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Showing 1–20 of 20 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Epigallocatechin gallate control Clear all
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Curcumin and EGCG Supplementation to Improve Serum BDNF and Mood Disturbance

NCT06531863
View directory record Official record
Conditions
Mood Disturbance
Interventions
Curcumin, Epigallocatechin Gallate, Placebo
Dietary Supplement · Other
Lead sponsor
Auburn University
Other
Eligibility
18 Years to 50 Years
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Auburn, Alabama
Source: ClinicalTrials.gov public record
Updated Feb 13, 2025 · Synced Sep 28, 2026, 8:26 PM EDT
Suspended Phase 2 Interventional

Reducing Frailty for Older Cancer Survivors Using Supplements II

NCT06068543
View directory record Official record
Conditions
Frailty, Inflammation
Interventions
Epigallocatechin-3-Gallate (EGCG), Microcrystalline cellulose (MCC), Ascorbic Acid (Vitamin C)
Drug · Dietary Supplement
Lead sponsor
University of Rochester
Other
Eligibility
65 Years and older
Enrollment
118 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2030
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Sep 28, 2026, 8:26 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Efficacy of a Tea Catechin Sports Drink for Enhancing Exercise-Induced Fat Loss

NCT00692731
View directory record Official record
Conditions
Overweight, Obesity
Interventions
500 mL/day of a beverage providing approximately 625 mg catechins, Control beverage matched for energy and caffeine content
Dietary Supplement · Other
Lead sponsor
Provident Clinical Research
Other
Eligibility
21 Years to 65 Years
Enrollment
132 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
2
States / cities
St. Petersburg, Florida • Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 5, 2008 · Synced Sep 28, 2026, 8:26 PM EDT
Completed Phase 2 Interventional Results available

Green Tea Extract in Treating Patients With Nonmetastatic Bladder Cancer

NCT00666562
View directory record Official record
Conditions
Stage I Bladder Cancer, Stage II Bladder Cancer, Stage III Bladder Cancer
Interventions
Defined Green Tea Catechin Extract, Laboratory Biomarker Analysis, Pharmacological Study, Placebo, Therapeutic Conventional Surgery
Dietary Supplement · Other · Drug + 1 more
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2017
U.S. locations
6
States / cities
Birmingham, Alabama • Burlington, Massachusetts • Minneapolis, Minnesota + 3 more
Source: ClinicalTrials.gov public record
Updated Nov 16, 2017 · Synced Sep 28, 2026, 8:26 PM EDT
Completed Phase 1 Interventional Results available

Study to Evaluate Safety and Toxicity of Polyphenon E (EGCG) in HIV-1-Infected Individuals

NCT01433289
View directory record Official record
Conditions
HIV Infection
Interventions
Polyphenon E, Placebo
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 65 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
2
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 18, 2023 · Synced Sep 28, 2026, 8:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Absorption, Metabolism and Excretion of Dietary Polyphenolic Bioactives in Humans

NCT03194620
View directory record Official record
Conditions
Healthy
Interventions
Thearubigins, Theaflavins, Procyanidin Dimer B2 (DB2), (-)-Epigallocatechin-3-O-gallate (EGCG), (-)-Epicatechin-3-O-gallate (ECG), (-)-Epicatechin (EC), (-)-Epigallocatechin (EGC), Control
Other
Lead sponsor
University of California, Davis
Other
Eligibility
25 Years to 60 Years · Male only
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Nov 5, 2017 · Synced Sep 28, 2026, 8:26 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Fibroblast Specific Inhibition of LOXL2 and TGFbeta1 Signaling in Patients With Pulmonary Fibrosis.

NCT03928847
View directory record Official record
Conditions
Idiopathic Pulmonary Fibrosis
Interventions
Epigallocatechin-3-gallate (EGCG)
Drug
Lead sponsor
Hal Chapman
Other
Eligibility
40 Years to 70 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Dec 21, 2022 · Synced Sep 28, 2026, 8:26 PM EDT
Terminated Phase 2 Interventional Results available

Safety and Neuroprotective Effects of Polyphenon E in MS; Phase II

NCT01451723
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
Polyphenon E, Placebo
Drug · Other
Lead sponsor
Louisiana State University Health Sciences Center in New Orleans
Other
Eligibility
18 Years to 60 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Mar 13, 2014 · Synced Sep 28, 2026, 8:26 PM EDT
Completed Phase 1 Interventional

Defined Green Tea Catechin Extract in Preventing Esophageal Cancer in Patients With Barrett's Esophagus

NCT00233935
View directory record Official record
Conditions
Barrett Esophagus
Interventions
placebo, defined green tea catechin extract
Other · Drug
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
3
States / cities
New York, New York • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 10, 2014 · Synced Sep 28, 2026, 8:26 PM EDT
Terminated Phase 2 Interventional

Defined Green Tea Catechin Extract in Treating Patients With Localized Prostate Cancer Undergoing Surgery

