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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Essential Oil 1 Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Commercial "Sleep Lotion" on Salivary Melatonin Levels and Sleep Quality in Undergraduates

NCT06053385
View directory record Official record
Conditions
Sleep
Interventions
Melatonin sleep lotion, Placebo control lotion
Other
Lead sponsor
University of Redlands
Other
Eligibility
18 Years to 24 Years
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Redlands, California
Source: ClinicalTrials.gov public record
Updated Sep 27, 2023 · Synced Sep 24, 2026, 9:23 AM EDT
Completed Phase 2 Interventional Results available

Reduction of Opioid Dose Using Conditioning & Open-Label Placebo (COLP) in Intensive Rehabilitation

NCT03906721
View directory record Official record
Conditions
Spinal Cord Injuries, Polytrauma, Burn Injury, Pain Management
Interventions
Placebo, Oxycodone, Essential Oil
Drug · Other
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 3, 2026 · Synced Sep 24, 2026, 9:23 AM EDT
Completed No phase listed Observational

An Open-label Study Evaluating the Effectiveness of CGB-400 Topical Gel for Fungal Infection

NCT05202366
View directory record Official record
Conditions
Fungal Infection, Onychomycosis, Tinea Unguium
Interventions
CGB-400 Topical Gel
Drug
Lead sponsor
CAGE Bio Inc.
Industry
Eligibility
18 Years to 99 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Sep 24, 2026, 9:23 AM EDT
Completed Not applicable Interventional

Aromatherapy and Essential Oils in Improving Insomnia and Other Symptoms in Patients With Newly Diagnosed Acute Leukemia Undergoing Chemotherapy

NCT02445378
View directory record Official record
Conditions
Acute Leukemia, Anorexia, Anxiety, Depression, Dyspnea, Insomnia, Nausea, Pain
Interventions
Aromatherapy and Essential Oils, Placebo, Questionnaire Administration
Procedure · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
Not listed
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 4, 2019 · Synced Sep 24, 2026, 9:23 AM EDT
Completed Phase 1 Interventional

Nutrition, Neuromuscular Electrical Stimulation (NMES) and Secondary Progressive Multiple Sclerosis (SPMS)

NCT01381354
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
Progressive exercise, Neuromuscular electrical stimulation delivered using the electrical therapy device EMPI 300 PV, Modified paleolithic diet, Omega 3 fatty acids, Full Spectrum vitamin, Essential - hydroxytyrosol, Maltodextrin fiber supplement, Mineral boost (magnesium), Niacinamide, Methyl B12, Taurine, creatine, thiamine, riboflavin, N acetylcysteine, alpha lipoic acid, L acetyl carnitine, methyl folate, coenzyme Q, meditation, self massage, learning, Coconut oil
Other · Device · Dietary Supplement + 1 more
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 65 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jun 25, 2018 · Synced Sep 24, 2026, 9:23 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

My ESSENCE - A Research Study on Mindfulness for African-Americans With Type 2 Diabetes

NCT05208164
View directory record Official record
Conditions
Type 2 Diabetes, Sleep, Stress
Interventions
Mindfunlness Meditation
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
21 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 4, 2025 · Synced Sep 24, 2026, 9:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pharmacokinetics of Essential Oils in Different Capsules

NCT07581522
View directory record Official record
Conditions
Healthy, Health, Subjective
Interventions
Frankinscense Essential Oil Capsule, Lemon Essential Oil Capsule, Wild Orange Essential Oil Capsule
Other
Lead sponsor
University of Mississippi Medical Center
Other
Eligibility
18 Years to 35 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Jackson, Mississippi
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Sep 24, 2026, 9:23 AM EDT
Active, not recruiting Not applicable Interventional

Conditioning & Open-Label Placebo (COLP) for Opioid Management in Intensive Inpatient Rehabilitation

NCT05351333
View directory record Official record
Conditions
Spinal Cord Injuries, Polytrauma, Burns
Interventions
placebo
Other
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 26, 2025 · Synced Sep 24, 2026, 9:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of a Novel Supplement on Glycemic Variability Measured by Continuous Glucose Monitoring

NCT05832463
View directory record Official record
Conditions
Healthy
Interventions
Carbohydrate blocking supplement (CBS), Placebo capsule
Dietary Supplement
Lead sponsor
dōTERRA International
Industry
Eligibility
18 Years to 65 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Pleasant Grove, Utah
Source: ClinicalTrials.gov public record
Updated Apr 26, 2023 · Synced Sep 24, 2026, 9:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Lavender Essential Oil-based Product System for Sleep

NCT06510335
View directory record Official record
Conditions
Healthy
Interventions
Lavender essential oil-based product system
Other
Lead sponsor
dōTERRA International
Industry
Eligibility
35 Years to 50 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Pleasant Grove, Utah
Source: ClinicalTrials.gov public record
Updated Jul 21, 2024 · Synced Sep 24, 2026, 9:23 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Essential Oils for Enhancing QOL in ASD

NCT02543203
View directory record Official record
Conditions
Autism Spectrum Disorder, Quality of Life, Sleep, Anxiety
Interventions
Reconnect, Coconut oil Comparator
Biological
Lead sponsor
Jill Hollway
Other
Eligibility
3 Years to 9 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 31, 2021 · Synced Sep 24, 2026, 9:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Clinical Study to Assess a Dietary Supplement on Sleep Health and Quality

NCT05368909
View directory record Official record
Conditions
Sleep Quality, Sleep Health
Interventions
Sleep Supplement, Placebo
Dietary Supplement
Lead sponsor
4Life Research, LLC
Industry
Eligibility
18 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Sandy City, Utah
Source: ClinicalTrials.gov public record
Updated Jul 11, 2022 · Synced Sep 24, 2026, 9:23 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Efficacy and Safety of Acute Topical and Aromatic Essential Oil-Based Products for Cognitive Support

