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Conditions: Colorectal Cancer, Coffee, Gastrointestinal Microbiome, Stenosis, Fibrosis, Liver, Ultrasound Elastography, Proton Magnetic Resonance Spectroscopy
Interventions: Nestlé NESCAFÉ® TASTER'S CHOICE® House Blend capsule., Placebo; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Smoking
Interventions: Leading U.S. non-menthol cigarette, Leading U.S. menthol cigarette, Electronic cigarette #1, Electronic cigarette #2, Electronic cigarette #3, U.S. Market-sample electronic cigarettes; Other
Lead sponsor: R.J. Reynolds Vapor Company; Industry
Eligibility: 21 Years to 99 Years
Enrollment: 71 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Stockbridge, Georgia

Conditions: Healthy Volunteers
Interventions: Myblu flavor A_2.4, Myblu flavor B_2.4, Myblu flavor C_2.4, Myblu flavor D_2.4, Myblu flavor E_1.2, Myblu flavor F_1.2, Myblu flavor G_2.4, Myblu flavor H_2.4; Other
Lead sponsor: Fontem US LLC; Industry
Eligibility: 21 Years to 65 Years
Enrollment: 39 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Lincoln, Nebraska

Conditions: Alzheimer's Disease, Oxidative Stress, Dementia, Hyperlipidemia, Inflammation
Interventions: Fish Oil, Lipoic Acid, Fish Oil Placebo, Lipoic Acid Placebo; Dietary Supplement · Other
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 55 Years and older
Enrollment: 39 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2007
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Tobacco Use
Interventions: Test Product A, Test Product B, Test Product C, Test Product D, Test Product E, Reference Product F: Subjects' OBMST; Other
Lead sponsor: Altria Client Services LLC; Industry
Eligibility: 22 Years to 65 Years
Enrollment: 64 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 2
States / cities: Bentonville, Arkansas • Springfield, Missouri

Conditions: Smoking, Smoking Cessation
Interventions: Potentially Reduced Exposure Product (PREP): a smokeless, spit-free tobacco product; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 19 Years and older
Enrollment: 1,236 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2016
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Lifestyle, Diet, Healthy
Interventions: Diet Recommendations, Lifestyle Recommendations, Exercise Recommendations, Stress Management Recommendations, PhytoGanix (tropical fruit flavor), UltraFlora Intensive Care; Other
Lead sponsor: National University of Natural Medicine; Other
Eligibility: 50 Years to 72 Years · Male only
Enrollment: 44 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2024
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Tobacco Use Disorder
Interventions: Either normal nicotine content cigarettes (15.8mg/g) or reduced nicotine content cigarettes (0.4mg/g), E-Cigarettes; Other
Lead sponsor: Brown University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 326 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 2
States / cities: Providence, Rhode Island • Burlington, Vermont

Conditions: Tobacco Products
Interventions: Tobacco product administration and assessment; Other
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 18 Years to 21 Years
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Amino Acid Absorption
Interventions: Milk protein + GBI-30, Milk protein; Dietary Supplement
Lead sponsor: Lindenwood University; Other
Eligibility: 18 Years to 50 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019
U.S. locations: 1
States / cities: Saint Charles, Missouri

Conditions: Electronic Cigarette Use
Interventions: RELX ENDS Tobacco Flavor, RELX ENDS Menthol Flavor, RELX ENDS Tobacco and Menthol Flavors; Other
Lead sponsor: Cheerain HK Limited; Industry
Eligibility: 22 Years to 65 Years
Enrollment: 194 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2021
U.S. locations: 5
States / cities: Bentonville, Arkansas • Lexington, Kentucky • Springfield, Missouri + 2 more

Conditions: Electronic Cigarette Use
Interventions: RELX ENDS Tobacco Flavor, RELX ENDS Menthol Flavor, Usual Brand Cigarette, Nicorette White Ice Mint nicotine polacrilex gum; Other
Lead sponsor: Cheerain HK Limited; Industry
Eligibility: 22 Years to 59 Years
Enrollment: 41 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Overland Park, Kansas

Conditions: Dietary Quality, Feasibility Studies, College Student, Dietary Guidelines for Americans, Gut Microbiome, Lipid Profiles, Herbs and Spices, Acceptability, Inflammation Biomarkers, Body Composition, Anthropometrics
Interventions: Herbs and Spices Nutrition Education Program; Behavioral
Lead sponsor: University of Nevada, Las Vegas; Other
Eligibility: 18 Years to 39 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Las Vegas, Nevada

Conditions: Nicotine Dependence
Interventions: nicotine, menthol; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 30 Years
Enrollment: 57 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2016
U.S. locations: 2
States / cities: West Haven, Connecticut

Conditions: Behavior and Behavior Mechanisms, Food Habits, Feeding Behavior, Behavior
Interventions: Food Feelings, Other Feelings; Behavioral
Lead sponsor: The University of Tennessee, Knoxville; Other
Eligibility: 18 Years to 35 Years · Female only
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014
U.S. locations: 1
States / cities: Knoxville, Tennessee