NCT01340599
View directory record Official record
Conditions
Stage I Prostate Cancer, Stage IIA Prostate Cancer, Stage IIB Prostate Cancer
Interventions
defined green tea catechin extract, placebo, immunohistochemistry staining method, immunoenzyme technique, questionnaire administration, therapeutic conventional surgery, high performance liquid chromatography, mass spectrometry
Dietary Supplement · Other · Procedure
Lead sponsor
Case Comprehensive Cancer Center
Other
Eligibility
45 Years to 75 Years · Male only
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 14, 2012 · Synced Sep 28, 2026, 8:26 PM EDT
Terminated Phase 2 Interventional

Green Tea Extract: a Non-Surgical Alternative for Treatment of Uterine Fibroids

NCT01311869
View directory record Official record
Conditions
Leiomyoma
Interventions
EGCG ( Green Tea extract), Brown rice pills
Dietary Supplement
Lead sponsor
Meharry Medical College
Other
Eligibility
18 Years and older · Female only
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 23, 2013 · Synced Sep 28, 2026, 8:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Gut-brain Axis in Food Reward and Alcohol Consumption

NCT01902069
View directory record Official record
Conditions
Impulsivity, Alcohol Consumption
Interventions
Phospholean, Placebo
Dietary Supplement
Lead sponsor
Yale University
Other
Eligibility
21 Years to 45 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 2, 2020 · Synced Sep 28, 2026, 8:26 PM EDT
Completed Phase 2 Interventional Results available

Reducing Frailty for Older Cancer Survivors Using Supplements

NCT04553666
View directory record Official record
Conditions
Frailty, Inflammation
Interventions
Epigallocatechin-3-Gallate (EGCG) plus Ascorbic Acid (Vitamin C)
Drug
Lead sponsor
University of Rochester
Other
Eligibility
65 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Sep 28, 2026, 8:26 PM EDT
Recruiting Phase 2 Interventional

EGCG for Hepatocellular Carcinoma Chemoprevention

NCT06015022
View directory record Official record
Conditions
Cirrhosis, Liver
Interventions
Epigallocatechin gallate (EGCG), Placebo
Drug · Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 4, 2025 · Synced Sep 28, 2026, 8:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Gut-brain Axis: a Novel Target for Treating Behavioral Alterations in Obesity

NCT01976156
View directory record Official record
Conditions
Neural Response in Caudate, Weight Loss Trial, Impulsivity
Interventions
PhosphoLean, Placebo
Dietary Supplement
Lead sponsor
Yale University
Other
Eligibility
18 Years to 45 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 26, 2018 · Synced Sep 28, 2026, 8:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Fish Oil and Green Tea Extract in Preventing Prostate Cancer in Patients Who Are at Risk for Developing Prostate Cancer

NCT00253643
View directory record Official record
Conditions
Precancerous Condition, Prostate Cancer
Interventions
green tea catechin extract, fish oil, placebo
Dietary Supplement · Other
Lead sponsor
OHSU Knight Cancer Institute
Other
Eligibility
21 Years to 120 Years · Male only
Enrollment
89 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2013
U.S. locations
3
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Apr 17, 2017 · Synced Sep 28, 2026, 8:26 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Green Tea and Reduction of Breast Cancer Risk

NCT00917735
View directory record Official record
Conditions
Breast Cancer
Interventions
Green tea extract supplement, Placebo
Drug · Other
Lead sponsor
University of Minnesota
Other
Eligibility
50 Years to 70 Years · Female only
Enrollment
1,075 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2014
U.S. locations
5
States / cities
Edina, Minnesota • Maple Grove, Minnesota • Minneapolis, Minnesota + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 21, 2016 · Synced Sep 28, 2026, 8:26 PM EDT
Completed Phase 1 Interventional

Defined Green Tea Catechin Extract in Treating Women With Hormone Receptor Negative Stage I-III Breast Cancer

NCT00516243
View directory record Official record
Conditions
Estrogen Receptor-negative Breast Cancer, Progesterone Receptor-negative Breast Cancer, Stage I Breast Cancer, Stage II Breast Cancer, Stage IIIA Breast Cancer, Stage IIIB Breast Cancer
Interventions
placebo, quality-of-life assessment, questionnaire administration, laboratory biomarker analysis, defined green tea catechin extract
Other · Procedure · Drug
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
21 Years to 65 Years · Female only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
4
States / cities
New York, New York • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 11, 2014 · Synced Sep 28, 2026, 8:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Slowly Digestible Carbohydrates on the Gut-brain Axis

NCT05349903
View directory record Official record
Conditions
Appetitive Behavior, Obesity, Diabetes Mellitus, Type 2
Interventions
Rice flour, Alternanoligosaccharide 15, Inulin, Waxy potato starch, Waxy potato starch + epigallocatechin gallate (EGCG), Chickpea flour + epigallocatechin gallate (EGCG)
Other
Lead sponsor
Purdue University
Other
Eligibility
22 Years to 45 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated Apr 26, 2022 · Synced Sep 28, 2026, 8:26 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Salivary Interactions With Chemosensations

NCT03883880
View directory record Official record
Conditions
Diet, Food Choice, Taste
Interventions
Epigallocatechin gallate, Epigallocatechin gallate control, Linoleic acid, Linoleic acid control, Capsaicin solution, Capsaicin control
Other
Lead sponsor
Purdue University
Other
Eligibility
18 Years to 45 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated May 24, 2023 · Synced Sep 28, 2026, 8:26 PM EDT