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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Withdrawn Phase 4 Interventional

Decreasing the Incidence of Delirium After Cardiac Surgery

NCT02119806
View directory record Official record
Conditions
C.Surgical Procedure; Cardiac, Delirium
Interventions
Benzodiazepine, Fentanyl, Propofol
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 11, 2018 · Synced Sep 22, 2026, 5:09 AM EDT
Terminated Phase 4 Interventional Results available

Pediatric Ketamine Study for Pain Management

NCT02388321
View directory record Official record
Conditions
Pain
Interventions
Ketamine, Fentanyl
Drug
Lead sponsor
Antonios Likourezos
Other
Eligibility
3 Years to 17 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated May 7, 2018 · Synced Sep 22, 2026, 5:09 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Staccato Fentanyl Single and Multidose PK

NCT00402350
View directory record Official record
Conditions
Breakthrough Pain
Interventions
Inhaled Placebo, Inhaled Fentanyl 25 mcg, Intravenous Fentanyl 25 mcg, Inhaled Fentanyl 25 mcg x 2, Inhaled Fentanyl 25 mcg x 4, Inhaled Fentanyl 25 mcg x 6, Inhaled Fentanyl 25 mcg x 12
Drug
Lead sponsor
Alexza Pharmaceuticals, Inc.
Other
Eligibility
18 Years to 55 Years
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 14, 2017 · Synced Sep 22, 2026, 5:09 AM EDT
Completed Phase 4 Interventional Results available

Optimizing Outpatient Anesthesia (OSPREy-Outpatient Surgery Pain Relief Enhancement)

NCT03726268
View directory record Official record
Conditions
Opioid Use, Pain, Postoperative
Interventions
Methadone, Fentanyl, Hydromorphone, Morphine, Sufentanil
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 65 Years
Enrollment
907 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 18, 2025 · Synced Sep 22, 2026, 5:09 AM EDT
Completed Not applicable Interventional

TAP Versus Thoracic Epidural in Major Abdominal Resections

NCT02197988
View directory record Official record
Conditions
Malignant Neoplasm of Abdomen, Surgery
Interventions
Exparel 1.33% (20ml Volume), 0.125% bupivicaine with 2 mcg/ml Fentanyl.
Drug
Lead sponsor
Corewell Health West
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Grand Rapids, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 16, 2018 · Synced Sep 22, 2026, 5:09 AM EDT
Completed Phase 4 Interventional

Postoperative Pain Control With Fentanyl Patch in Patients Undergoing Mastectomy and TRAM or DIEP Flap Reconstruction

NCT01258296
View directory record Official record
Conditions
Postoperative Pain After Breast Reconstruction With Abdominal Flap
Interventions
Fentanyl, Inactive patch
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older · Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2007
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Dec 11, 2023 · Synced Sep 22, 2026, 5:09 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Development of an Algorithm That Predicts Hypoventilation Due to an Opioid Overdose

NCT03845699
View directory record Official record
Conditions
Drug Overdose, Opioid-Related Disorders
Interventions
Diagnostic algorithms that detects/predicts hypoventilation
Device
Lead sponsor
RTM Vital Signs, LLC
Industry
Eligibility
18 Years to 40 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 8, 2019 · Synced Sep 22, 2026, 5:09 AM EDT
Withdrawn Phase 2 Interventional Accepts healthy volunteers

Postoperative Pain and Headache After Craniotomy

NCT03908944
View directory record Official record
Conditions
Postoperative Pain
Interventions
Methadone, Standard of Care
Drug
Lead sponsor
Steven Edelstein
Other
Eligibility
18 Years to 75 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 11, 2020 · Synced Sep 22, 2026, 5:09 AM EDT
Completed Not applicable Interventional Results available

The Effect of Anesthesia on Neurodevelopmental Outcome (NDO)

NCT03882788
View directory record Official record
Conditions
Anesthesia; Adverse Effect, Congenital Heart Disease, Neurodevelopmental Disorders
Interventions
Isoflurane, Fentanyl (high dose), Fentanyl (low dose)
Drug
Lead sponsor
Stanford University
Other
Eligibility
1 Day to 36 Months
Enrollment
153 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2020
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated May 8, 2022 · Synced Sep 22, 2026, 5:09 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Anesthetic Optimization in Pediatric LeFort Surgeries

NCT05260320
View directory record Official record
Conditions
Le Fort, Pain, Postoperative
Interventions
Standardized Anesthetic Course from Premedication to Induction
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
14 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced Sep 22, 2026, 5:09 AM EDT
Withdrawn Phase 3 Interventional Accepts healthy volunteers

Parturient Controlled Epidural Analgesia (PCEA) With or Without a Basal Infusion for Early Labor

NCT00871442
View directory record Official record
Conditions
Labor Pain
Interventions
No Basal Infusion, Basal infusion, PCEA solution (bupivacaine and fentanyl)
Other · Drug
Lead sponsor
Neil Roy Connelly, MD
Other
Eligibility
18 Years to 45 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Springfield, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 17, 2015 · Synced Sep 22, 2026, 5:09 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Bupivacaine With Epidural Volume Extension

NCT03110003
View directory record Official record
Conditions
Spinal Anesthesia, Epidural; Anesthesia
Interventions
10 mg Bupivacaine, 5 mg Bupivacaine
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 18, 2018 · Synced Sep 22, 2026, 5:09 AM EDT
Completed Phase 4 Interventional Results available

Airway Responses During Desflurane Anesthesia Via a Laryngeal Mask Airway: Effects of Fentanyl Pretreatment

