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ClinicalTrials.gov public records Last synced Nov 5, 2026, 8:46 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 343 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Epinephrine injection Clear all

Conditions: Pain
Interventions: Placebo, Liposomal bupivacaine; Drug
Lead sponsor: TriHealth Inc.; Other
Eligibility: 18 Years and older · Female only
Enrollment: 18 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Pain
Interventions: Slow, Room Temperature Injection, Rapid, Room Temperature Injection, Slow, Warm Temperature Injection, Rapid, Warm Temperature Injection, Buffered Injection, Non-Buffered Injection, Lidocaine, Buffer; Procedure · Drug
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years to 89 Years
Enrollment: 26 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2025
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Shoulder Arthroplasty
Interventions: Liposomal bupivacaine, Bupivacaine with adjuvants; Drug
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Breast Cancer, Postoperative Pain
Interventions: Liposomal bupivacaine, Bupivacaine with epinephrine, Morphine sulfate, Hydrocodone/acetaminophen, Diazepam; Drug
Lead sponsor: Loma Linda University; Other
Eligibility: 18 Years to 99 Years · Female only
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Loma Linda, California

Conditions: Giant Cell Arteritis
Interventions: Tocilizumab, Prednisone, Tocilizumab Placebo, Prednisone Placebo, Corticosteroids, Methotrexate; Drug
Lead sponsor: Hoffmann-La Roche; Industry
Eligibility: 50 Years and older
Enrollment: 251 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2018
U.S. locations: 14
States / cities: Los Angeles, California • Boca Raton, Florida • Sarasota, Florida + 10 more

Conditions: Pain, Osteoarthritis
Interventions: Canal Block and Capsular Injection, Femoral with Tibial Nerve Block; Procedure
Lead sponsor: Trinity Health Of New England; Other
Eligibility: 18 Years to 80 Years
Enrollment: 56 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013
U.S. locations: 1
States / cities: Hartford, Connecticut

Conditions: Septic Shock
Interventions: Hydrocortisone, sodium succinate, Normal saline; Drug
Lead sponsor: Jerry Zimmerman; Other
Eligibility: 1 Month to 17 Years
Enrollment: 500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2026
U.S. locations: 18
States / cities: Tucson, Arizona • Los Angeles, California • Oakland, California + 15 more

Conditions: Sleep Restriction
Interventions: Ketoconazole Pill, Ganirelix, Dexamethasone, Dexamethasone Injection, Cosyntropin Injectable Product, Recombinant Human Luteinizing Hormone, Hydrocortisone Injection, Gonadorelin, Corticorelin, Placebo oral capsule, Saline Solution, Saline Solution for Injection; Drug
Lead sponsor: Peter y. Liu; Other
Eligibility: 22 Years to 45 Years · Male only
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2026
U.S. locations: 1
States / cities: Torrance, California

Conditions: Video-Assisted Thoracic Surgery, Video-Assisted Thoracoscopic Surgery
Interventions: Normal Saline, Ropivacaine, Epinephrine, Dexamethasone; Drug
Lead sponsor: University at Buffalo; Other
Eligibility: 18 Years to 85 Years
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2022
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Chronic Rhinosinusitis (Diagnosis)
Interventions: Bupivacaine or Ropivacaine with epinephrine plus dexamethasone - Group 1, Bupivacaine or Ropivacaine with epinephrine plus dexamethasone - Group 2; Drug
Lead sponsor: University of Florida; Other
Eligibility: 18 Years to 90 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2026
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Trauma, Trauma Injury, Pain, Acute
Interventions: Bupivacaine Liposome Injection, Bupivacaine; Drug
Lead sponsor: Chadrick Evans; Other
Eligibility: 18 Years and older
Enrollment: 258 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: Peoria, Illinois

Conditions: Knee Osteoarthritis
Interventions: Microfragmented Adipose Tissue (Lipogems), Corticosteroid injection, Saline; Device · Drug
Lead sponsor: Dustin L. Richter, MD; Other
Eligibility: 18 Years and older
Enrollment: 75 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2023
U.S. locations: 1
States / cities: Albuquerque, New Mexico

Conditions: Kidney Transplantation
Interventions: CFZ533 - Cohort 1/Cohort 2, Mycophenolate Mofetil (MMF), Corticosteroids (CS), Tacrolimus, Induction therapy: basiliximab, Induction therapy: rabbit anti-thymocyte globulin (rATG), Maintenance population: EC-MPS, Maintenance population: MMF, Placebo 1 mL; Biological · Drug
Lead sponsor: Novartis Pharmaceuticals; Industry
Eligibility: 18 Years and older
Enrollment: 418 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 15
States / cities: Los Angeles, California • San Francisco, California • Aurora, Colorado + 10 more

Conditions: Subacromial Impingement Syndrome, Partial Thickness Rotator Cuff Tear
Interventions: platelet rich plasma injection, corticosteroid injection; Biological · Drug
Lead sponsor: Loma Linda University; Other
Eligibility: 18 Years to 89 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Loma Linda, California

Conditions: Fasciitis, Plantar
Interventions: ReNu Injection, Corticosteroid Injection; Other
Lead sponsor: NuTech Medical, Inc; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2021
U.S. locations: 6
States / cities: Denver, Colorado • Orlando, Florida • West Des Moines, Iowa + 3 more

