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ClinicalTrials.gov public records Last synced Oct 18, 2026, 5:42 AM EDT

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Showing 289–312 of 321 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Exparel Clear all
Completed Phase 4 Interventional Results available

A Randomized Trial of Exparel vs Saline in Opioid Reduction of Pain Management Following Lumbar Spine Surgeries.

NCT04644796
View directory record Official record
Conditions
Lumbar Spine Degeneration
Interventions
saline 0.9%, Liposomal bupivacaine
Drug
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 13, 2023 · Synced Oct 18, 2026, 5:42 AM EDT
Completed Phase 4 Interventional Results available

Liposomal Bupivacaine vs Dexamethasone ISB

NCT04047446
View directory record Official record
Conditions
Shoulder Pain
Interventions
Exparel 133 MG Per 10 ML Injection, Dexamethasone
Drug
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 1, 2022 · Synced Oct 18, 2026, 5:42 AM EDT
Enrolling by invitation Phase 2Phase 3 Interventional

Exparel vs. Marcaine ESP Block for Post-cardiac Surgical Pain

NCT06077422
View directory record Official record
Conditions
Pain, Postoperative, Opioid Use, Perioperative Complication, Heart Diseases
Interventions
bupivacaine liposome injectable suspension, Bupivacaine Hydrochloride
Drug
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Oct 18, 2026, 5:42 AM EDT
Terminated Phase 4 Interventional Results available

Phase 4 Study in Adult Subjects Undergoing Posterior Lumbar Spine Surgeries

NCT03927911
View directory record Official record
Conditions
Postoperative Pain Management
Interventions
EXPAREL and Bupivacaine, Standard of Care
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years to 75 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
12
States / cities
New Haven, Connecticut • Boca Raton, Florida • Miami, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Nov 9, 2021 · Synced Oct 18, 2026, 5:42 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Regional Anesthesia in Hip Arthroscopy

NCT02674113
View directory record Official record
Conditions
Femoroacetabular Impingement
Interventions
regional anesthesia bupivacaine, regional anesthesia placebo
Drug
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 45 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 10, 2017 · Synced Oct 18, 2026, 5:42 AM EDT
Terminated Phase 2 Interventional

"The Efficacy of Exparel Versus a Multidrug Cocktail in Soft Tissue Tumors"

NCT05355597
View directory record Official record
Conditions
Musculoskeletal Diseases, Soft Tissue Mass
Interventions
Exparel Injectable Product, Multi-Drug Cocktail (Ropivicaine, Epinephrine, Ketolorac, Clonidine)
Drug
Lead sponsor
Atlantic Health System
Other
Eligibility
18 Years and older
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Morristown, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 9, 2025 · Synced Oct 18, 2026, 5:42 AM EDT
Recruiting Not applicable Interventional

Postoperative Pain Control in AIS Using Liposomal Bupivacaine vs. 0.25% Bupivacaine With Epinephrine

NCT06471348
View directory record Official record
Conditions
Post Operative Pain, Spinal Fusion
Interventions
Bupivacaine liposome injectable suspension, Bupivacaine Hydrochloride and Epinephrine Injection
Drug
Lead sponsor
Boston Children's Hospital
Other
Eligibility
10 Years to 17 Years
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 22, 2025 · Synced Oct 18, 2026, 5:42 AM EDT
Completed Phase 4 Interventional Results available

Liposomal Bupivacaine for Post Operative Pain After Knee Replacement Surgery

NCT02274870
View directory record Official record
Conditions
Post-operative Pain
Interventions
Liposome Bupivacaine, Bupivacaine HCl
Drug
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 74 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Valley Stream, New York
Source: ClinicalTrials.gov public record
Updated Jun 14, 2018 · Synced Oct 18, 2026, 5:42 AM EDT
Completed Phase 3 Interventional Results available

Transversus Abdominis Plane Block in Microsurgical Breast Recon w/Abdominal Free Flap in Breast CA

NCT02601027
View directory record Official record
Conditions
Breast - Female
Interventions
Transversus Abdominis Plane (TAP) block, Nimbus Infusion Pump IV Administration, Bupivacaine infusion, Acetominophen, Hydromorphone, Oxycodone, Ondansetron
Procedure · Device · Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older · Female only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Sep 23, 2021 · Synced Oct 18, 2026, 5:42 AM EDT
Withdrawn Phase 4 Interventional

Exparel vs Exparel Plus ACB in TKAs

NCT02365727
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Liposomal bupivacaine, Ropivacaine, Epinephrine, Clonidine, Saline
Drug
Lead sponsor
The Hawkins Foundation
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 14, 2016 · Synced Oct 18, 2026, 5:42 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Efficacy of Rectal Infiltration of Exparel for Analgesic Benefit Following Hemorrhoidectomy

NCT02104414
View directory record Official record
Conditions
Hemorrhoid
Interventions
Exparel, Bupivacaine HCl with Epinephrine, Normal Saline
Drug
Lead sponsor
St. Luke's-Roosevelt Hospital Center
Other
Eligibility
21 Years to 65 Years
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 4, 2018 · Synced Oct 18, 2026, 5:42 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Ultrasound Guided Posterior Quadratus Lumborum Block for Postoperative Analgesia in Gynecologic Surgery

