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ClinicalTrials.gov public records Last synced Oct 11, 2026, 6:23 PM EDT

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Showing 97–120 of 305 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Exparel + Bupivacaine Clear all
Completed Phase 4 Interventional Results available

TAP-patients With Robotic Assisted Lap Prostatectomy

NCT01582477
View directory record Official record
Conditions
Postsurgical Pain, Analgesia, Prostatectomy
Interventions
EXPAREL 20 mL, EXPAREL 40 mL
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years to 75 Years · Male only
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Brighton, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 14, 2021 · Synced Oct 11, 2026, 6:23 PM EDT
Completed Phase 4 Interventional Results available

Comparison of Local Anesthetic Infusion Pump Versus Depofoam Bupivacaine for Pain Management

NCT04284930
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Depobupivacaine, OnQ pump, 0.25% Bupivacaine
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older · Female only
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 7, 2021 · Synced Oct 11, 2026, 6:23 PM EDT
Completed Phase 1 Interventional

Study to Evaluate the Pharmacokinetics, Pharmacodynamics and Safety, of EXPAREL Administered as Sciatic Nerve Block (In Popliteal Fossa), for Postsurgical Analgesia in Subjects Undergoing Bunionectomy

NCT04002089
View directory record Official record
Conditions
Bunion
Interventions
Exparel Injectable Product, Bupivacaine
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Bellaire, Texas
Source: ClinicalTrials.gov public record
Updated Jan 11, 2021 · Synced Oct 11, 2026, 6:23 PM EDT
Completed Phase 4 Interventional Results available

Adult Patients Undergoing Open Colectomy MA402S23B303

NCT01507246
View directory record Official record
Conditions
Bowel Obstruction
Interventions
IV morphine sulfate, EXPAREL (bupivacaine liposome injectable suspension)
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Riverdale, Georgia
Source: ClinicalTrials.gov public record
Updated May 8, 2013 · Synced Oct 11, 2026, 6:23 PM EDT
Completed Phase 4 Interventional Results available

A Randomized Trial of Exparel vs Saline in Opioid Reduction of Pain Management Following Lumbar Spine Surgeries.

NCT04644796
View directory record Official record
Conditions
Lumbar Spine Degeneration
Interventions
saline 0.9%, Liposomal bupivacaine
Drug
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 13, 2023 · Synced Oct 11, 2026, 6:23 PM EDT
Completed Phase 4 Interventional Results available

The Use Of Liposomal Bupivacaine For Pain Control

NCT03722927
View directory record Official record
Conditions
Pain, Breast
Interventions
Bupivacaine, Liposomal Bupivacaine
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older · Female only
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 27, 2022 · Synced Oct 11, 2026, 6:23 PM EDT
Completed Phase 4 Interventional Results available

Comparing Local Anesthetics for TAP Block During Abdominally-based Free Flap for Breast Reconstruction

NCT03700970
View directory record Official record
Conditions
Breast Reconstruction, Anesthesia, Transverse Abdominis Plane Block
Interventions
Liposomal bupivacaine, Regular bupivacaine
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 85 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 24, 2022 · Synced Oct 11, 2026, 6:23 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Double-Blinded Randomized Controlled Study Investigating the Efficacy of Exparel (Liposomal Bupivacaine) for Postoperative Pain Relief in Mandibular Third Molar Extractions

NCT05374499
View directory record Official record
Conditions
Post Operative Pain
Interventions
Liposomal bupivacaine, 0.5% bupivacaine with 1:100,000 epinephrine
Drug
Lead sponsor
University of Southern California
Other
Eligibility
14 Years and older
Enrollment
85 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Oct 11, 2026, 6:23 PM EDT
Completed Phase 3 Interventional Results available

Erector Spinae Block Versus Surgeon Infiltration in VATS Procedures

NCT03859635
View directory record Official record
Conditions
Pain, Postoperative, Thoracic, Acute Pain
Interventions
Liposomal Bupivacaine, Bupivacaine, 0.25%, Bupivacaine, 0.5%
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 100 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 28, 2025 · Synced Oct 11, 2026, 6:23 PM EDT
Enrolling by invitation Phase 2 Interventional

Hernia Abd Wall Recons - BDE vs Exparel

NCT07518238
View directory record Official record
Conditions
BDE for Hernia Patients, Exparel for Hernia Patients
Interventions
BDE Injectable Drug, Exparel Injectable Drug
Drug
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years and older
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Oct 11, 2026, 6:23 PM EDT
Terminated Phase 4 Interventional

Liposomal Bupivacaine Infiltration vs Continuous Perineural Ropivacaine Infusion for Post-operative Pain After Total Shoulder Arthroplasty

NCT02787226
View directory record Official record
Conditions
Postoperative Pain, Shoulder Arthritis
Interventions
Liposomal Bupivacaine Infiltration, Continuous Perineural Ropivicaine Infusion
Drug
Lead sponsor
Eric Shepard
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 9, 2018 · Synced Oct 11, 2026, 6:23 PM EDT
Completed Not applicable Interventional

