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ClinicalTrials.gov public records Last synced Nov 6, 2026, 4:10 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 98 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Exparel infiltration Clear all

Conditions: Pain, Postoperative
Interventions: liposomal bupivicaine; Drug
Lead sponsor: United States Naval Medical Center, San Diego; Federal
Eligibility: 18 Years to 65 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: San Diego, California

Conditions: Mammoplasty, Postoperative Pain
Interventions: Instillation - EXPAREL, Infiltration - EXPAREL; Drug
Lead sponsor: Pacira Pharmaceuticals, Inc; Industry
Eligibility: 18 Years to 75 Years · Female only
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012
U.S. locations: 1
States / cities: Brighton, Massachusetts

Conditions: Rotator Cuff Tear
Interventions: EXPAREL 1.3 % in 20 ML Injection; Drug
Lead sponsor: Andrews Research & Education Foundation; Other
Eligibility: 18 Years to 72 Years
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2022
U.S. locations: 1
States / cities: Gulf Breeze, Florida

Conditions: Craniotomy Surgery
Interventions: Liposomal bupivacaine, Bupivacaine Injection, Saline; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years and older
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Bowel Obstruction
Interventions: IV morphine sulfate or Sponsor-approved equivalent, EXPAREL; Drug
Lead sponsor: Pacira Pharmaceuticals, Inc; Industry
Eligibility: 18 Years and older
Enrollment: 122 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 6
States / cities: Washington D.C., District of Columbia • Miami, Florida • Tampa, Florida + 3 more

Conditions: Rotator Cuff Tears, Shoulder Pain
Interventions: Liposomal bupivacaine, Bupivacaine Hcl 0.5% Inj, Ropivacaine 0.5% Injectable Solution, Dexamethasone; Drug
Lead sponsor: Hospital for Special Surgery Florida; Other
Eligibility: 18 Years and older
Enrollment: 92 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: West Palm Beach, Florida

Conditions: Pain, Postoperative, Arthroplasty, Replacement, Knee, Osteoarthritis
Interventions: Liposomal bupivacaine, bupivacaine HCl, morphine, epinephrine, methylprednisolone; Drug
Lead sponsor: Miller Orthopedic Specialists; Other
Eligibility: 18 Years to 90 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Council Bluffs, Iowa

Conditions: Total Knee Arthroplasty
Interventions: Intra-articular Posteromedial Surgeon Administered (IPSA) Block of EXPAREL, Adductor Canal Block (ACB) and Local Local Infiltration Analgesia of EXPAREL, Local Infiltration Analgesia (LIA) of EXPAREL; Procedure
Lead sponsor: The Cleveland Clinic; Other
Eligibility: Not listed
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Pain, Postoperative
Interventions: Liposomal Injection Bupivacaine (Exparel), Standard bupivicaine; Drug
Lead sponsor: Emory University; Other
Eligibility: 18 Years and older
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 3
States / cities: Atlanta, Georgia

Conditions: Postoperative Pain, Cesarean Section
Interventions: Liposomal bupivacaine, Bupivacaine HCl; Drug
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older · Female only
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Charlotte, North Carolina

Conditions: Pain
Interventions: EXPAREL; Drug
Lead sponsor: Michael Moncure, MD; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Kansas City, Kansas

Conditions: Low Back Pain, Lumbosacral Radiculopathy, Lumbar Disc Degeneration, Lumbar Disc Herniation, Stenosis, Spondylolisthesis, Spondylolysis, Deformity of Spine
Interventions: Exparel, Bupivacaine; Drug
Lead sponsor: Virtua Health, Inc.; Other
Eligibility: 18 Years and older
Enrollment: 19 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Mount Holly, New Jersey

Conditions: ACL Repair
Interventions: Cryoneurolysis; Procedure
Lead sponsor: Virtua Health, Inc.; Other
Eligibility: 14 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 2
States / cities: Burlington, New Jersey • Cherry Hill, New Jersey

Conditions: Pain
Interventions: Intrathecal morphine injection, EXPAREL; Drug
Lead sponsor: Pacira Pharmaceuticals, Inc; Industry
Eligibility: 18 Years and older · Female only
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015
U.S. locations: 5
States / cities: Port Saint Lucie, Florida • Minneapolis, Minnesota • New Brunswick, New Jersey + 2 more

Conditions: Pain
Interventions: Bupivacaine SNB, EXPAREL Infiltration; Drug
Lead sponsor: Pacira Pharmaceuticals, Inc; Industry
Eligibility: 18 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2015
U.S. locations: 2
States / cities: Sheffield, Alabama • Minneapolis, Minnesota