NCT04549090
View directory record Official record
Conditions
Post-operative Pain, Gynecologic Surgery, Regional Anesthesia
Interventions
QL (quadratus lumborum) block administration
Drug
Lead sponsor
Pedram Bral
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Apr 12, 2022 · Synced Oct 18, 2026, 5:42 AM EDT
Terminated Phase 4 Interventional Results available

Cranial Blocks for Postoperative Anesthesia

NCT04749797
View directory record Official record
Conditions
Craniotomy Surgery
Interventions
Liposomal bupivacaine, Bupivacaine Injection, Saline
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 13, 2023 · Synced Oct 18, 2026, 5:42 AM EDT
Terminated Early Phase 1 Interventional

Multimodal Pain Management Following Primary TKA

NCT02369523
View directory record Official record
Conditions
Pain
Interventions
Exparel, Ropivacaine cocktail (PIC), Bupivacaine
Drug
Lead sponsor
University of Utah
Other
Eligibility
40 Years to 90 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Aug 15, 2023 · Synced Oct 18, 2026, 5:42 AM EDT
Completed Not applicable Interventional Results available

Bilateral Transversus Abdominis Plane Block With Exparel Verus Continuous Epidural Analgesia With Bupivacaine

NCT02996227
View directory record Official record
Conditions
Pain, Postoperative, Major Abdominal Surgery
Interventions
TAP block, Epidural analgesia, EXPAREL, Bupivacaine
Procedure · Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 85 Years
Enrollment
514 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
2
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 31, 2024 · Synced Oct 18, 2026, 5:42 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

The Effect of Exparel on Post Operative Pain and Narcotic Use After Colon Surgery

NCT02052557
View directory record Official record
Conditions
Post-operative Pain, Colon Cancer, Diverticulitis
Interventions
Bupivacaine, Bupivacaine liposome suspension
Drug
Lead sponsor
Des Moines University
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Des Moines, Iowa
Source: ClinicalTrials.gov public record
Updated Jan 8, 2021 · Synced Oct 18, 2026, 5:42 AM EDT
Withdrawn Phase 3 Interventional

Liposomal Bupivacaine in Shoulder Arthroscopy

NCT04461028
View directory record Official record
Conditions
Rotator Cuff Tears
Interventions
Liposomal bupivacaine, Bupivacaine with Dexamethasone Solution
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 12, 2024 · Synced Oct 18, 2026, 5:42 AM EDT
Withdrawn Phase 2Phase 3 Interventional

Laparoscopic Transversus Abdominis Plane (TAP) Block to Reduce Post-operative Opioids

NCT04655339
View directory record Official record
Conditions
Opioid Use
Interventions
Bilateral abdominal Lap-TAP
Drug
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Oct 18, 2026, 5:42 AM EDT
Not listed Phase 4 Interventional

EXPAREL IPSA Block in Knee Arthroplasty

NCT06619340
View directory record Official record
Conditions
Pain, Postoperative, Osteo Arthritis Knee
Interventions
Exparel
Drug
Lead sponsor
Campbell Clinic
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Germantown, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced Oct 18, 2026, 5:42 AM EDT
Not listed Not applicable Interventional

Early Post-Operative Pain Control Following Wrist Operations

NCT02052180
View directory record Official record
Conditions
Pain
Interventions
Exparel, Marcaine (Control)
Drug
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Chattanooga, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 31, 2014 · Synced Oct 18, 2026, 5:42 AM EDT
Completed Phase 4 Interventional Results available

Genicular Nerve Blocks for Anterior Cruciate Ligament Knee Surgery

NCT05720949
View directory record Official record
Conditions
ACL, Anterior Cruciate Ligament Injuries
Interventions
Genicular Nerve Block with bupivacaine and preservative free dexamethasone
Drug
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
192 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Oct 18, 2026, 5:42 AM EDT
Withdrawn Phase 4 Interventional

Liposomal Bupivacaine Versus Standard Bupivacaine Plus Dexamethasone in Quadriceps Sparing Femoral Nerve Block and Wound Infiltration for Total Knee Arthroplasty

NCT02624856
View directory record Official record
Conditions
Osteoarthritis, Pain, Postoperative
Interventions
Liposomal bupivacaine, Bupivacaine plus dexamethasone
Drug
Lead sponsor
Albany Medical College
Other
Eligibility
40 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated Jan 23, 2020 · Synced Oct 18, 2026, 5:42 AM EDT
Active, not recruiting Phase 2 Interventional

EXPAREL or Lidocane as Local Anesthetic in Patients Undergoing Pleuroscopy With Pleural Biopsy and Indwelling Pleural Catheter Placement

NCT05044468
View directory record Official record
Conditions
Malignant Pleural Neoplasm
Interventions
Lidocaine, Liposomal Bupivacaine, Questionnaire Administration
Drug · Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2028
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 9, 2026 · Synced Oct 18, 2026, 5:42 AM EDT
Enrolling by invitation Phase 3 Interventional Accepts healthy volunteers

Efficacy of Liposomal Bupivacaine Post Septorhinoplasty

NCT05964868
View directory record Official record
Conditions
Rhinoplasty, Pain Management
Interventions
Liposomal Bupivacaine, 0.25% bupivacaine with 1:200,000 epinephrine, Placebo - Saline solution
Drug · Other
Lead sponsor
Jessyka Lighthall
Other
Eligibility
18 Years to 99 Years
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 3, 2026 · Synced Oct 18, 2026, 5:42 AM EDT