Interscalene Block With and Without Liposomal Bupivacaine in Shoulder Surgery

NCT03728946
View directory record Official record
Conditions
Rotator Cuff Tear, Postoperative Pain
Interventions
Liposomal Bupivacaine
Drug
Lead sponsor
Orthopaedic & Neurosurgery Specialists
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
6
States / cities
Greenwich, Connecticut • Stamford, Connecticut • Atlantis, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 24, 2020 · Synced Oct 11, 2026, 6:23 PM EDT
Recruiting Phase 3 Interventional

R.E.C.K vs Exparel in Robotic Nephrectomy

NCT07092566
View directory record Official record
Conditions
Renal Carcinoma, Nephrectomy / Methods, Pain Management
Interventions
Ropivacaine HCL, Exparel, Epinephrine, Clonidine HCL, Ketorolac
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
170 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Oct 11, 2026, 6:23 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Multimodal Orthognathic Study Comparing Use of Exparel With Standard of Care.

NCT06499181
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Liposomal bupivacaine, Bupivacain, Epinephrin
Drug
Lead sponsor
United States Naval Medical Center, San Diego
Federal
Eligibility
18 Years to 80 Years
Enrollment
86 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jul 19, 2024 · Synced Oct 11, 2026, 6:23 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Efficacy Between Serratus Plane Block And Local Infiltration In Vats

NCT03642457
View directory record Official record
Conditions
Lung Cancer
Interventions
Bupivacaine, Bupivacaine liposome
Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 75 Years
Enrollment
65 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
2
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 30, 2020 · Synced Oct 11, 2026, 6:23 PM EDT
Terminated Phase 2 Interventional Results available

Exparel Interscalene vs Indwelling Catheter

NCT03827213
View directory record Official record
Conditions
Pain
Interventions
Exparel, Indwelling Interscalene Catheter
Drug · Device
Lead sponsor
Montefiore Medical Center
Other
Eligibility
40 Years to 74 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Mar 7, 2023 · Synced Oct 11, 2026, 6:23 PM EDT
Completed No phase listed Observational Results available

Serum Levels of Bupivacaine in Autotransfusion Drains Following Total Joint Arthroplasty

NCT02276040
View directory record Official record
Conditions
Knee Pain Arthritis
Interventions
periarticular bupivicaine and liposomal bupivicaine
Drug
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
4
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 30, 2017 · Synced Oct 11, 2026, 6:23 PM EDT
Completed Phase 4 Interventional Results available

Pharmacokinetic Evaluation of EXPAREL in Adults Undergoing Tonsillectomy

NCT02199574
View directory record Official record
Conditions
Pain
Interventions
EXPAREL
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
2
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 8, 2021 · Synced Oct 11, 2026, 6:23 PM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Liposomal Bupivacaine Vs Bupivacaine with Dexmedetomidine in Erector Spinae Plane Blocks for Mastectomies

NCT06252662
View directory record Official record
Conditions
Breast Cancer
Interventions
Dexmedetomidine, Liposomal bupivacaine
Drug
Lead sponsor
United States Naval Medical Center, Portsmouth
Federal
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Portsmouth, Virginia
Source: ClinicalTrials.gov public record
Updated Nov 19, 2024 · Synced Oct 11, 2026, 6:23 PM EDT
Completed Phase 4 Interventional Results available

Exparel vs. Bupivacaine Hydrochloride vs. Placebo for Hernia Repair

NCT03541941
View directory record Official record
Conditions
Analgesia, Postoperative
Interventions
Exparel, Bupivacaine Hcl 0.25% Inj, Placebo
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
164 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 12, 2021 · Synced Oct 11, 2026, 6:23 PM EDT
Completed Phase 4 Interventional Results available

Liposomal Bupivacaine (Exparel) for Postoperative Pain Control for Open and Laparoscopic Abdominal Hernia Repair

NCT02128646
View directory record Official record
Conditions
Pain
Interventions
EXPAREL, Ketorolac, laparoscopic abdominal hernia repair, an open surgery for abdominal hernia repair
Drug · Procedure
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Sep 10, 2025 · Synced Oct 11, 2026, 6:23 PM EDT
Enrolling by invitation Phase 3 Interventional Accepts healthy volunteers

RCT to Test Regional Anesthesia Effect on Decreased Opiate Use

NCT06989866
View directory record Official record
Conditions
Postoperative Pain
Interventions
Bupivacaine, Saline (NaCl 0,9 %) (placebo)
Drug
Lead sponsor
United States Naval Medical Center, Portsmouth
Federal
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Portsmouth, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 9, 2025 · Synced Oct 11, 2026, 6:23 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Regional Anesthesia in Hip Arthroscopy

NCT02674113
View directory record Official record
Conditions
Femoroacetabular Impingement
Interventions
regional anesthesia bupivacaine, regional anesthesia placebo
Drug
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 45 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 10, 2017 · Synced Oct 11, 2026, 6:23 PM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Exparel v Dexamethasone in RCR

NCT06575010
View directory record Official record
Conditions
Rotator Cuff Tears, Postoperative Pain
Interventions
Liposomal bupivacaine, Bupivacaine Hcl 0.5% Inj, Dexamethasone
Drug
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 28, 2024 · Synced Oct 11, 2026, 6:23 PM EDT