Conditions: Pelvic Girdle Pain
Interventions: Corticosteroid, Placebo Injection; Drug
Lead sponsor: Loyola University; Other
Eligibility: 21 Years to 50 Years · Female only
Enrollment: 2 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: Maywood, Illinois

Conditions: Pain, Postoperative
Interventions: Liposomal bupivacaine, Bupivacaine Injection, Placebo; Drug
Lead sponsor: Cooper Norcross Health; Other
Eligibility: 18 Years to 75 Years
Enrollment: 90 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Camden, New Jersey

Conditions: Low Back Pain
Interventions: Intra-articular corticosteroid injection, Intra-articular saline injection; Drug
Lead sponsor: University of Florida; Other
Eligibility: 45 Years to 90 Years
Enrollment: 28 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Overactive Bladder, Overactive Bladder Syndrome, Urinary Urgency, Urinary Frequency, Urge Incontinence, Neurogenic Bladder
Interventions: Lidocaine 2% without vessel constrictor; Drug
Lead sponsor: University of Louisville; Other
Eligibility: 18 Years and older · Female only
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Louisville, Kentucky

Conditions: Post Operative Pain, Spinal Fusion
Interventions: Bupivacaine liposome injectable suspension, Bupivacaine Hydrochloride and Epinephrine Injection; Drug
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 10 Years to 17 Years
Enrollment: 128 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Distribution of Ropivacaine in Erector Spinae Plane Block
Interventions: Ropivacaine, Epinephrine; Drug
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 18 Years to 60 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: Hershey, Pennsylvania

Conditions: Trigger Point Pain, Myofascial
Interventions: Trigger point injection (lidocaine), Sham Comparator; Drug · Other
Lead sponsor: David Grant U.S. Air Force Medical Center; Federal
Eligibility: 45 Years and older
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025
U.S. locations: 1
States / cities: Fairfield, California

Conditions: Osteoarthritis, Hip
Interventions: Dexamethasone, Bupivacaine, Epinephrine, Lumbar Plexus Nerve Block, Saline; Drug · Procedure
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years to 90 Years
Enrollment: 115 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Polymyalgia Rheumatica
Interventions: ABBV-154, Placebo, Glucocorticoid; Drug
Lead sponsor: AbbVie; Industry
Eligibility: 50 Years and older
Enrollment: 181 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 31
States / cities: Jonesboro, Arkansas • Fullerton, California • Huntington Beach, California + 28 more

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Impact of Liposomal Bupivacaine Administered Following Placement of a Transobturator Suburethral Sling

Pain Perception: Lidocaine Rate/Temp/Buffer

Interscalene Block With Liposomal Bupivacaine vs. Interscalene Block With Bupivacaine and Adjuvants

Liposomal Bupivacaine in Implant Based Breast Reconstruction

An Efficacy and Safety Study of Tocilizumab (RoActemra/Actemra) in Participants With Giant Cell Arteritis (GCA)

Adductor Canal Block With Posterior Capsular Injection for Total Knee Replacement

Stress Hydrocortisone In Pediatric Septic Shock

Hormonal Mechanisms of Sleep Restriction - Axis Study

Optimal Timing of Intercostal Nerve Blocks During Video-Assisted Thoracic Surgeries

Functional Endoscopic Sinus Surgery Study

Liposomal Bupivacaine Intercostal Nerve Block vs Thoracic Epidural for Regional Analgesia in Multiple Rib Fractures

Efficacy of Micro-fragmented Adipose Tissue Injection for Knee Osteoarthritis.

Study of Efficacy, Safety, Tolerability, Pharmacokinetic (PK) and Pharmacodynamic (PD) of an Anti-CD40 Monoclonal Antibody, CFZ533, in Kidney Transplant Recipients

Treatment of the Rotator Cuff Disease With Platelet Rich Plasma Injection

ReNu™ vs. Corticosteroids for the Treatment of Plantar Fasciitis

Ultrasound Guided Posterior Sacroiliac Ligament Corticosteroid Injection in Pregnancy-Related Pelvic Girdle Pain

Does a ThoracoLumbar Interfacial Plane (TLIP) Block With Liposomal Bupivacaine Provide TLIP Block in Spinal Surgery

Intraarticular Lumbar Joint Corticosteroid Injection(s) as a Treatment of Chronic Low Back Pain in a Selected Population

Optimal Intravesical Lidocaine Volume for Pain Relief During Office Intra-detrusor Onabotulinum Toxin a Injections

Postoperative Pain Control in AIS Using Liposomal Bupivacaine vs. 0.25% Bupivacaine With Epinephrine

Distribution, Pharmacokinetics and Extent of Sensory Blockade in ESP Blocks

Trigger Point Injection in Reducing Pain Following Total Knee Arthroplasty

Systemic Steroids for Peripheral Nerve Blocks

A Study to Evaluate the Change in Disease State and Adverse Events in Adult Participants With Polymyalgia Rheumatica (PMR) Dependent on Glucocorticoid Treatment, Receiving Subcutaneous Injections of ABBV-154