Conditions: Substance-Related Disorders
Interventions: SPECTRUM cigarettes, SPECTRUM cigarettes between; Drug
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 305 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Tobacco
Interventions: Smoking Behavioral Research (IQOS), Smoking Behavioral Research (UBC); Behavioral
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 21 Years to 65 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Eye Health, Vision, Cognitive Function
Interventions: VisionPure Dietary Supplement, Placebo; Dietary Supplement
Lead sponsor: Applied Science & Performance Institute; Industry
Eligibility: 18 Years to 40 Years
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 3
States / cities: Lutz, Florida • Tampa, Florida

Conditions: Dyspepsia
Interventions: Melatonin, Placebo; Dietary Supplement
Lead sponsor: Children's Mercy Hospital Kansas City; Other
Eligibility: 8 Years to 17 Years
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Kansas City, Missouri

Conditions: Oral Bacteria Levels in the Mouth
Interventions: Total Flavor option 1, Total Flavor option 2, Placebo toothpaste: Crest Cavity Protection toothpaste; Drug
Lead sponsor: Colgate Palmolive; Industry
Eligibility: 22 Years to 58 Years
Enrollment: 128 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014
U.S. locations: 1
States / cities: Newark, New Jersey

Conditions: Auditory Perceptual Impairment, Aging
Interventions: Nicotine gum, Placebo gum; Other
Lead sponsor: University of California, Irvine; Other
Eligibility: 18 Years to 85 Years
Enrollment: 48 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Irvine, California

Conditions: Dental Plaque
Interventions: Sodium Monofluorophosphate, Triclosan/Fluoride/Copolymer; Drug
Lead sponsor: Colgate Palmolive; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 19 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008
U.S. locations: 1
States / cities: New York, New York

Conditions: Electronic Cigarette Use, Cigarette Use, Electronic, Tobacco Use, Tobacco Smoking
Interventions: JUUL ENDS 5% Virginia Tobacco, JUUL 3% Virginia Tobacco ENDS, JUUL 5% Mint ENDS, JUUL 3% Mint ENDS, JUUL 5% Menthol ENDS, JUUL 3% Menthol ENDS, JUUL 5% Mango ENDS, JUUL 3% Mango ENDS, US Cigarette, Non-menthol - Marlboro Gold King Size, US Cigarette, Menthol - Newport King Size; Other
Lead sponsor: Juul Labs, Inc.; Industry
Eligibility: 21 Years to 65 Years
Enrollment: 135 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019
U.S. locations: 3
States / cities: Secaucus, New Jersey • Charlotte, North Carolina • Raleigh, North Carolina

Conditions: Hydration
Interventions: Beverage. Incomplete block where each participant will complete 3 of the 6 possible glycerol-sodium blends in random order.; Other
Lead sponsor: PepsiCo Global R&D; Industry
Eligibility: 18 Years to 50 Years
Enrollment: 37 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: Valhalla, New York

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COffee and Metabolites Modulating the Gut MicrobiomE in Colorectal caNCER

Evaluation of Environmental Emissions From Electronic Cigarettes and Tobacco-Burning Cigarettes

A Study to Evaluate Nicotine Uptake and Biomarkers in Adult Smokers Using mybluTM Electronic Cigarettes

Fish Oil and Alpha Lipoic Acid in Treating Alzheimer's Disease

Nicotine Pharmacokinetics and Subjective Effects of Oral Nicotine Products Relative to Smokeless Tobacco in Adult Users

A Test of Short and Long Term Naturalistic Outcomes of Smokers Who Sample Smokeless Tobacco

Methylation Diet and Lifestyle Study

Low Nicotine Content Cigarettes in Vulnerable Populations: Affective Disorders

Effects of Cigar Flavors on Measures of Abuse Liability Among Young Adults

Changes in Amino Acid Absorption After Adding a Probiotic to an Acute Protein Feeding

Characterization of Product Use in Smokers Switching From Cigarettes to a RELX Electronic Nicotine Delivery System

Nicotine Uptake, Measures of Abuse Liability, and Puffing Topography With Use of RELX ENDS Products by Smokers

Feasibility and Potential Efficacy of Herbs and Spices for Improving Dietary Quality in College Students: A Pilot Study

The Effects of Menthol as Delivered by an Electronic Cigarette on the Desirability of Nicotine in Tobacco Users

Assessment of Thoughts and Feelings Occurring During and After a Meal

Abuse Liability of Reduced Nicotine Content Cigarettes Within a Complex Tobacco Marketplace

The Abuse Liability of IQOS Heated Tobacco Products Among Adults Who Smoke

The Effects of VisionPure™ on Indices of Vision Health and Cognitive Function

Melatonin in Pediatric FD Population

Clinical Investigation to Examine Toothpaste Effect on Oral Bacteria

Using Nicotine to Reverse Age-related Auditory Processing Deficits

Investigation of Dental Plaque and Gingival Index

Evaluating Selected Constituents in the Exhaled Breath Samples

Effect of Glycerol-Electrolyte Beverages on Fluid Balance in Healthy Euhydrated Men and Women at Rest