2026, 6:19 PM EDT
Recruiting Phase 2 Interventional

EGCG for Hepatocellular Carcinoma Chemoprevention

NCT06015022
View directory record Official record
Conditions
Cirrhosis, Liver
Interventions
Epigallocatechin gallate (EGCG), Placebo
Drug · Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 5, 2025 · Synced Oct 3, 2026, 6:19 PM EDT
Withdrawn Phase 2 Interventional Accepts healthy volunteers

Effect of EGCG on the Body's Response to Insulin

NCT00434499
View directory record Official record
Conditions
Hypertension, Obesity, Type 2 Diabetes, Insulin Resistance
Interventions
EGCG
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
21 Years to 65 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2015
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2022 · Synced Oct 3, 2026, 6:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

An Exploratory Investigation of a Supplement to Promote Brain Health

NCT05520424
View directory record Official record
Conditions
Memory Deficits, Cognitive Change, Stress
Interventions
The Daily Supplement
Dietary Supplement
Lead sponsor
Parable
Industry
Eligibility
30 Years to 60 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Apr 3, 2024 · Synced Oct 3, 2026, 6:19 PM EDT