Conditions: Breast Cancer
Interventions: Liposomal bupivacaine, Bupivacaine, epinephrine, dexamethasone, and clonidine; Drug
Lead sponsor: Tufts Medical Center; Other
Eligibility: 18 Years to 75 Years
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Postoperative Pain
Interventions: Bupivacaine HCl, SKY0402; Drug
Lead sponsor: Pacira Pharmaceuticals, Inc; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 138 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2009
U.S. locations: 6
States / cities: Birmingham, Alabama • Davis, California • Laguna Hills, California + 3 more

Conditions: Urologic Diseases, Hypospadias, Undescended Testes, Chordee, Hydrocele, Orchiectomy
Interventions: Exparel 133 miligrams per 10 milliliter injection, Bupivacaine Hydrochloride; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 6 Years and older
Enrollment: 104 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Pain
Interventions: EXPAREL, Bupivacaine; Drug
Lead sponsor: Pacira Pharmaceuticals, Inc; Industry
Eligibility: 18 Years and older · Male only
Enrollment: 140 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 17
States / cities: Fremont, California • Loma Linda, California • Fort Lauderdale, Florida + 13 more

Conditions: Osteoarthritis, Pain, Postoperative
Interventions: Liposomal bupivacaine, Bupivacaine plus dexamethasone; Drug
Lead sponsor: Albany Medical College; Other
Eligibility: 40 Years to 70 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: Albany, New York

Conditions: Pain Management, Analgesia, Anesthetic
Interventions: Opioids delivered through PCA, EXPAREL® infiltration; Drug
Lead sponsor: University of Miami; Other
Eligibility: 18 Years to 65 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Postoperative Pain Management
Interventions: Exparel, 0.5% Bupivacaine HCl; Drug
Lead sponsor: Pacira Pharmaceuticals, Inc; Industry
Eligibility: 6 Years to 17 Years
Enrollment: 98 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019
U.S. locations: 17
States / cities: Loma Linda, California • Sacramento, California • Stanford, California + 14 more

Conditions: Retraction of Colostomy
Interventions: Group 1 Standard of Care, Group 2 EXPAREL; Drug
Lead sponsor: Pacira Pharmaceuticals, Inc; Industry
Eligibility: 18 Years and older
Enrollment: 47 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012
U.S. locations: 2
States / cities: Weston, Florida • Beachwood, Ohio

Conditions: Total Knee Arthroplasty
Interventions: Peripheral nerve blocks with Bupivacaine, Intra articular injection with Ropivacaine, Intra articular injection with liposomal bupivacaine; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 165 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Rochester, Minnesota

Search by objective public record fields.

Trial of Liposomal Versus Plain Bupivacaine in Minimally Invasive General Surgery Procedures

Study of EXPAREL in Patients Undergoing Breast Augmentation

The Effect of EXPAREL® on Postsurgical Pain, and the Use of Narcotics

Cranial Blocks for Postoperative Anesthesia

A Health Economic Trial in Adult Patients Undergoing Laparoscopic Colectomy

Liposomal Bupivacaine Plus Bupivacaine Peripheral Nerve Blockade Versus Ropivacaine Plus Dexamethasone Peripheral Nerve Blockade for Arthroscopic Rotator Cuff Repair

Liposomal Bupivacaine in Total Knee Arthroplasty

Effectiveness of Exparel Anesthetic Administered by the Surgeon During Knee Surgery

Exparel vs. Standard Bupivicaine for Abdominoplasty

Liposomal Bupivacaine + Bupivacaine vs. Bupivacaine Alone on Opioid Use After Elective c/Section

Exparel for Pain Control During Care of Rib Fractures

A Prospective Study to Compare Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Pain Relief

The Effect of Pre-Operative Cryoneurolysis on Post-Operative Narcotic Consumption in Patients Undergoing Autograft ACL Reconstruction

Evaluation of the Safety and Efficacy of EXPAREL When Administered Into the TAP in Subjects Undergoing Cesarean Section

Pharmacokinetics and Safety of Bupivacaine HCl Spinal Block and EXPAREL Local Infiltration in Total Knee Arthroplasty

RCT Comparing ESPB Solutions in Breast Surgery

Dose-Ranging Study for Prolonged Postoperative Analgesia in Subject Undergoing Total Knee Arthroplasty

Opioid Reduction Initiative During Outpatient Pediatric Urologic Procedures Using Exparel

Local Infiltration Analgesia With and Without EXPAREL Following Total Knee Arthroplasty

Liposomal Bupivacaine Versus Standard Bupivacaine Plus Dexamethasone in Quadriceps Sparing Femoral Nerve Block and Wound Infiltration for Total Knee Arthroplasty

Post-Operative Pain Management Following Spine Surgery

Multicenter Study for Pediatric Subjects Evaluating Pharmacokinetics and Safety of EXPAREL

A Health Economic Trial in Adult Patients Undergoing Ileostomy Reversal MA402S23B501

Peripheral Nerve Blocks vs Periarticular Local Anesthetic Injection for Total Knee Arthroplasty (TKA)