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Showing 1–15 of 15 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Experimental plus Nicotine Replacement Therapy Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Randomized Clinical Trial to Reduce Harm From Tobacco

NCT02328794
View directory record Official record
Conditions
Smoking Cessation
Interventions
E-cigarette free access, E-cigarette/NRT/Zyban/Chantix Choice, Outcome Incentive arm, Loss framing incentive arm, Control
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 99 Years
Enrollment
6,006 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 1, 2017 · Synced Sep 17, 2026, 12:02 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Twitter-enabled Mobile Messaging for Smoking Relapse Prevention (Tweet2Quit)

NCT02823028
View directory record Official record
Conditions
Smoking Cessation
Interventions
NRT, Web Guide, Tweet2Quit
Drug · Behavioral
Lead sponsor
University of California, Irvine
Other
Eligibility
21 Years to 59 Years
Enrollment
980 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
2
States / cities
Irvine, California • Stanford, California
Source: ClinicalTrials.gov public record
Updated Nov 20, 2024 · Synced Sep 17, 2026, 12:02 PM EDT
Completed Phase 2 Interventional Results available

Do Treatments for Smoking Cessation Affect Alcohol Drinking? Study 1: Nicotine Replacement Therapy

NCT00699556
View directory record Official record
Conditions
Alcohol Drinking
Interventions
21mg transdermal nicotine patch (Nicoderm CQ), 1mg nicotine nasal spray, placebo nasal spray
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2016
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 11, 2018 · Synced Sep 17, 2026, 12:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Improving the Reach & Effectiveness of Smoking Cessation Services Targeted to Veterans Living With HIV

NCT04505371
View directory record Official record
Conditions
HIV Infections, Smoking, Smoking Cessation
Interventions
Wellness Intervention for Smokers with HIV
Behavioral
Lead sponsor
Seattle Institute for Biomedical and Clinical Research
Other
Eligibility
18 Years and older
Enrollment
235 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 30, 2026 · Synced Sep 17, 2026, 12:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

YMCA Exercise Intervention for Smoking Cessation Study

NCT03080090
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Aerobic exercise, Smoking Cessation Intervention
Behavioral
Lead sponsor
Jasper A. Smits
Other
Eligibility
18 Years to 65 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Sep 17, 2026, 12:02 PM EDT
Recruiting Not applicable Interventional

Effects of Tax Proposals and Cigarette Availability on Tobacco Purchasing

NCT07142668
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Harm Reduction Tax - Normal Nicotine Cigarettes Available, Harm Reduction Tax - Normal Nicotine Cigarettes Not Available, Modified Risk Tobacco Product Tax - Normal Nicotine Cigarettes Available, Modified Risk Tobacco Product Tax - Normal Nicotine Cigarettes Not Available, Nicotine Content Tax - Normal Nicotine Cigarettes Available, Nicotine Content Tax - Normal Nicotine Cigarettes Not Available, Tobacco Parity Tax - Normal Nicotine Cigarettes Available, Tobacco Parity Tax - Normal Nicotine Cigarettes Not Available
Behavioral
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
21 Years and older
Enrollment
316 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Buffalo, New York • Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Sep 17, 2026, 12:02 PM EDT
Completed Not applicable Interventional

The Impact of Innovative Tax Proposals on Purchase Patterns

NCT05370313
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Market Price Condition (control), Tobacco Parity Tax Condition, Nicotine-Content Tax Condition, Harm-Reduction Tax Condition, Modified Risk Tobacco Product (MRTP) Tax Condition
Behavioral
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
21 Years and older
Enrollment
285 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
2
States / cities
Buffalo, New York • Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 17, 2025 · Synced Sep 17, 2026, 12:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Assessment of Biomarkers in Children to Help Parents Quit Tobacco

NCT04832659
View directory record Official record
Conditions
Tobacco Dependence
Interventions
CEASE, CEASE + BIO
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
865 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Sep 17, 2026, 12:02 PM EDT
Completed Phase 4 Interventional Results available

Helping Those With Mental Illness Quit Smoking

NCT01783912
View directory record Official record
Conditions
Smoking, Nicotine Dependence, Mental Disorders
Interventions
Cognitive / Motivational Individual Sessions, Attention Control Individual Sessions, Nicotine Patch, Group Curriculum
Behavioral · Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 99 Years
Enrollment
270 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 28, 2016 · Synced Sep 17, 2026, 12:02 PM EDT
Completed Not applicable Interventional

Web-Delivered Acceptance & Commitment Therapy for Smokers With Bipolar Disorder

NCT02750904
View directory record Official record
Conditions
Smoking, Bipolar Disorder
Interventions
Experimental plus Nicotine Replacement Therapy, Control plus Nicotine Replacement Therapy
Behavioral
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
4
States / cities
Palo Alto, California • Denver, Colorado • Bedford, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 13, 2019 · Synced Sep 17, 2026, 12:02 PM EDT
Completed Not applicable Interventional

Mobile Contingency Management for Smoking Cessation in Returning US Veterans

NCT02513069
View directory record Official record
Conditions
Smoking, Veterans
Interventions
Nicotine gum, mobile contingency management, Telephone counseling, Nicotine patch, Nicotine lozenge, Smart phone, Carbon monoxide monitor
Other · Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
291 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 20, 2020 · Synced Sep 17, 2026, 12:02 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers

Smoking Cessation Intervention

NCT03072511
View directory record Official record
Conditions
Smoking Cessation
Interventions
Spotlight on Smoke-Free Living: Mindsets and Decisions, Transdermal Nicotine Patch
Behavioral · Drug
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 22, 2020 · Synced Sep 17, 2026, 12:02 PM EDT
Completed Not applicable Interventional Results available

Kids Safe and Smokefree (KiSS)

NCT01745393
View directory record Official record
Conditions
Second Hand Tobacco Smoke, Nicotine Dependence
Interventions
Clinic Quality Improvement + Behavioral Counseling, Clinic Quality Improvement + Attention Control
Behavioral
Lead sponsor
Temple University
Other
Eligibility
18 Years and older
Enrollment
327 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
4
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 7, 2018 · Synced Sep 17, 2026, 12:02 PM EDT
Completed Phase 1Phase 2 Interventional

Positively Smoke Free on the Web (PSFW) for Smokers Living With HIV

NCT01570595
View directory record Official record
Conditions
Tobacco Use Cessation, Tobacco Cessation, Tobacco Use Disorder, Tobacco Dependence, Tobacco-Use Disorder, Virus, Human Immunodeficiency
Interventions
Web-Based Tailored Smoking Cessation Intervention, Standard of Care
Behavioral
Lead sponsor
Georgetown University
Other
Eligibility
18 Years and older
Enrollment
138 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated May 11, 2014 · Synced Sep 17, 2026, 12:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Developing Genetic Education for Smoking Cessation

NCT01186016
View directory record Official record
Conditions
Tobacco Smoking
Interventions
Genetic Education Session, Nutrition Education Session
Behavioral
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years and older
Enrollment
103 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Oct 3, 2023 · Synced Sep 17, 2026, 12:02 PM EDT