NCT07623811
View directory record Official record
Conditions
Healthy
Interventions
Placebo, Cognitive Support System
Other
Lead sponsor
dōTERRA International
Industry
Eligibility
18 Years to 64 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Pleasant Grove, Utah
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Sep 24, 2026, 9:23 AM EDT
Withdrawn Not applicable Interventional

Investigating the Effects of Mikei® Red Reishi Essence EX on the Immune System of Prostate Cancer Patients and Patients With Non-cancerous Conditions of the Prostate

NCT03589781
View directory record Official record
Conditions
Prostate Cancer
Interventions
Mikei Red Reishi Essence EX, Placebo
Dietary Supplement
Lead sponsor
Nikkei (Canada) Marketing Limited
Industry
Eligibility
50 Years to 85 Years · Male only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Mar 29, 2021 · Synced Sep 24, 2026, 9:23 AM EDT
Recruiting Phase 4 Interventional

Safety Study of SMOFlipid to Evaluate the Risk of Developing EFAD and/or PNAC in Pediatric and Adult Patients

NCT06049680
View directory record Official record
Conditions
Malnutrition, Child, Malnutrition, Essential Fatty Acid Deficiency (EFAD), Parenteral Nutrition Associated Cholestasis
Interventions
SMOFlipid® (lipid injectable emulsion)
Drug
Lead sponsor
Fresenius Kabi
Industry
Eligibility
1 Month to 17 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
5
States / cities
Atlanta, Georgia • Chicago, Illinois • Indianapolis, Indiana + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Sep 24, 2026, 9:23 AM EDT
Withdrawn Phase 2 Interventional

Coronavirus Smell Therapy for Anosmia Recovery

NCT04422275
View directory record Official record
Conditions
Anosmia
Interventions
Budesonide, High-Concentration Essential Oil, Placebo, Low-Concentration Essential Oil
Drug · Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 85 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 1, 2021 · Synced Sep 24, 2026, 9:23 AM EDT
Recruiting Not applicable Interventional

Virtual Reality and Olfactory Stimuli Multimodal Intervention to Reduce Post-Operative Pain and Anxiety in Patients Undergoing Cardiothoracic Surgery

NCT04912531
View directory record Official record
Conditions
Postoperative Pain, Anxiety Postoperative, Opioid Use
Interventions
Virtual Realty using a Microsoft Hololens, Empatica HR wristband, and EEG, Essence Olfactory Necklace, Bedside Olfaction Device
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Sep 24, 2026, 9:23 AM EDT
Completed Not applicable Interventional

Essential Fatty Acids for Major Depression

NCT00256412
View directory record Official record
Conditions
Major Depression
Interventions
Eicosapentaenoic acid (EPA) 0.7 grams/day or 1.5 grams/day, Placebo
Drug
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 55 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jun 4, 2008 · Synced Sep 24, 2026, 9:23 AM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers Results available

Mouth Rinses for Inactivation of COVID-19

NCT04584684
View directory record Official record
Conditions
Covid19, Coronavirus Infection, SARS-CoV-2 Infection
Interventions
0.9% w/v NaCL Saline, 1.5% w/v Hydrogen Peroxide, 0.12% Chlorohexidine Gluconate, 27% Ethanol plus essential oils, 0.5% w/v Povidone-iodide, 0.075% Cetylpyridinium Chloride
Other · Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 65 Years
Enrollment
128 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 24, 2024 · Synced Sep 24, 2026, 9:23 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Temple Massager System Study in Women Ages 35-65

NCT07639658
View directory record Official record
Conditions
Tension Headaches, Stress, Sleep Quality, Quality of Life
Interventions
Temple Massager System
Device
Lead sponsor
Meisch Temple Massager, Inc.
Industry
Eligibility
35 Years to 65 Years · Female only
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Fairfax, California
Source: ClinicalTrials.gov public record
Updated Sep 22, 2026 · Synced Sep 24, 2026, 9:23 AM EDT
Terminated Early Phase 1 Interventional

Aromatherapy for Chemotherapy-induced Symptoms

NCT02670941
View directory record Official record
Conditions
Chemotherapy Symptoms
Interventions
Ginger, Lavender, Orange, Jojoba
Drug
Lead sponsor
University of Rochester
Other
Eligibility
21 Years to 89 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jan 23, 2019 · Synced Sep 24, 2026, 9:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

An Exploratory Investigation of a CBD Supplement's Impact on Sleep, Stress, and Focus

NCT05518019
View directory record Official record
Conditions
Anxiety, Fear, Stress, Low Mood, Sleep
Interventions
The Daily Supplement
Dietary Supplement
Lead sponsor
Prima CBD
Industry
Eligibility
18 Years to 60 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Aug 30, 2022 · Synced Sep 24, 2026, 9:23 AM EDT
Completed Not applicable Interventional

Nutrient Levels Alter Transplant Outcome

NCT00560014
View directory record Official record
Conditions
Chronic Renal Disease
Interventions
Arginine and canola oil, Coromega and Arginine
Dietary Supplement
Lead sponsor
University of Cincinnati
Other
Eligibility
Not listed
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2005
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 18, 2007 · Synced Sep 24, 2026, 9:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Natural Product System and Lifestyle Modification

NCT06931977
View directory record Official record
Conditions
Healthy
Interventions
Supplement system + copaiba softgels, Supplement system + placebo softgels
Dietary Supplement
Lead sponsor
dōTERRA International
Industry
Eligibility
30 Years to 55 Years
Enrollment
97 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Pleasant Grove, Utah
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Sep 24, 2026, 9:23 AM EDT