NCT01277861
View directory record Official record
Conditions
Administration Site Reaction
Interventions
Fentanyl
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 64 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 14, 2013 · Synced Sep 22, 2026, 5:09 AM EDT
Completed Phase 4 Interventional Results available

ACL Repair and Multimodal Analgesia

NCT01868425
View directory record Official record
Conditions
Pain
Interventions
multimodal:acetaminophen, gabapentin, ketamine, bupivacaine, placebo pills and injectables
Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 55 Years
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Mar 29, 2020 · Synced Sep 22, 2026, 5:09 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

A Pilot Study of Local Anesthesia for Inguinal Hernia Surgery in Older Adults

NCT04706026
View directory record Official record
Conditions
Inguinal Hernia, Anesthesia, Local
Interventions
Open Inguinal Hernia Repair - Local Anesthesia, Inguinal Hernia Repair - General Anesthesia
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
60 Years and older
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
3
States / cities
Dallas, Texas • Houston, Texas • Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Sep 22, 2026, 5:09 AM EDT
Completed Not applicable Interventional Results available

Compare Propofol to Fentanyl and Midazolam for Colonoscopy

NCT01488045
View directory record Official record
Conditions
Colon Cancer, Rectal Cancer, Colonic Diverticulosis
Interventions
Fentanyl, Propofol, Midazolam
Drug
Lead sponsor
Trinity Health Michigan
Other
Eligibility
18 Years and older
Enrollment
289 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 22, 2023 · Synced Sep 22, 2026, 5:09 AM EDT
Active, not recruiting Phase 4 Interventional Accepts healthy volunteers

Safety of Driving After Minor Surgery With Monitored Anesthesia Care

NCT00577200
View directory record Official record
Conditions
Minor Surgical Procedures With Monitored Anesthesia Care, Driving Performance After Minor Ambulatory Surgery
Interventions
Midazolam, Sufentanil, Propofol
Drug
Lead sponsor
Rush University Medical Center
Other
Eligibility
21 Years to 70 Years
Enrollment
625 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Sep 22, 2026, 5:09 AM EDT
Completed Not applicable Interventional

Fentanyl With or Without Bupivacaine in Reducing Pain in Patients Undergoing Video-Assisted Chest Surgery

NCT00538499
View directory record Official record
Conditions
Pain, Perioperative/Postoperative Complications
Interventions
Fentanyl citrate, Bupivacaine hydrocloride, videothoracoscopy
Drug · Procedure
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
Up to 120 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2009
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Feb 8, 2017 · Synced Sep 22, 2026, 5:09 AM EDT
Completed Early Phase 1 Interventional

Improving Pain and Reducing Opioid Use (IPaRO) in Lumbar Spine Surgery Patients

NCT03088306
View directory record Official record
Conditions
Lumbar Spinal Stenosis, Lumbar Spinal Instability, Lumbar Spine Degeneration
Interventions
Standard analgesia use [Oxygen], Standard analgesia use [Hydromorphone], Standard analgesia use [Volatile Anesthesia], Standard analgesia use [Fentanyl], Multi-modal pain management [Acetaminophen + Gabapentin], Multi-modal pain management [Fentanyl], Multi-modal pain management [Intravenous Ketamine], Multi-modal pain management [Valium + Gabapentin]
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 100 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 15, 2018 · Synced Sep 22, 2026, 5:09 AM EDT
Completed Phase 4 Interventional Results available

Labetalol and Esmolol: Vital Signs and Post Operative Pain Management

NCT01114971
View directory record Official record
Conditions
Laparoscopic Surgery
Interventions
Fentanyl, Labetalol, Esmolol
Drug
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2018
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 19, 2020 · Synced Sep 22, 2026, 5:09 AM EDT
Withdrawn Not applicable Interventional

The Effect of Ketamine in the Prevention of Hypoventilation in Patients Undergoing Deep Sedation Using Propofol and Fentanyl

NCT01825083
View directory record Official record
Conditions
Hypercarbia
Interventions
Ketamine, Placebo
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 64 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
Ends 2014
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 7, 2014 · Synced Sep 22, 2026, 5:09 AM EDT
Completed Phase 2 Interventional Results available

Multiple Dose Safety and Efficacy Study Evaluating CNS 7056 Versus Midazolam in Patients Undergoing Colonoscopy

NCT01145222
View directory record Official record
Conditions
Sedation
Interventions
A. CNS 7056, B. CNS 7056, C. CNS 7056, D. Midazolam
Drug
Lead sponsor
Paion UK Ltd.
Industry
Eligibility
18 Years to 70 Years
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
9
States / cities
Sheffield, Alabama • Phoenix, Arizona • Anaheim, California + 5 more
Source: ClinicalTrials.gov public record
Updated Jan 7, 2019 · Synced Sep 22, 2026, 5:09 AM EDT
Withdrawn Phase 4 Interventional

Effect of Dexmedetomidine Upon Sleep Postoperatively

NCT00333632
View directory record Official record
Conditions
Sleep
Interventions
Dexmedetomidine, Propofol, Midazolam, Fentanyl, Isoflurane
Drug
Lead sponsor
Duke University
Other
Eligibility
21 Years to 50 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 13, 2014 · Synced Sep 22, 2026, 5:09 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Combined Ketamine/Propofol for Emergency Department Procedural Sedation

NCT01126957
View directory record Official record
Conditions
Procedural Sedation and Analgesia
Interventions
Ketamine, Placebo, Fentanyl, Propofol
Drug
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
1 Year and older
Enrollment
107 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2010
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 23, 2023 · Synced Sep 22, 2026, 5:09 AM EDT